Comparative Effects of a High Glucose and a High Fructose Diet on Activity, Body Weight and Various Constituents of the Liver and Body of the Albino Rat Exercising at Will

1938 ◽  
Vol 16 (3) ◽  
pp. 239-248 ◽  
Author(s):  
John Haldi ◽  
George Bachmann ◽  
Charles Ensor ◽  
Winfrey Wynn
Keyword(s):  
Body Weight ◽  
High Glucose ◽  
Albino Rat ◽  
High Fructose Diet ◽  
High Fructose ◽  
At Will

CHRONIC AEROBIC EXERCISE PREVENTS HIGH-FRUCTOSE DIET-INDUCED IMPAIRMENT IN BLOOD PRESSURE IN HEALTHY YOUNG ADULTS: A DOUBLE-BLIND, RANDOMIZED CLINICAL TRIAL

2021 ◽  
pp. 1-41
Author(s):  
Alexandra Ferreira Vieira ◽  
Cesar Eduardo Jacintho Moritz ◽  
Thiago Rozales Ramis ◽  
Francesco Pinto Boeno ◽  
Gabriela Cristina dos Santos ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Young Adults ◽  
Body Weight ◽  
Uric Acid ◽  
Aerobic Exercise ◽  
Pancreatic Beta Cell ◽  
Resistance Index ◽  
Sensitivity Index ◽  
High Fructose Diet ◽  
High Fructose

Abstract The purpose of the study was to verify the effect of 4 weeks of a high-fructose diet associated with aerobic training on the risk factors for cardiometabolic diseases. Twenty-one young adults were randomized into three groups: high-fructose diet (HFD: 1 g/kg body weight of fructose/day), high-glucose diet (HGD: 1 g/kg body weight of glucose/day), and high-fructose diet and exercise (HFDE: 1 g/kg body weight of fructose/day + 3 weekly 60-minute sessions of aerobic exercise). Before and after the 4 weeks of the intervention, blood samples were taken and flow-mediated dilatation, insulin resistance index, pancreatic beta cell functional capacity index, insulin sensitivity index, and 24-hour blood pressure were evaluated. HFD showed an increase in uric acid concentrations (p = 0.040), and HGD and HFDE groups showed no changes in this outcome between pre- and post-intervention; however, the HFDE group showed increased uric acid concentrations from the middle to the end of the intervention (p = 0.013). In addition, the HFD group showed increases in nocturnal systolic blood pressure (SBP) (p = 0.022) and nocturnal diastolic blood pressure (DBP) (p = 0.009). The HGD group exhibited decreases in nocturnal SBP (p = 0.028) and nocturnal DBP (p = 0.031), and the HFDE group showed a decrease in 24-hour SBP (p = 0.018). The consumption of 1 g/kg of fructose per day can increase uric acid concentrations and blood pressure in adults. Additionally, aerobic exercises along with fructose consumption attenuate changes in uric acid concentrations and prevent impairment in nocturnal blood pressure.

Effect of Mimosa pudica Cured Extract against High Fructose Diet Induced Type 2 Diabetes in Rats

2015 ◽  
Vol 39 ◽  
pp. 1-9 ◽  
Author(s):  
Arjunan Sundaresan ◽  
Thangaiyan Radhiga
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Insulin Sensitivity ◽  
Control Diet ◽  
The Body ◽  
Metabolic Effects ◽  
Improve Insulin Sensitivity ◽  
High Fructose Diet ◽  
High Fructose

The study evaluated the effects of Mimusa pudica (M. pudica) leaf extract on type 2 diabetes in rats fed high fructose diet (HFD). Rats were fed either control diet or HFD for 14 days, following which the diet was fortified with M. Pudica at a dose of 500 mg/kg BW. After 8 weeks, HFD caused deleterious metabolic effects, including increased body weight, hyperglycemia, hyperinsulinemia, dyslipidemia and liver dysfunction. Further, rats fed HFD alone showed increased activities of hepatocellular enzymes in plasma and lipid deposition in liver. Treatment with M. pudica significantly reduced the body weight, improved insulin sensitivity, managed the dyslipidemia and reduced liver damage towards normal. Histopathology of the liver confirmed the changes induced by HFD and the M. pudiac treatment significantly reversed towards normality. These data suggest that M. pudica treatment improve insulin sensitivity and attenuates fat accumulation in liver.

scholarly journals Investigation of the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high-fructose diet

