1411Alcohol and tobacco use and risk of multiple myeloma: a case-control study

Abstract Background Although responsible for significant mortality and morbidity, our knowledge of modifiable causes of multiple myeloma (MM) remains limited. This analysis of an Australian population-based case-control family study investigated associations between smoking and alcohol consumption and MM risk. Methods Incident cases (n = 789) of MM were recruited mainly via cancer registries in Victoria and NSW. The controls included in the analysis (n = 1,113) were either family members of cases (n = 696) or recruited as part of a similarly designed case-control family study of renal cancer (n = 417). Unconditional multivariable logistic regression was used to estimate ORs, 95% CIs and p-values for associations between alcohol- and tobacco-related exposures and risk of MM. Results Heavy drinkers of alcohol had lower MM risk compared with non-drinkers (OR = 0.68, 95% CI = 0.50 – 0.93), and there was an inverse dose-response relationship for alcohol intake (OR per 10g ethanol per day = 0.92, 95% CI: 0.86 – 0.99); there was no evidence of interaction with sex (p = 0.27). There was no evidence of association between smoking-related exposures and MM risk. Conclusions These findings extend the knowledge of MM risk factor epidemiology. Further research into the causality of the association of alcohol with MM risk and potential underlying mechanisms is recommended. Key messages We found alcohol consumption to be inversely associated with risk of multiple myeloma.

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MC1R genotypes and risk of melanoma before age 40 years: A population-based case-control-family study

International Journal of Cancer ◽

10.1002/ijc.27357 ◽

2012 ◽

Vol 131 (3) ◽

pp. E269-E281 ◽

Cited By ~ 24

Author(s):

Anne E. Cust ◽

Chris Goumas ◽

Elizabeth A. Holland ◽

Chantelle Agha-Hamilton ◽

Joanne F. Aitken ◽

...

Keyword(s):

Family Study ◽

Population Based ◽

Case Control ◽

Control Family

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Population-based, Case-Control-Family Design to Investigate Genetic and Environmental Influences on Melanoma Risk: Australian Melanoma Family Study

American Journal of Epidemiology ◽

10.1093/aje/kwp307 ◽

2009 ◽

Vol 170 (12) ◽

pp. 1541-1554 ◽

Cited By ~ 37

Author(s):

A. E. Cust ◽

H. Schmid ◽

J. A. Maskiell ◽

J. Jetann ◽

M. Ferguson ◽

...

Keyword(s):

Family Study ◽

Environmental Influences ◽

Population Based ◽

Case Control ◽

Melanoma Risk ◽

Control Family

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Design and Analysis Issues in a Population-Based, Case-Control-Family Study of the Genetic Epidemiology of Breast Cancer and the Co-operative Family Registry for Breast Cancer Studies (CFRBCS)

JNCI Monographs ◽

10.1093/oxfordjournals.jncimonographs.a024232 ◽

1999 ◽

Vol 1999 (26) ◽

pp. 95-100 ◽

Cited By ~ 55

Author(s):

J. L. Hopper ◽

G. Chenevix-Trench ◽

D. J. Jolley ◽

G. S. Dite ◽

M. A. Jenkins ◽

...

Keyword(s):

Breast Cancer ◽

Genetic Epidemiology ◽

Family Study ◽

Population Based ◽

Case Control ◽

Cancer Studies ◽

Control Family

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Familial Correlations of Onset Age of Hepatocellular Carcinoma: A Population-Based Case-Control Family Study

PLoS ONE ◽

10.1371/journal.pone.0108391 ◽

2014 ◽

Vol 9 (9) ◽

pp. e108391 ◽

Cited By ~ 3

Author(s):

Li Liu ◽

Lixia Li ◽

Shudong Zhou ◽

Qingwu Jiang ◽

Sidong Chen ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Family Study ◽

Population Based ◽

Case Control ◽

Onset Age ◽

Control Family

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Main Source of Drinking Water and Familial Aggregation of Kashin-Beck Disease: A Population Based on Case-Control Family Study

Annals of Epidemiology ◽

10.1016/j.annepidem.2009.04.007 ◽

2009 ◽

Vol 19 (8) ◽

pp. 560-566 ◽

Cited By ~ 9

Author(s):

Yongzhong Zhang ◽

Xiong Guo ◽

Zhiguang Ping ◽

Min Yu ◽

Xiaowei Shi ◽

...

Keyword(s):

Drinking Water ◽

Family Study ◽

Familial Aggregation ◽

Population Based ◽

Case Control ◽

Control Family ◽

Beck Disease

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Incidence and Trends of the Leading Cancers with Elevated Incidence Among American Indian and Alaska Native Populations, 2012–2016

American Journal of Epidemiology ◽

10.1093/aje/kwaa222 ◽

2020 ◽

Author(s):

Stephanie C Melkonian ◽

Hannah K Weir ◽

Melissa A Jim ◽

Bailey Preikschat ◽

Donald Haverkamp ◽

...

