The interaction of cefotetan with cefsulodin against clinical isolates of aerobic and anaerobic bacteria

1986 ◽  
Vol 18 (6) ◽  
pp. 766-768
Author(s):  
B. WATT ◽  
F. V. BROWN
Keyword(s):  
Anaerobic Bacteria ◽  
Clinical Isolates ◽  
Aerobic And Anaerobic

scholarly journals Comparative In Vitro Activities of Torezolid (DA-7157) against Clinical Isolates of Aerobic and Anaerobic Bacteria in South Korea

2010 ◽  
Vol 54 (12) ◽  
pp. 5381-5386 ◽  
Author(s):  
Jong Hwa Yum ◽  
Sung Hak Choi ◽  
Dongeun Yong ◽  
Yunsop Chong ◽  
Weon Bin Im ◽  
...  
Keyword(s):  
South Korea ◽  
Antimicrobial Agents ◽  
Anaerobic Bacteria ◽  
Clinical Isolates ◽  
Bacterial Isolates ◽  
First Line ◽  
Gram Positive ◽  
The World ◽  
Aerobic And Anaerobic

ABSTRACT Resistance of Gram-positive pathogens to first-line antimicrobial agents has been increasing in many parts of the world. We compared the in vitro activities of torezolid with those of other antimicrobial agents, including linezolid, against clinical isolates of major aerobic and anaerobic bacteria. Torezolid had an MIC90 of ≤0.5 μg/ml for the Gram-positive bacterial isolates tested and was more potent than either linezolid or vancomycin.

scholarly journals Bactericidal and Morphological Effects of NE-2001, a Novel Synthetic Agent Directed against Helicobacter pylori

2005 ◽  
Vol 49 (8) ◽  
pp. 3468-3473 ◽  
Author(s):  
Guofei Dai ◽  
Ni Cheng ◽  
Lei Dong ◽  
Mutsumi Muramatsu ◽  
Shudong Xiao ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Anaerobic Bacteria ◽  
Antibacterial Activities ◽  
Clinical Isolates ◽  
Synthetic Compound ◽  
Morphological Alterations ◽  
Transmission Electron Microcopy ◽  
Transmission Electron ◽  
Bactericidal Effects ◽  
Aerobic And Anaerobic

ABSTRACT The antibacterial activities of NE-2001 were tested against 24 clinical isolates of Helicobacter pylori and compared with those of amoxicillin, clarithromycin, metronidazole, and furazolidone. The MIC50 and MIC90 of this synthetic compound on the isolates were 8 and 16 μg/ml, respectively. This action was highly selective against Helicobacter pylori; there was a >4-fold difference between the concentration of NE-2001 required to inhibit the growth of Helicobacter pylori and that required to inhibit the growth of common aerobic and anaerobic bacteria. Exposure of Helicobacter pylori (ATCC43504) to NE-2001 at the MIC (4 μg/ml), or at a greater concentration, resulted in an extensive loss of viability. The phenomenon was also observed at pH levels between 3.0 and 7.0. When two clinical Helicobacter pylori strains were successively cultured at subinhibitory concentrations of NE-2001, no significant changes in the bactericidal effects were found. The morphological alterations of Helicobacter pylori cells (ATCC43504), exposed to NE-2001 at various concentrations for 6 h, were observed using transmission electron microcopy. The bacterium displayed features such as swelling, vacuole-like structures in the cytoplasm, and cell destruction following exposure to NE-2001. The efficacy of NE-2001 was maintained when evaluated in eight clinical isolates resistant to metronidazole and five isolates resistant to both metronidazole and clarithromycin (MIC ranging between 4 and 16 μg/ml). The above-described results suggest that NE-2001 may have the potential to be developed as a candidate agent for the treatment of Helicobacter pylori infection.

scholarly journals In Vitro Activities of DA-7867, a Novel Oxazolidinone, against Recent Clinical Isolates of Aerobic and Anaerobic Bacteria

2004 ◽  
Vol 48 (5) ◽  
pp. 1918-1918
Author(s):  
Dongeun Yong ◽  
Jong Hwa Yum ◽  
Kyungwon Lee ◽  
Yunsop Chong ◽  
Sung Hak Choi ◽  
...  
Keyword(s):  
Anaerobic Bacteria ◽  
Clinical Isolates ◽  
Aerobic And Anaerobic

