Anatomical Localization

2017 ◽  
pp. 47-90
Author(s):  
Eduardo E. Benarroch ◽  
Jeremy K. Cutsforth-Gregory ◽  
Kelly D. Flemming
Keyword(s):  
Nervous System ◽  
Scientific Information ◽  
Clinical Problem ◽  
Basic Approach ◽  
Neurologic Disorders ◽  
Anatomical Localization

The diagnosis of neurologic disorders is a skill that requires the application of basic scientific information to a clinical problem. As knowledge about the nervous system increases, more complicated neurologic problems can be solved in more sophisticated ways; however, the basic approach to the solution of all neurologic problems remains unchanged.

Neurocytology and Pathologic Reactions of the Nervous System

2017 ◽  
pp. 91-130
Author(s):  
Eduardo E. Benarroch ◽  
Jeremy K. Cutsforth-Gregory ◽  
Kelly D. Flemming
Keyword(s):  
Nervous System ◽  
Pathologic Condition ◽  
System P ◽  
Neurologic Disorders ◽  
Pathologic Features ◽  
Anatomical Localization ◽  
Noxious Stimuli

Anatomical localization is but one part of the diagnosis of neurologic disorders, however, because it is also necessary to determine the pathologic features of the lesion involved. Identification of the pathologic condition requires knowledge of the cellular elements of the nervous system (neurocytology), the molecular and biochemical bases of their function, and the ways in which these cells react to noxious stimuli (pathologic reactions).

scholarly journals Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Robert F. Hoey ◽  
Daniel Medina-Aguiñaga ◽  
Fahmi Khalifa ◽  
Beatrice Ugiliweneza ◽  
Sharon Zdunowski ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Surface Area ◽  
Electrode Array ◽  
Frequency Dependent ◽  
Epidural Stimulation ◽  
Sphincter Electromyography ◽  
Neurologic Disorders ◽  
Movement Threshold

AbstractSpinal cord epidural stimulation (scES) mapping at L5-S1 was performed to identify parameters for bladder and bowel inhibition and/or contraction. Using spinally intact and chronic transected rats of both sexes in acute urethane-anesthetized terminal preparations, scES was systematically applied using a modified Specify 5–6–5 (Medtronic) electrode during bladder filling/emptying cycles while recording bladder and colorectal pressures and external urethral and anal sphincter electromyography activity. The results indicate frequency-dependent effects on void volume, micturition, bowel peristalsis, and sphincter activity just above visualized movement threshold intensities that differed depending upon neurological intactness, with some sex-dependent differences. Thereafter, a custom-designed miniature 15-electrode array designed for greater selectivity was tested and exhibited the same frequency-dependent urinary effects over a much smaller surface area without any concurrent movements. Thus, select activation of autonomic nervous system circuitries with scES is a promising neuromodulation approach for expedient translation to individuals with SCI and potentially other neurologic disorders.

scholarly journals Neural Prosthetics:A Review of Empirical vs. Systems Engineering Strategies

2018 ◽  
Vol 2018 ◽  
pp. 1-17 ◽  
Author(s):  
Gerald E. Loeb
Keyword(s):  
Nervous System ◽  
Systems Engineering ◽  
Neural Control ◽  
Cardiac Pacemaker ◽  
Clinical Problem ◽  
Neural Prosthetic ◽  
The Many ◽  
Almost All ◽  
Electronic Technologies ◽  
Interface Materials

Implantable electrical interfaces with the nervous system were first enabled by cardiac pacemaker technology over 50 years ago and have since diverged into almost all of the physiological functions controlled by the nervous system. There have been a few major clinical and commercial successes, many contentious claims, and some outright failures. These tend to be reviewed within each clinical subspecialty, obscuring the many commonalities of neural control, biophysics, interface materials, electronic technologies, and medical device regulation that they share. This review cites a selection of foundational and recent journal articles and reviews for all major applications of neural prosthetic interfaces in clinical use, trials, or development. The hard-won knowledge and experience across all of these fields can now be amalgamated and distilled into more systematic processes for development of clinical products instead of the often empirical (trial and error) approaches to date. These include a frank assessment of a specific clinical problem, the state of its underlying science, the identification of feasible targets, the availability of suitable technologies, and the path to regulatory and reimbursement approval. Increasing commercial interest and investment facilitates this systematic approach, but it also motivates projects and products whose claims are dubious.

