scholarly journals The Impact of ApoE e4 Allele in the Effects of Physical Activity Interventions on Major Mobility Disability Incidence

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 145-145
Author(s):  
Erta Cenko ◽  
Todd Manini
Keyword(s):  
Physical Activity ◽  
Proportional Hazards ◽  
Intervention Group ◽  
P Value ◽  
Carrier Status ◽  
Mobility Disability ◽  
Life Study ◽  
Beneficial Effects ◽  
E4 Allele ◽  
The Impact

Abstract The apolipoprotein E (ApoE) e4 polymorphism is traditionally linked to increased rates of cognitive impairments and Alzheimer’s Disease. Recently, however, studies have connected ApoE e4 to self-reported mobility disability in those without cognitive impairment. We aimed to estimate the extent to which ApoE status is associated with incident major mobility disability (MMD) and whether it modifies the known beneficial effects of physical activity on incident MMD. Data were from 1,372 participants 70+ years old at risk for mobility impairments, enrolled in The LIFE Study. Participants were randomized to a structured physical activity (PA) or a health education program. The primary outcome was MMD, defined as the inability to walk 400 meters and measured every 6 months for an average follow-up period of 2.6 years. We used proportional hazards regression to examine the main effect of ApoE allele status and interaction with intervention group on MMD incidence. Cumulative MMD incident rates were similar in ApoE-e2 (31.46%), ApoE e3 (33.41%), and ApoE-e4 (33.33%) carriers. Compared to the common ApoE-e3, MMD risk was similar in ApoE-e2 (hazard ratio [HR], 0.945 [95%CI, 0.70-1.27], P=0.71) and ApoE-e4 carriers ([HR], 1.187 [95%CI, 0.95-1.48], P=0.41). Additionally, ApoE carrier status did not modify the positive effect that a PA intervention had on MMD risk (interaction p-value > 0.20). These results suggest that ApoE carrier status is not associated with incident mobility disability. ApoE carrier status does not impact the effect a structured PA program has on reducing the risk of MMD in older adults.

Relation between cognitive disorders and type of physical activity: Results of the FréLE cohort

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
C Dupré ◽  
N Barth ◽  
A El Moutawakkil ◽  
F Béland ◽  
F Roche ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cognitive Decline ◽  
Proportional Hazards ◽  
Cognitive Disorders ◽  
The Elderly ◽  
Cognitive Status ◽  
Global Test ◽  
Professional Activities ◽  
Beneficial Effects ◽  
The Impact

Abstract Background Few previous cohorts have studied the different type of physical activities and the degree of cognitive decline. The objective of this work was to analyze the leisure, domestic and professional activities with mild and moderate cognitive disorders in older people living in community. Methods The study used data from the longitudinal and observational study, FrèLE (FRagility: Longitudinal Study of Expressions). The collected data included: socio-demographic variables, lifestyle, and health status (frailty, comorbidities, cognitive status, depression). Cognitive decline was assessed by using: MMSE (Mini-Mental State Examination) and MoCA (Montreal Cognitive Assessment). MoCA was used with two cut-offs (26 and 17) so as to define mild and moderate cognitive disorders Physical activity was assessed by the PASE (Physical Activity Scale for the Elderly), structured in three sections: leisure, domestic and professional activities. Spline and proportional hazards regression models (Cox) were used to estimate the risk of cognitive disorders. Results At baseline, 1623 participants were included and the prevalence of cognitive disorders was 6.9% (MMSE) and 7.2% (MoCA), mild cognitive disorders was 71.3%. The mean age was 77 years, and 52% of the participants were women. After a 2 years long follow-up, we found 6.9% (MMSE) and 6% (MoCA) cognitive disorders on participants. Analyses showed that domestic activities were associated to cognitive decline (HR = 0.52 [0.28-0.94] for MMSE and HR = 0.48 [0.28-0.80] for MoCA). No association were found with leisure and professional activities, and no spline were significant with mild cognitive disorders. Conclusions Analysis showed a relationship between cognitive disorders and type of physical activity, thanks to the use of specific questionnaire of elderly and two global test of cognition. These findings will contribute to the debate on the beneficial effects of physical activity on cognition. Key messages This work allowed to compare two test of cognition and their link with physical activity. It contributes to the debate on the beneficial effects of physical activity on cognition. The work allowed us to see the effect of the different types of physical activity and the impact of the statistical method on the results.