Multilaboratory evaluation of the in vitro activity of 13 β-lactam antibiotics against 1474 clinical isolates of aerobic and anaerobic bacteria

1993 ◽  
Vol 16 (3) ◽  
pp. 191-203 ◽  
Author(s):  
Patrick R. Murray ◽  
Ronald N. Jones ◽  
Stephen D. Allen ◽  
Meredith E. Erwin ◽  
Peter C. Fuchs ◽  
...  
Keyword(s):  
Anaerobic Bacteria ◽  
Vitro Activity ◽  
Clinical Isolates ◽  
In Vitro Activity ◽  
Aerobic And Anaerobic

scholarly journals In Vitro Activities of DA-7867, a Novel Oxazolidinone, against Recent Clinical Isolates of Aerobic and Anaerobic Bacteria

2004 ◽  
Vol 48 (1) ◽  
pp. 352-357 ◽  
Author(s):  
Dongeun Yong ◽  
Jong Hwa Yum ◽  
Kyungwon Lee ◽  
Yunsop Chong ◽  
Sung Hak Choi ◽  
...  
Keyword(s):  
Anaerobic Bacteria ◽  
Clinical Isolates ◽  
Bacterial Strains ◽  
Gram Positive ◽  
Aerobic And Anaerobic

ABSTRACT In vitro activities of DA-7867, a novel oxazolidinone, were compared to those of linezolid and commonly used antimicrobials. DA-7867 had the lowest MIC for 90% of the aerobic gram-positive bacterial strains tested, ≤0.25 μg/ml, and it was more potent than linezolid.

Aerobic and Anaerobic Bacteria in the Middle ear and ear Canal in Acute Otitis Media

1982 ◽  
Vol 93 (sup386) ◽  
pp. 100-102 ◽  
Author(s):  
J. Luotonen ◽  
A. M. M. Jokipii ◽  
P. Sipilä ◽  
J. Väyrynen ◽  
L. Jokipii ◽  
...  
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Anaerobic Bacteria ◽  
Acute Otitis Media ◽  
Ear Canal ◽  
Aerobic And Anaerobic

Decontamination of the Oral Cavity. Effect of Six Local Anti-Microbial Preparations in Comparison to Water and Parafilm as Controls

1988 ◽  
Vol 16 (2) ◽  
pp. 98-106 ◽  
Author(s):  
C. Matula ◽  
M. Hildebrandt ◽  
G. Nahler
Keyword(s):  
Hydrogen Peroxide ◽  
Oral Cavity ◽  
Anaerobic Bacteria ◽  
Crossover Design ◽  
Double Blind ◽  
Bacterial Counts ◽  
Aerobic And Anaerobic ◽  
Cavity Effect ◽  
Bacterial Effect ◽  
Observation Period

Six preparations (four liquid and two solid) were tested in a double-blind crossover design for their anti-bacterial effect on aerobic and anaerobic bacteria in saliva of 12 volunteers. The four liquid preparations contained either tyrothricin, hexetidine, hydrogen peroxide or ethanol and were tested against a rinse with water as control. The two solid preparations, in the form of lozenges, contained tyrothricin in doses of 4 or 10 mg and were tested against parafilm. A single rinse with either tyrothricin or hexetidine resulted in a significant reduction of aerobic and anaerobic bacteria in saliva which lasted for the whole 1h observation period and was considerably more effective than hydrogen peroxide or ethanol. Similar results were seen with the solid preparations. The lozenge containing 10 mg tyrothricin was the most effective and was the only formulation capable of reducing oral aerobic bacterial counts by a factor of approximately 100.

scholarly journals In Vitro and In Vivo Antibacterial Activities of a Novel Glycylcycline, the 9-t-Butylglycylamido Derivative of Minocycline (GAR-936)

