Significant structural change in both O- and N-linked carbohydrate moieties of the antigenic galactomannan from Aspergillus fumigatus grown under different culture conditions

Glycobiology ◽  
2014 ◽  
Vol 25 (1) ◽  
pp. 74-87 ◽  
Author(s):  
Atsushi Kudoh ◽  
Yoshio Okawa ◽  
Nobuyuki Shibata
Keyword(s):  
Structural Change ◽  
Aspergillus Fumigatus ◽  
Culture Conditions ◽  
Significant Structural Change

From unit-and-ten to ten-before-unit order in the history of English numerals

2014 ◽  
Vol 26 (1) ◽  
pp. 21-43 ◽  
Author(s):  
Thomas Berg ◽  
Marion Neubauer
Keyword(s):  
Structural Change ◽  
Old English ◽  
Language Change ◽  
Unit Order ◽  
Low Level ◽  
Number Words ◽  
Significant Structural Change ◽  
History Of ◽  
Order Change

AbstractIn the course of its history, English underwent a significant structural change in its numeral system. The number words from 21 to 99 switched from the unit-and-ten to the ten-before-unit pattern. This change is traced on the basis of more than 800 number words. It is argued that this change, which took seven centuries to complete and in which the Old English pattern was highly persistent, can be broken down into two parts—the reordering of the units and tens and the loss of the conjoining element. Although the two steps logically belong to the same overall change, they display a remarkably disparate behavior. Whereas the reordering process affected the least frequent number words first, the deletion process affected the most frequent words first. This disparity lends support to the hypothesis that the involvement or otherwise of low-level aspects of speech determines the role of frequency in language change (Phillips, 2006). Finally, the order change is likely to be a contact-induced phenomenon and may have been facilitated by a reduction in mental cost.

Term Structure of Interest Rates with B-Spline Model during the Money-Shortage-Event in China

2014 ◽  
Vol 989-994 ◽  
pp. 5634-5637
Author(s):  
Peng Zheng ◽  
Lian Qiang Yang ◽  
Zhen Ni Dai
Keyword(s):  
Structural Change ◽  
Interest Rates ◽  
Term Structure ◽  
Yield Curves ◽  
B Spline ◽  
Parametric Test ◽  
B Splines ◽  
Price Data ◽  
Significant Structural Change ◽  
Total Test

Using the price data of bonds’ transactions during June 2013, the discounting function is fitted by non-uniform cubic B-Splines and yield curves are modeled. Models’ single parametric test and total test are both significant. Furthermore, the structural change’s test shows that there is no significant structural change between adjacent transaction days, which means that the bonds’ market is relatively steady during June 2013.

scholarly journals Inducible Cell Fusion Permits Use of Competitive Fitness Profiling in the Human Pathogenic Fungus Aspergillus fumigatus

2018 ◽  
Vol 63 (1) ◽  
Author(s):  
Darel Macdonald ◽  
Darren D. Thomson ◽  
Anna Johns ◽  
Adriana Contreras Valenzuela ◽  
Jane M. Gilsenan ◽  
...  
Keyword(s):  
Aspergillus Fumigatus ◽  
Cell Fusion ◽  
Pathogenic Fungus ◽  
Brefeldin A ◽  
Culture Conditions ◽  
Competitive Fitness ◽  
Content Type ◽  
Genetic Profiling ◽  
Standard Culture ◽  
Human Pathogenic Fungus

ABSTRACT Antifungal agents directed against novel therapeutic targets are required for treating invasive, chronic, and allergic Aspergillus infections. Competitive fitness profiling technologies have been used in a number of bacterial and yeast systems to identify druggable targets; however, the development of similar systems in filamentous fungi is complicated by the fact that they undergo cell fusion and heterokaryosis. Here, we demonstrate that cell fusion in Aspergillus fumigatus under standard culture conditions is not predominately constitutive, as with most ascomycetes, but can be induced by a range of extracellular stressors. Using this knowledge, we have developed a barcode-free genetic profiling system that permits high-throughput parallel determination of strain fitness in a collection of diploid A. fumigatus mutants. We show that heterozygous cyp51A and arf2 null mutants have reduced fitness in the presence of itraconazole and brefeldin A, respectively, and a heterozygous atp17 null mutant is resistant to brefeldin A.

scholarly journals Structural change and productivity growth in Brazil: where do we stand?

