scholarly journals 861Mendelian randomization on habitual coffee intake and plasma lipid profile: evidence from UK Biobank

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Ang Zhou ◽  
Elina Hyppönen
Keyword(s):  
Lipid Profile ◽  
Plasma Lipid ◽  
Coffee Consumption ◽  
Plasma Lipid Profile ◽  
Robust Methods ◽  
Uk Biobank ◽  
Cvd Risk ◽  
Coffee Intake ◽  
The Uk

Abstract Background Long-term heavy coffee consumption may adversely affect individuals’ cardiovascular disease (CVD) risk. As hyperlipidemia is a well-established contributor to CVD, we investigated the association between habitual coffee intake and plasma lipid profile. Methods We used data from up to 362,571 UK Biobank participants to examine associations between coffee intake and plasma lipid profiles, including LDL-C, HDL-C, total-C, triglycerides, ApoA1 and ApoB. Inverse variance weighted mendelian randomization (MR) was used to interrogate the causal nature of coffee-lipid associations, complemented by pleiotropy-robust methods, including MR-median, MR-Mode, MR-PRESSO and MR-Egger. Results We observed positive dose-dependent associations between self-reported coffee intake and plasma concentration of LDL-C, ApoB and total-C, with the highest lipid levels seen among participants drinking >6 cups/day (Plinear trend≤1.97E-57 for all). Genetic instrument for coffee intake was robustly associated with self-reported intake in the UK Biobank (F-statistic = 416). One cup increase in genetically instrumented intake was associated with 0.07 mmol/L (95%CI 0.03 to 0.12), 0.02 g/L (95%CI 0.01 to 0.03), and 0.09 mmol/L (95%CI 0.04 to 0.14) increase in LDL-C, ApoB, and total-C, respectively. Pleiotropy-robust methods provided largely consistent results albeit with greater imprecision when using MR-Egger. Conclusions Our phenotypic and genetic analysis consistently suggests that long-term heavy coffee consumption can lead to unfavourable lipid profile, which could potentially increase individuals’ risk for CVD. Individuals with elevated cholesterol may need to reduce their daily coffee intake. Key messages Our study provides evidence that long-term heavy coffee consumption can lead to unfavourable lipid profile.

Abstract 021: C-reactive Protein Partially Mediates The Inverse Association Between Coffee Consumption And Risk Of Type 2 Diabetes: Findings From The UK Biobank And The Rotterdam Studies

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Carolina Ochoa-Rosales ◽  
Niels van der Schaft ◽  
Kim V Braun ◽  
Frederick Ho ◽  
Fanny Petermann ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coffee Consumption ◽  
Inverse Association ◽  
Statistical Regression ◽  
Uk Biobank ◽  
C Reactive Protein ◽  
Coffee Intake ◽  
Reactive Protein ◽  
The Uk

Background: Coffee intake has been linked to lower type 2 diabetes (T2D) risk. We hypothesized this may be mediated by coffee’s effects on inflammation. Methods: Using participants from the UK Biobank (UKB n=145370) and Rotterdam Study (RS n=7172) cohorts, we studied associations of coffee intake with incident T2D; longitudinally measured insulin resistance (HOMA IR); serum levels of inflammation markers; and the mediating role of inflammation. Statistical regression models were adjusted for sociodemographic, lifestyle and health factors. Results: The median follow up was 7 (UKB) and 9 (RS) years. An increase of one coffee cup/day was associated with 4-6% lower T2D risk (RS HR=0.94 [95% CI 0.90; 0.98]; UKB HR=0.96 [0.94; 0.98]); lower HOMA IR (RS β=-0.017 [-0.024; -0.010]); with lower C reactive protein (CRP) and higher adiponectin (Figure1). Consumers of filtered coffee had the lowest T2D risk (UKB HR=0.88 [0.83; 0.93]). CRP levels mediated 9.6% (UKB) and 3.4% (RS) of the total effect of coffee on T2D (Figure 1). Conclusions: We suggest that coffee’s beneficial effects on lower T2D risk are partially mediated by improvements in systemic inflammation.Figure 1. a CRP and a adiponectin refer to the effect of coffee intake on CRP and adiponectin levels. a CRP RS : β=-0.014 (-0.022; -0.005); UKBB a CRP UKB : β=-0.011 (-0.012; -0.009) and RS a adiponectin : β=0.025 (0.007; 0.042). b CRP and b adiponectin refer to the effect of coffee related levels in CRP and adiponectin on incident T2D, independent of coffee. RS b CRP : HR=1.17 (1.04; 1.31); UKB b CRP : HR=1.45 (1.37; 1.54); and b adiponectin : HR=0.58 (0.32; 0.83). c′ refers to coffee’ effect on T2D going directly or via others mediators. UKB c′ independent of CRP : HR=0.96 (0.94; 0.99); RS c′ independent of CRP : HR=0.94 (0.90; 0.99); and RS c′ independent of CRP+adiponectin : HR=0.90 (0.80; 1.01). Coffee related changes in CRP may partially explain the beneficial link between coffee and T2D, mediating a 3.4% (0.6; 4.8, RS) and 9.6% (5.7; 24.4, UKB). Evidence of mediation was also found for adiponectin.