1999 ◽  
Vol 43 (4) ◽  
pp. 738-744 ◽  
Author(s):  
P. J. Petersen ◽  
N. V. Jacobus ◽  
W. J. Weiss ◽  
P. E. Sum ◽  
R. T. Testa
Keyword(s):  
Anaerobic Bacteria ◽  
Tetracycline Resistance ◽  
Protective Effects ◽  
Gram Negative ◽  
E Coli ◽  
Resistance Determinants ◽  
Aerobic And Anaerobic ◽  
Ribosomal Protection

ABSTRACT The 9-t-butylglycylamido derivative of minocycline (TBG-MINO) is a recently synthesized member of a novel group of antibiotics, the glycylcyclines. This new derivative, like the first glycylcyclines, theN,N-dimethylglycylamido derivative of minocycline and 6-demethyl-6-deoxytetracycline, possesses activity against bacterial isolates containing the two major determinants responsible for tetracycline resistance: ribosomal protection and active efflux. The in vitro activities of TBG-MINO and the comparative agents were evaluated against strains with characterized tetracycline resistance as well as a spectrum of recent clinical aerobic and anaerobic gram-positive and gram-negative bacteria. TBG-MINO, with an MIC range of 0.25 to 0.5 μg/ml, showed good activity against strains expressing tet(M) (ribosomal protection), tet(A), tet(B),tet(C), tet(D), and tet(K) (efflux resistance determinants). TBG-MINO exhibited similar activity against methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant streptococci, and vancomycin-resistant enterococci (MICs at which 90% of strains are inhibited, ≤0.5 μg/ml). TBG-MINO exhibited activity against a wide diversity of gram-negative aerobic and anaerobic bacteria, most of which were less susceptible to tetracycline and minocycline. The in vivo protective effects of TBG-MINO were examined against acute lethal infections in mice caused by Escherichia coli, S. aureus, andStreptococcus pneumoniae isolates. TBG-MINO, administered intravenously, demonstrated efficacy against infections caused byS. aureus including MRSA strains and strains containingtet(K) or tet(M) resistance determinants (median effective doses [ED50s], 0.79 to 2.3 mg/kg of body weight). TBG-MINO demonstrated efficacy against infections caused by tetracycline-sensitive E. coli strains as well asE. coli strains containing either tet(M) or the efflux determinant tet(A), tet(B), ortet(C) (ED50s, 1.5 to 3.5 mg/kg). Overall, TBG-MINO shows antibacterial activity against a wide spectrum of gram-positive and gram-negative aerobic and anaerobic bacteria including strains resistant to other chemotherapeutic agents. The in vivo protective effects, especially against infections caused by resistant bacteria, corresponded with the in vitro activity of TBG-MINO.

scholarly journals Bacteriological Findings within Internal Implant Hole Following Flapless Implant Placement

2018 ◽  
Vol 30 (3) ◽  
pp. 13-16
Author(s):  
Khudair A Abd ◽  
Basima G Ali ◽  
Abbas S AL-Mizraqchi
Keyword(s):  
Health Status ◽  
Anaerobic Bacteria ◽  
Bacterial Count ◽  
Oral Health Status ◽  
Viable Count ◽  
Screw Hole ◽  
Implant Placement ◽  
Significant Difference ◽  
Edentulous Patients ◽  
Aerobic And Anaerobic

Back ground: Microbial penetration inside the implant's internal hole creates a bacterial reservoir that is related with an area of inflamed connective tissue opposite the fixture-abutment junction and this can affect the health of the peri-implant tissue. Aims of the study: Evaluate the types aerobic and anaerobic bacterial count-percentage and difference between Aerobic and Anaerobic microflora in the implant screw hole three months after implant placement. Monitor the periodontal health status of all patients, throughout the study. Material and methods: Study methodology; Eight partially edentulous patients received 20 dental implants and these implants done with flapless surgical procedure. All patients examined clinically to determined their oral health status by examination of their plaque index, Gingival index and Bleeding on probing, each two weeks for 90 days (8visits) throughout the study period. Three months after that, the plaque sample collected from the internal hole of fixture and transfer to bacterial investigation and assessment the amount of anaerobic and aerobic bacteria. Results: Although the anaerobic viable count is higher than that of aerobic, but with statistically not significant difference between those counts (P>0.05). Keywords: screw hole, flapless surgical implant placement, bacterial count, Aerobic and Anaerobic bacteria

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