Familial Correlations of Onset Age of Hepatocellular Carcinoma: A Population-Based Case-Control Family Study

Abstract Background Although responsible for significant mortality and morbidity, our knowledge of modifiable causes of multiple myeloma (MM) remains limited. This analysis of an Australian population-based case-control family study investigated associations between smoking and alcohol consumption and MM risk. Methods Incident cases (n = 789) of MM were recruited mainly via cancer registries in Victoria and NSW. The controls included in the analysis (n = 1,113) were either family members of cases (n = 696) or recruited as part of a similarly designed case-control family study of renal cancer (n = 417). Unconditional multivariable logistic regression was used to estimate ORs, 95% CIs and p-values for associations between alcohol- and tobacco-related exposures and risk of MM. Results Heavy drinkers of alcohol had lower MM risk compared with non-drinkers (OR = 0.68, 95% CI = 0.50 – 0.93), and there was an inverse dose-response relationship for alcohol intake (OR per 10g ethanol per day = 0.92, 95% CI: 0.86 – 0.99); there was no evidence of interaction with sex (p = 0.27). There was no evidence of association between smoking-related exposures and MM risk. Conclusions These findings extend the knowledge of MM risk factor epidemiology. Further research into the causality of the association of alcohol with MM risk and potential underlying mechanisms is recommended. Key messages We found alcohol consumption to be inversely associated with risk of multiple myeloma.

Download Full-text

Population-based, Case-Control-Family Design to Investigate Genetic and Environmental Influences on Melanoma Risk: Australian Melanoma Family Study

American Journal of Epidemiology ◽

10.1093/aje/kwp307 ◽

2009 ◽

Vol 170 (12) ◽

pp. 1541-1554 ◽

Cited By ~ 37

Author(s):

A. E. Cust ◽

H. Schmid ◽

J. A. Maskiell ◽

J. Jetann ◽

M. Ferguson ◽

...

Keyword(s):

Family Study ◽

Environmental Influences ◽

Population Based ◽

Case Control ◽

Melanoma Risk ◽

Control Family

Download Full-text

Design and Analysis Issues in a Population-Based, Case-Control-Family Study of the Genetic Epidemiology of Breast Cancer and the Co-operative Family Registry for Breast Cancer Studies (CFRBCS)

JNCI Monographs ◽

10.1093/oxfordjournals.jncimonographs.a024232 ◽

1999 ◽

Vol 1999 (26) ◽

pp. 95-100 ◽

Cited By ~ 55

Author(s):

J. L. Hopper ◽

G. Chenevix-Trench ◽

D. J. Jolley ◽

G. S. Dite ◽

M. A. Jenkins ◽

...

Keyword(s):

Breast Cancer ◽

Genetic Epidemiology ◽

Family Study ◽

Population Based ◽

Case Control ◽

Cancer Studies ◽

Control Family

Download Full-text

Main Source of Drinking Water and Familial Aggregation of Kashin-Beck Disease: A Population Based on Case-Control Family Study

Annals of Epidemiology ◽

10.1016/j.annepidem.2009.04.007 ◽

2009 ◽

Vol 19 (8) ◽

pp. 560-566 ◽

Cited By ~ 9

Author(s):

Yongzhong Zhang ◽

Xiong Guo ◽

Zhiguang Ping ◽

Min Yu ◽

Xiaowei Shi ◽

...

Keyword(s):

Drinking Water ◽

Family Study ◽

Familial Aggregation ◽

Population Based ◽

Case Control ◽

Control Family ◽

Beck Disease

Download Full-text

Population-Based Estimates of the Age-Specific Cumulative Risk of Breast Cancer for Pathogenic Variants in CHEK2: Findings from the Australian Breast Cancer Family Registry

Cancers ◽

10.3390/cancers13061378 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1378

Author(s):

Tú Nguyen-Dumont ◽

James G. Dowty ◽

Jason A. Steen ◽

Anne-Laure Renault ◽

Fleur Hammet ◽

...

