Imaging-based definition of lower uterine segment carcinoma to improve the detection sensitivity of probable Lynch syndrome

Abstract Objective The aim of this study was to investigate a magnetic resonance imaging-based definition of lower uterine segment carcinoma. Methods We retrospectively reviewed 587 consecutive patients with endometrial cancer who underwent hysterectomy. Lower uterine segment carcinoma was determined through pathological examination and magnetic resonance imaging assessment. For imaging assessment, the location of the inner lining of the uterus was classified into four equal parts on a sagittal section image. A tumor was defined as lower uterine segment carcinoma when its thickest part was located in the second or the third part from the uterine fundus. Lower uterine segment carcinoma was further divided into lower uterine segment in a narrow sense, upon which diagnosis was exclusively based on pathological findings, and lower uterine segment in a broad sense that were the remaining lower uterine segment carcinomas except lower uterine segment carcinomas in a narrow sense. The relationship between lower uterine segment carcinoma and probable Lynch syndrome was investigated. Patients with loss of MSH2, MSH6, and PMS2 expression or those with tumors with loss of MLH1 and absence of MLH1 promoter methylation were diagnosed as probable Lynch syndrome. Results Lower uterine segment carcinoma was identified in 59 (10.2%) patients. Twenty-eight (47.5%) patients were categorized as lower uterine segment in a narrow sense and 31 (52.5%) as lower uterine segment in a broad sense. Among them, probable Lynch syndrome was identified in 12 (20.3%) cases. There was no difference in clinical profiles, including the prevalence of probable Lynch syndrome between the two categories. Conclusions A magnetic resonance imaging-based expanded definition of lower uterine segment carcinoma is likely to secure characteristics equivalent to a conventional pathology-based definition of lower uterine segment carcinoma. The novel definition of lower uterine segment carcinoma might improve the detection of probable Lynch syndrome.

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Laparoscopic resection of two peritoneal loose bodies on the rectosigmoid colon

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20180204 ◽

2018 ◽

Vol 7 (2) ◽

pp. 736

Author(s):

Ken-ichi Honda ◽

Tomoko Nakagawa ◽

Yasushi Kurihara ◽

Koji Kajitani ◽

Tetsuji Ando ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Laparoscopic Resection ◽

Preoperative Magnetic Resonance Imaging ◽

Pathological Examination ◽

Resonance Imaging ◽

Loose Bodies ◽

Rectosigmoid Colon ◽

Preoperative Magnetic Resonance

Laparoscopic examination of a 77-year-old woman revealed two peritoneal loose bodies connected to fatty appendices on the rectosigmoid colon and resected at the stalks. The peritoneal loose bodies were found to be fat-containing masses on preoperative magnetic resonance imaging, and postoperative pathological examination revealed fat degeneration tissue with or without fibrous outer layers.

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Anterior cruciate ligament ganglion: case report

Sao Paulo Medical Journal ◽

10.1590/s1516-31802002000600009 ◽

2002 ◽

Vol 120 (6) ◽

pp. 195-197 ◽

Cited By ~ 9

Author(s):

André Pedrinelli ◽

Fábio Bonini Castellana ◽

Ricardo Bragança de Vasconcellos Fontes ◽

Rafael Ferreira Coelho ◽

Luiz Álvaro de Menezes F°.

Keyword(s):

Magnetic Resonance Imaging ◽

Anterior Cruciate Ligament ◽

Case Report ◽

Magnetic Resonance ◽

Cruciate Ligament ◽

Clinical Signs ◽

Left Knee ◽

Pathological Examination ◽

Resonance Imaging ◽

Anterior Cruciate

CONTEXT: A ganglion is a cystic formation close to joints or tendinous sheaths, frequently found in the wrist, foot or knee. Intra-articular ganglia of the knee are rare, and most of them are located in the anterior cruciate ligament. The clinical picture for these ganglia comprises pain and movement restrictions in the knee, causing significant impairment to the patient. Symptoms are non-specific, and anterior cruciate ligament ganglia are usually diagnosed through magnetic resonance imaging or arthroscopy. Not all ganglia diagnosed through magnetic resonance imaging need to undergo surgical treatment: only those that cause clinical signs and symptoms do. Surgical results are considered good or excellent in the vast majority of cases. CASE REPORT: A 29-year-old male presented with pain in the left knee during a marathon race. Physical examination revealed limitation in the maximum range of knee extension and pain in the posterior aspect of the left knee. Radiographs of the left knee were normal, but magnetic resonance imaging revealed a multi-lobed cystic structure adjacent to the anterior cruciate ligament, which resembled a ganglion cyst. The mass was removed through arthroscopy, and pathological examination revealed a synovial cyst. Patient recovery was excellent, and he resumed his usual training routine five months later.

