PSIII-15 The interactions of change in nutrition after artificial insemination on plasma metabolites, steroid hormones, and uterine histotroph in beef heifers

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 290-291
Author(s):  
Taylor Andrews ◽  
Julie Walker ◽  
Kaitlin M Epperson ◽  
Jerica J Rich ◽  
Adalaide C Kline ◽  
...  
Keyword(s):  
Steroid Hormones ◽  
Plasma Protein ◽  
Artificial Insemination ◽  
Plasma Metabolites ◽  
Beef Heifers ◽  
Plasma Nefa ◽  
Embryo Recovery ◽  
Mineral Concentrations ◽  
The Impact ◽  
Over Time

Abstract The objective was to evaluate the impact of nutritional changes after artificial insemination (AI) on plasma metabolites, steroid hormones, and uterine histotroph. Beef heifers (n = 50) were randomly assigned to a post-AI dietary treatment (High=161.5% or Low=77.45% of maintenance energy) until uteri were flushed for embryo recovery (d14). Blood samples were collected on d -3, 0 (AI), 3, 6, 9, 12, and 14 for analysis of plasma non-esterified fatty acid (NEFA), total protein (protein), glucose, cholesterol, and progesterone concentrations. Uterine flushes (UF) were analyzed for concentrations of Mg, P, S, K, Ca, Cu, Zn, Se, Mn, Co, B, Cr, and Fe. Plasma NEFA, protein, glucose, cholesterol, and progesterone concentrations were analyzed as repeated measures in SAS (PROC MIXED). Mineral concentrations in UF were analyzed using the MIXED procedures in SAS. Diet influenced plasma NEFA concentrations, with Low heifers having elevated concentrations (P < 0.01); however, diet did not influence plasma protein, glucose, cholesterol, or progesterone concentrations (P > 0.10). Plasma NEFA, glucose, and progesterone concentrations changed over time (P < 0.05), but protein and cholesterol did not differ over time (P > 0.10). Diet by time interactions influenced plasma NEFA, protein, and cholesterol concentrations (P < 0.05), but glucose and progesterone concentrations were not different (P > 0.10). Presence of a recovered embryo by time interaction influenced plasma protein concentrations (P < 0.04), but NEFA, glucose, cholesterol, and progesterone concentrations were not affected by the interaction (P > 0.10). Embryo recovery and diet by embryo recovery by time did not impact plasma NEFA, protein, glucose, cholesterol and progesterone concentrations (P > 0.10). When an embryo was recovered, Mg (P = 0.02) and S (P = 0.02) were decreased in UF. Diet and diet by embryo recovery did not affect UF mineral concentrations (P>0.10). In conclusion, post-AI nutrition influenced plasma NEFA, protein, glucose, cholesterol, and progesterone concentrations. Additionally, uterine histotroph mineral concentrations were affected by presence of an embryo.

258 The Interactions of Change in Nutrition on Uterine Environment and Plasma Cholesterol Concentrations in Beef Cattle

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 110-110
Author(s):  
Taylor Andrews ◽  
Kaitlin Epperson ◽  
Jerica Rich ◽  
Saulo Menegatti Zoca ◽  
Abigail L Zezeski ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Colorimetric Assay ◽  
Plasma Cholesterol ◽  
Dietary Treatment ◽  
Treatment Groups ◽  
Embryo Recovery ◽  
Uterine Environment ◽  
New Treatment ◽  
Mineral Concentrations ◽  
The Impact

Abstract The objective was to evaluate the impact of nutritional changes prior to and after artificial insemination (AI) on uterine environment and plasma cholesterol concentrations. Beef heifers (n = 79) were randomly assigned to two dietary treatment groups (High=155% or Low=86% of maintenance energy) for 30 d prior to AI (pre-AI). At AI, heifers were randomly assigned new treatment groups (post-AI) which created four pre- x post-AI diet treatments (High-High, High-Low, Low-High, and Low-Low). Post-AI dietary treatments continued until uteri were flushed for embryo recovery (d 7 or 8 post-AI). Blood samples were collected on d -3,-2,-1, 0 (AI day), 1,3,5,7, and 8 for analysis of plasma cholesterol concentrations using a colorimetric assay. Uterine flushes were analyzed for concentrations of Mg, Al, P, S, K, Ca, Cu, Zn, Se, and Fe by ICPMS. Plasma cholesterol (repeated measures) and uterine mineral concentrations were analyzed using the MIXED procedures in SAS. Plasma cholesterol concentrations changed over time (P < 0.0001); however, there were no differences between treatments (P > 0.10). There was an effect of embryo presence on uterine flush mineral concentrations for Mg (P < 0.04), Al (P < 0.01), S (P < 0.01), K (P < 0.01), and Ca (P < 0.01), with decreased concentrations when uterine flushes contained an embryo. There was no effect of pre-AI diet on mineral concentrations; however, there was an effect of post-AI diet on S (P < 0.02) and Ca (P = 0.03). High diet heifers had increased S and Ca concentrations compared to low diet heifers. Sulfur concentration was affected by a pre-AI diet by embryo interaction (P < 0.03). There was a post-AI by embryo interaction on P (P < 0.03), Zn (P = 0.02), and Se (P = 0.02). Also, there was a pre-AI by post-AI by embryo interaction on Mg (P < 0.05). In conclusion, changing plane of nutrition pre- and post-AI had no effect on plasma cholesterol concentrations; however, presence of an embryo affected uterine mineral concentrations.

