scholarly journals Survival and prognostic factors of patients with breast cancer in the state of São Paulo

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
R J Almeida ◽  
C T M Luizaga ◽  
J Eluf-Neto ◽  
E C Pessoa ◽  
A M M Chiarotti ◽  
...  
Keyword(s):  
Public Health ◽  
Breast Cancer ◽  
Prognostic Factors ◽  
Health Problem ◽  
Public Health Problem ◽  
Sao Paulo ◽  
São Paulo ◽  
Breast Cancer Specific Survival ◽  
Cancer Specific Survival

Abstract Introduction Breast cancer is a public health problem worldwide, being the most common malignant neoplasm in the female population. Objectives To estimate 5- and 10-year breast cancer-specific survival probabilities of patients included in the hospital-based cancer registry (HBCR) of the Fundação Oncocentro de São Paulo (FOSP, in Portuguese) and to assess the prognostic factors for this neoplasm. Methods Historical cohort study that included women with breast cancer included in HBCR-FOSP and diagnosed between 2002 and 2012. The event of interest was breast cancer-specific mortality. Living cases at the end of follow-up (December 31, 2017), loss to follow-up and death other than that due to breast cancer were considered censored on the date of the last contact or date of death. Descriptive analysis and survival analysis were performed using the Kaplan-Meyer method. Survival curves were compared using the log-rank test. Hazard ratios (HR) and their 95%CI were estimated using Cox's proportional hazards model. The study was approved by the Human Research Ethics Committee of the Botucatu Medical School, São Paulo State University, Brazil. Results 53,146 cases of invasive breast cancer were registered at HBCR-FOSP between 2002-2012. The median age at diagnosis was 55.9 years. By the end of the follow-up, 20,683 patients died, and 71.4% were due to breast cancer. The 5- and 10-year breast cancer-specific survival for the entire cohort was 76.1% (95%CI 75.7-76.5%) and 64.8% (95% CI 64.2-65.3%), respectively. In the multivariate analysis, the factors associated with prognosis were age at diagnosis, year of diagnosis, educational level, clinical stage, and histological type. Conclusions These findings may contribute to the development of policies for the identification of breast tumors at earlier stages. Key messages Breast cancer is an important public health problem in Brazil and worldwide. The findings of this study may contribute to the development of public policies for the control of breast cancer in the state of São Paulo.

scholarly journals Survival and prognostic factors of breast cancer in women in the state of São Paulo

Mastology ◽  
2020 ◽  
Vol 30 (Suppl 1) ◽  
Author(s):  
Raissa Janine de Almeida ◽  
Carolina Terra de Moraes Luizaga ◽  
Cristiane Murta-Nascimento
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Clinical Stage ◽  
Sao Paulo ◽  
The State ◽  
Rank Test ◽  
São Paulo ◽  
Historical Cohort ◽  
Female Population

Introduction: Breast cancer is the first most common malignancy in the female population worldwide. Monitoring the survival of women with breast cancer has been a strategy often adopted at the international level as a measure to assess public policy progress for disease control. Objectives: To estimate the probability of five-year survival and to investigate the prognostic factors of women with breast cancer included in the São Paulo State Cancer Hospital Records Base (RHC-SP), established in 2000 and maintained by the Oncocentro Foundation of São Paulo (Fundação Oncocentro de São Paulo – FOSP). Material and methods: This is a historical cohort. The sample consisted of women with breast cancer diagnosed between 2002 and 2012 and included in the RHC-FOSP. The event studied was specific mortality from breast cancer. Live cases at the end of follow-up (December 31st, 2017), loss of follow-up and those who died from causes other than breast cancer were considered censures on the date of the last contact or date of death. Survival analysis was performed using the Kaplan-Meyer method and the survival curves were compared using the log-rank test. Hazard ratios (HR) and respective 95% confidence intervals (95%CI) were also estimated using the Cox's proportional hazards model. This study was approved by the Human Research Ethics Committee of the School of Medicine of Botucatu, UNESP. Results: In the period between 2002‒2012, 53,146 cases of invasive breast cancer were registered at RHC-FOSP. The median age of women at diagnosis was 55.9 years. By the end of the follow-up (December 31st, 2017), 20,683 patients died and 71.4% were due to breast cancer. The probability of specific survival for the entire cohort at 5 and 10 years was 76.1% (95%CI 75.7‒76.5%) and 64.8% (95%CI 64.2‒65.3%), respectively. In the multivariate analysis, the factors associated with the prognosis were: age at diagnosis, year of diagnosis, educational level, grouped clinical stage and histological type. Conclusion: Specific survival for breast cancer in the state of São Paulo is significantly associated with several characteristics. The knowledge of these characteristics can contribute to the development of public policies in the area.

