scholarly journals 369 Impact of an extended-release dewormer on fetal development and subsequent calf performance

2019 ◽  
Vol 97 (Supplement_2) ◽  
pp. 154-154
Author(s):  
Ashley M Reiner ◽  
Stephanie D Perkins ◽  
Jerica J J Rich ◽  
Emmalee J Northrop ◽  
George A Perry

Abstract Parasitism decreases the nutrients available for cow and fetal/calf performance. The objective of this study was to evaluate the impact of an extended-release dewormer [LongRange® (eprinomectin)] compared to a traditional dewormer [Dectomax® (doramectin)] on fetal/calf performance. Postpartum suckled beef cows (n = 349) were grouped by age and randomly allotted to one of two treatments over a two year period 1) treatment with LongRange at AI and calves treated with Eprinex® or 2) cows and calves treated with Dectomax. In year 2, half of each treatment was switched to the opposite treatment and half remained on the same treatment to result in a 2x2 design (calf sex was included in the statistical model). Cow weight was determined at AI, d60, d135, and d365 (treatment year 2). Calves born in year 2 were weighed at time of AI and at weaning. Pregnancy rates (determined at 60 and 135 d after AI) did not differ in year 1 (P = 0.85, 0.29) or in year 2 (P = 0.44, 0.98). Both treatments lost weight from AI to d60 of the breeding season (P = 0.98); however, there was a weak tendency (P = 0.15) for LongRange cows to gain more from d60 to 135 compared to Dectomax cows. Performance did not differ from d135 to AI in year 2 (P = 0.79). Calves that were in utero during year 1 when their dam received LongRange treatment had increased weight per day of age at year 2 AI (mean calf age =58d) compared to Dectomax treatment (P = 0.05; 2.2 ± 0.09 vs 2.0 ± 0.07kg). Furthermore, year 2 treatment tended (P = 0.09) to impact weight per day of age at weaning (LongRange=1.4 ± 0.03kg, Dectomax=1.3 ± 0.02). There was no year 1 by year 2 interaction (P = 0.87). In summary, administering an extended-release dewormer at AI did not impact pregnancy success, but increased calf performance both at 50d of age and at weaning.

2018 ◽  
Vol 3 (1) ◽  
pp. 273-287 ◽  
Author(s):  
Claire E Andresen ◽  
Dan D Loy ◽  
Troy A Brick ◽  
Lee L Schulz ◽  
Patrick J Gunn

Abstract The objective of this study was to estimate the impact of a single injection of extended-release eprinomectin on economically relevant production variables in beef cows and calves as well as subsequent feedlot health, performance, and carcass traits of calves compared with a traditional, short duration anthelmintic. Animals from 13 cooperator herds across seven states were stratified within herd and assigned to one of two treatments; injectable doramectin (DOR; Dectomax; n = 828) or injectable eprinomection (EPR; Longrange; n = 832). Fecal samples were randomly collected from a subset of cows at both treatment and the end of grazing to evaluate fecal egg count (FEC). Continuous and categorical data were analyzed using the MIXED and GLIMMIX procedures of SAS, respectively. Cow treatment body weight (BW) and final BW were not different (P ≥ 0.40) between treatments. There were no differences (P ≥ 0.12) between treatments in cow ADG, change in BW, or body condition scores during the grazing season. While FEC at treatment did not differ (P = 0.18), cows treated with EPR had lower final FEC at the end of the grazing season (P = 0.02) and a greater reduction of FEC over the grazing season (P = 0.01). Calf treatment BW, weaning BW, and ADG did not differ between treatments (P ≥ 0.34). Incidence of pinkeye tended to be less (P = 0.06) for cows treated with EPR but was not different for calves (P = 0.43). Conception to AI, overall pregnancy rates, and calving interval were not different between treatments (P ≥ 0.45). A subset of calves from each herd was sent to Tri-County Steer Carcass Futurity (TCSCF) feedlot for the finishing phase. Calf BW did not differ at initiation of feeding (P = 0.20). While EPR calves tended to be heavier at reimplantation (P = 0.07), final BW and overall ADG were not different between treatments (P ≥ 0.13). Health records indicated lower morbidity for EPR calves (P = 0.05). Carcass performance including HCW, dressing percent, backfat, KPH, REA, YG, were not different between treatment groups (P ≥ 0.12). However, EPR calves had a greater marbling score, greater average quality grade (P < 0.01), and higher proportion of calves that graded average choice or greater (P = 0.03). Results of this study indicate no difference in cow or preweaning calf performance, however, carcass quality in the feedlot phase was improved. Thus, economic analysis indicates opportunities for return on investment if animals treated with EPR have improved health status and/or carcass quality during the feeding phase.