Abstract 17335: Dietary Carbohydrate Quality Affects Plasma Lipid Profile and the Microbiome

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Nirupa R Matthan ◽  
Anne V Kane ◽  
William Evan Johnson ◽  
Solaiappan Manimaran ◽  
Tyler Faits ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lipid Profile ◽  
Plasma Lipids ◽  
Plasma Lipid ◽  
Inflammatory Factors ◽  
Plasma Lipid Profile ◽  
Cvd Risk ◽  
Fecal Microbiome ◽  
Negatively Associated ◽  
The Impact

Considerable data is available on the effect of carbohydrate (carb) quantity on CVD risk factors but data for carb quality is limited. Our objective was to determine the relative comparability for an isocaloric exchange of unrefined-carb (endosperm+germ+bran, e.g., whole wheat flour), refined-carb (endosperm only, e.g., white flour) and simple-carb (sucrose, e.g., high fructose corn syrup), on cardiometabolic risk factors and the gut microbiome. All foods/beverages (60%E total carb, 15%E protein, 27%E fat [7%E SFA, 10%E MUFA, 10%E PUFA], 80mg cholesterol/1000 kcal) were provided to study subjects (n=11 men and women, 65 years, BMI 27.5 kg/m 2 , LDL-C ≥100 mg/dL) for 5 weeks (randomized, single-blind, cross-over design). Body weight was maintained constant. At the end of each diet phase plasma lipid profile, inflammatory factors and glucose homeostasis were determined using standard methods. Fecal microbiota taxa was characterized by 16S rRNA sequencing and data analyzed using QIIME and PathoScope. Plasma LDL-C levels differed among diets (125 ± 29 mg/dL b , 129 ± 29 mg/dL a,b and 136 ± 24 mg/dL a , unrefined-, simple- and refined-carb , respectively). Carb quality had no significant effect on HDL-C, TG, FFA, glucose, insulin, CRP or IL-6 levels. There were 21 genera that had a mean relative abundance (RA) of ≥1% and 4 genera (Roseburia, Oscillospira, Ruminococcus and Coprococcus) varied significantly across diets but after multiple testing adjustment, only Roseburia RA variations remained significant ( 2.58% a , 0.99% b , and 0.81% b , unrefined-, simple- and refined-carb , respectively). Interesting trends were observed between the RA of the following genera and plasma lipids: Roseburia was negatively associated with LDL-C (r=0.28, p=0.097) and HDL-C (r=-0.39, p=0.022); Oscillospira was negatively associated with TG (r=-0.53, p=0.097), and Anaerostipes was positively associated with TG (r=0.40, p=0.0585) levels. These data suggest that carb quality alters the RA of butyrate-producing bacteria, presumably leading to higher short chain fatty acid production, with subsequent alterations in plasma lipids. This study provides novel information about the impact of carb quality on the phylogenetic structure and functional capacity of the fecal microbiome.

Influence of long-term bopindolol treatment on plasma lipid profile and blood pressure in hypertensives

1988 ◽  
Vol 3 ◽  
pp. S133-S136
Author(s):  
R. Colnago ◽  
M. Nazzari ◽  
D. Turn ◽  
G. Fiorella ◽  
C. Mazzola
Keyword(s):  
Blood Pressure ◽  
Lipid Profile ◽  
Plasma Lipid ◽  
Plasma Lipid Profile

scholarly journals Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases

2019 ◽  
Vol 109 (3) ◽  
pp. 509-516 ◽  
Author(s):  
Ang Zhou ◽  
Elina Hyppönen
Keyword(s):  
Cardiovascular Disease ◽  
Coffee Consumption ◽  
Cvd Risk ◽  
Coffee Intake ◽  
Genetic Score ◽  
Increased Risk ◽  
Decaffeinated Coffee ◽  
Caffeine Metabolism ◽  
The Uk ◽  
Cyp1a2 Genotype

ABSTRACT Background Coffee is one of the most widely consumed stimulants worldwide and is generally considered to be safe or even beneficial for health. However, increased risk of myocardial infarction and hypertension has been suggested for individuals who carry a functional variant at cytochrome P450 1A2 (CYP1A2), which makes them less effective at metabolizing caffeine. Objectives The aim of this study was to examine if the CYP1A2 genotype or a genetic score for caffeine metabolism (caffeine-GS) modifies the association between habitual coffee consumption and the risk of cardiovascular disease (CVD). Methods Genetic data and information on habitual coffee intake and relevant covariates were available for 347,077 individuals in the UK Biobank, including 8368 incident CVD cases. We used logistic regression to test for the association between coffee intake and CVD risk, and whether the association varies with CYP1A2 genotype or caffeine-GS. Results The association between habitual coffee intake and CVD risk was nonlinear, and, compared with participants drinking 1–2 cups/day, the risk of CVD was elevated for nondrinkers, drinkers of decaffeinated coffee, and those who reported drinking >6 cups/day (increase in odds by 11%, 7%, and 22%, respectively, P-curvature = 0.013). CYP1A2 genotype and caffeine-GS were not associated with CVD (P ≥ 0.22 for all comparisons). There was no evidence for an interaction between the CYP1A2 genotype or caffeine-GS and coffee intake with respect to risk of CVD (P ≥ 0.53). Conclusions Heavy coffee consumption was associated with a modest increase in CVD risk, but this association was unaffected by genetic variants influencing caffeine metabolism.