scholarly journals ОСНОВНІ НЕВРОЛОГІЧНІ СИМТОМИ ТА ЇХ ПОШИРЕННЯ У СОБАК

2016 ◽  
Vol 18 (3(71)) ◽  
pp. 240-243
Author(s):  
V. Fedorovych ◽  
L. Slivinska ◽  
N. Fedorovych
Keyword(s):  
Nervous System ◽  
Pathological Process ◽  
Neurological Symptoms ◽  
Nervous System Diseases ◽  
Anatomical Localization ◽  
Neurological Research ◽  
The Brain

As a result of the ambulatory reception it was investigated 12233 animals, of which 5653 (46.2%) were dogs. In the neurological research it had shown the symptoms of the nervous system damage in 653 dogs (11.5%). In particular it was found that paresis and paralysis (23.4%) were the most common neurological symptoms in dogs. Number of animals with inclination of head, ataxia, myoclonus and epileptiform state was respectively 19.8; 14.7; 11.7 and 10.5%. The manifestations of the nervous system damage as nystagmus, tremor and lameness were registered in accordance with 8.3; 4.4 and 4.1% of sick dogs. The least number of dogs were with a disorder of vision (2,8%) and hearing (0,3%), which was associated with the pathology of the nervous system. The above mentioned symptoms of the nervous system diseases do not occur as a symptom, but it was marked their combination – syndromes. The conducted neurological research makes it possible to establish the location of the pathological process in the departments of nervous system (neurons anatomical localization).As a result of the research and the results found that most dogs manifest the symptoms of damage to the brain and spinal mozkupaytiyi. Based on the results of verification of the diagnosis will be made using the methods of visual diagnostics. 

scholarly journals Historical aspects of studying the influence of physical activity on the mental health of people

2021 ◽  
Vol 8 (1) ◽  
pp. 39-48
Author(s):  
Sergii Ivashchenko
Keyword(s):  
Mental Health ◽  
Physical Activity ◽  
Higher Education ◽  
Central Nervous System ◽  
Nervous System ◽  
Physiological State ◽  
Scientific Information ◽  
Teaching Staff ◽  
Historical Process ◽  
Joint Activities

This article presents the main results of work on the study of the issue of the historical process of improving knowledge about the influence of physical activity of a person on the level of his mental health. Based on the results of the analysis of scientific information presented in modern domestic and foreign literary sources, the conclusion was substantiated that the historical process of improving knowledge about human nature and his mental activity in recent years has reached the highest level of development. The study of the long-term experience of scientists in many countries of the world gives grounds to assert that the beginning of the process of targeted study of the effect of physical activity on human mental functions was laid back in the last century. However, scientists have achieved the most outstanding results in this area of scientific research in recent decades. The historical need for in-depth research in this scientific direction was maturing gradually and was due to the peculiarities of the course of scientific and technological progress in general. Due to the fact that it was in recent decades that many discoveries were made, which formed the basis of modern methods for studying the physiological state of a person and his intellectual functions, there was obvious progress in the study of the mental health of persons whose central nervous system works under conditions of extreme intellectual and psycho-emotional stress. Scientists working in the field of physical education and sports, in collaboration with scientists in the field of education and health, have significantly intensified their joint activities and developed modern complexes of measures aimed at studying the mental health of students and representatives of the teaching staff of state institutions of higher education. This contingent of the subjects was not chosen by chance. The fact is that the learning process in higher education institutions is associated with intense loads on the central nervous system of both students and teachers, as well as on some of their senses (in particular, on the visual and auditory analyzers).