Keyword(s):

American Indian ◽

Cancer Incidence ◽

Alaska Native ◽

Cancer Registries ◽

Population Based ◽

Incidence Rates ◽

Breast Cancers ◽

Age Adjusted Rates ◽

Incident Cases ◽

Hispanic White

Abstract Cancer incidence varies among American Indian and Alaska Native (AI/AN) populations, as well as between AI/AN and White populations. This study examined trends for cancers with elevated incidence among AI/AN compared with non-Hispanic White populations and estimated potentially avoidable incident cases among AI/AN populations. Incident cases diagnosed during 2012–2016 were identified from population-based cancer registries and linked with the Indian Health Service patient registration databases to improve racial classification of AI/AN populations. Age-adjusted rates (per 100,000) and trends were calculated for cancers with elevated incidence among AI/AN compared with non-Hispanic White populations (rate ratio >1.0), by region. Trends were estimated using joinpoint regression analyses. Expected cancers were estimated by applying age-specific cancer incidence rates among non-Hispanic White populations to population estimates for AI/AN populations. Excess cancer cases among AI/AN populations were defined as observed minus expected cases. Liver, stomach, kidney, lung, colorectal and female breast cancers had higher incidence rate among AI/AN populations across most regions. Between 2012 and 2016, nearly 5,200 excess cancers were diagnosed among AI/AN populations, with the largest number of excess cancers (1,925) occurring in the Southern Plains region. Culturally informed efforts may reduce cancer disparities associated with these and other cancers among AI/AN populations.

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Population-Based Estimates of the Age-Specific Cumulative Risk of Breast Cancer for Pathogenic Variants in CHEK2: Findings from the Australian Breast Cancer Family Registry

Cancers ◽

10.3390/cancers13061378 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1378

Author(s):

Tú Nguyen-Dumont ◽

James G. Dowty ◽

Jason A. Steen ◽

Anne-Laure Renault ◽

Fleur Hammet ◽

...

Keyword(s):

Breast Cancer ◽

Cumulative Risk ◽

Population Based ◽

Case Control ◽

Cancer Information ◽

Case Control Studies ◽

Breast Cancer Family ◽

Pathogenic Variants ◽

Increased Risk ◽

Control Family

Case-control studies of breast cancer have consistently shown that pathogenic variants in CHEK2 are associated with about a 3-fold increased risk of breast cancer. Information about the recurrent protein-truncating variant CHEK2 c.1100delC dominates this estimate. There have been no formal estimates of age-specific cumulative risk of breast cancer for all CHEK2 pathogenic (including likely pathogenic) variants combined. We conducted a population-based case-control-family study of pathogenic CHEK2 variants (26 families, 1071 relatives) and estimated the age-specific cumulative risk of breast cancer using segregation analysis. The estimated hazard ratio for carriers of pathogenic CHEK2 variants (combined) was 4.9 (95% CI 2.5–9.5) relative to non-carriers. The HR for carriers of the CHEK2 c.1100delC variant was estimated to be 3.5 (95% CI 1.02–11.6) and the HR for carriers of all other CHEK2 variants combined was estimated to be 5.7 (95% CI 2.5–12.9). The age-specific cumulative risk of breast cancer was estimated to be 18% (95% CI 11–30%) and 33% (95% CI 21–48%) to age 60 and 80 years, respectively. These findings provide important information for the clinical management of breast cancer risk for women carrying pathogenic variants in CHEK2.

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Moderate alcohol consumption may protect against overt autoimmune hypothyroidism: a population-based case–control study

Acta Endocrinologica ◽

10.1530/eje-12-0356 ◽

2012 ◽

Vol 167 (4) ◽

pp. 483-490 ◽

Cited By ~ 41

Author(s):

Allan Carlé ◽

Inge Bülow Pedersen ◽

Nils Knudsen ◽

Hans Perrild ◽

Lars Ovesen ◽

...

Keyword(s):

Alcohol Consumption ◽

Alcohol Intake ◽

Case Control Study ◽

Reference Group ◽

Population Based ◽

Case Control ◽

Overt Hypothyroidism ◽

Autoimmune Hypothyroidism ◽

Normal Thyroid Function ◽

Control Study

ObjectiveAlcohol consumption is an important protective risk factor for many autoimmune diseases. We wished to study the association between alcohol consumption and autoimmune hypothyroidism.DesignPopulation-based, case–control study, 1997–2001, Denmark.MethodsPatients with newly diagnosed autoimmune overt hypothyroidism (n=140) were prospectively identified in a population (2 027 208 person-years of observation), and their matched controls with normal thyroid function (n=560) were recruited simultaneously from the same population. Participants gave information on alcohol intake, smoking, previous diseases, education, and family history of hypothyroidism. The association between alcohol intake and development of hypothyroidism was analyzed in conditional regression models.ResultsHypothyroid cases had reported a lower alcohol consumption than controls (median units of alcohol (12 g) per week: 3 vs 5,P=0.002). In a multivariate regression model, alcohol consumption was associated with a reduction in risk for development of overt autoimmune hypothyroidism. Odds ratios (95% confidence interval) compared with the reference group with a recent (last year) consumption of 1–10 units of alcohol per week were as follows: 0 units/week, 1.98 (1.21–3.33); 11–20 units/week, 0.41 (0.20–0.83); and ≥21 units/week, 0.90 (0.41–2.00). Similar results were found for maximum previous alcohol consumption during a calendar year. No interaction was found with type of alcohol consumed (wine vs beer), sex, or region of inhabitancy.ConclusionsAlcohol consumption seems to confer considerable protection against development of overt autoimmune hypothyroidism irrespective of sex and type of alcohol consumed.

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