scholarly journals Long-term (≥15 years) post-treatment changes and outcome quality after Class II:1 treatment in comparison to untreated Class I controls

2017 ◽  
Vol 40 (2) ◽  
pp. 206-213 ◽  
Author(s):  
Niko C Bock ◽  
Mitra Saffar ◽  
Helge Hudel ◽  
Marjut Evälahti ◽  
Kaisa Heikinheimo ◽  
...  
Keyword(s):  
Class Ii ◽  
Post Treatment ◽  
Class I ◽  
Outcome Quality ◽  
Treatment Changes

scholarly journals Assessment of arch width changes in Class I and Class II Division 1 patients treated with fixed orthodontics

2021 ◽  
Vol 14 (1) ◽  
pp. 3-7
Author(s):  
Umesh Parajuli ◽  
Manish Bajracharya ◽  
Manju Pandey ◽  
Ima Gurung ◽  
Sapna Laxmi Tuladhar
Keyword(s):  
Study Groups ◽  
Class Ii ◽  
Cross Sectional Study ◽  
T Test ◽  
Post Treatment ◽  
Class I ◽  
Sectional Study ◽  
Cross Sectional ◽  
Arch Width ◽  
Treatment Changes

Background: The orthodontic treatment should aim to maintain the inter-canine and inter-molar width to that of the pre-treatment values. The study was conducted with objective to evaluate arch width changes in Class I and Class II patients treated with fixed orthodontics. Methods: This was a hospital-based cross-sectional study with two study groups. The first group included patients with Class I malocclusion, treated with four first premolar extractions and the second group included patients with Class II Div 1 malocclusion, treated with upper two first premolar extractions. The inter-canine and inter-molar width of the pre and post-treatment study model were measured. To compare the changes observed amongst two groups, independent samples t-test was performed. A paired sample t-test was used to evaluate the treatment changes within each group. Results: There was significant increase in inter-canine width in both maxillary and mandibular arches in both the groups. In Class I extraction group there was significant decrease in the inter-molar width in both maxillary and mandibular arches. The Class II Div1 maxillary extraction group also showed significant increase in inter-canine width in both maxillary and mandibular arches. In the same group there was decrease in post treatment Methods: This was a hospital-based cross-sectional study with two study groups. The first group included patients with Class I malocclusion, treated with four first premolar extractions and the second group included patients with Class II Div 1 malocclusion, treated with upper two first premolar extractions. The inter-canine and inter-molar width of the pre and post-treatment study model were measured. To compare the changes observed amongst two groups, independent samples t-test was performed.  A paired sample t-test was used to evaluate the treatment changes within each group. Results: There was significant increase in inter-canine width in both maxillary and mandibular arches in both the groups. In Class I extraction group there was significant decrease in the inter-molar width in both maxillary and mandibular arches. The Class II Div1 maxillary extraction group also showed significant increase in inter-canine width in both maxillary and mandibular arches. In the same group there was decrease in post-treatment inter-molar width in both arches with significant decrease in the maxillary inter-molar width. Conclusion: There was increase in inter-canine width in both Class I extraction group and Class II Div 1 maxillary extraction group with decrease in inter-molar width in both the groups.  

scholarly journals Outcome quality and long-term (≥15 years) stability after Class II:2 Herbst-multibracket appliance treatment in comparison to untreated Class I controls

2017 ◽  
Vol 40 (5) ◽  
pp. 488-495 ◽  
Author(s):  
Niko C Bock ◽  
Mitra Saffar ◽  
Helge Hudel ◽  
Marjut Evälahti ◽  
Kaisa Heikinheimo ◽  
...  
Keyword(s):  
Class Ii ◽  
Class I ◽  
Outcome Quality ◽  
Multibracket Appliance

scholarly journals Long-term skeletal effects of high-pull headgear followed by fixed appliances for the treatment of Class II malocclusions

2018 ◽  
Vol 88 (5) ◽  
pp. 530-537
Author(s):  
E. Erin Bilbo ◽  
Steven D. Marshall ◽  
Karin A. Southard ◽  
Verrasathpurush Allareddy ◽  
Nathan Holton ◽  
...  
Keyword(s):  
Class Ii ◽  
Class I ◽  
Control Group ◽  
Orthodontic Appliances ◽  
Skeletal Changes ◽  
Fixed Orthodontic Appliances ◽  
Horizontal Growth ◽  
Skeletal Effects ◽  
Fixed Appliances