scholarly journals First record on Loxosceles laeta (Nicolet, 1849) (Araneae, Sicariidae) in the West Zone of São Paulo City, São Paulo, Brazil, and considerations regarding its geographic distribution

2003 ◽  
Vol 36 (3) ◽  
pp. 425-426 ◽  
Author(s):  
Rute Maria Gonçalves-de-Andrade ◽  
Denise Vilarinho Tambourgi
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Public Health Problem ◽  
First Record ◽  
Sao Paulo ◽  
São Paulo ◽  
The West ◽  
Important Public Health Problem ◽  
Important Public Health ◽  
Loxosceles Laeta

Loxosceles laeta spiders were captured in the West zone of São Paulo City, this being the first record of the specie in this area. Since loxoscelism is an important public health problem in the South region of Brazil, it is necessary to investigate the presence of this spider in São Paulo City.

scholarly journals Urbanization and increased cases of scorpionism in Brazilian cities

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
S Zanetta ◽  
C Germino ◽  
I Rodrigues ◽  
A Waragaia
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Urban Areas ◽  
Public Health Problem ◽  
Sao Paulo ◽  
São Paulo ◽  
Urban Centers ◽  
New Public Health ◽  
Venomous Animals ◽  
Basic Sanitation

Abstract Introduction Scorpionism is a growing problem in Brazil; the hot climate in most of the country makes it suitable for the proliferation in urban and domestic regions alike. The temperatures, low levels of basic sanitation and disorganized urbanization result in an perfect environment for scorpionic accidents. Objectives Analyze the urbanization of scorpion accidents in the State of São Paulo - SSP as a public health problem. Methods Observational and descriptive study with data from the National System of Notifiable Diseases - SINAN of the Department of Health of Brazil, with direct risk calculation, from the analysis of the incidence of accidents with scorpions in urban areas of SSP, in the period from 1975 to 2019. Results In SSP, accidents with scorpions increased 642% between the years 1975 and 2019 in the most densely urbanized nuclei: the cities of São Paulo, Guarulhos, Campinas, São Bernardo do Campo and Santo André. These cases are associated with increased mortality in children and the elderly and corresponded to 56.63% of the total accidents with venomous animals in the SSP. This increase in the occurrence of scorpionic accidents is associated with the behavior of the animal, which finds conditions for its proliferation in the urban environment facilitated by the absence of predators and becomes a relevant public health problem. Conclusions Urban areas have become a propitious environment to scorpions' proliferation. Urban dynamics, garbage and other urban waste displacement, human habitation, combined with deficiencies in infrastructure and basic sanitation, created the conditions for the emergence of accidents with scorpions in urban areas as a relevant public health problem with significant mortality numbers, especially vulnerable groups of elderly people and children, in the large urban centers of SSP, Brazil. Key messages Discuss the synanthropy and proliferation of venomous animals in urban centers. New public health challenges with the change of accidents with venomous animals from rural to urban areas.

scholarly journals Evolution of bacterial meningitis diagnosis in Sao Paulo State-Brazil and future challenges

2013 ◽  
Vol 71 (9B) ◽  
pp. 672-676 ◽  
Author(s):  
Maristela Marques Salgado ◽  
Maria Gisele Goncalves ◽  
Lucila Okuyama Fukasawa ◽  
Fabio Takenori Higa ◽  
Juliana Thalita Paulino ◽  
...  
Keyword(s):  
Public Health ◽  
Bacterial Meningitis ◽  
Public Health Problem ◽  
Sao Paulo ◽  
Immunological Methods ◽  
Haemophilus Influenzae Type ◽  
Molecular Technique ◽  
São Paulo ◽  
Paulo State ◽  
São Paulo State