The Therapist’s Reaction to a Patient’s Suicide

Crisis ◽  
2011 ◽  
Vol 32 (2) ◽  
pp. 99-105 ◽  
Author(s):  
Friedrich Martin Wurst ◽  
Isabella Kunz ◽  
Gregory Skipper ◽  
Manfred Wolfersdorf ◽  
Karl H. Beine ◽  
...  
Keyword(s):  
Emotional Responses ◽  
Well Being ◽  
Emotional Reaction ◽  
Emotional Reactions ◽  
Analog Scale ◽  
General Hospitals ◽  
Item Questionnaire ◽  
Retrospective Nature ◽  
The Impact ◽  
Over Time

Background: A substantial proportion of therapists experience the loss of a patient to suicide at some point during their professional life. Aims: To assess (1) the impact of a patient’s suicide on therapists distress and well-being over time, (2) which factors contribute to the reaction, and (3) which subgroup might need special interventions in the aftermath of suicide. Methods: A 63-item questionnaire was sent to all 185 Psychiatric Clinics at General Hospitals in Germany. The emotional reaction of therapists to patient’s suicide was measured immediately, after 2 weeks, and after 6 months. Results: Three out of ten therapists suffer from severe distress after a patients’ suicide. The item “overall distress” immediately after the suicide predicts emotional reactions and changes in behavior. The emotional responses immediately after the suicide explained 43.5% of the variance of total distress in a regression analysis. Limitations: The retrospective nature of the study is its primary limitation. Conclusions: Our data suggest that identifying the severely distressed subgroup could be done using a visual analog scale for overall distress. As a consequence, more specific and intensified help could be provided to these professionals.

Has Aid Helped in Pakistan?

1997 ◽  
Vol 36 (4II) ◽  
pp. 947-957 ◽  
Author(s):  
Shahrukh Rafi Khan
Keyword(s):  
Economic Growth ◽  
Negative Impact ◽  
Negative Association ◽  
Causal Impact ◽  
The Impact ◽  
Over Time

This paper has a two-fold objective: first, to examine the terms on which Pakistan receives aid and whether its debt situation is sustainable, and second, to examine the impact of aid and debt on economic growth. It is found that there is little encouraging that can be said about how the terms on which Pakistan has received aid over time have changed, and its current debt situation is not sustainable. Also reported is the analysis done elsewhere which shows that aid has a negative (Granger) causal impact on GDP, and aid has a robust negative impact on economic growth after controlling for supplyside shocks. We provide various reasons for this negative association.

The Role of Vascular Aging in Atherosclerotic Plaque Development and Vulnerability

2019 ◽  
Vol 25 (29) ◽  
pp. 3098-3111 ◽  
Author(s):  
Luca Liberale ◽  
Giovanni G. Camici
Keyword(s):  
Atherosclerotic Plaque ◽  
Molecular Mechanisms ◽  
Driving Forces ◽  
Plaque Burden ◽  
Vascular Aging ◽  
Age Related ◽  
Plaque Development ◽  
Increased Risk ◽  
The Impact ◽  
Over Time

Background: The ongoing demographical shift is leading to an unprecedented aging of the population. As a consequence, the prevalence of age-related diseases, such as atherosclerosis and its thrombotic complications is set to increase in the near future. Endothelial dysfunction and vascular stiffening characterize arterial aging and set the stage for the development of cardiovascular diseases. Atherosclerotic plaques evolve over time, the extent to which these changes might affect their stability and predispose to sudden complications remains to be determined. Recent advances in imaging technology will allow for longitudinal prospective studies following the progression of plaque burden aimed at better characterizing changes over time associated with plaque stability or rupture. Oxidative stress and inflammation, firmly established driving forces of age-related CV dysfunction, also play an important role in atherosclerotic plaque destabilization and rupture. Several genes involved in lifespan determination are known regulator of redox cellular balance and pre-clinical evidence underlines their pathophysiological roles in age-related cardiovascular dysfunction and atherosclerosis. Objective: The aim of this narrative review is to examine the impact of aging on arterial function and atherosclerotic plaque development. Furthermore, we report how molecular mechanisms of vascular aging might regulate age-related plaque modifications and how this may help to identify novel therapeutic targets to attenuate the increased risk of CV disease in elderly people.