scholarly journals The Effect of Javanese Language Videos with a Community Based Interactive Approach Method as an Educational Instrument for Knowledge, Perception, and Adherence amongst Tuberculosis Patients

Pharmacy ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 86
Author(s):  
Fauna Herawati ◽  
Yuni Megawati ◽  
Aslichah ◽  
Retnosari Andrajati ◽  
Rika Yulia
Keyword(s):  
Intervention Group ◽  
Personal Control ◽  
Control Group ◽  
P Value ◽  
Interactive Approach ◽  
Community Based ◽  
Tuberculosis Patients ◽  
Level Of Knowledge ◽  
The Impact

The long period of tuberculosis treatment causes patients to have a high risk of forgetting or stopping the medication altogether, which increases the risk of oral anti-tuberculosis drug resistance. The patient’s knowledge and perception of the disease affect the patient’s adherence to treatment. This research objective was to determine the impact of educational videos in the local language on the level of knowledge, perception, and adherence of tuberculosis patients in the Regional General Hospital (RSUD) Bangil. This quasi-experimental study design with a one-month follow-up allocated 62 respondents in the intervention group and 60 in the control group. The pre- and post-experiment levels of knowledge and perception were measured with a validated set of questions. Adherence was measured by pill counts. The results showed that the intervention increases the level of knowledge of the intervention group higher than that of the control group (p-value < 0.05) and remained high after one month of follow-up. The perceptions domains that changed after education using Javanese (Ngoko) language videos with the Community Based Interactive Approach (CBIA) method were the timeline, personal control, illness coherence, and emotional representations (p-value < 0.05). More than 95% of respondents in the intervention group take 95% of their pill compared to 58% of respondents in the control group (p-value < 0.05). Utilization of the local languages for design a community-based interactive approach to educate and communicate is important and effective.

scholarly journals Augmented Rehabilitation Program for Young Patients Following Total Hip Arthroplasty

2021 ◽  
Author(s):  
Ahmed Negm ◽  
Milad Yavarai ◽  
Gian Jhangri ◽  
Robert Haennel ◽  
Allyson Jones
Keyword(s):  
Physical Activity ◽  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Intervention Group ◽  
Young Patients ◽  
Rehabilitation Program ◽  
Control Group ◽  
Total Hip ◽  
The Impact

Abstract BackgroundThe increase rate seen in Total Hip Arthroplasty (THA) for younger patients has implications for future rehabilitation demands for primary and revision THA surgery. This study aims to determine the impact of a 6-week post-operative rehabilitation program designed for THA patients ≤ 60 years on physical activity (PA) and function compared to age- and a sex-matched control group received usual postoperative care at 12-week post-THA. MethodsIn this quasi-experimental study, a cohort of THA candidates was recruited during their 6-week postoperative visit to their surgeons. The out-patient rehabilitation program consisted of 12 structured exercise classes (2 hrs/class) over 6 weeks. Physical activity was assessed using Sense Wear Pro ArmbandTM [SWA]. Participants completed the Hip Osteoarthritis Outcome Score (HOOS), and THA satisfaction questionnaire before and immediately after the intervention. ResultsThe intervention group took significantly more steps/day at the follow-up compared to baseline. The intervention group had a higher mean change in the number of weekly PA bouts than the control group. Within the intervention groups, all HOOS subscales were significantly higher at the follow-up compared to baseline. ConclusionThe augmented rehabilitation program may have immediate effects on pain relief and symptom reduction for patients (≤60 years) following THA.

Abstract 62: The Role of Physical Activity in the Hypertension Pathway: A longitudinal pathway-based analysis across 18 years in modernizing China

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Annie Green Howard ◽  
Penny Gordon-Larsen ◽  
Amy Herring ◽  
Shufa Du ◽  
Barry Popkin
Keyword(s):  
Physical Activity ◽  
Structural Equation ◽  
Leisure Activity ◽  
Equation Model ◽  
Dietary Factors ◽  
Occupational Activity ◽  
P Value ◽  
Nutrition Survey ◽  
Middle Income ◽  
The Impact