Bacterial meningitis (BM) is a severe disease and still represents a serious public health problem with high rates of morbidity and mortality. The most common cases of BM around the world, mainly in Brazil, have been caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae type b. Bacterial culture is the gold-standard technique for BM confirmation, but approximately 50% of suspected cases are not culture-confirmed, due to problems related to improper transportation and seeding or previous antibiotic treatment. Immunological methods present low sensitivity and have possibility of cross-reactions. Real time PCR (qPCR) is a molecular technique and has been successful used for BM diagnosis at Instituto Adolfo Lutz in São Paulo State, Brazil, since 2007. The incorporation of qPCR in the Public Health surveillance routine in our state resulted in diminishing 50% of undetermined BM cases. Our efforts are focused on qPCR implementation in the BM diagnostic routine throughout Brazil.

scholarly journals SEROPREVALENCE OF CHAGASIC INFECTION IN YOUNG INDIVIDUALS IN A BLOOD CENTER IN THE STATE OF SAO PAULO, BRAZIL

2013 ◽  
Vol 55 (4) ◽  
pp. 245-250 ◽  
Author(s):  
Elaine Cristina Navarro ◽  
Renata Leme Goto ◽  
Isabella Silva Ricoboni ◽  
Jose Eduardo Corrente ◽  
Rita Maria Saccomano Henriques ◽  
...  
Keyword(s):  
Public Health ◽  
Chagas Disease ◽  
Blood Donors ◽  
Public Health Problem ◽  
Sao Paulo ◽  
São Paulo ◽  
Blood Center ◽  
Negative Results ◽  
Central Regions ◽  
The City

SUMMARY This study aimed at estimating the number of cases of non-negative serological reactions to Chagas disease in blood donors at the Blood Center of Botucatu, São Paulo, Brazil, from 2003 to 2010 and at relating them to their cities of origin. Five hundred and seventy-four non-negative results for Chagas disease were evaluated. Of these, 371 (64.8%) were reagent, and 203 (35.4%) were inconclusive. The prevalence of Chagas disease in blood donors was 0.05%. There were, on average, 72 cases/year, and a prevalence of males was observed (64.8%). Forty-three (7.49%) individuals were 18 to 30 years old; 92 (16.02%) were 31 to 40; 147 (25.61%) 41 to 50, and 292 (50.87%) were older than 50 years. It was observed that 29.3% of females with reagent serology were at their fertile age (18 and 45 years). The majority of donors were originally from cities in the southwestern and central regions of São Paulo, but individuals from other states contributed with 20%. The provenance of most donors was the city of Botucatu/SP, followed by the city of Taquarituba/SP. Therefore, the profile of donors at this blood center favors the occurrence of a larger number of non-negative serological reactions. Although there has been a significant reduction in the number of new cases/year for this disease, it is still a public-health problem, and results suggest the need for new epidemiological assessments in the studied region.

scholarly journals Breast conserving therapy and mastectomy revisited: Breast cancer-specific survival and the influence of prognostic factors in 129,692 patients

2017 ◽  
Vol 142 (1) ◽  
pp. 165-175 ◽  
Author(s):  
Mirelle Lagendijk ◽  
Marissa C. van Maaren ◽  
Sepideh Saadatmand ◽  
Luc J.A. Strobbe ◽  
Philip M.P. Poortmans ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Breast Conserving Therapy ◽  
Breast Cancer Specific Survival ◽  
Cancer Specific Survival

scholarly journals Breast cancer among women over 75 years: an important public health problem?

2012 ◽  
Vol 22 (3) ◽  
pp. 422-424 ◽  
Author(s):  
G. van Schoor ◽  
J. D. M. Otten ◽  
G. J. den Heeten ◽  
R. Holland ◽  
M. J. M. Broeders ◽  
...  
Keyword(s):  
Public Health ◽  
Breast Cancer ◽  
Health Problem ◽  
Public Health Problem ◽  
Important Public Health Problem ◽  
Important Public Health

scholarly journals Lumpectomy Plus Tamoxifen With or Without Irradiation in Women Age 70 Years or Older With Early Breast Cancer: Long-Term Follow-Up of CALGB 9343

2013 ◽  
Vol 31 (19) ◽  
pp. 2382-2387 ◽  
Author(s):  
Kevin S. Hughes ◽  
Lauren A. Schnaper ◽  
Jennifer R. Bellon ◽  
Constance T. Cirrincione ◽  
Donald A. Berry ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Distant Metastasis ◽  
Early Stage ◽  
Breast Cancer Specific Survival ◽  
Cancer Specific Survival ◽  
Er Positive ◽  
Long Term Follow Up