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Teka Obsa Feyisa ◽  
Daniel Seifu Melka ◽  
Menakath Menon ◽  
Wajana Lako Labisso ◽  
Mezgebu Legesse Habte
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Uric Acid ◽  
Lipid Profile ◽  
Wistar Rats ◽  
Serum Glucose ◽  
Control Group ◽  
Fasting Serum ◽  
High Fructose Diet ◽  
High Fructose

AbstractCoffee is one of the most commonly consumed beverages in the worldwide and is assumed to have protective effects against metabolic syndrome. The present study was aimed at investigating the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high fructose diet. A post-test experimental study was conducted on a total of 30 (9–10 weeks old) male albino Wistar rats. The rats were divided into 6 groups: group I (normal control)-fed on standard chow and plain tap water only; group II (fructose control)-fed on standard chow and 20% of fructose solution; group III–VI (treatment groups)-fed on standard chow, 20% of fructose solution and treated with 71, 142, 213 and 284 mg/kg body weight/day of coffee respectively for six weeks. At the end, body weight, serum glucose, uric acid and lipid profile levels were investigated. Data was entered and cleared by epi-data software version 3.1 and analyzed by one way ANOVA followed by Tukey post hoc multiple comparison tests using SPSS V. 23.00. Statistical significance was considered at p < 0.05. The results showed that body weight, fasting serum glucose and uric acid levels significantly lowered in rats treated with 213 (p = 0.047; 0.049; 0.026) and 284 (p = 0.035; 0.029; 0.010) mg/kg body weight/day of coffee compared to fructose control group. Fasting serum triglycide (TG) and low density lipoprotein (LDL-C) levels showed significant reduction in rats treated with 284 mg/kg body weight/day of coffee as compared to fructose control group (p = 0.031; 0.046) respectively. In conclusion, treating rats with coffee decreased body weight, fasting serum glucose, uric acid, TC, TG and LDL-C, and increased HDL-C in a dose dependent manner in rats feeding on high fructose diet, suggesting that coffee consumption may be helpful in ameliorating metabolic syndrome.

scholarly journals Etlingera elatior (Jack) R.M, Sm Containing Diet Normalizes some Metabolic Syndrome Markers due to High-Fat High-Fructose Diet in Wistar Rats

2020 ◽  
Vol 16 ◽  
Author(s):  
Nur Islami Dini Hanifah ◽  
Retno Murwani ◽  
Achmad Zulfa Juniarto
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Total Cholesterol ◽  
Wistar Rats ◽  
Density Lipoprotein ◽  
Standard Diet ◽  
High Fat ◽  
High Fructose Diet ◽  
High Fructose ◽  
Etlingera Elatior

Background: Etlingera elatior (Ee) contains phytochemical compounds that are rich in antioxidants, which may reduce several biochemical markers of metabolic syndrome (MetS). Objective: We aimed to study the effect of fresh Etlingera elatior (FEe) and steamed Etlingera elatior (SEe) as a part of rat diet on the body weight, serum lipid, and malondialdehyde (MDA) level in Wistar rats with MetS induced by a highfat, high-fructose diet. Method: Our research was a true experimental randomized control group design with pre- and post-test. A total of 24 male Wistar rats were divided randomly into the following four groups: 1) Control, fed standard rat diet during the whole duration of the study, 2) HFFr-Sd, fed high-fat high-fructose (HFFr) diet for 29 days, followed by 29 days of the standard diet, 3) HFFr-FEe, fed HFFr diet for 29 days, followed by 29 days of a standard diet containing 33.3% FEe, and 4) HFFrSEe, fed HFFr diet for 29 days, followed by 29 days of a standard diet containing 33.3% SEe. The HFFr diet was given at 15 g/day along with fructose drink (20% pure fructose) at 100 ml/day. The diets in each group after the MetS induction period is referred to as intervention diets. Data at the end of HFFr (pre) and intervention diets (post) were analyzed by paired t-test. The data among groups were analyzed by one-way analysis of variance followed by post hoc test. Results: HFFr diet for 29 days induced MetS in Wistar rats fulfilling the criteria of obesity (Lee Index), hypertriglyceridemia, and decreased high-density lipoprotein cholesterol (HDL-C). Also, there was a significant increase in serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), and MDA level (p < 0.05). Feeding a diet contaning FEe or SEe can significantly reduce body weight, serum triglyceride, total cholesterol, LDL-C, and MDA, and increase HDL-C levels (p < 0.05). The effect of FEe was more pronounced in ameliorating body weight and lipid profile than SEe. Conclusion: Fresh Ee and Steamed Ee can ameliorate obesity, dyslipidemia, and oxidative stress in MetS Wistar rats induced by a high-fat high-fructose diet. It suggests that dietary Ee accounting for one-third of daily standard diet can assist in normalizing some MetS markers in rats.

