scholarly journals Cumulative Histologic Inflammation Predicts Colorectal Neoplasia in Ulcerative Colitis: A Validation Study

2020 ◽  
Author(s):  
Olivia V Yvellez ◽  
Victoria Rai ◽  
Philip H Sossenheimer ◽  
John Hart ◽  
Jerrold R Turner ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Colorectal Neoplasia ◽  
Low Grade ◽  
Inflammatory Index ◽  
Surveillance Interval ◽  
Matched Case ◽  
The Mean ◽  
The University ◽  
Selection Of ◽  
Inflammatory Burden

Abstract Background Chronic inflammation in ulcerative colitis (UC) is associated with the development of colorectal neoplasia (CRN). A group at St. Mark’s Hospital reported a novel cumulative inflammatory index that predicted the development of CRN in UC patients that we validated with an independent, well-described, matched, case-controlled cohort from the University of Chicago. Methods Cumulative inflammatory burden (CIB) was calculated by summing each histological inflammatory activity (HIA) score and multiplying it by the length of the surveillance interval. Persistency was defined by the number of surveillance episodes (with a severity score >2) divided by the total number of surveillance procedures. T tests compared the mean and maximum HIA scores, assessing mean and maximum severity, CIB, and persistency. Results Sixty-two UC patients (26 patients with CRN, 36 control patients without CRN) were analyzed. Fifty-five percent were men, mean disease duration was 20.6 years, and mean age at CRN diagnosis was 43.9. Of the CRN patients, 6 (23%) had colorectal cancer, 16 (62%) had low-grade dysplasia, and 4 (15%) had indefinite dysplasia. Using mean HIA scores, we found CIB to be statistically greater in CRN patients (P = 0.04). Using maximum HIA scores, we found CIB (P = 0.02), mean severity (P = 0.03), and persistency (P = 0.01) to be significantly greater in CRN patients. Maximum severity was numerically greater for mean and maximum HIA scores but did not reach significance. Conclusion Cumulative histologic inflammation is significantly associated with the development of CRN in UC patients. This suggests a management strategy of controlling inflammation to reduce the risk of CRN and may influence the selection of surveillance intervals.

scholarly journals Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: a large single-centre study

Gut ◽  
2017 ◽  
Vol 68 (3) ◽  
pp. 414-422 ◽  
Author(s):  
Chang-Ho Ryan Choi ◽  
Ibrahim Al Bakir ◽  
Nik-Sheng (John) Ding ◽  
Gui-Han Lee ◽  
Alan Askari ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Risk Stratification ◽  
Cox Regression ◽  
Colorectal Neoplasia ◽  
Single Centre ◽  
Centre Study ◽  
Unit Increase ◽  
Single Centre Study ◽  
Microscopic Inflammation ◽  
Inflammatory Burden

ObjectiveUlcerative colitis (UC) is a dynamic disease with its severity continuously changing over time. We hypothesised that the risk of colorectal neoplasia (CRN) in UC closely follows an actuarial accumulative inflammatory burden, which is inadequately represented by current risk stratification strategies.DesignThis was a retrospective single-centre study. Patients with extensive UC who were under colonoscopic surveillance between 2003 and 2012 were studied. Each surveillance episode was scored for a severity of microscopic inflammation (0=no activity; 1=mild; 2=moderate; 3=severe activity). The cumulative inflammatory burden (CIB) was defined as sum of: average score between each pair of surveillance episodes multiplied by the surveillance interval in years. Potential predictors were correlated with CRN outcome using time-dependent Cox regression.ResultsA total of 987 patients were followed for a median of 13 years (IQR, 9-18), 97 (9.8%) of whom developed CRN. Multivariate analysis showed that the CIB was significantly associated with CRN development (HR, 2.1 per 10-unit increase in CIB (equivalent of 10, 5 or 3.3 years of continuous mild, moderate or severe active microscopic inflammation); 95% CI 1.4 to 3.0; P<0.001). Reflecting this, while inflammation severity based on the most recent colonoscopy alone was not significant (HR, 0.9 per-1-unit increase in severity; 95% CI 0.7 to 1.2; P=0.5), a mean severity score calculated from all colonoscopies performed in preceding 5 years was significantly associated with CRN risk (HR, 2.2 per-1-unit increase; 95% CI 1.6 to 3.1; P<0.001).ConclusionThe risk of CRN in UC is significantly associated with accumulative inflammatory burden. An accurate CRN risk stratification should involve assessment of multiple surveillance episodes to take this into account.