ABSTRACT Objectives: The long-term skeletal effects of Class II treatment in growing individuals using high-pull facebow headgear and fixed edgewise appliances have not been reported. The purpose of this study was to evaluate the long-term skeletal effects of treatment using high-pull headgear followed by fixed orthodontic appliances compared to an untreated control group. Materials and Methods: Changes in anteroposterior and vertical cephalometric measurements of 42 Class II subjects (n = 21, mean age = 10.7 years) before treatment, after headgear correction to Class I molar relationship, after treatment with fixed appliances, and after long-term retention (mean 4.1 years), were compared to similar changes in a matched control group (n = 21, mean age = 10.9 years) by multivariable linear regression models. Results: Compared to control, the study group displayed significant long-term horizontal restriction of A-point (SNA = −1.925°, P < .0001; FH-NA = −3.042°, P < .0001; linear measurement A-point to Vertical Reference = −3.859 mm, P < .0001) and reduction of the ANB angle (−1.767°, P < .0001), with no effect on mandibular horizontal growth or maxillary and mandibular vertical skeletal changes. A-point horizontal restriction and forward mandibular horizontal growth accompanied the study group correction to Class I molar, and these changes were stable long term. Conclusions: One phase treatment for Class II malocclusion with high-pull headgear followed by fixed orthodontic appliances resulted in correction to Class I molar through restriction of horizontal maxillary growth with continued horizontal mandibular growth and vertical skeletal changes unaffected. The anteroposterior molar correction and skeletal effects of this treatment were stable long term.

Class II treatment in early mixed dentition with the eruption guidance appliance: effects and long-term stability

2019 ◽  
Vol 42 (2) ◽  
pp. 151-156 ◽  
Author(s):  
Katri Keski-Nisula ◽  
Leo Keski-Nisula ◽  
Juha Varrela
Keyword(s):  
Treatment Group ◽  
Class Ii ◽  
Post Treatment ◽  
Mixed Dentition ◽  
Term Stability ◽  
Long Term Stability ◽  
Class Ii Treatment ◽  
Significant Correction ◽  
The Mean

Summary Objectives Our aim was to analyse dentoskeletal effects and long-term stability of Class II treatment carried out with an eruption guidance appliance (EGA) in early mixed dentition. Materials and methods Sixty-five Class II patients (38 females and 27 males), treated with an EGA in early mixed dentition, were compared with 58 children (26 females and 32 males) with untreated Class II malocclusion. The mean age in the treatment group at the start (T1) and end of treatment (T2) was 5.4 years (±0.4) and 8.5 years (±0.9), respectively, and at the final examination in the early permanent dentition (T3) 16.7 years (±0.4). In the control group, the mean age at T1 and T2 were 5.1 years (±0.5) and 8.4 years (±0.5), respectively. The independent and dependent sample t-tests, Chi-square test, and Fisher’s test were used in the statistical evaluation. Results In the treatment group, the frequency of Class II decreased from 100 to 14% during the treatment (T1–T2) and a significant correction took place in all occlusal variables. At T2, the treatment and control groups showed statistically significant differences (P < 0.05) in all occlusal variables. In the treated children, mandibular length increased 5 mm more (P < 0.001) from T1 to T2 compared to the control children, and the ANB angle became significantly smaller (P = 0.006). During the post-treatment period (T2–T3), the frequency of Class II in the treatment group decreased from 14 to 2% (P < 0.05), overbite increased from 2.2 to 3.1 mm (P < 0.05), and lower crowding increased from 2to 14% (P < 0.05). Post-treatment changes in overjet and upper crowding were not statistically significant. At T3, the mean values of the SNA, SNB, and ANB angles were 83.0° (SD 3.9°), 81.3° (SD 3.8°), and 2.4° (SD 1.5°), respectively. Conclusions A clinically significant correction of the molar relationship, overjet, overbite, incisor alignment, and growth enhancement of the mandible were observed after treatment in early mixed dentition. The treatment results remained largely stable in the early permanent dentition. However, an increase was observed in overbite and lower crowding. None of the children treated in early mixed dentition needed a second treatment phase.

