scholarly journals Social patterning of inflammation over the lifecourse and its relationship with mortality

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
R Castagné ◽  
M Chadeau-Hyam ◽  
M Karimi ◽  
S Stringhini ◽  
P Vineis ◽  
...  
Keyword(s):  
Educational Attainment ◽  
Life Course ◽  
Allostatic Load ◽  
Health Behaviours ◽  
Cox Proportional Hazards ◽  
Mortality Data ◽  
Risk Of Death ◽  
The Life Course ◽  
The Impact ◽  
Physiological Systems

Abstract Background This study explores (i) the relationship between socioeconomic position (SEP) across the life course and circulating C-reactive protein (CRP), a marker of systemic inflammation, in 6 European cohort studies (in up to N = 23 008) participating in the Lifepath project and (ii) interrogate the hypothesis of a cumulative biological risk (allostatic load, AL) reflecting 4 physiological systems, including inflammation, potentially predicting future risk of death in one of the cohort. Methods First, we estimated the association between measures of three time point SEP and adulthood CRP, adjusting for health behaviours and body mass index (BMI). To mimic life course experiences, we sequentially adjusted for the chronologically ordered measures of SEP. Next we used mortality data from the 1958 British birth cohort to operationalise AL from 14 biomarkers collected at age 44. Multivariate Cox proportional hazards regression was used to estimate hazard ratios for the association between AL, biological sub-scores and individual biomarkers with mortality. Results Educational attainment was most strongly related to inflammation where low educational attainment was associated with higher log-transformed levels of CRP (β = 0.30, (0.22-0.38)). Higher AL at 44 years old was a significant predictor of mortality 11 years later (HR = 3.56 (2.3 to 5.53)). Among the four physiological systems, only the immune-inflammatory and cardiovascular sub-scores were significantly related to mortality. Conclusions Socioeconomic circumstances across the life course are associated with higher levels of inflammation in adulthood which in turn predict subsequent risk of death. But our findings also suggest that the cumulative AL measure consisting of all the biomarkers was a better measure for predicting death adding evidence on the biological embodiment in response to chronic stress, suggesting that social-to-biological processes are at play, beyond the impact of health behaviours and BMI.

scholarly journals Discrimination, Stress, and Health Across the Life Course

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 580-581
Author(s):  
Roland Thorpe ◽  
Carl Hill
Keyword(s):  
African American ◽  
Health Disparities ◽  
Depressive Symptoms ◽  
Life Course ◽  
Mortality Data ◽  
Using Data ◽  
The Life Course ◽  
The Impact ◽  
Everyday Discrimination ◽  
African American Health

Abstract There is a paucity of research that seeks to understand why race disparities in health across the life course remain elusive. Two such explanations that have been garnering attention is stress and discrimination. This symposium contains papers seeking to address the impact of discrimination or stress on African American health or health disparities across the life course. First, Nguyen and colleagues examine 1) the associations between discrimination and objective and subjective social isolation and 2) how these associations vary by age in using data from the National Survey of American Life. Discrimination was positively associated with being subjectively isolated from friends only and family only. This relationship varied by age. Discrimination did not predict objective isolation. Second, Brown examines evidence of the black-white paradox in anxiety and depressive symptoms among older adults using data from 6,019 adults ages 52+ from the 2006 HRS. After adjusting for socioeconomic factors, everyday discrimination, chronic conditions, and chronic stress, there are no black-white differences in anxiety and depressive symptoms. Third, Cobb and colleagues investigate the joint consequences of multiple dimensions of perceived discrimination on mortality risk using mortality data from the 2006-2016 HRS. The authors report the number of attributed reasons for everyday discrimination is a particularly salient risk factor for mortality in later life. This collection of papers provides insights into how discrimination or stress impacts African American health or health disparities in middle to late life.