2020 ◽  
Vol 40 (2) ◽  
pp. 243-263
Author(s):  
ANDRÉ NASSIF ◽  
LUCILENE MORANDI ◽  
ELIANE ARAÚJO ◽  
CARMEM FEIJÓ
Keyword(s):  
Structural Change ◽  
Interest Rates ◽  
Labor Productivity ◽  
Productivity Growth ◽  
Labour Productivity ◽  
Trade Openness ◽  
Labor Productivity Growth ◽  
Catching Up ◽  
Significant Structural Change ◽  
Low Degree

ABSTRACT The aim of this paper is to discuss the evolution of the Brazilian labour productivity in the 1990s and 2000s to shed some light on the resilience of the Brazilian economy to recover growth. Labor productivity growth in Brazil, after showing positive annual rates between 1950 and 1979, became stagnant after 1980. Following McMillan and Rodrik’s (2011) methodology, this paper at first decompose labor productivity growth in the period 1950-2011, according to “structural change” (which is considered growth-enhancing) and “within effect” (which is growth-reducing, if not accompanied by significant structural change while the country is still pursuing its catching-up process). Next, an econometric exercised is presented to explain the determinants of the structural change component of the labour productivity since economic opening in the 1990s. The results show that the stagnation of the Brazilian productivity is explained by the overvaluation trend of the Brazilian currency, the reprimarization of the export basket, the low degree of Brazil’s trade openness and the high real interest rates prevailing in the period.

Pattern and Levels of Income among Loan Waiver Beneficiary Households in Punjab

2020 ◽  
pp. 426-431
Keyword(s):  
Structural Change ◽  
Household Income ◽  
Major Change ◽  
Primary Data ◽  
Total Income ◽  
Indian Economy ◽  
Agriculture Sector ◽  
Significant Structural Change ◽  
Average Household Income

After a major change of 1991 in the Indian economy, there is a significant structural change not only in India but also in Punjab. Productivity in agriculture has reached its peak in Punjab and now the whole agriculture sector is burdened with the crisis of stagnation, overcapitalization, indebtedness, etc. Now it would be interesting to know the pattern and levels of income. This paper is an attempt to analyze the pattern and levels of income among loan waiver beneficiary households in Punjab using primary data of 318 households. The average household income of loan waiver beneficiary households was `229072.38, while it was the highest in Mansa district, followed by Ludhiana district and Hoshiarpur district. The study found that nearly 81 percent of the total income of households comes from agricultural sources and remaining from non-agricultural sources. Further huge inequalities of income were observed among beneficiary households. Inter-district inequalities showed that the Hoshiarpur district had minimum inequalities of income.

scholarly journals Metabolites from endophytic Aspergillus fumigatus and their in vitro effect against the causal agent of tuberculosis

2018 ◽  
Vol 48 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Emily Marcele Soares SILVA ◽  
Ingrid Reis da SILVA ◽  
Mauricio Morishi OGUSKU ◽  
Clarice Maia CARVALHO ◽  
Cristina Sayuri MAKI ◽  
...  
Keyword(s):  
Aspergillus Fumigatus ◽  
Fermentation Broth ◽  
Antimicrobial Effect ◽  
Culture Conditions ◽  
Causal Agent ◽  
Flash Chromatography ◽  
Biochemical Tests ◽  
Natural Sources ◽  
Vitro Effect