Background: Urbanization is associated with a decline in physical activity and an increase in CVD, particularly hypertension in lower and middle income countries. We investigate the impact of modernization-related declines in physical activity and pathways through body mass to hypertension in Chinese adults. Methods: Data come from the China Health and Nutrition Survey (CHNS), a household-based study that covers 9 diverse Chinese provinces from 1991 to 2009 across eight waves of data (n=12,018 adults; aged 18-66). We used detailed activity recall across multiple domains (leisure, work, and home), 3 repeated 24-hour-dietary-recalls, measured anthropometry and blood pressure at each exam. We created a multi-level structural equation model in Mplus to estimate direct pathways from specific domains of physical activity to hypertension and indirect paths through BMI. All pathways, including pathways to physical activity domains, were adjusted for gender, age, socioeconomic factors, urbanicity and region. Hypertension-related dietary factors were included in all pathways to BMI and hypertension. Results: The impact of physical activity on hypertension was most notable in the direct pathway to hypertension. Occupational and leisure activity were significantly associated with hypertension (p-value < 0.001), and individuals who were more active were less likely to have hypertension. Estimated from this model, a typical active, highly-educated, high-income middle aged female has a 12% probability of having hypertension, compared to a 43% probability for a similar non-active woman. There was however no direct association between physical activity and BMI. Conclusions: In China, declining physical activity over 18 years of modernization is strongly and directly related to increasing hypertension prevalence, with little evidence for effects along the pathway through BMI. Given continued declines in leisure and occupational activity, it is unlikely that hypertension will decline without additional intervention.

EFFECT OF HEALTH EDUCATION ON STUDENT KNOWLEDGE IN DEALING DISASTER IN SD PADOKAN BANTUL YOGYAKARTA

2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Masta Hutasoit
Keyword(s):  
Health Education ◽  
Disaster Preparedness ◽  
Quantitative Research ◽  
Age Groups ◽  
Intervention Group ◽  
Disaster Mitigation ◽  
Control Group ◽  
P Value ◽  
Earthquake Disaster ◽  
The Impact

Background: Bantul is one of the areas in Yogyakarta that is at risk of disaster. The results of interviews with the head of SD N 2 Padokan found that the school had never had any training on disaster and not yet implemented the curriculum on disaster mitigation. Children are age groups that are very vulnerable to the impact of both physical and psychological disasters. Knowledge of disaster preparedness is important for disaster preventionThe purpose of the study: to determine the effect of health education on knowledge of student preparedness to earthquake disaster events in SD N 2 Padokan, Bantul.Method: This research is quantitative research with quasi experiment design. The design used was pre test and post test nonequivalent control group. The number of samples in the intervention group and the control group were 27 students of class V. The sampling were collected by purposive sampling according to the criteria. Methods of data collection using questionnaires and using nonparametric statistical analysis Wilcoxon with the help of SPSS v.17 for Windows program.Results: The results showed no effect of health education on earthquake disaster preparedness knowledge in SD N 2 Padokan obtained p value 0.480 with α 0.05. In the intervention group the difference of knowledge before and after is indicated by p value 0.180, while for the control group 1,000.Conclusion: there is no effect of health education on disaster preparedness knowledge in SD N 2 Padokan.  

Pharmacist-Led Transition of Care Pilot Targeting Older People After Emergency Department Discharge

2020 ◽  
Vol 35 (6) ◽  
pp. 273-282
Author(s):  
Scott M. Pearson ◽  
Anushka Tandon ◽  
Danielle R. Fixen ◽  
Sunny A. Linnebur ◽  
Gretchen M. Orosz ◽  
...  
Keyword(s):  
Emergency Department ◽  
Older People ◽  
Primary Outcome ◽  
Transitional Care ◽  
Intervention Group ◽  
Chronic Obstructive ◽  
P Value ◽  
Historical Cohort ◽  
Obstructive Pulmonary Disease ◽  
The Impact

OBJECTIVE: To evaluate the impact of a pharmacist-led transitional care intervention targeting high-risk older people after an emergency department (ED) visit.<br/> DESIGN: Retrospective cohort study of older people with ED visits prior to and during a pharmacist-led intervention.<br/> SETTING: Patients receiving primary care from the University of Colorado Health Seniors Clinic.<br/> PARTICIPANTS: The intervention cohort comprised 170 patients with an ED visit between August 18, 2018, and February 19, 2019, and the historical cohort included 166 patients with an ED visit between August 18, 2017, and February 19, 2018. All included patients either had a historical diagnosis of heart failure or chronic obstructive pulmonary disease, or they had an additional ED visit in the previous six months.<br/> INTERVENTIONS: The pilot intervention involved postED discharge telephonic outreach and assessment by a clinical pharmacist, with triaging to other staff if necessary.<br/> MAIN OUTCOME MEASURE: The primary outcome was the proportion of patients with at least one repeat ED visit, hospitalization, or death within 30 days of ED discharge. Outcome rates were also assessed at 90 days postdischarge.<br/> RESULTS: The primary outcome occurred in 21% of the historical cohort and 25% of the intervention cohort (adjusted P-value = 0.48). The incidence of the composite outcome within 90 days of ED discharge was 43% in the historical group compared with 38% in the intervention group (adjusted P-value = 0.29).<br/> CONCLUSION: A pharmacist-led telephonic intervention pilot targeting older people did not appear to have a significant effect on the composite of repeat ED visit, hospitalization, or death within 30 or 90 days of ED discharge. A limited sample size may hinder the ability to make definitive conclusions based on these findings.