scholarly journals Association of daily coffee consumption with cardiovascular health – results from the UK Biobank

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
J Simon ◽  
K Fung ◽  
Z Raisi-Estabragh ◽  
N Aung ◽  
M Y Khanji ◽  
...  
Keyword(s):  
Regression Models ◽  
Cox Regression ◽  
Multivariable Analysis ◽  
Coffee Consumption ◽  
Uk Biobank ◽  
Coffee Intake ◽  
Stroke Incidence ◽  
Age Related ◽  
Lv Mass ◽  
The Uk

Abstract Background There are conflicting reports on the association of coffee consumption with cardiovascular (CV) health. The UK Biobank is a prospective cohort study including data for half a million middle-aged individuals. Purpose We studied the association of daily coffee consumption with all-cause and CV mortality, and incidence of the major CV diseases in the UK Biobank. In a subgroup of participants who underwent cardiovascular magnetic resonance (CMR), we evaluated the association between regular coffee intake and cardiac structure and function parameters. Methods UK Biobank cohort of participants without clinically manifested heart disease at the time of recruitment were included. Regular coffee intake was categorized into 3 groups: zero, light-to-moderate (0.5–3 cups/day) and high (>3 cups/day) coffee drinkers. We estimated association of daily coffee consumption with incident outcomes using multivariable Cox-regression models (median follow-up of 11 years) and, in the subset with CMR data, with left and right ventricular (LV, RV) end-systolic and end-diastolic volumes, LV mass, and LV/RV stroke volume using multivariable linear regression. Models were adjusted for potential confounders and mediators, including: age, sex, non-European ethnicities, body mass index, smoking, physical activity, Townsend deprivation index, alcohol, meat, fruit and vegetable intake, hypertension, diabetes mellitus, and cholesterol level. Results We included 468,629 individuals (mean age 56.2±8.1 years, 44.2% male). Among them, 22.1% did not consume coffee on a regular basis, 58.4% had 0.5–3 cups per day and 19.5% had >3 cups per day. After adjustment for potential confounders and mediators, compared to non-coffee drinkers, light-to-moderate coffee drinking was associated with lower risk of all-cause mortality (HR=0.88, p<0.001), CV mortality (HR=0.83, p=0.006), and incident stroke (HR=0.79; p=0.037). CMR data were available in 30,650 participants. In multivariable analysis, compared to non-coffee drinkers, both the light-to-moderate and high coffee consuming categories, were associated with significantly increased LV and RV ventricular end-systolic (β=0.91 and 1.64 for LV and 1.10 and 1.72 for RV), end-diastolic (β=2.21 and 3.28 for LV and 2.24 and 3.35 for RV) and stroke volumes (β=1.31 and 1.64 for LV and 1.15 and 1.63 for RV), as well as greater LV mass (β=0.78 and 1.64; all p<0.001). Conclusion In this large study of the UK Biobank population, regular coffee consumption of up to 3 cups per day was associated with favorable cardiovascular outcomes, in particular, decreased all-cause and CV mortality and stroke incidence. Regular coffee consumption was also associated with a pattern of CMR metrics in keeping with the reverse of age-related cardiac alterations. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women

2001 ◽  
pp. 457-461 ◽  
Author(s):  
A Lasco ◽  
N Frisina ◽  
N Morabito ◽  
A Gaudio ◽  
E Morini ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Lipid Profile ◽  
Postmenopausal Women ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Term Treatment ◽  
Plasma Lipid Profile ◽  
Long Term Treatment

OBJECTIVE: To investigate whether long-term treatment with dehydroepiandrosterone (DHEA) in postmenopausal women can modify insulin sensitivity and plasma lipid profile. DESIGN AND METHODS: Twenty healthy postmenopausal women with serum dehydroepiandrosterone sulfate (DHEA-S) concentrations <2.5 micromol/l were enrolled and randomly assigned to two different treatment groups: group 1 were treated with micronized DHEA, 25 mg/day at 0800 h for 12 months; group 2 were treated with an identical placebo tablet. At the beginning and at the end of the study, plasma lipid profile, glucose tolerance (oral glucose tolerance test) and insulin sensitivity (euglycemic hyperinsulinemic clamp: M index) were assessed. RESULTS: After 12 months, the group treated with DHEA showed a considerable improvement of insulin sensitivity (M index +29.55%, P=0.01) and lipid pattern (high-density lipoprotein cholesterol +11.61%, P=0.03; low-density lipoprotein cholesterol -11.07%, P=0.04; triglycerides -19.60%, P=0.03), but glucose tolerance did not change. No modifications were observed in the placebo group. CONCLUSIONS: Long-term treatment with DHEA ameliorates some metabolic parameters that are linked to increased cardiovascular risk and, consequently, this seems to be an interesting therapeutic tool in the management of the postmenopausal syndrome.

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