scholarly journals Relationship between egg weight, hatching weight and subsequent body weight in the Japanese quail

2020 ◽  
Vol 47 (1) ◽  
pp. 19-23
Author(s):  
V. O. Chimezie ◽  
A. A. Ademola ◽  
O. I. Alli ◽  
A. E. Jubril ◽  
B. O. Josiah
Keyword(s):  
Body Weight ◽  
Japanese Quail ◽  
Coefficient Of Determination ◽  
Egg Weight ◽  
Body Weights ◽  
The Mean ◽  
The University ◽  
Large Groups ◽  
The Relationship ◽  
Selection Of

An experiment to determine the relationship between egg weight, hatch weight and subsequent body weight of the Japanese quail was conducted. A total of 607 eggs collected over 6 days from an existing flock at the Animal Pavilion of the University of Ilorin were used for the experiment. Eggs were individually numbered, weighed and grouped into small (S) medium (M) and large (L) sized eggs based on the mean and standard deviation of the eggs. Mean egg weight were correlated and regressed with mean hatch weight and subsequent weight. Average egg weights were 10.23± 0.84g, 8.49± 0.72g and 6.94± 0.93g for the large, medium and small group respectively. The result showed relationship between egg weight and hatch weight were positive and highly significant (P < 0.01) with values of 0.973, 0.977 and 0.967 for small, medium and large groups, respectively. Relationship between hatch weights and weekly body weights were also positive and significant (P<0.01) for the medium and large groups only but decreased with age. Linear regression equation showed a significant coefficient of determination for weekly body weight using the values for small, medium and large egg weight values. The results of the study showed that egg weight can be reliably used for estimating body weight in Japanese quail and may be used as criteria for early selection of Japanese quail for body weight.

Serum tryptophan, kynurenine, phenylalanine, tyrosine and neopterin concentrations in 100 healthy blood donors

Pteridines ◽  
2015 ◽  
Vol 26 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Simon Geisler ◽  
Peter Mayersbach ◽  
Kathrin Becker ◽  
Harald Schennach ◽  
Dietmar Fuchs ◽  
...  
Keyword(s):  
Regulatory Networks ◽  
Acid Metabolism ◽  
Phenylalanine Hydroxylase ◽  
Enzyme Linked Immunosorbent Assay ◽  
Low Grade ◽  
Human Immune System ◽  
Biochemical Alterations ◽  
The Mean ◽  
Human Immune ◽  
The University