scholarly journals The impact of a gender-specific physical activity intervention on the fitness and fatness profile of men in Ireland

2019 ◽  
Vol 29 (6) ◽  
pp. 1154-1160 ◽  
Author(s):  
Liam Kelly ◽  
Michael Harrison ◽  
Noel Richardson ◽  
Paula Carroll ◽  
Steve Robertson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Aerobic Fitness ◽  
Physical Activity Intervention ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Scale Up ◽  
Intervention Group ◽  
Unhealthy Lifestyle ◽  
The Impact ◽  
Gender Specific

Abstract Background Amid increasing concerns about rising obesity rates and unhealthy lifestyle behaviours, physical activity (PA) is seen as a prophylactic to many chronic conditions affecting men. Men respond best to community-based PA programmes, using gender-specific promotional and delivery strategies. ‘Men on the Move’ (MOM) was developed on this basis and targeted inactive adult men in Ireland. Methods Sedentary men (n = 927; age = 50.7 ± 10.9 years; weight = 92.7 ± 16.0 kg; METS = 6.06 ± 2.13) were recruited across eight counties: four ‘intervention group’ (IG; n = 501) and four ‘comparison-in-waiting group’ (CG; n = 426). The MOM programme involved structured group exercise twice weekly for 12 weeks (W), along with health-related workshops with the groups maintained up to 52 W. Primary outcome measures [aerobic fitness, bodyweight and waist circumference (WC)] together with self-administered questionnaires were used to gather participant data at baseline, 12, 26 and 52 W. Results Results show a net positive effect on aerobic fitness, bodyweight and WC, with significant (P &lt; 0.05) net change scores observed in the IG compared to the CG (METS: 12 W = +2.20, 26 W = +1.89, 52 W = +0.92; weight: 12 W = −1.72 kg, 26 W = −1.95 kg, 52 W = −1.89 kg; WC: 12 W = −4.54 cm, 26 W = −2.69 cm, 52 W = −3.16 cm). The corresponding reduction in cardiovascular disease risk is particularly significant in the context of a previously inactive and overweight cohort. The high ‘dropout’ (42.7% presenting at 52 W), however, is of particular concern, with ‘dropouts’ having lower levels of aerobic fitness and higher bodyweight/WC at baseline. Conclusions Notwithstanding dropout issues, findings address an important gap in public health practice by informing the translational scale-up of a small controllable gender-specific PA intervention, MOM, to a national population-based PA intervention targeting inactive men.

The impact of sorafenib on the treatment and survival of advanced hepatocellular carcinoma (HCC): Analysis of the National Cancer Database (NCDB) from 2004 to 2014.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15682-e15682
Author(s):  
Aman Opneja ◽  
Gino Cioffi ◽  
Asrar Alahmadi ◽  
Nirav Patil ◽  
David Lawrence Bajor ◽  
...  
Keyword(s):  
Proportional Hazards ◽  
Single Agent ◽  
Cox Proportional Hazards ◽  
P Value ◽  
Advanced Hepatocellular Carcinoma ◽  
Advanced Hcc ◽  
Cox Proportional Hazards Models ◽  
Before And After ◽  
Time Frames ◽  
The Impact