Author(s):  
Parker A Henley ◽  
Frank A Ireland ◽  
Igor F Canisso ◽  
J Lannett Edwards ◽  
Daniel W Shike

Abstract This study evaluated the effect of heifer development system on body weight (BW), body condition score (BCS), fescue toxicosis symptoms, reproductive performance, and subsequent calf growth of fall-calving beef heifers. Angus × Simmental heifers [n = 399; 240 ± 20.0 kg initial BW; age = 252 ± 20 d] were stratified by BW and BCS and assigned to 1 of 12 groups in each of the 2 production years. The study utilized a stratified randomized design. Pens were randomly assigned to 4 treatments: drylot (DL) development (fed ad-libitum diet consisting of 90% hay and 10% DDGS on a dry matter basis), grazing endophyte-infected fescue supplemented daily (2.3 kg as-fed/heifer/d; 50:50 mix of soybean hulls and DDGS; E+/S), grazing endophyte-infected fescue and supplemented from the midpoint of treatment period until breeding (4.5 kg as-fed/heifer/d; 50:50 mix of soybean hulls and DDGS; E+/LS), and grazing novel endophyte-infected fescue with no supplement (NE+/NS). Treatments ceased on d 168 [time of artificial insemination (AI)] and heifers were commingled and managed as a group through second breeding season. Heifers in DL had greatest (P ≤ 0.05) BW and BCS from d 28 until d 254. Furthermore, E+/S heifers had greater (P ≤ 0.05) BW and BCS than both E+/LS and NE+/NS from d 28 until d 168. On d 56 and 84, E+/LS heifers had lower (P ≤ 0.05) BW and BCS compared to NE+/NS, but on d 148 treatments reranked and E+/LS remained at a greater (P ≤ 0.05) BW and BCS compared to NE+/NS through the first breeding season. Drylot heifers had greatest (P ≤ 0.05) percentage cycling and percentage of mature BW at AI (66.6%) and had greater (P ≤ 0.05) AI and overall pregnancy rates compared to E+/LS and NE+/NS. The E+/S (55%) and E+/LS (53.7%) heifers were developed to a greater (P < 0.01) percentage of mature BW than NE+/NS (49.3%). A greater (P ≤ 0.02) percentage of DL and E+/S heifers were pregnant at the end of the first breeding season (89.3 and 85.1%; respectively) compared to NE+/NS (61.5%). In summary, DL heifers had the greatest BW and BCS at AI, percentage cycling, and AI pregnancy rate. However, this strategy did not result in differing overall pregnancy rates between DL, E+/S, and E+/LS and there were no differences in milk production, rebreeding reproductive performance, and calf performance between all treatments. Finally, the poorest AI and overall pregnancy rates of the NE+/NS heifers suggests this is not a viable development strategy for fall-born heifers.


2019 ◽  
Vol 97 (Supplement_1) ◽  
pp. 43-44
Author(s):  
Anna L Smith ◽  
Rebecca K Poole ◽  
Kyle Mayberry ◽  
McKayla A Newsome ◽  
Harrison B Dudley ◽  
...  

Abstract Advancements in reproductive technologies have improved pregnancy rates in postpartum cows; however, undesirable consequences leading to reduced fertility still occur. Thus, the objectives were to determine if presence of a corpus luteum (CL) at the start of estrous synchronization (AIM1) or if the length of proestrus (interval from progesterone removal to a GnRH-induced LH surge; AIM2) alters fixed timed artificial insemination (FTAI) pregnancy rates. Cycling postpartum cows (n = 285) at two locations were synchronized using the CO-Synch+CIDR® FTAI protocol. Ultrasonographic measurements of luteal area were recorded at CIDR insertion. To determine the impact of proestrus length, cows were randomly assigned to either undergo CIDR removal at the time of PGF2a injection (long proestrus, n = 145), or CIDR removal 24 hours post PGF2a injection (short proestrus, n = 140). Blood samples were collected at CIDR insertion and at insemination for progesterone (P4) analysis. Pregnancy status to FTAI was assessed using ultrasonographic diagnosis at 30 d post insemination. Data were analyzed using a MIXED procedure of SAS and examined for effects of length of proestrus, P4 concentration, luteal area, sire, location, and age. Statistical significance was determined at P0.05) pregnancy rates. Pregnancy rates were greater in cows with >1 ng/mL P4 compared to cows with 0.05). Cows > 4 y old had higher AI pregnancy rates compared to 2–3 y cows (70.2±7.4 vs. 51±5.8%, respectively; P > 0.05). Based on these data, incorporating a presynchronization program to ensure the presence of a functional CL at the start of a FTAI protocol may improve pregnancy success in postpartum beef cows.