scholarly journals Maxillary anterior alignment stability in Class I and Class II malocclusions treated with or without extraction

2015 ◽  
Vol 86 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Willian Juarez Granucci Guirro ◽  
Karina Maria Salvatore Freitas ◽  
Guilherme Janson ◽  
Marcos Roberto de Freitas ◽  
Camila Leite Quaglio
Keyword(s):  
Class Ii ◽  
Class I ◽  
Maxillary Incisor ◽  
Class Ii Malocclusion ◽  
Group 4 ◽  
Posttreatment Period ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

ABSTRACT Objective:  To compare the postretention stability of maxillary incisors alignment in subjects with Class I and II malocclusion treated with or without extractions. Materials and Methods:  The sample comprised 103 subjects with initial maxillary anterior irregularity greater than 3 mm and was divided into four groups: group 1 comprised 19 patients with Class I malocclusion treated with nonextraction (mean initial age = 13.06 years); group 2 comprised 19 patients with Class II malocclusion treated with nonextraction (mean initial age = 12.54 years); group 3 comprised 30 patients with Class I malocclusion treated with extractions (mean initial age = 13.16 years); group 4 comprised 35 patients with Class II malocclusion treated with extractions (mean initial age = 12.99 years). Dental casts were obtained at three different stages: pretreatment (T1), posttreatment (T2), and long-term posttreatment (T3). Maxillary incisor irregularity and arch dimensions were evaluated. Intergroup comparisons were performed by one-way analysis of variance followed by Tukey tests. Results:  In the long-term posttreatment period, relapse of maxillary crowding and arch dimensions was similar in all groups. Conclusion:  Changes in maxillary anterior alignment in Class I and Class II malocclusions treated with nonextractions and with extractions were similar in the long-term posttreatment period.

Abstract 16546: Pre-Pregnancy Body Mass Index and Risk of Peripartum Cardiomyopathy and Heart Failure in the Years Following Delivery

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Yuliya Mints ◽  
Asya Lyass ◽  
Michelle D Schmiegelow ◽  
morten schou ◽  
Gunnar H Gislason ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Body Mass Index ◽  
Body Mass ◽  
Class Ii ◽  
Elevated Risk ◽  
Peripartum Cardiomyopathy ◽  
Class I ◽  
Increased Risk

Introduction: Peripartum cardiomyopathy (PPCM) is a form of systolic heart failure that occurs during pregnancy or in the early post-partum period. Obesity is known to be associated with other forms of heart failure in young adults, however it is unclear if it is also a risk factor for the development of PPCM. Objectives: To investigate the association of body mass index (BMI) with PPCM and heart failure in the years following childbirth. Methods: We conducted a retrospective review of pregnant women in the Danish National Patient Registry between 2004 - 2017. Baseline characteristics and other risk factors were obtained at the first prenatal visit (occurring at 8-11 weeks post-conception). Women were followed until the end of the study period, emigration, or death. Logistic regression was performed, adjusting for age as well as other known risk factors for PPCM. Cox proportional hazards analysis was used to assess the long-term risk of development of heart failure. Results: There were 403,820 pregnancies evaluated in 300,892 women, with an average age of 29 years. The average BMI was 24.4 kg/m2, with 21.6% classified as overweight (BMI 25 - 30 kg/m2) and 12.8% as obese (BMI > 30 kg/m2). The rate of PPCM was 0.1 per 1,000 in normal weight and overweight groups, and 0.3 per 1,000 in the obese women. After adjustment for age, ethnicity, smoking status, gestational diabetes, and presence of preeclampsia, there was a statistically significant increased risk of the development of PPCM up to 6 months after childbirth in patients who had class I (odds ratio [OR] 2.25, 95% CI 1.08-4.68) but not class II/III obesity (OR 1.63, 95% CI 0.60-4.43). This elevated risk persisted during long term follow up, with hazard ratios of 2.43 (95% CI 1.55 - 3.80) in women with class I obesity and 3.20 (95% CI 1.93 - 5.30) in women with class II/III obesity. Conclusions: High early pregnancy BMI is associated with elevated risk of development of peripartum cardiomyopathy even after adjustment for traditional risk factors. This risk of heart failure persists for several years after childbirth.