AbstractFormation of neopterin, a biomarker of the activated human immune system, is linked with tryptophan (TRP) and phenylalanine (PHE) metabolism. To obtain normal values, in this study, serum concentrations of neopterin as well as of TRP, PHE and their respective metabolites kynurenine (KYN) and tyrosine (TYR) were investigated in 100 successive blood donor serum specimens from the University Clinics of Innsbruck, Austria. In addition, nitrite concentrations were determined. Donors had passed anamnestic examination at entry and were therefore considered as healthy. The mean age of participants was 49±11.4 (mean±SD) years; 18% were older than 60 years. Both genders were included in the analysis. Neopterin concentrations measured by enzyme-linked immunosorbent assay were 5.9±1.6 nmol/L (mean±SD). Levels of amino acids and metabolites were determined by HPLC. Mean KYN and TRP concentrations were 1.78±0.42 μmol/L and 67.4±10.2 μmol/L, respectively. KYN to TRP ratio (KYN/TRP), an estimate for the activity of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase, was 26.7±6.2 μmol/mmol. Mean PHE and TYR concentrations were 65.2±11.1 μmol/L and 90.6±22.9 μmol/L. PHE to TYR ratio (PHE/TYR), an estimate for the activity of PHE-converting enzyme phenylalanine hydroxylase, was 0.75±0.14 μmol/μmol. Nitrite concentrations, estimated by Griess-Ilosvay reagent, were 44.9±32.0 μmol/L. Males were taller and heavier than females (both p<0.01), but body mass index did not differ. Males presented with significantly higher TRP and TYR concentrations than females (both p<0.05). There existed significant correlations between neopterin and KYN (rs=0.368), KYN/TRP (rs=0.453), TYR (rs=–0.267; all p<0.01) and PHE/TYR (rs=0.236; p<0.05) concentrations. Data indicate that also in a population of healthy individuals an association exists between “low-grade” immune activation as is indicated by slightly higher neopterin concentrations and biochemical alterations in the amino acid metabolism. Although minor, such changes may interfere with psychoneuroimmunological regulatory networks and thus be of clinical relevance.

Faecal haemoglobin concentration is related to severity of colorectal neoplasia

2013 ◽  
Vol 66 (5) ◽  
pp. 415-419 ◽  
Author(s):  
Jayne Digby ◽  
Callum G Fraser ◽  
Francis A Carey ◽  
Paula J McDonald ◽  
Judith A Strachan ◽  
...  
Keyword(s):  
Colorectal Neoplasia ◽  
Haemoglobin Concentration ◽  
Occult Blood ◽  
Outcome Data ◽  
Neoplastic Disease ◽  
Low Grade ◽  
First Line ◽  
Hb Concentration ◽  
Pathology Data ◽  
Selection Of

AimsGuaiac faecal occult blood tests are being replaced by faecal immunochemical tests (FIT). We investigated whether faecal haemoglobin concentration (f-Hb) was related to stage in progression of colorectal neoplasia, studying cancer and adenoma characteristics in an evaluation of quantitative FIT as a first-line screening test.MethodsWe invited 66 225 individuals aged 50–74 years to provide one sample of faeces. f-Hb was measured on samples from 38 720 responders. Colonoscopy findings and pathology data were collected on the 943 with f-Hb≥400 ng Hb/ml (80 µg Hb/g faeces).ResultsOf the 814 participants with outcome data (median age: 63 years, range 50–75, 56.4% male), 39 had cancer, 190 high-risk adenoma (HRA, defined as ≥3 or any ≥10 mm) and 119 low-risk adenoma (LRA). 74.4% of those with cancer had f-Hb>1000 ng Hb/ml compared with 58.4% with HRA, and 44.1% with no pathology. Median f-Hb concentration was higher in those with cancer than those with no (p<0.002) or non-neoplastic (p<0.002) pathology, and those with LRA (p=0.0001). Polyp cancers had lower concentrations than more advanced stage cancers (p<0.04). Higher f-Hb was also found in those with HRA than with LRA (p<0.006), large (>10 mm) compared with small adenoma (p<0.0001), and also an adenoma displaying high-grade dysplasia compared with low-grade dysplasia (p<0.009).Conclusionsf-Hb is related to severity of colorectal neoplastic disease. This has ramifications for the selection of the appropriate cut-off concentration adopted for bowel screening programmes.

scholarly journals The association between dietary inflammatory index (DII) and obesity indices in university students in Tehran

2020 ◽  
Author(s):  
Narges Khamoush Cheshm ◽  
Asal Ataie-Jafari ◽  
Shahryar Eghtesadi ◽  
Aniseh Nikravan ◽  
Nitin Shivappa ◽  
...  
Keyword(s):  
University Students ◽  
Health Indicators ◽  
Bioelectrical Impedance ◽  
Public Health Issue ◽  
Low Grade ◽  
Dietary Inflammatory Index ◽  
Cross Sectional ◽  
Inflammatory Index ◽  
The Mean ◽  
Obesity Indices

