Possible approaches to the simulation of antibiotic kinetics and the determination of antibacterial activity in vitro

1985 ◽  
Vol 15 (suppl A) ◽  
pp. 117-120 ◽  
Author(s):  
W. Tosch ◽  
R. Schnell
Keyword(s):  
Antibacterial Activity

The prediction of the spectrum of biological activity and antimicrobial properties of diaminoazoles

2019 ◽  
Vol 65 (2) ◽  
pp. 99-102 ◽  
Author(s):  
Yu.V. Butina ◽  
T.V. Kudayarova ◽  
E.A. Danilova ◽  
M.K. Islyaikin
Keyword(s):  
Antibacterial Activity ◽  
Biological Activity ◽  
Antimicrobial Properties ◽  
Biological Properties ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Wide Range ◽  
Alternative Drugs

The work is devoted to predicting and studying biological properties of N-substituted analogs of 3,5-diamino-1,2,4-thiadiazole, which, in their turn, include in the composition of many drugs that exhibit a wide range of pharmacological actions. For searching of new alternative drugs with an antibacterial activity, but lacking resistance of microorganism strains to them, a computer screening of 2N-alkyl-substituted 5-amino-3-imino-1,2,4-thiadiazolines previously synthesized by us was carried out. The prediction of the spectrum of biological activity, as well as the determination of the probable toxicity of these compounds, was performed using the freely available computer programs PASS, Anti-Bac-Pred, and GUSAR. The study of the antibacterial activity in vitro against gram-positive (Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus epidermidis) and gram-negative (Escherichia coli, Pseudomonas aeruginosae) bacterial strains was performed by the disco-diffusion method. Experimental data roughly correspond to the predictions.

scholarly journals Determination of Untreated Whole-Milk Effects on In Vitro Antibacterial Activity

1970 ◽  
Vol 19 (2) ◽  
pp. 220-223
Author(s):  
J. P. Van Natta ◽  
P. W. Lo ◽  
T. S. Chang
Keyword(s):  
Antibacterial Activity ◽  
Whole Milk ◽  
In Vitro Antibacterial Activity

DETERMINATION OF CHARANTIN CONTENT, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY IN-VITRO OF THE BITTER MELON (MOMORDICA CHARANTIA ) IN THUA THIEN HUE

2014 ◽  
pp. 99-104
Author(s):  
Thi Hong Yen Nguyen ◽  
Viet Khan Nguyen
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Solvent Mixture ◽  
Momordica Charantia ◽  
Bitter Melon ◽  
Test Results ◽  
Antioxidant And Antimicrobial Activity ◽  
Melon Fruit

Background: To determine the charantin content, antioxidant and antimicrobial activity in-vitro of the bitter melon (Momordica charantia) in Thua Thien Hue.); Materials and Methods: bitter melon fruit was collected in Thua Thien Hue province, then taken to the laboratory for extraction, quantitation and activity test. Results: charantin content of bitter melon in Thua Thien Hue extracted with a solvent mixture of MeOH - CHCl3 (1:1 v/v) was found to be 0.204 %; antioxidant activity of FRAP content of fresh bitter melon extracted with solvent methanol was found to be 972.16 μmol Fe2+/L; the samples exhibited the antibacterial activity for four strains of bacterial pathogens with antimicrobial diameters from 14-17 mm. Conclusion: the charantin content of bitter melon fruit in Thua Thien Hue is high, the antioxidant and antibacterial activity are medium levels. Key words: bitter melon, charantin, antioxidants, FRAP, antibacterial.

scholarly journals Antibacterial Activity and Chemical Composition of Turkish Propolis

2001 ◽  
Vol 56 (11-12) ◽  
pp. 1112-1115 ◽  
Author(s):  
Nevin Keskin ◽  
Selçuk Hazir ◽  
K. Hüsnü Can Baser ◽  
Mine Kürkçüoglu
Keyword(s):  
Antibacterial Activity ◽  
Chemical Compounds ◽  
Antibacterial Activities ◽  
Fatty Acid Esters ◽  
E Coli ◽  
Weak Activity ◽  
Gram Positive Cocci ◽  
Acid Esters

Abstract The antibacterial activities of propolis samples have been examined in vitro, according to the principles accepted for the determination of a similar activity of antibiotics with the use of solid and liquid media. It has been found that propolis extracts showed antibacterial activity through a range of commonly encountered gram positive cocci (5. aureus, beta hem. Streptococus), but had weak activity against gram negative bacteria (E . coli, P. aeruginosa). GC/MS analysis showed that propolis samples contain a variety of chemical compounds in­ cluding aromatic compounds, fatty acid esters and sesquiterpenes.