2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 48-48
Author(s):  
Alice Brandão ◽  
Reinaldo F Cooke ◽  
G Cliff C Lamb ◽  
José Luiz Vasconcelos ◽  
Ky G Pohler

Abstract Responses of Bos taurus (BT) and B. indicus (BI) beef cows were compared according to their body condition score (BCS) at initiation of breeding season. Cows were assigned to an estrus synchronization + AI protocol and classified as BCS < 5.0 (LBCS, BT, n = 158; BI, n = 248) or BCS ≥ 5.0 (HBCS; BT, n = 173; BI, n = 122). Pregnancy status was verified via transrectal ultrasonography at 30 and 40 d after AI for BI and BT cows, respectively. All BT cows were exposed to natural service for 50 d (beginning 18 d after AI), and all non-pregnant BI cows were immediately exposed to natural service for 60 d. Pregnancy rates to AI did not differ (P ≥ 0.16) between HBCS or LBCS cows (60.9 vs. 53.5% for BT; 37.0 vs. 31.4% for BI; respectively). Pregnancy rates to natural service were greater (P = 0.03) in HBCS BT cows compared with LBCS (82.7 vs. 67.9%; respectively) but did not differ in BI cows (78.9 vs. 71.5%; respectively). Calving rate was greater (P < 0.03) in HBCS cows, which also calved earlier (P < 0.01) compared with LBCS (93.7 vs. 85.1% in BT, 83.6 vs. 73.3% in BI; respectively). HBCS Cows weaned more (P ≤ 0.05) calves compared with LBCS, which were older (P ≤ 0.04) (215 vs. 211 d in BT, 219 vs. 209 d in BI; respectively) and heavier (P ≤ 0.09) at weaning (258 vs. 252 kg in BT, 213 vs. 203 d in BI; respectively). Lastly, kg of calf weaned/cow was greater (P ≤ 0.03) in HBCS cows compared with LBCS (221 vs. 200 d in BT, 159 vs. 129 d in BI; respectively). Therefore, HBCS cows had greater reproductive efficiency and overall productivity, and this was observed in both BT and BI.


2019 ◽  
Vol 97 (Supplement_1) ◽  
pp. 85-85
Author(s):  
Anna L Smith ◽  
Rebecca K Poole ◽  
Kyle Mayberry ◽  
McKayla A Newsome ◽  
Harrison B Dudley ◽  
...  

Abstract Advancements in reproductive technologies have improved pregnancy rates in postpartum cows; however, undesirable consequences leading to reduced fertility still occur. Thus, the objectives were to determine if presence of a corpus luteum (CL) at the start of estrous synchronization (AIM1) or if the length of proestrus (interval from progesterone removal to a GnRH-induced LH surge; AIM2) alters fixed timed artificial insemination (FTAI) pregnancy rates. Cycling postpartum cows (n = 285) at two locations were synchronized using the CO-Synch+CIDR® FTAI protocol. Ultrasonographic measurements of luteal area were recorded at CIDR insertion. To determine the impact of proestrus length, cows were randomly assigned to either undergo CIDR removal at the time of PGF2a injection (long proestrus, n = 145), or CIDR removal 24 hours post PGF2a injection (short proestrus, n = 140). Blood samples were collected at CIDR insertion and at insemination for progesterone (P4) analysis. Pregnancy status to FTAI was assessed using ultrasonographic diagnosis at 30 d post insemination. Data were analyzed using a MIXED procedure of SAS and examined for effects of length of proestrus, P4 concentration, luteal area, sire, location, and age. Statistical significance was determined at P 0.05) pregnancy rates. Pregnancy rates were greater in cows with >1 ng/mL P4 compared to cows with 0.05). Cows > 4 y old had higher AI pregnancy rates compared to 2–3 y cows (70.2±7.4 vs. 51±5.8%, respectively; P > 0.05). Based on these data, incorporating a presynchronization program to ensure the presence of a functional CL at the start of a FTAI protocol may improve pregnancy success in postpartum beef cows.