Vaccine Coverage Across the Life Course in Michigan During the COVID-19 Pandemic: January–September 2020

2021 ◽  
pp. e1-e9
Author(s):  
Angela K. Shen ◽  
Cristi A. Bramer ◽  
Lynsey M. Kimmins ◽  
Robert Swanson ◽  
Patricia Vranesich ◽  
...  
Keyword(s):  
Life Course ◽  
Vaccination Coverage ◽  
Vaccine Coverage ◽  
Childhood Vaccination ◽  
Local Health ◽  
Immunization Registry ◽  
Immunization Services ◽  
Vaccines For Children ◽  
The Life Course ◽  
The Impact

Objectives. To assess the impact of the COVID-19 pandemic on immunization services across the life course. Methods. In this retrospective study, we used Michigan immunization registry data from 2018 through September 2020 to assess the number of vaccine doses administered, number of sites providing immunization services to the Vaccines for Children population, provider location types that administer adult vaccines, and vaccination coverage for children. Results. Of 12 004 384 individual vaccine doses assessed, 48.6%, 15.6%, and 35.8% were administered to children (aged 0–8 years), adolescents (aged 9–18 years), and adults (aged 19–105 years), respectively. Doses administered overall decreased beginning in February 2020, with peak declines observed in April 2020 (63.3%). Overall decreases in adult doses were observed in all settings except obstetrics and gynecology provider offices and pharmacies. Local health departments reported a 66.4% decrease in doses reported. For children, the total number of sites administering pediatric vaccines decreased while childhood vaccination coverage decreased 4.4% overall and 5.8% in Medicaid-enrolled children. Conclusions. The critical challenge is to return to prepandemic levels of vaccine doses administered as well as to catch up individuals for vaccinations missed. (Am J Public Health. Published online ahead of print October 7, 2021: e1–e9. https://doi.org/10.2105/AJPH.2021.306474 )

scholarly journals Ovine prenatal growth restriction impacts glucose metabolism and body composition throughout life in both sexes

Reproduction ◽  
2018 ◽  
Vol 156 (2) ◽  
pp. 103-119 ◽  
Author(s):  
Jacqueline M Wallace ◽  
John S Milne ◽  
Raymond P Aitken ◽  
Graham W Horgan ◽  
Clare L Adam
Keyword(s):  
Body Composition ◽  
Glucose Metabolism ◽  
Life Course ◽  
Growth Rates ◽  
Growth Restriction ◽  
Negative Consequences ◽  
Mineral Density ◽  
Prenatal Growth ◽  
The Life Course ◽  
The Impact

Low birthweight is a risk factor for later adverse health. Here the impact of placentally mediated prenatal growth restriction followed by postnatal nutrient abundance on growth, glucose metabolism and body composition was assessed in both sexes at key stages from birth to mid-adult life. Singleton-bearing adolescent dams were fed control or high nutrient intakes to induce normal or growth-restricted pregnancies respectively. Restricted lambs had ~40% reduced birthweight. Fractional growth rates were higher in restricted lambs of both sexes predominantly during suckling/juvenile phases. Thereafter, rates and patterns of growth differed by sex. Absolute catch-up was not achieved and restricted offspring had modestly reduced weight and stature at mid-adulthood necropsy (~109 weeks). Dual-energy X-ray absorptiometry revealed lower bone mineral density in restricted vs normal lambs at 11, 41, 64 and 107 weeks, with males > females from 41 weeks onwards. Body fat percentage was higher in females vs males throughout, in restricted vs normal lambs at weaning (both sexes) and in restricted vs normal females at mid-adulthood. Insulin secretion after glucose challenge was greater in restricted vs normal of both sexes at 7 weeks and in restricted males at 32 weeks. In both sexes, fasting glucose concentrations were greater in restricted offspring across the life course, while glucose area under the curve after challenge was higher in restricted offspring at 32, 60, 85 and 106 weeks, indicative of persistent glucose intolerance. Therefore, prenatal growth restriction has negative consequences for body composition and metabolism throughout the life course with the effects modulated by sex differences in postnatal growth rates, fat deposition and bone mass accrual.

Abstract 031: Socioeconomic Trajectories Across the Life Course and Risk of All-cause and Cardiovascular Mortality: Prospective Findings From the Moli-sani Study

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Marialaura Bonaccio ◽  
Augusto Di Castelnuovo ◽  
Simona Costanzo ◽  
Mariarosaria Persichillo ◽  
Chiara Cerletti ◽  
...  
Keyword(s):  
General Population ◽  
Educational Attainment ◽  
Life Course ◽  
Lower Risk ◽  
Cox Regression ◽  
Low Ses ◽  
Increased Risk ◽  
Higher Educational ◽  
Higher Educational Attainment ◽  
The Life Course