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Reasons for discordances between ultrasonography and magnetic resonance imaging in the evaluation of the ankle, hindfoot and heel of the patients with rheumatoid arthritis

Medical Ultrasonography ◽

10.11152/mu-2304 ◽

2019 ◽

Vol 21 (4) ◽

pp. 405 ◽

Cited By ~ 2

Author(s):

Oana Șerban ◽

Daniela Fodor ◽

Iulia Papp ◽

Mihaela Cosmina Micu ◽

Dan Gabriel Duma ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Disease Activity ◽

Activity Index ◽

Imaging Techniques ◽

Disease Activity Index ◽

Resonance Imaging ◽

Magnetic Resonance Imaging Mri ◽

Definition Of

Aim: To compare the ultrasonography (US) performance with magnetic resonance imaging (MRI) in identifying pathology in ankles, hindfeet and heels of rheumatoid arthritis (RA) patients and to evaluate the reasons for discordances between the two imaging methods.Material and methods: RA patients were enrolled and evaluated using the Clinical Disease Activity Index (CDAI) and the Disease Activity Score 28 with C-reactive Protein (DAS28-CRP). The ankle (tibiotalar joint, tendons), hindfoot (talonavicular, subtalar joints) and heel of the most symptomatic or dominant foot (for the asymptomatic patient)were evaluated by two pairs of examiners using US and contrast-enhanced MRI.Results: Totally, 105 joints, 245 tendons and 35 heels in 35 patients [mean age 59.2±11.25 years old, median disease duration 36 (16.5-114), mean CDAI 19.87±12.7] were evaluated. The interobserver agreements between the two sonographers, and the two radiologists were good and very good (k=0.624-0.940). The overall agreement between US and MRI was very good for subcalcaneal panniculitis (k=0.928, p<0.001), moderate for synovitis (k=0.463, p<0.001) and tenosynovitis (k=0.514, p<0.001), fair for osteophytes (k=0.260, p=0.004), and poor for erosions (k=0.063, p=0.308) and heel’s structures. MRI found more erosions, synovitis, osteophytes,tenosynovitis and retrocalcaneal bursitis, but US found more enthesophytes and plantar fasciitis. Many of the discordancesbetween the two imaging techniques have explanations related to the technique itself or definition of the pathologic findings.Conclusions: US is comparable to MRI for the evaluation of ankle, hindfoot and heel in RA patients and discordances in theinterpretation of the pathological findings/normal structures must be carefully analyzed.

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Role of magnetic resonance imaging in prediction of chondrosarcoma of bone grade

Medical alphabet ◽

10.33667/2078-5631-2020-38-21-24 ◽

2021 ◽

pp. 21-24

Author(s):

A. V. Fedorova ◽

N. V. Kochergina ◽

A. B. Bludov ◽

I. V. Boulycheva ◽

E. A. Sushentsov ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Diagnostic Value ◽

Low Grade ◽

High Grade ◽

Resonance Imaging ◽

Accurate Definition ◽

Definition Of ◽

Decisive Rule

Purpose. Determining the diagnostic value of magnetic resonance imaging in the accurate definition of chondrosarcoma of bone grade at the pre-surgery examination. Material and methods. We analyzed examination data (magnetic resonance imaging with no contrast enhancement) of 70 patients with chondrosarcoma (35 patients with low-grade chondrosarcoma and 35 patients with high grade chondrosarcoma). Informative weighted coefficients were determined separately for ‘learning’ and ‘examination’ samples. On the basis of weighted coefficients, the decisive rule was created for differentiation between low-grade and high-grade chondrosarcoma. Results. The sensitivity of the method was 87.0%, specificity was 95.6%, total correct classification was 91.03%. Conclusion. Magnetic resonance imaging is a highly informative method for prediction of chondrosarcoma grade at the pre-surgery examination.