Keyword(s):

Breast Cancer ◽

Cumulative Risk ◽

Population Based ◽

Case Control ◽

Cancer Information ◽

Case Control Studies ◽

Breast Cancer Family ◽

Pathogenic Variants ◽

Increased Risk ◽

Control Family

Case-control studies of breast cancer have consistently shown that pathogenic variants in CHEK2 are associated with about a 3-fold increased risk of breast cancer. Information about the recurrent protein-truncating variant CHEK2 c.1100delC dominates this estimate. There have been no formal estimates of age-specific cumulative risk of breast cancer for all CHEK2 pathogenic (including likely pathogenic) variants combined. We conducted a population-based case-control-family study of pathogenic CHEK2 variants (26 families, 1071 relatives) and estimated the age-specific cumulative risk of breast cancer using segregation analysis. The estimated hazard ratio for carriers of pathogenic CHEK2 variants (combined) was 4.9 (95% CI 2.5–9.5) relative to non-carriers. The HR for carriers of the CHEK2 c.1100delC variant was estimated to be 3.5 (95% CI 1.02–11.6) and the HR for carriers of all other CHEK2 variants combined was estimated to be 5.7 (95% CI 2.5–12.9). The age-specific cumulative risk of breast cancer was estimated to be 18% (95% CI 11–30%) and 33% (95% CI 21–48%) to age 60 and 80 years, respectively. These findings provide important information for the clinical management of breast cancer risk for women carrying pathogenic variants in CHEK2.

Download Full-text

Use of cyclooxygenase inhibitor and the risk of hepatocellular carcinoma in patients with chronic hepatitis B: A nested case‐control study using a nationwide population‐based data

Journal of Viral Hepatitis ◽

10.1111/jvh.13201 ◽

2019 ◽

Vol 27 (1) ◽

pp. 68-73 ◽

Cited By ~ 1

Author(s):

Kyoung Sun Cho ◽

Won Sohn ◽

Yeong Chan Lee ◽

Sang Ah Chi ◽

Ju‐Yeon Cho ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Chronic Hepatitis ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Cyclooxygenase Inhibitor ◽

Nested Case Control ◽

Control Study

Download Full-text

Cardiovascular diseases in grandparents and the risk of congenital heart diseases in grandchildren

Journal of Developmental Origins of Health and Disease ◽

10.1017/s2040174414000026 ◽

2014 ◽

Vol 5 (2) ◽

pp. 152-158 ◽

Cited By ~ 1

Author(s):

K. P. J. Wijnands ◽

S. A. Obermann-Borst ◽

E. J. G. Sijbrands ◽

M. F. Wildhagen ◽

W. A. Helbing ◽

...

Keyword(s):

Metabolic Pathways ◽

Congenital Heart ◽

Family Study ◽

Heart Diseases ◽

Case Control ◽

Fetal Origins ◽

Increased Risk ◽

Health And Disease ◽

Control Family ◽

Detailed Questionnaire

Hyperglycemia, dyslipidemia and hyperhomocysteinemia are associated with both adult cardiovascular disease (CVD) and having a child with a congenital heart disease (CHD). We investigated associations between CVD in grandparents and the risk of CHD in grandchildren. In a case–control family study, we obtained detailed questionnaire information on CVD and CHD in 247 families with a CHD child and 203 families without a CHD child. Grandparents with CVD or intermittent claudication (IC) were significantly associated with an increased risk for CHD in grandchildren [OR 1.39 (95% CI 1.03–1.89) and OR 2.77 (95% CI 1.02–7.56), respectively]. The risk of CHD grandchildren was particularly increased in paternal grandfathers with CVD [OR 1.85 (95% CI 1.01–3.37)]. Overall, having a grandparent with CVD increased the risk for CHD in the grandchild by 1.65 (95% CI 1.12–2.41). After adjustment for potential maternal confounders, this risk was 1.44 (95% CI 0.94–2.21). Having two or more grandparents with CVD was associated with an approximately threefold risk for CHD grandchildren [OR adjusted 2.72 (95% CI 1.08–6.89)]. Our data suggest that CVD and IC in grandparents are associated with an increased risk of having a CHD grandchild. These first findings may be explained by shared causality of derangements in metabolic pathways and are in line with the fetal origins of health and disease.

Download Full-text