Purpose To determine whether there is a benefit to adjuvant radiation therapy after breast-conserving surgery and tamoxifen in women age ≥ 70 years with early-stage breast cancer. Patients and Methods Between July 1994 and February 1999, 636 women (age ≥ 70 years) who had clinical stage I (T1N0M0 according to TNM classification) estrogen receptor (ER) –positive breast carcinoma treated by lumpectomy were randomly assigned to receive tamoxifen plus radiation therapy (TamRT; 317 women) or tamoxifen alone (Tam; 319 women). Primary end points were time to local or regional recurrence, frequency of mastectomy, breast cancer–specific survival, time to distant metastasis, and overall survival (OS). Results Median follow-up for treated patients is now 12.6 years. At 10 years, 98% of patients receiving TamRT (95% CI, 96% to 99%) compared with 90% of those receiving Tam (95% CI, 85% to 93%) were free from local and regional recurrences. There were no significant differences in time to mastectomy, time to distant metastasis, breast cancer–specific survival, or OS between the two groups. Ten-year OS was 67% (95% CI, 62% to 72%) and 66% (95% CI, 61% to 71%) in the TamRT and Tam groups, respectively. Conclusion With long-term follow-up, the previously observed small improvement in locoregional recurrence with the addition of radiation therapy remains. However, this does not translate into an advantage in OS, distant disease-free survival, or breast preservation. Depending on the value placed on local recurrence, Tam remains a reasonable option for women age ≥ 70 years with ER-positive early-stage breast cancer.

scholarly journals El estudio histopatológico del tejido de cervical y la importancia de su revisión a más niveles en el bloque de parafina para su precisión diagnóstica

Tequio ◽  
2018 ◽  
Vol 2 (4) ◽  
pp. 15-25
Author(s):  
Édgar Villegas Hinojosa ◽  
Verónica Gallegos García ◽  
Anahid Elizabeth Campuzano Barajas ◽  
Omar Medina de la Cruz ◽  
Luz Eugenia Alcántara Quintana
Keyword(s):  
Public Health ◽  
Cervical Cancer ◽  
Health Problem ◽  
Public Health Problem ◽  
Accurate Diagnosis ◽  
Histopathological Study ◽  
Cervical Biopsy ◽  
Paraffin Block ◽  
Different Levels

Cervical cancer (CeCa) is a public health problem, the prevention efforts have focused on the screening of women at risk of contracting the disease since timely prevention can predict the evolution of the disease. The purpose of the histopathological study is to provide a more accurate diagnosis in order to give guidelines on the basis of which the treatment and follow-up of the patients is planned. However, despite the certainty of the histopathological study, certain methodological improvements have been suggested in which some researches report that making cuts at different levels in the paraffin block of the cervical biopsy could increase the sensitivity of the histopathological study.

scholarly journals Serology can help in the early diagnosis of leprosy in monitoring household contacts

2015 ◽  
Vol 9 (2) ◽  
pp. 181
Author(s):  
Gabriela Tayrine CAETANO ◽  
Ludmila MOREIRA ◽  
Charles Scott FOREMAN ◽  
Lucas Henrique SAMPAIO
Keyword(s):  
Public Health ◽  
Early Diagnosis ◽  
Key Words ◽  
Health Problem ◽  
Home Visits ◽  
Public Health Problem ◽  
Household Contacts ◽  
Incident Cases ◽  
Great Step

Phenolic glycolipid antibody (PGL-I) is considered a relevant marker of leprosy. However anti PGL-I test is not been widely implemented in field situations. In this work we performed a study of examining the anti-PGL-I to HHC recruited in Anápolis, Brazil, endemic city for leprosy. They were performed three evaluations during this follow up. During this study a proportion of incident cases significantly higher (p<0.005) was detected among PGL-I positive contacts (13/108). PGL-I positive contacts presented a 6.5-fold higher risk for leprosy compared with PGL-I negative contacts. This work has shown that the majority HHC that became ill presented anti PGL-I positive before the first signs of leprosy. After this study, we uphold that home visits to find new patients among HHC and the realization of PGL-I test can be a great step to control leprosy as a public health problem in endemic locals. Key words: PGL-I; Hansen's disease; HHC.

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