scholarly journals ANALYTICAL CONSIDERATIONS OF DEVELOPING A PHENOTYPIC AGING MEASURE: THE CONCEPTUAL FRAMEWORK MUST COME FIRST!

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S579-S580
Author(s):  
Michelle Shardell ◽  
Michelle Shardell ◽  
Pei-Lun Kuo ◽  
Jennifer Schrack ◽  
Eleanor M Simonsick ◽  
...  

Abstract We propose a latent structural model framework where phenotypic aging is a latent variable influenced by chronological age, genes and environment. Within this framework, phenotypic age influences aging-related outcomes and is reflected by latent domains of aging (body composition, energetics, homeostasis, and neural functioning) reflected by biomarkers. First, we validate the framework by selecting age-associated domain-specific biomarkers and assessing internal consistency and convergent construct validity (Cronbach’s alpha). Using data from the Baltimore Longitudinal Study of Aging, within-domain Cronbach’s alphas ranged from 0.80 to 0.92, supporting convergent construct validity. Second, we evaluate two broad methods for combining biomarkers into one phenotypic age measure customized to different objectives: 1) confirmatory factor analysis of chronological age-adjusted biomarkers to create a measure to identify pleiotropic genetic and environmental mechanisms, and 2) machine-learning methods to create a measure optimizing predictive and concurrent criterion validity. This framework will enable evaluation of candidate biological mechanisms of aging.

2019 ◽  
Author(s):  
Rina PY Lai ◽  
Michelle Renee Ellefson ◽  
Claire Hughes

Executive functions and metacognition are two cognitive predictors with well-established connections to academic performance. Despite sharing several theoretical characteristics, their overlap or independence concerning multiple academic outcomes remain under-researched. To address this gap, the present study applies a latent-variable approach to test a novel theoretical model that delineates the structural link between executive functions, metacognition, and academic outcomes. In whole-class sessions, 469 children aged 9 to 14 years (M = 11.93; SD = 0.92) completed four computerized executive function tasks (inhibition, working memory, cognitive flexibility, and planning), a self-reported metacognitive monitoring questionnaire, and three standardized tests of academic ability. The results suggest that executive functions and metacognitive monitoring are not interchangeable in the educational context and that they have both shared and unique contributions to diverse academic outcomes. The findings are important for elucidating the role between two domain-general cognitive skills (executive functions and metacognition) and domain-specific academic skills.


2019 ◽  
Author(s):  
Jeffrey A. Shero ◽  
Sara Ann Hart

Using methods like linear regression or latent variable models, researchers are often interested in maximizing explained variance and identifying the importance of specific variables within their models. These models are useful for understanding general ideas and trends, but often give limited insight into the individuals within said models. Data envelopment analysis (DEA), is a method with roots in organizational management that make such insights possible. Unlike models mentioned above, DEA does not explain variance. Instead, it explains how efficiently an individual utilizes their inputs to produce outputs, and identifies which input is not being utilized optimally. This paper provides readers with a brief history and past usages of DEA from organizational management, public health, and educational administration fields, while also describing the underlying math and processes behind said model. This paper then extends the usage of this method into the psychology field using two separate studies. First, using data from the Project KIDS dataset, DEA is demonstrated using a simple view of reading framework identifying individual efficiency levels in using reading-based skills to achieve reading comprehension, determining which skills are being underutilized, and classifying and comparing new subsets of readers. Three new subsets of readers were identified using this method, with direct implications leading to more targeted interventions. Second, DEA was used to measure individuals’ efficiency in regulating aggressive behavior given specific personality traits or related skills. This study found that despite comparable levels of component skills and personality traits, significant differences were found in efficiency to regulate aggressive behavior on the basis of gender and feelings of provocation.


2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 804-805
Author(s):  
Nicole Armstrong ◽  
Jennifer Deal ◽  
Hang Wang ◽  
Jennifer Schrack ◽  
Qu Tian ◽  
...  

Abstract Individual sensory deficits have been associated with adverse outcomes, including dementia, in older adults. Using data from the Baltimore Longitudinal Study of Aging (BLSA) (N=259) and Atherosclerosis Risk in Communities Study (ARIC) (N=962), we examined the prevalence of one, two, or three sensory deficits (hearing, vision, and olfaction) among older adults ≥70 years. Any hearing loss was the most prevalent sensory deficit (70-79 year-olds: 41.3% [BLSA] and 51.2% [ARIC]; ≥80 year-olds: 82.6% [BLSA] and 74.2% [ARIC]), followed by vision loss and olfactory loss. Hearing and vision impairments were more prevalent than hearing and olfactory losses as well as vision and olfactory losses in both age groups and studies There were few people with deficits in all three senses (70-79 year-olds: 3.3% [BLSA] and 2.0% [ARIC]; ≥80 year-olds: 5.8% [BLSA] and 7.4% [ARIC]). Further research should investigate the potential impact of multisensory impairments on older adults.