2019 ◽  
Vol 31 (1) ◽  
pp. 131
Author(s):  
G. A. Pessoa ◽  
A. P. Martini ◽  
A. P. Baioco ◽  
E. F. Machado Filho ◽  
H. F. Pinto ◽  
...  

The objective of this study was to compare the effects of 1 and 2 prostaglandin doses in a timed AI (TAI) resynchronization protocol on the pregnancy rate. This study was performed during the 2017-2018 breeding season on 10 commercial farms located in the central and southwest region of Rio Grande do Sul, Brazil. A total of 2347Bos taurus beef cows (Angus, Hereford) with a body condition score 2.90±0.15 (1=thin, 5=obese) and 40±5.1 days postpartum were used. In the beginning of first synchronization TAI protocol, on Day −11, the animals received 2mg of oestradiol benzoate IM (Gonadiol®, Zoetis Saúde Animal, São Paulo, SP, Brazil) and a progesterone (P4) intravaginal device (CIDR®, Zoetis). On Day −4, the cows received 12.5mg of dinoprost tromethamine IM (PGF, Lutalyse®, Zoetis). On Day −2, the animals received 1.0mg of oestradiol cypionate IM (ECP®, Zoetis) associated with the treatment with 300IU of eCG IM (Novormon®, Zoetis) and the P4 device was removed. The TAI was done on Day 0 (48 h after P4 device removal). The resynchronization protocol was started on Day 23 without pregnancy or oestrus detection; all cows were randomly assigned to receive a new, once-used, or twice-used P4 device (CIDR®) and given 2mg of oestradiol benzoate. On Day 30, pregnancy diagnosis was performed with transrectal ultrasonography. Pregnant cows (n=1021) had the P4 device withdrawn and received no further treatment. Nonpregnant cows (n=1326) were randomly assigned into 2 groups. The 1PGF group (n=674) received a single dose of PGF on Day 30, and the 2PGF group (n=652) received PGF on Days 30 and 32. On Day 32, all cows received eCG and ECP, and the P4 device was removed. In both groups the TAI was performed 48h after the P4 device removal (Day 34). Pregnancy diagnosis was performed by ultrasound 30 days after TAI (Day 64 of the breeding season). Data were analysed using the GLIMMIX procedure of SAS (SAS Institute Inc., Cary, NC, USA). The pregnancy rate obtained in the first synchronization protocol was 43.5% (1021/2347). The pregnancy rate in the resynchronization protocol was similar (P=0.49) between PGF doses [1PGF=39.5% (266/674); 2PGF=40.6% (265/652). No interactions were observed between P4 device use and PGF dose (P=0.38). The pregnancy rates were similar when comparing 1PGF and 2PGF using a new P4 device [1PGF=43.2% (35/81); 2PGF=56% (93/166); P=0.67], once-used P4 device [1PGF=39% (163/418); 2PGF=40.6% (140/345); P=0.64], or twice-used P4 device [1PGF=38.9% (68/175); 2PGF=22.7% (32/141); P=0.14]. In conclusion, a second dose of prostaglandin in the resynchronization protocol was not necessary to achieve high resynchronization pregnancy rates with TAI in Bos taurus beef cows.


2005 ◽  
Vol 17 (6) ◽  
pp. 641 ◽  
Author(s):  
Janna L. Morrison ◽  
K. Wayne Riggs ◽  
Dan W. Rurak