Abstract Background: Obesity, a major cause of low-grade chronic inflammation, is a major public health issue globally. Inflammation arising from obesity affects organs, such as kidney and liver, and is associated with chronic diseases such as diabetes and cardiovascular disease. We aimed to investigate the association between the dietary inflammatory index (DII®) and obesity indices in university students. Methods: This cross-sectional study included 361 college students. DII scores were calculated from dietary data collected using a semi-quantitative food frequency questionnaire (FFQ). Anthropometric measurements were taken, and body composition analyzed by bioelectrical impedance analysis (BIA). Results: The mean age of the 361 students was 21.94 ± 4.04 years and 53.2% were female The mean DII was 1.26 ± 1.08. Among participants, 36.8% were overweight and obese and 9.1% suffered from abdominal obesity. The DII score was not associated with body weight, body mass index (BMI), body fat, waist circumference or visceral fat (both unadjusted and after adjustment for covariates). Conclusion: The present study showed no association between the DII and obesity indices given the proven effects of both the DII and obesity on health indicators, it would be a good strategy to conduct studies with prospective designs to determine the exact effects of DII on obesity indicators. Key words: dietary inflammatory index, obesity, fat mass, anthropometric.

Is the diagnosis of low-grade dysplasia in ulcerative colitis consistent?

2001 ◽  
Vol 120 (5) ◽  
pp. A733-A733
Author(s):  
C LIM ◽  
A AXON ◽  
A VAIL ◽  
D FORMAN ◽  
M DIXON
Keyword(s):  
Ulcerative Colitis ◽  
Low Grade ◽  
Low Grade Dysplasia

Der Sommer und Herbst 2003 aus phänologischer Sicht | Summer and autumn 2003 from a phenological point of view

2004 ◽  
Vol 155 (5) ◽  
pp. 142-145 ◽  
Author(s):  
Claudio Defila
Keyword(s):  
Time Series ◽  
New Record ◽  
Point Of View ◽  
Late Spring ◽  
Mean Deviation ◽  
Leaf Shedding ◽  
The Mean ◽  
Very High ◽  
Selection Of

The record-breaking heatwave of 2003 also had an impact on the vegetation in Switzerland. To examine its influences seven phenological late spring and summer phases were evaluated together with six phases in the autumn from a selection of stations. 30% of the 122 chosen phenological time series in late spring and summer phases set a new record (earliest arrival). The proportion of very early arrivals is very high and the mean deviation from the norm is between 10 and 20 days. The situation was less extreme in autumn, where 20% of the 103 time series chosen set a new record. The majority of the phenological arrivals were found in the class «normal» but the class«very early» is still well represented. The mean precocity lies between five and twenty days. As far as the leaf shedding of the beech is concerned, there was even a slight delay of around six days. The evaluation serves to show that the heatwave of 2003 strongly influenced the phenological events of summer and spring.

Caracterização da Peneira Média em Clones de Coffea canephora

REVISTA FIMCA ◽  
2018 ◽  
Vol 5 (2) ◽  
pp. 28-31
Author(s):  
Darlan Darlan Sanches Barbosa Alves ◽  
Victor Mouzinho Spinelli ◽  
Marcos Santana Moraes ◽  
Carolina Augusto De Souza ◽  
Rodrigo da Silva Ribeiro ◽  
...  
Keyword(s):  
Genetic Improvement ◽  
Block Design ◽  
Coffea Canephora ◽  
Coffee Production ◽  
Randomized Block Design ◽  
Significant Difference ◽  
The Mean ◽  
Four Blocks ◽  
Selection Of