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Can Ex Vivo Magnetic Resonance Imaging of Rectal Cancer Specimens Improve the Mesorectal Lymph Node Yield for Pathological Examination?

Investigative Radiology ◽

10.1097/rli.0000000000000581 ◽

2019 ◽

Vol 54 (10) ◽

pp. 645-652 ◽

Cited By ~ 3

Author(s):

Rutger Stijns ◽

Bart Philips ◽

Carla Wauters ◽

Johannes de Wilt ◽

Iris Nagtegaal ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Rectal Cancer ◽

Lymph Node ◽

Magnetic Resonance ◽

Ex Vivo ◽

Pathological Examination ◽

Resonance Imaging ◽

Lymph Node Yield ◽

Mesorectal Lymph Node ◽

Node Yield

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Spinal intramedullary ependymal cyst and tethered cord in an adult

Journal of Neurosurgery Spine ◽

10.3171/spi.2006.4.6.506 ◽

2006 ◽

Vol 4 (6) ◽

pp. 506-508 ◽

Cited By ~ 12

Author(s):

Erhan Takci ◽

Goksin Sengul ◽

Muzaffer Keles

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Tethered Cord ◽

Pathological Examination ◽

Resonance Imaging ◽

Ependymal Cyst ◽

Congenital Lesion ◽

Post Surgery

✓ Spinal intramedullary ependymal cysts are extremely rare. Fourteen cases have been reported in the literature, and only one was associated with another congenital lesion. The authors describe the case of a 33-year-old man in whom an intramedullary ependymal cyst and filar lipoma were present. These lesions were diagnosed using magnetic resonance imaging and were treated surgically. Pathological examination confirmed the diagnosis. At 6 months post-surgery, there was no evidence of recurrence.

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Relationship Between Magnetic Resonance T2-Mapping and Matrix Metalloproteinase 1,3 in Knee Osteoarthritis

Indian Journal of Orthopaedics ◽

10.1007/s43465-020-00293-2 ◽

2020 ◽

Author(s):

Lei Shi ◽

Kexin Wang ◽

Jinghong Yu ◽

Mingkai Li ◽

Guangmei Men ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Matrix Metalloproteinase ◽

Knee Osteoarthritis ◽

T2 Mapping ◽

Cartilage Degeneration ◽

Pathological Examination ◽

Lesion Group ◽

Control Group ◽

Resonance Imaging

Abstract Objective To investigate the relationship between quantitative analysis of MRI (T2-mapping) and the expression of matrix metalloproteinase (MMP-1, MMP-3) in osteoarthritis of the knee joint and the role of MMP-1,3 in the pathogenesis of osteoarthritis. Methods Thirty cases of knee osteoarthritis (KOA) patients with total knee arthroplasty (TKA) (lesion group) and 30 healthy adult volunteers (control group) were scanned with 1.5 T routine MR and T2-mapping, and their T2 values were measured and statistically analyzed. The pathological examination of the knee cartilage that was replaced during the operation and the immunohistochemical assay were used to measure the expression of MMP-1,3. The correlation between the T2 value of magnetic resonance imaging and the expression of MMP-1,3 was analyzed. Results (1) According to the Recht grading standard for magnetic resonance, the T2 value of magnetic resonance increased significantly with the increase of cartilage degeneration. The differences in T2 values between each level and the normal group were statistically significant (P < 0.05). (2) The T2 value of magnetic resonance imaging increased with the severity of the cartilage degeneration pathological Mankin grading, and the difference was statistically significant (P < 0.05). (3) The expression of MMP-1,3 increased with cartilage degeneration. (4) The T2 value and the expression of MMP-1 in cartilage showed a linear trend. The result of Spearman correlation analysis showed that the expression of MMP-1,3 increased as the cartilage T2 value increased. There was a positive linear correlation between the two. Conclusion The T2 value of magnetic resonance increased with the degeneration of KOA cartilage. The expression of MMP-1,3 increased with the severity of articular cartilage destruction. The T2 value of KOA magnetic resonance was positively correlated with the expression of MMP-1,3.

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