scholarly journals Acute Toxic Effects of Telmisartan in Spontaneously Hypertensive Rats Fed a High Fructose Diet

2018 ◽  
pp. 851-856
Author(s):  
J. ŠILHAVÝ ◽  
P. MLEJNEK ◽  
M. ŠIMÁKOVÁ ◽  
I. VANĚČKOVÁ ◽  
M. BEHULIAK ◽  
...  
Keyword(s):  
Body Weight ◽  
Spontaneously Hypertensive Rats ◽  
Toxic Effects ◽  
Metabolic Effects ◽  
Brown Norway ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
High Fructose Diet ◽  
High Fructose ◽  
Acute Toxic

Telmisartan is an angiotensin receptor blocker (ARB) and a selective peroxisome proliferator activated receptor gamma (PPARG) modulator. Recently, we tested metabolic effects of telmisartan (5 mg/kg body weight) in spontaneously hypertensive rats (SHR) fed a diet containing 60 % fructose, a widely used model of the metabolic syndrome. Surprisingly, we observed acute toxic effects of telmisartan. Rats lost body weight rapidly and died within 2 to 3 weeks due to bleeding into the upper gastrointestinal tract. SHR fed a high fructose diet and treated with telmisartan exhibited rapid decrease in blood pressure when compared to the SHR fed a high fructose diet and treated with valsartan. Concentrations of both unconjugated telmisartan and telmisartan glucuronide in the liver of SHR rats fed a high fructose diet were approximately 4 fold higher when compared to Brown Norway (BN) rats fed the same diet. Plasma concentrations of unconjugated telmisartan in the SHR were about 5 fold higher when compared to BN rats while plasma levels of telmisartan glucuronide were similar between the strains. Testing of other rat strains, diets, and the ARB valsartan showed that toxic effects of telmisartan in combination with high fructose diet are specific for the SHR. These results are consistent with the possibility that in some circumstances, SHR are predisposed to telmisartan toxicity possibly because of a genetically determined disturbance in telmisartan metabolism.

scholarly journals The protective role of amla (Emblica officinalis Gaertn.) against fructose-induced metabolic syndrome in a rat model

2009 ◽  
Vol 103 (4) ◽  
pp. 502-512 ◽  
Author(s):  
Hyun Young Kim ◽  
Tsutomu Okubo ◽  
Lekh Raj Juneja ◽  
Takako Yokozawa
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Total Cholesterol ◽  
Rat Model ◽  
Regulatory Element ◽  
Thiobarbituric Acid Reactive Substance ◽  
Emblica Officinalis ◽  
Etoac Extract ◽  
High Fructose Diet ◽  
High Fructose

We investigated the effects of amla (Emblica officinalis Gaertn.) on fructose-induced metabolic syndrome using a rat model. Male Wistar rats were fed a high-fructose (65 %) diet or standard chow for 1 week, and treated with an ethyl acetate (EtOAc) extract of amla, a polyphenol-rich fraction, at 10 or 20 mg/kg body weight per d, or vehicle, for 2 weeks. Serum glucose, TAG, total cholesterol and blood pressure levels of the high-fructose diet-fed rats were increased compared with those of the normal rats (P < 0·001). However, the EtOAc extract of amla ameliorated the high fructose-induced metabolic syndrome, including hypertriacylglycerolaemia and hypercholesterolaemia. Also, the elevated levels of hepatic TAG and total cholesterol in rats given the high-fructose diet were significantly reduced by 33·8 and 24·6 %, respectively (P < 0·001), on the administration of the EtOAc extract of amla at the dose of 20 mg/kg with the regulation of sterol regulatory element-binding protein (SREBP)-1 expression. The protein levels of PPARα and SREBP-2 were not affected by the feeding of the high-fructose diet or EtOAc extract of amla. In addition, oral administration of the amla extract at the dose of 20 mg/kg significantly inhibited the increased serum and hepatic mitochondrial thiobarbituric acid-reactive substance levels (21·1 and 43·1 %, respectively; P < 0·001). Furthermore, the amla extract inhibited the increase of cyclo-oxygenase-2 with the regulation of NF-κB and bcl-2 proteins in the liver, while the elevated expression level of bax was significantly decreased by 8·5 and 10·2 % at the doses of 10 and 20 mg/kg body weight per d, respectively. These findings suggest that fructose-induced metabolic syndrome is attenuated by the polyphenol-rich fraction of amla.

Sign in / Sign up

Export Citation Format

Share Document