2007 ◽  
Vol 97 (4) ◽  
pp. 1217-1249 ◽  
Author(s):  
Michael Conlin ◽  
Ted O'Donoghue ◽  
Timothy J Vogelsang

Evidence suggests that people understand qualitatively how tastes change over time, but underestimate the magnitudes. This evidence is limited, however, to laboratory evidence or surveys of reported happiness. We test for such projection bias in field data. Using data on catalog orders of cold-weather items, we find evidence of projection bias over the weather—specifically, people's decisions are overinfluenced by the current weather. Our estimates suggest that if the order-date temperature declines by 30°F, the return probability increases by 3.95 percent. We also estimate a structural model to measure the magnitude of the bias. (JEL D12, L81)


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Cristian Morosan ◽  
Agnes DeFranco

Purpose As social distancing procedures can be facilitated by various hotel technologies, the purpose of this paper is to investigate the extent to which consumers develop perceptions of value regarding the use of certain hotel technologies for social distancing in hotels. Design/methodology/approach Drawing from the social exchange theory, this study conceptualized the benefits of using technologies for social distancing, health risks, social rewards and privacy concerns as antecedents of value of using technologies for social distancing in hotels. The structural model was validated by using data from more than 1,000 nationwide US consumers. Findings Benefits and consumers’ privacy concerns of using technologies for social distancing in hotels were the strongest predictors of value. Social rewards also had a significant but relatively lower effect on value. Health risks was found to have no influence on value. Originality/value The study is the first to examine the role of technologies in mitigating the effects of coronavirus. Thus, it extends the information technology and hospitality literature by examining the role of these technologies in safeguarding individual and public health.


2021 ◽  
Vol 56 ◽  
pp. 0-0
Author(s):  
Claudia Bauer-Krösbacher ◽  
Josef Mazanec

Purpose. In this study, the authors explore the role of museum visitors’ perceptions and experiences of authenticity. They introduce several variants of authenticity experience and analyse how they are intertwined and feed visitor satisfaction. Method. The authors apply a multi-step model fitting and validation procedure including inferred causation methods and finite mixture modelling to verify whether the visitors’ perceptions of authenticity are subject to unobserved heterogeneity. They elaborate an Authenticity Model that demonstrates out-of-sample validity and generalisability by being exposed to new data for another cultural attraction in another city. Then, they address the heterogeneity hypothesis and evaluate it for the case study with the larger sample. Findings. In both application cases, the Sisi museum in Vienna and the Guinness Storehouse in Dublin, the empirical results support the assumed cause-effect sequence, translating high quality information display—from traditional and multimedia sources—into Perceived Authenticity and its experiential consequences such as Depth and Satisfaction. Accounting for unobserved heterogeneity detects three latent classes with segment-specific strength of relationships within the structural model. Research and conclusions limitations. The combined latent-class, structural-equation model needs validation with another sample that would have to be larger than the available Guinness database. Future studies will have to complement the purely data-driven search for heterogeneity with theory-guided reasoning about potential causes of diversity in the strength of the structural relationships. Practical implications. Cultural heritage sites are among the attractions most typical of city tourism. History tends to materialise in the artefacts accumulated by the population among the urban agglomerations, and museums are the natural places for preserving exhibits of cultural value. Authenticity must be considered an important quality assessment criterion for many visitors, whereby, the distinction between object authenticity and existential authenticity is crucial. Originality. In addition to making substantive contributions to authenticity theory, the authors also extend previous research in terms of methodological effort. Authenticity research, so far, has neither exploited inferred causation methods nor combined latent variable modelling with detecting unobserved heterogeneity. Type of paper: Research article.


Author(s):  
Yulin Yang ◽  
M Carrington Reid ◽  
Hanna Grol-Prokopczyk ◽  
Karl Pillemer

Abstract Background This study aims to better understand differing pain experiences across U.S. racial/ethnic subgroups by estimating racial-ethnic disparities in both pain intensity and domain-specific pain-related interference. To address this issue, we use a nationally-representative sample of non-Hispanic White, non-Hispanic Black, and Hispanic adults ages 50+ who report recently experiencing pain. Methods Using data from the 2010 wave of the Health and Retirement Study (HRS; N=684), we conducted a series of multivariate analyses to assess possible racial/ethnic disparities in pain intensity and seven domains of pain interference, controlling for relevant sociodemographic variables and other health problems. Results Black and Hispanic participants reported higher pain intensity than White participants after controlling for socioeconomic status (SES) and other health conditions. Both Black and Hispanic individuals reported more domain-specific pain interference in bivariate analyses. In multivariate analyses, Black (vs. White) participants reported significantly higher levels of pain interference with family-home responsibilities, occupation, sexual behavior, and daily self-care. We did not find significant Hispanic-White differences in the seven pain interference domains, nor did we find Black-White differences in three domains (recreation, social activities, and essential activities). Conclusions Our findings highlight the need for using multi-dimensional measures of pain when assessing for possible pain disparities with respect to race/ethnicity. Future studies on pain interventions should consider contextualizing the pain experience across different racial subgroups to help pain patients with diverse needs, with the ultimate goal of reducing racial/ethnic disparities in pain.


2017 ◽  
Vol 107 (3) ◽  
pp. 858-896 ◽  
Author(s):  
Manolis Galenianos ◽  
Alessandro Gavazza

We estimate a model of illicit drugs markets using data on purchases of crack cocaine. Buyers are searching for high-quality drugs, but they determine drugs' quality (i.e., their purity) only after consuming them. Hence, sellers can rip off first-time buyers or can offer higher-quality drugs to induce buyers to purchase from them again. In equilibrium, a distribution of qualities persists. The estimated model implies that if drugs were legalized, in which case purity could be regulated and hence observable, the average purity of drugs would increase by approximately 20 percent and the dispersion would decrease by approximately 80 percent. Moreover, increasing penalties may raise the purity and affordability of the drugs traded by increasing sellers' relative profitability of targeting loyal buyers versus first-time buyers. (JEL D12, K42, L15, L65)


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