ABSTRACT Tuberculosis (TB) remains one of the most deadly communicable infectious diseases, causing 1.4 million deaths in 2015 worldwide due to many conditions, including the inadequate treatment and the emergence of multidrug-resistant strains of the causal agent, Mycobacterium tuberculosis. Therefore, drugs developed from natural sources, as microorganisms and plant extracts, are a frequent target for the research and discovery of antimicrobial compounds. The current study started the characterization of compounds produced by an Aspergillus fumigatus isolated from copaíba (Copaifera multijuga) that efficiently inhibits M. tuberculosis by releasing the compounds into the fermentation broth under specific culture conditions. A preliminary assay was carried out with a correlate species, M. smegmatis, aiming to detect an antimicrobial effect related to A. fumigatus fermentation broth. The direct use of this substrate in antibiosis assays againstM. tuberculosis H37Rv strain (ATCC 27294) allowed the detection of antimicrobial activity with a minimal inhibitory concentration of 256 μg mL-1, demonstrating that purification processes developed by the Biotage Flash Chromatography System are robust and reliable techniques for purification of compounds from natural sources. Also, this chromatographic system can be used in combination with specific biochemical tests, improving the search for reliable results. We conclude that this fraction can express a broad action range, inhibiting both Mycobacterium species used as target organisms.

scholarly journals The binding of two moles of neuron-specific protein NAP22 induces a significant structural change in Ca^/CaM

2001 ◽  
Vol 41 (supplement) ◽  
pp. S98
Author(s):  
Y. Izumi ◽  
N. Hayashi ◽  
Y. Jinbo ◽  
T. Matsufuji ◽  
N. Matsushima
Keyword(s):  
Structural Change ◽  
Specific Protein ◽  
Significant Structural Change

scholarly journals Coordinated Diel Gene Expression of Cyanobacteria and Their Microbiome

2021 ◽  
Vol 9 (8) ◽  
pp. 1670
Author(s):  
Kai Wang ◽  
Xiaozhen Mou
Keyword(s):  
Gene Expression ◽  
Structural Change ◽  
Vitamin B12 ◽  
Lake Erie ◽  
Expression Patterns ◽  
Microcosm Experiment ◽  
Gene Expressions ◽  
Significant Structural Change ◽  
Set Up ◽  
Whole Water

Diel rhythms have been well recognized in cyanobacterial metabolisms. However, whether this programmed activity of cyanobacteria could elicit coordinated diel gene expressions in microorganisms (microbiome) that co-occur with cyanobacteria and how such responses in turn impact cyanobacterial metabolism are unknown. To address these questions, a microcosm experiment was set up using Lake Erie water to compare the metatranscriptomic variations of Microcystis cells alone, the microbiome alone, and these two together (whole water) over two day-night cycles. A total of 1205 Microcystis genes and 4779 microbiome genes exhibited significant diel expression patterns in the whole-water microcosm. However, when Microcystis and the microbiome were separated, only 515 Microcystis genes showed diel expression patterns. A significant structural change was not observed for the microbiome communities between the whole-water and microbiome microcosms. Correlation analyses further showed that diel expressions of carbon, nitrogen, phosphorous, and micronutrient (iron and vitamin B12) metabolizing genes were significantly coordinated between Microcystis and the microbiome in the whole-water microcosm. Our results suggest that diel fluxes of organic carbon and vitamin B12 (cobalamin) in Microcystis could cause the diel expression of microbiome genes. Meanwhile, the microbiome communities may support the growth of Microcystis by supplying them with recycled nutrients, but compete with Microcystis for iron.

Trace element immobilization by uranyl minerals in granite-hosted uranium ores: Evidences from the Xiazhuang ore field of Guangdong province, China

2007 ◽  
Vol 95 (1) ◽  
Author(s):  
Long Lu ◽  
Fanrong Chen ◽  
Rodney C. Ewing ◽  
Rucheng Wang
Keyword(s):  
Trace Elements ◽  
Structural Change ◽  
Guangdong Province ◽  
Compositional Variation ◽  
X Ray Diffraction ◽  
Ore Deposit ◽  
Geochemical Behavior ◽  
X Ray ◽  
Significant Structural Change ◽  
Diffraction Patterns

The oxidative alteration of uraninite and the fate of trace elements (Y, LREE, Zr, and Th) in a granite-hosted uranium ore deposit in north Guangdong province, China, were investigated to understand the geochemical behavior of spent UOCompositionally, the cation atomic ratios in uranyl phases often deviate considerably from their respective stoichiometric values as indicated by the nominal formulae, but the compositional variation does not result in significant structural change as indicated by X-ray diffraction patterns. This observation indicates that the structure of U

Sign in / Sign up

Export Citation Format

Share Document