scholarly journals Surprises in cardiology: efficacy of gliflozines in heart failure even in the absence of diabetes

2021 ◽  
Vol 23 (Supplement_E) ◽  
pp. E40-E44
Author(s):  
Alessio Bragagni ◽  
Federica Piani ◽  
Claudio Borghi
Keyword(s):  
Heart Failure ◽  
Glycaemic Control ◽  
Type Ii Diabetes ◽  
Radical Change ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
The Past ◽  
Patients With Heart Failure ◽  
Diabetic Population ◽  
Innovative Drugs

Abstract It is now well-established that the therapy of type II diabetes mellitus has undergone a radical change in the past 15 years: countless innovative drugs, such as SGLT2I, able to guarantee an optimization of glycaemic control without causing hypoglycaemia, today represent real therapeutic cornerstones not only for the intrinsic ability of these molecules to ensure better glycaemic control but also for the effects they exert on the cardiovascular system. Several pioneering clinical trials, such as EMPA-REG, CANVAS, and DECLARE-TIMI-58, have demonstrated clear benefits of empagliflozin, canagliflozin, and dapagliflozin, respectively, in reducing cardiovascular risk and diabetes-associated macrovascular complications in the diabetic population. The promising results that emerged from these trials represent the spark that triggered a series of studies aimed at evaluating the efficacy of gliflozines in the treatment of patients with heart failure even in the absence of diabetes. Preliminary results confirm the efficacy of SGLT2I in the treatment of this population, representing a real therapeutic revolution.

scholarly journals Ossification of the Posterior Longitudinal Ligament

2003 ◽  
Vol 30 (1) ◽  
pp. 61-62
Author(s):  
A.P. Mitha ◽  
J.H. Wong ◽  
S.J. du Plessis
Keyword(s):  
Diabetes Mellitus ◽  
Neck Pain ◽  
Type Ii Diabetes ◽  
Posterior Longitudinal Ligament ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Past Medical History ◽  
The Past ◽  
Chinese Descent ◽  
History Of

A 51-year-old gentleman of Chinese descent presented for neurological evaluation following a two-year history of cervical neck pain associated with left arm numbness. His symptoms were initially stable, but had progressed over the past six months to include weakness of his entire left arm and leg and symptoms of bladder urgency. Two weeks prior to presentation, he suffered repeated falls due to worsening gait difficulties. The past medical history was significant for type II diabetes mellitus.

scholarly journals Burning issues in the prevention of heart failure

2019 ◽  
Vol 61 (4) ◽  
pp. 11-12
Author(s):  
J. A. Ker ◽  
K. Outhoff
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Lifestyle Interventions ◽  
Clinical Question ◽  
Type Ii ◽  
Treatment Of Hypertension ◽  
Lack Of Exercise ◽  
The Impact

Chronic heart failure is common, debilitating, and often the culmination of pervasive cardiovascular insults that systematically undermine the heart’s circulatory capacity and invoke counterproductive neuro-hormonal compensatory changes. Prevention of chronic heart failure therefore requires minimising the impact of traditional cardiovascular risk factors with incisive treatment of hypertension and type II Diabetes Mellitus (T2DM) and prompt lifestyle interventions for smoking, lack of exercise, obesity and hypercholesterolemia. This review is narrative, with selected emphasis on major studies, rather than structured on a specific clinical question, and should be read as such.

Type II Diabetes Mellitus Is a Risk Factor for Heart Failure in Pre-Dialysis Patients

2012 ◽  
Vol 16 (6) ◽  
pp. 541-547 ◽  
Author(s):  
Michio Kuwahara ◽  
Junichi Ishigami ◽  
Satomi Shikuma ◽  
Wataru Akita ◽  
Yoshihiro Mori ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Risk Factor ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Dialysis Patients

Type II diabetes mellitus, congestive heart failure, and zinc metabolism

1993 ◽  
Vol 39 (2-3) ◽  
pp. 171-175 ◽  
Author(s):  
Ahuva Golik ◽  
Nathan Cohen ◽  
Yoram Ramot ◽  
Joseph Maor ◽  
Rita Moses ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Congestive Heart Failure ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Zinc Metabolism ◽  
Type Ii

scholarly journals Erythromycin improves glycaemic control in patients with Type II diabetes mellitus

Diabetologia ◽  
2000 ◽  
Vol 43 (4) ◽  
pp. 411-415 ◽  
Author(s):  
N. Ueno ◽  
A. Inui ◽  
A. Asakawa ◽  
F. Takao ◽  
S. Tani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glycaemic Control ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii

scholarly journals Asymptomatic bacteriuria and its associated factors in type II diabetes mellitus

2017 ◽  
Vol 4 (6) ◽  
pp. 1633
Author(s):  
Dinesh Gurjar ◽  
Akash Mathur ◽  
Ramkrishna Sai ◽  
Arvind Lakesar ◽  
Puneet Saxena
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Asymptomatic Bacteriuria ◽  
Type Ii Diabetes Mellitus ◽  
Control Group ◽  
Healthy Controls ◽  
Type Ii ◽  
E Coli ◽  
Diabetic Population ◽  
Culture Negative

Background: With the dawn of modern era the diabetes epidemic has spread over continents affecting the developed and the developing nations alike. Asymptomatic bacteriuria which is quite prevalent in the diabetic population is associated with increased diabetic complications and thereby increased morbidity. Thus, the aim of this study was to assess the proportion of cases with asymptomatic bacteriuria (ASB) among type II diabetes mellitus patients as compared to non-diabetic healthy controls and studying the factors associated with ASB.Methods: 93 eligible type II diabetes mellitus cases without genitourinary symptoms or abnormalities along with 93 non-diabetic healthy controls were recruited. Mid-stream urine was collected after taking informed consent and each sample tested using the dipstick, microscopy and culture techniques. Isolates were identified using standard biochemical tests.Results: Prevalence of ASB in our study was found to be 34.4% among cases of type II diabetes mellitus while it was 6.45% among non-diabetic healthy controls. Amongst the diabetics with ASB 71.9 % were females and 28.13 % were males. E. Coli was isolated in 21 subjects among diabetic cases (22.58%) and in 5 subjects among non-diabetic healthy controls (5.38%). Fasting blood sugar (FBS) in diabetic cases group was 151.08 ± 48.16 and in control group was found to be 98.57 ± 25.95 (p<0.001). Mean duration of patients with DM who had ASB (32) was 8.46 ± 4.14 years and those who were culture negative was 4.59 ± 4.2 years (p < 0.05). 24 subjects (75%) out of 32 diabetic ASB cases had glycosuria compared to 27 subjects (44.26%) out of 61 culture negative cases (p < 0.05). 9 out of 32 (28.13%) diabetic ASB subjects had proteinuria compared to 4 out of 61 (6.56%) culture negative cases (p < 0.05).Conclusions: Overall prevalence of ASB was significantly more in diabetic population as compared to non-diabetic healthy controls (34.4% vs 6.45%). Females have an increased likelihood of developing ASB as compared to males. E. Coli was the most common pathogen isolated in ASB cases. Longer duration of diabetes and poor glycemic control are independent predictors for the development of ASB. The risk of ASB is also significantly increased in those with glycosuria and proteinuria.

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