Conclusion

2018 ◽  
Author(s):  
Manuel Fröhlich ◽  
Abiodun Williams
Keyword(s):  
Security Council ◽  
International Context ◽  
Peace And Security ◽  
Executive Action ◽  
Trends Over Time ◽  
The Impact ◽  
Over Time ◽  
The Way ◽  
Guiding Questions

The Conclusion returns to the guiding questions introduced in the Introduction, looking at the way in which the book’s chapters answered them. As such, it identifies recurring themes, experiences, structures, motives, and trends over time. By summarizing the result of the chapters’ research into the interaction between the Secretaries-General and the Security Council, some lessons are identified on the changing calculus of appointments, the conditions and relevance of the international context, the impact of different personalities in that interaction, the changes in agenda and composition of the Council as well as different formats of interaction and different challenges to be met in the realm of peace and security, administration, and reform, as well as concepts and norms. Taken together, they also illustrate the potential and limitations of UN executive action.

Understanding Rising Income Inequality and Stagnating Ordinary Living Standards in Germany

2018 ◽  
Author(s):  
Gerhard Bosch ◽  
Thorsten Kalina
Keyword(s):  
Income Inequality ◽  
Labour Market ◽  
Economic Crisis ◽  
Household Income ◽  
Wage Bargaining ◽  
Living Standards ◽  
Social Model ◽  
Real Wages ◽  
The Impact ◽  
Over Time

This chapter describes how inequality and real incomes have evolved in Germany through the period from the 1980s, through reunification, up to the economic Crisis and its aftermath. It brings out how reunification was associated with a prolonged stagnation in real wages. It emphasizes how the distinctive German structures for wage bargaining were eroded over time, and the labour market and tax/transfer reforms of the late 1990s-early/mid-2000s led to increasing dualization in the labour market. The consequence was a marked increase in household income inequality, which went together with wage stagnation for much of the 1990s and subsequently. Coordination between government, employers, and unions still sufficed to avoid the impact the economic Crisis had on unemployment elsewhere, but the German social model has been altered fundamentally over the period

A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway

2021 ◽  
pp. 1-10
Author(s):  
Varvara Kanti ◽  
Lia Puder ◽  
Irina Jahnke ◽  
Philipp Maximilian Krabusch ◽  
Jan Kottner ◽  
...  
Keyword(s):  
Leptin Receptor ◽  
Skin Pigmentation ◽  
Gene Mutations ◽  
Continuous Treatment ◽  
Whole Body ◽  
Hair Color ◽  
Phase 2 ◽  
Loss Of Function ◽  
The Impact ◽  
Over Time

<b><i>Background and Objectives:</i></b> Gene mutations within the leptin-melanocortin signaling pathway lead to severe early-onset obesity. Recently, a phase 2 trial evaluated new pharmacological treatment options with the MC4R agonist <i>setmelanotide</i> in patients with mutations in the genes encoding proopiomelanocortin (POMC) and leptin receptor (LEPR). During treatment with <i>setmelanotide,</i> changes in skin pigmentation were observed, probably due to off-target effects on the closely related melanocortin 1 receptor (MC1R). Here, we describe in detail the findings of dermatological examinations and measurements of skin pigmentation during this treatment over time and discuss the impact of these changes on patient safety. <b><i>Methods:</i></b> In an investigator-initiated, phase 2, open-label pilot study, 2 patients with loss-of-function POMC gene mutations and 3 patients with loss-of-function variants in LEPR were treated with the MC4R agonist <i>setmelanotide</i>. Dermatological examination, dermoscopy, whole body photographic documentation, and spectrophotometric measurements were performed at screening visit and approximately every 3 months during the course of the study. <b><i>Results:</i></b> We report the results of a maximum treatment duration of 46 months. Skin pigmentation increased in all treated patients, as confirmed by spectrophotometry. During continuous treatment, the current results indicate that elevated tanning intensity levels may stabilize over time. Lips and nevi also darkened. In red-haired study participants, hair color changed to brown after initiation of <i>setmelanotide</i> treatment. <b><i>Discussion:</i></b> <i>Setmelanotide</i> treatment leads to skin tanning and occasionally hair color darkening in both POMC- and LEPR-deficient patients. No malignant skin changes were observed in the patients of this study. However, the results highlight the importance of regular skin examinations before and during MC4R agonist treatment.

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