e15682 Background: HCC is a common cause of mortality in the U.S. among men and women (5thand 7th, respectively) with overall five-year survival of ~18%. Sorafenib was the only FDA approved therapy for advanced HCC from 2007 until 2018. This study analyzes trends in the treatment and survival of advanced HCC before and after sorafenib approval. Methods: Adult patients ( > 18 years) with diagnosis of HCC treated with only chemotherapy from 2004 – 2014 were identified in NCDB database. Comparisons were made between 3 time frames: 2004 – 2007 (pre-sorafenib), 2008 – 2011 (early sorafenib) and 2012 – 2014 (late sorafenib). Patients treated with single or multi-agent chemotherapy were analyzed. Cox proportional hazards models were used for univariate and multivariable analyses. Kaplan-Meier method was used for survival analysis. Results: The NCDB contained 33,136 patients with HCC diagnosed between 2004 – 2014 and treated with chemotherapy alone. Patients were generally men (77.4%), over the age of 50 years (92.4%), with an elevated AFP at diagnosis (64.4%), and had limited co-morbidities (76.0%, Charlson/Deyo score of 0-1). The T-stages were T1 (26.3%), T2 (20.5%), T3 (25.6%), and T4 (16.2%). The number and proportion of patients treated with single agent chemotherapy increased significantly during the study period: 2,733 (45.3%) pre-sorafenib, 9,723 (72.7%) early sorafenib, and 13,502 (86.1%) late sorafenib. The proportion of all HCC patients in the NCDB receiving only chemotherapy increased from 17.2% to 26.4% to 28.3% across the 3 time frames. The survival of patients with advanced HCC treated only with chemotherapy improved significantly in the early and late sorafenib cohorts compared to the pre-sorafenib cohort (10.3 months (95% CI: 9.8-10.6) vs. 12.3 months (12.0-12.7) vs. 15.5 months (15.1-15.9), p-value < 0.001). Age > 70 years, male sex, higher Charlson/Deyo score ( > 1), elevated AFP at diagnosis, and higher T-stage were associated with worse survival (p value < 0.001). Conclusions: The approval of sorafenib has dramatically increased the use of chemotherapy for the treatment of advanced HCC and has resulted in a significant survival advantage.

scholarly journals The Effect Of Family Psychoeducation On Social Support Among Congestive Heart Failure Patients

2020 ◽  
Vol 8 (1) ◽  
pp. 9
Author(s):  
Susanti Niman ◽  
Achir Yani S Hamid ◽  
Ice Yulia W
Keyword(s):  
Social Support ◽  
Intervention Group ◽  
Sampling Procedure ◽  
Control Group ◽  
P Value ◽  
Comprehensive Treatment ◽  
Family Psychoeducation ◽  
The Family ◽  
The Impact ◽  
Support Family

The prevalence of CHF is increasing every year. The impact of a psychosocial condition requiring comprehensive treatment for CHF in all aspects. One contributing factor to success is the involvement of the family. Purpose: This study aimed to determine the differences of social support towards clients with CHF who were receiving family psychoeducation.  Method: This study used a Quasi -experimental pre-post test without a control group”.  A sample of  25 respondents and sample retrieval techniques with a purposive sampling procedure. The instrument used was an ISSB questionnaire for measuring social support. The intervention group was provided with family psychoeducation that performed 5 sessions. Result and conclusion: The finding this study showed was a significant change before and after the family support family psychoeducation (p-value 0.00<α).  Characteristics of the family and the client is not associated with social support. Family psychoeducation research way recommended developed in a public hospital.

scholarly journals The impact of using a mobile application to improve asthma patients’ adherence to medication in Jordan

2021 ◽  
Vol 27 (3) ◽  
pp. 146045822110429
Author(s):  
Mohammad K Al-Nawayseh ◽  
Montaha AL-Iede ◽  
Eman Elayeh ◽  
Rima Hijazeen ◽  
Khaled Al Oweidat ◽  
...  
Keyword(s):  
Medication Adherence ◽  
Asthma Control ◽  
Mobile Application ◽  
Intervention Group ◽  
P Value ◽  
Asthma Control Test ◽  
Adherence To Medication ◽  
Asthma Patients ◽  
Act Score ◽  
The Impact

The main aim of this study is to assess the effectiveness of using a developed asthma mobile application to enhance medication adherence in Jordan. Asthma patients visiting outpatient respiratory clinics and using inhalers were recruited. Patients were assigned into two groups: intervention and control. The intervention group was instructed to download and use the application. Asthma control was assessed using Asthma Control Test (ACT) at baseline and at follow-up of 3 months for both groups. A total of 171 patients (control, n = 83, and intervention, n = 88) participated in the study. After 3 months of usage, patients in the intervention group achieved a significant improvement in ACT score compared to control ( p-value <0.05), and reported a significant satisfaction of the application use. Therefore, the asthma mobile application is found as an effective tool to enhance medication adherence in asthma patients.

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