scholarly journals Antibacterial activity of vegetal extracts against serovars of Salmonella

2011 ◽  
Vol 41 (2) ◽  
pp. 314-320 ◽  
Author(s):  
Daiane Voss-Rech ◽  
Cátia Silene Klein ◽  
Vânia Helena Techio ◽  
Gerson Neudi Scheuermann ◽  
Gilberto Rech ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Bactericidal Activity ◽  
Inhibitory Concentration ◽  
Minimum Bactericidal Concentration ◽  
Punica Granatum ◽  
Eugenia Jambolana ◽  
In Vitro Antibacterial Activity ◽  
Achyrocline Satureioides

in vitro antibacterial activity of 21 hydroethanolic vegetal extracts was assessed against 20 serovars of Salmonella. Regarding the tested extracts, 85.7% of them presented antibacterial activity. The six active extracts which showed activity on the largest number of serovars and the extract of Eucalyptus sp. were submitted to the determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Of these, six extracts showed bacteriostatic and bactericidal activity with MIC and MBC for Punica granatum (pomegranate) from 20 and 60mg mL-1, for Eugenia jambolana (rose apple) from 40 and 240mg mL-1, Eugenia uniflora (surinam cherry) from 80 and 240mg mL-1, Caryophyllus aromaticus (clove) from 10 and 60mg mL-1, Psidium araca from 30 and 320mg mL-1 and Eucalyptus sp. from 40 and 160mg mL-1. Achyrocline satureioides (macela) presented only bacteriostatic potential and MIC from 160mg mL-1. Caryophyllus aromaticus, Eucalyptus sp., and Psidium araca presented the best results for bactericidal activity, inhibiting, respectively, 84.2%, 42.1%, and 17.6% of Salmonella's serovars. The activity of each extract varied for different serovars; S. London presented resistance to the six extracts in MBC, while S. Pullorum was the most susceptible serovar.

scholarly journals Determination of Untreated Whole-Milk Effects on In Vitro Antibacterial Activity

1970 ◽  
Vol 19 (2) ◽  
pp. 220-223 ◽  
Author(s):  
J. P. Van Natta ◽  
P. W. Lo ◽  
T. S. Chang
Keyword(s):  
Antibacterial Activity ◽  
Whole Milk ◽  
In Vitro Antibacterial Activity

scholarly journals Interaction between bark extract of Anadenanthera colubrina var. cebil (Griseb.) Altschul with antibiotics against methicillin-resistant Staphylococcus aureus (MRSA)

2021 ◽  
Vol 10 (6) ◽  
pp. e14210615469
Author(s):  
Pérola Paloma Silva do Nascimento ◽  
Rafaela de Siqueira Ferraz-Carvalho ◽  
Thaís Soares da Silva ◽  
Thiago Antônio de Sousa Araújo ◽  
Elba Lúcia Cavalcanti de Amorim ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Clinical Isolates ◽  
Northeastern Brazil ◽  
Bark Extract ◽  
Methicillin Resistant ◽  
In Vitro Interaction

Anadenanthera colubrina var. cebil (Griseb.) Altschul, a plant often found in areas of the Caatinga in northeastern Brazil, is widely used in unconventional medicine for the treatment of infections and inflammations. Thus, the aim of the present study was to evaluate the antibacterial activity of A. colubrina bark extracts against methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates, to investigate if intact and regenerated bark extracts have the same effect against MRSA and to determine the interaction between these extracts and antibiotics. The antibacterial activity was performed by the determination of the minimum inhibitory concentration (MIC) according to the Clinical and Laboratory Standards Institute (CLSI) and the interaction assay was performed by the checkerboard method. A. colubrina extracts showed bacteriostatic activity (MIC = 8-32 mg/L) against MRSA clinical strains and no difference was found in antibacterial activity between intact and regenerated barks, suggesting that even after regeneration, the barks of this species have the same antibacterial activity. Moreover, the in vitro interaction of A. colubrina extracts with ciprofloxacin or erythromycin was additive (FICI = 0.52). Thus, the bark extracts of Anadenanthera colubrina exhibit antibacterial activity and can be used alone or in combination with antibiotics against MRSA clinical isolates.

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