Introdução: O estado de Rondônia se destaca como tradicional produtor de café, sendo o segundo maior produtor brasileiro de C. canephora. No melhoramento genético de C. canephora, a seleção de plantas de elevada peneira média está associada à bebida de qualidade superior. Objetivos: O objetivo desse estudo foi avaliar a variabilidade genética de clones de C. canephora para o tamanho dos grãos, mensurado a partir da avaliação da peneira média (PM). Materiais e Métodos: Para isso, foi conduzido ao longo de dois anos agrícolas experimento no campo experimental da Embrapa no município de Ouro Preto do Oeste-RO, para a avaliação da peneira média de 130 genótipos (clones) com características das variedades botânicas Conilon, Robusta e híbridos intervarietais. O delineamento experimental utilizado foi de blocos ao acaso, com quatro repetições de quatro plantas por parcela. Resultados: Não houve resultados significativos para a interação clones X anos, indicando uma maior consistência no comportamento das plantas ao longo do tempo. Porém foram observadas diferenças significativas para o tamanho dos grãos entre os genótipos avaliados, possibilitando selecionar genótipos superiores. Conclusão: Os genótipos agruparam-se em cinco classes de acordo com o teste de média, subsidiando a caracterização de um gradiente de variabilidade da característica avaliada ABSTRACTIntroduction: Coffea canephora accounts for approximately 35% of the world's coffee production. The state of Rondônia stands out as a traditional coffee producer, being the second largest Brazilian producer of C. canephora. In the classical genetic improvement of C. anephora, the selection of plants of high average sieve is associated with a drink of superior quality. Objectives: The objective of this udy was to evaluate the genetic variability of Coffea canephora clones for the agronomic medium sieve (PM). Materials and Methods: The experiment was conducted in the experimental field of Embrapa, municipality of OuroPreto do Oeste-RO, located at coordinates 10º44'53 "S and 62º12'57". One hundred thirty genotypes (clones) of botanical characteristics Conilon, Robusta and intervarietal hybrids were evaluated in the agricultural years 2013-2014 and 2014-2015. The experimental design was a randomized block design with four blocks and four plants per plot, spacing 3.5 x 1.5 meters between plants. Results: Significant difference was found for the grain size. According to the F test, at 5% probability, the genotypes were grouped into five classes according to the mean test. Conclusion: The results obtained subsidized the characterization of a variability gradient of the evaluated trait.

Effect of Surgical Versus Pharmacological Decompression of Ludwig’s Angina on Airway Compromise among Nigerian Patients

2020 ◽  
Author(s):  
Ekaniyere EB
Keyword(s):  
Length Of Hospital Stay ◽  
Surgical Decompression ◽  
Airway Compromise ◽  
Inclusion Criteria ◽  
Hospital Stays ◽  
Ludwig’S Angina ◽  
The Mean ◽  
The University ◽  
Ludwig's Angina ◽  
Gender Type

Background: Even though the decompression of the cellulitis phase of Ludwig’s angina (LA) by surgical or pharmacological approach is well documented, it is unclear which approach is more effective. Objective: We aim to compare the outcome of treatment between surgical versus pharmacological decompression in patients with LA. Subjects and Methods: A retrospective cohort study was designed. Data were collected from the case notes of patients that met the inclusion criteria from 2004 to 2018 at the University of Benin Teaching Hospital, Nigeria.The data were age, gender, type of decompression approach, length of hospital stay (LOS) and airway compromise. Result: A total of 62 patients comprising 37(59.7%) surgical decompression group and 25(40.3%) pharmacological decompression group were studied. Thirty-six (58.1%) males and 26 (41.9%) females were studied. Their mean age and standard deviation were 40.6 years and 11.9 years respectively. The mean length of hospital stays between the pharmacological and surgical decompression groups were 8.05 days and 13.8 days respectively. The incidence of airway compromise in the surgical decompression group was 19.9% lower than that of the pharmacological decompression group (P=0.47), which was not significant. The type of decompression approach also failed to influence the incidence of airway compromise (P = 0.41). Conclusion: The use of surgical versus pharmacological decompression does not significantly alter the incidence of airway compromise in the management of LA. The Patients that had surgical decompression had a shorter stay in the hospital as compared to those who had pharmacological decompression. This was not statistically significant.

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