Women are at greatest risk of suffering from depression during the childbearing years and thus may either become pregnant while taking an antidepressant or may require a prescription for one during pregnancy. The antidepressant fluoxetine (FX) is a selective serotonin reuptake inhibitor (SSRI), which increases serotonin neurotransmission. Serotonin is involved in the regulation of a variety of physiological systems, including the sleep–wake cycle, circadian rhythms and the hypothalamic–pituitary–adrenal axis. Each of these systems also plays an important role in fetal development. Compared with other antidepressant drugs, the SSRIs, such as FX, have fewer side effects. Because of this, they are now frequently prescribed, especially during pregnancy. Clinical studies suggest poor neonatal outcome after exposure to FX in utero. Recent studies in the sheep fetus describe the physiological effects of in utero exposure to FX with an 8 day infusion during late gestation in the sheep. This is a useful model for determining the effects of FX on fetal physiology. The fetus can be studied for weeks in its normal intrauterine environment with serial sampling of blood, thus permitting detailed studies of drug disposition in both mother and fetus combined with monitoring of fetal behavioural state and cardiovascular function. Fluoxetine causes an acute increase in plasma serotonin levels, leading to a transient reduction in uterine blood flow. This, in turn, reduces the delivery of oxygen and nutrients to the fetus, thereby presenting a mechanism for reducing growth and/or eliciting preterm delivery. Moreover, because FX crosses the placenta, the fetus is exposed directly to FX, as well as to the effects of the drug on the mother. Fluoxetine increases high-voltage/non-rapid eye movement behavioural state in the fetus after both acute and chronic exposure and, thus, may interfere with normal fetal neurodevelopment. Fluoxetine also alters hypothalamic function in the adult and increases the magnitude of the prepartum rise in fetal cortisol concentrations in sheep. Fetal FX exposure does not alter fetal circadian rhythms in melatonin or prolactin. Studies of the effects of FX exposure on fetal development in the sheep are important in defining possible physiological mechanisms that explain human clinical studies of birth outcomes after FX exposure. To date, there have been insufficient longer-term follow-up studies in any precocial species of offspring exposed to SSRIs in utero. Thus, further investigation of the long-term consequences of in utero exposure to FX and other SSRIs, as well as the mechanisms involved, are required for a complete understanding of the impact of these agents on development. This should involve studies in both humans and appropriate animal models.


Author(s):  
Olukorede Abiona

Abstract This paper evaluates the short-term health effects of in utero drought shock using repeated cross-section household data on Malawi. The main finding reveals that the effects of in utero harvest variability caused by rainfall shocks on child growth indices are driven by the deleterious effects of negative rainfall deviations, namely droughts. Negative rainfall deviation during the agricultural season prior to the gestational period of a child leads to a 21.8 per cent average local level reduction in age-standardized height scores, with the counterpart positive rainfall deviation having no apparent effect. The paper also uses harvest and consumption patterns to establish an important link between early-life malnutrition and growth serving as a precursor for the fetal period programming hypothesis in the literature. The direct impact of embryonic period shocks on growth provides supportive evidence on potential interaction between nutritional and environmental pathways.


2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 116-117
Author(s):  
Emily G Smith ◽  
Rachael C Bonacker ◽  
Carson M Andersen ◽  
Jordan M Thomas

Abstract Estrus detection patches were evaluated as a tool to classify postpartum cows as estrous cycling or anestrous at the start of the breeding season. EstrotectTM Breeding Indicators were applied to 257 postpartum beef cows in three locations 25 days prior to the start of estrus synchronization. Coincident with the start of estrus synchronization, patches were scored using a 1 to 4 scale (1 = 0–25%; 2 = 25–50%; 3 = 50–75%; 4 = 75–100%) with scores of 3 or 4 considered activated. Blood samples were collected from each cow 10 days prior to, and at the start of the estrus synchronization. Serum progesterone concentrations were determined via radioimmunoassay; cows were considered estrous cycling if one or both samples exceeded a concentration of 0.5 ng/ml. Based on progesterone, 54.9% of cows were estrous cycling at the start of estrus synchronization. When missing patches were considered inconclusive results, use of patches to infer estrous cyclicity resulted in 85.0% sensitivity and 79.2% specificity with a positive predictive value of 87.2%. However, 75.1% of all cows presented with missing patches at the start of synchronization. If missing patches were considered activated, sensitivity was 95.7%, but specificity (16.4%) and PPV (58.2%) were poor, as 47.6% of cows presenting with missing patches were anestrous based on progesterone. Across all cows, pregnancy rate to AI was 58.0% (149/257). Cows with activated patches that were classified as false positives based on serum progesterone concentrations achieved a 71.4% (5/7) pregnancy rate to AI, raising questions as to whether sensitivity was underestimated due to inherent Type II errors in classification of cyclicity via progesterone. In summary, estrus detection aids are a sensitive tool to identify estrous cycling postpartum cows prior to the start of the breeding season; however, poor specificity and patch retention are limitations for this application.


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