Introduction: A life course approach has been suggested as the most appropriated to establish the actual impact of socioeconomic status (SES) on health outcomes. Hypothesis: We assessed the hypothesis that SES trajectories from childhood to adulthood are useful to better evaluate the role of SES towards mortality risk in a large general population-based cohort. Methods: Longitudinal analysis on 22,194 subjects recruited in the general population of the Moli-sani study, Italy (2005-2010). Educational attainment (low/high) and SES in adulthood (measured by a score including occupational social class, housing and overcrowding, and dichotomized as low/high) were used to define four possible trajectories both in low and high SES in childhood (age of 8). Hazard ratios (HR) with 95% confidence intervals (95%CI) were calculated by multivariable Cox regression and competing risk models. Results: Over a median follow-up of 8.3 years (182,924 person-years), 1155 all-cause, of which 414 cardiovascular (CVD), deaths were ascertained. In the group with low SES in childhood, as opposed to those stably low (low education and low SES in adulthood), an upward in both educational attainment and material factors in adulthood was associated with lower risk of both all-cause (HR=0.64; 95%CI 0.52-0.79; Table) and CVD mortality (HR=0.62; 0.43-0.88), respectively. Subjects with high childhood SES experienced an increased risk of total and CVD death in absence of higher educational attainment despite a higher SES in adulthood (HR=1.47; 1.04-2.07 and HR=1.75;1.00-3.05, respectively) as compared to the group with both high education and high SES in adulthood. Conclusions: In conclusion, for individuals with low SES in childhood, an upward of both educational attainment and material factors over the life course is associated with lower risk of total and CVD death. In advantaged groups in childhood, lack of a higher educational attainment, rather than material factors, over the life course appears to be unfavourably associated with survival.

The Impact of Diversity on Career Transitions over the Life Course

2015 ◽  
pp. 151-185 ◽  
Author(s):  
Jenell L. S. Wittmer ◽  
Cort W. Rudolph
Keyword(s):  
Life Course ◽  
Future Research ◽  
Career Transitions ◽  
Career Trajectories ◽  
Dynamic Perspective ◽  
Societal Changes ◽  
The Life Course ◽  
The Impact ◽  
Early Developmental ◽  
Potential Mobility

There are many aspects of diversity that impact career transitions over the life course. Whereas traditional conceptualizations of career stages emphasize a clear career path for the majority of people, modern career transitions are better characterized by both the multitude and variety of potential mobility paths. Modern career trajectories have also been linked to early developmental activities, which are similarly related to increases in diversity and other societal changes. This chapter discusses the impact of different forms of diversity on career transitions from both psychological/developmental and sociological life course perspectives, as well from a dynamic perspective where one's career transitions are dictated by lesser-planned socio-contextual and personal circumstances. The authors conclude this discussion by outlining some trends that are likely to influence career development in the future, including suggestions for future research.

Environment and ageing biology

2017 ◽  
pp. 317-322
Author(s):  
Arun S. Karlamangla ◽  
Teresa E. Seeman
Keyword(s):  
Older Adults ◽  
Health Outcomes ◽  
Functional Status ◽  
Life Events ◽  
Allostatic Load ◽  
The Body ◽  
Major Life Events ◽  
Major Life ◽  
The Life Course ◽  
The Impact

Psychosocial factors over the life course and major life events are associated with the health, functional status, and survival of older adults. This chapter discusses the biological mechanisms through which these influences are thought to operate, and how life stresses might accelerate the usual ageing of biological systems. It starts with a brief description of psychosocial determinants of health and functioning before elaborating on the allostatic mechanisms by which the body adapts its internal physiological milieu in response to perceived stressors. The price paid for frequent and recurring adaptation is eventual dysregulation of the mediators of allostasis, or allostatic load. We close with a brief discussion of allostatic load links to health outcomes in older adults and potential interventions that might ameliorate the impact of psychosocial adversities on health.

scholarly journals The Impact of Multiple Dimensions of Socioeconomic Status on Physical Functioning Across the Life Course

2018 ◽  
Vol 4 ◽  
pp. 233372141879402 ◽  
Author(s):  
Grace A. Noppert ◽  
Candace S. Brown ◽  
Marianne Chanti-Ketterl ◽  
Katherine S. Hall ◽  
L. Kristin Newby ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Life Course ◽  
Physical Functioning ◽  
Multiple Dimensions ◽  
The Life Course ◽  
The Impact
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