scholarly journals Clinical Evaluation of Resin-Based Composites in Posterior Restorations: 12-Month Results

2010 ◽  
Vol 04 (01) ◽  
pp. 057-065 ◽  
Author(s):  
Cigdem Celik ◽  
Neslihan Arhun ◽  
Kivanc Yamanel
Keyword(s):  
Clinical Performance ◽  
Clinical Results ◽  
Class Ii ◽  
Class I ◽  
Chi Square ◽  
Exact Test ◽  
Usphs Criteria ◽  
Nanohybrid Composite

ABSTRACTObjectives: The purpose of this study was to evaluate and compare the 12 month clinical performances of two different posterior composites in Class I and Class II restorations.Methods: Thirty-one patients (10 male, 21 female) were recruited into the study. A total of 82 Class I and Class II cavities were restored with either a nanohybrid composite (Grandio) or a low-shrinkage composite (Quixfil), using their self etch adhesives (Futura Bond and Xeno III) according to manufacturers’ instructions. The restorations were clinically evaluated 1 week after placement as baseline, and after 6 and 12 months post-operatively using modified USPHS criteria by two previously calibrated operators. Statistical analysis were performed using Pearson Chi-square and Fisher’s Exact Test (P<.05).Results: All patients attended the 12-month recall. Lack of retention was not observed in any of the restorations. With respect to color match, marginal adaptation, secondary caries and surface texture, no significant differences were found between two restorative materials tested after 12 months (P>.05). None of the restorations had marginal discoloration and anatomic form loss on the 12 month follow-up. Restorations did not exhibit post-operative sensitivity at any evaluation period.Conclusions: Clinical assessment of nanohybrid (Grandio) and low-shrinkage posterior composite (Quixfil) exhibited good clinical results with predominating alpha scores after 12 months. However; further evaluations are necessary for the long-term clinical performance of these materials. (Eur J Dent 2010;4:57-65)

scholarly journals Genetic Modification of Limbal Stem Cells to Decrease Allogeneic Immune Responses

2021 ◽  
Vol 12 ◽  
Author(s):  
Emilio Valdivia ◽  
Marina Bertolin ◽  
Claudia Breda ◽  
Marco Carvalho Oliveira ◽  
Anna Katharina Salz ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
Genetic Modification ◽  
Hla Class I ◽  
Class Ii ◽  
Class I ◽  
Limbal Stem Cells ◽  
Term Survival ◽  
Efficient Treatment

Limbal stem cell (LSC) transplantation is the only efficient treatment for patients affected by LSC deficiency (LSCD). Allogeneic LSC transplantation is one of the most successful alternative for patients with bilateral LSCD. Nevertheless, the high variability of the human leukocyte antigens (HLA) remains a relevant obstacle to long-term allogeneic graft survival. This study characterized the immunologic properties of LSCs and proposed a genetic engineering strategy to reduce the immunogenicity of LSCs and of their derivatives. Hence, LSC HLA expression was silenced using lentiviral vectors encoding for short hairpin (sh) RNAs targeting β2-microglobulin (β2M) or class II major histocompatibility complex transactivator (CIITA) to silence HLA class I and II respectively. Beside the constitutive expression of HLA class I, LSCs showed the capability to upregulate HLA class II expression under inflammatory conditions. Furthermore, LSCs demonstrated the capability to induce T-cell mediated immune responses. LSCs phenotypical and functional characteristics are not disturbed after genetic modification. However, HLA silenced LSC showed to prevent T cell activation, proliferation and cytotoxicity in comparison to fully HLA-expressing LSCs. Additionally; HLA-silenced LSCs were protected against antibody-mediated cellular-dependent cytotoxicity. Our data is a proof-of-concept of the feasibility to generate low immunogenic human LSCs without affecting their typical features. The use of low immunogenic LSCs may support for long-term survival of LSCs and their derivatives after allogeneic transplantation.

Sign in / Sign up

Export Citation Format

Share Document