NEUROLOGIC DISEASES IN INFANCY AND CHILDHOOD

PEDIATRICS ◽  
1957 ◽  
Vol 19 (5) ◽  
pp. 949-957
Author(s):  
William A. Hawke ◽  
John S. Prichard
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Stem ◽  
Developmental Patterns ◽  
Basic Emotions ◽  
Neurologic Diseases ◽  
Neurologic Disorders ◽  
Infancy And Childhood ◽  
The Central Nervous System ◽  
The Brain

THE SEMINAR was conducted in four 3-hour sessions and aimed to cover the more important features of pediatric neurology. DEVELOPMENT Dr. Hawke reviewed the normal development of the central nervous system in the infant and child which is so important in the assessment of neurologic disorders in this age group. It was noted that the nervous system was particularly immature and changing rapidly in the first 2 years of life. Development was related to myelination and it was emphasized that this was not a steady process but a pattern of sequences of rapid and slow growth. Motor and sensory development appeared to develop from above and to proceed downward, so that eye-control develops before hand- and legcontrol. Development was related to three functioning levels of the central nervous system—the brain stem, the archipallium, and the neopallium. It was observed that the newborn baby functioned at the brain stem level, and to illustrate this an example was given of the hydranencephalic baby which behaves perfectly normally for the first few weeks of life. The anchipallium, which includes part of the temporal lobe, the cingulate gyrus and basal ganglia, supervenes on the brain stem and may be considered responsible for the basic emotions and some primitive motor and sensory control. The neopallium, which includes most of the cerebral hemisphere, becomes dominant in primates. Its function is intellectual rather than emotional and is responsible for skills, discrimination and fine movements. The clinical application of these developmental patterns are innumerable but illustrations were given of changes in physical signs in static brain lesions.

Clinical Applications

2016 ◽  
pp. 236-252
Author(s):  
Elson L. So
Keyword(s):  
Intensive Care Unit ◽  
Central Nervous System ◽  
Nervous System ◽  
Specific Treatment ◽  
Clinical Problem ◽  
Clinical Applications ◽  
Neural Function ◽  
Central Nervous System Disorders ◽  
Progression Of Disease ◽  
The Central Nervous System

Many electrophysiological assessment and techniques of clinical neurophysiology can be used in the assessment of patients with suspected disease of the central nervous system. Each of the techniques is applied either to assist clinicians in assessing disease of the central nervous system or, less commonly, to monitor changes in neural function. These techniques can be used to monitor neural function in observing progression of disease, such as the frequency of seizures, or improvement in a patient’s condition with specific treatment. They are also used in the intensive care unit and operating room to identify progressive neural damage. The clinical neurophysiological testing technique that is most appropriate for a patient depends on the clinical problem, and, often, some combination of techniques best provides the necessary data. This chapter focuses on the application of clinical neurophysiological techniques in assessing patients with suspected central nervous system disorders.

scholarly journals Deepening the Mechanisms of Visceral Pain Persistence: An Evaluation of the Gut-Spinal Cord Relationship

Cells ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1772 ◽  
Author(s):  
Elena Lucarini ◽  
Carmen Parisio ◽  
Jacopo J. V. Branca ◽  
Cristina Segnani ◽  
Chiara Ippolito ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Visceral Pain ◽  
Clinical Problem ◽  
Nerve Fibers ◽  
Morphological Alterations ◽  
Mhc Ii ◽  
Maladaptive Plasticity ◽  
Central Nervous Systems ◽  
Major Clinical Problem

The management of visceral pain is a major clinical problem in patients affected by gastrointestinal disorders. The poor knowledge about pain chronicization mechanisms prompted us to study the functional and morphological alterations of the gut and nervous system in the animal model of persistent visceral pain caused by 2,4-dinitrobenzenesulfonic acid (DNBS). This agent, injected intrarectally, induced a colonic inflammation peaking on day 3 and remitting progressively from day 7. In concomitance with bowel inflammation, the animals developed visceral hypersensitivity, which persisted after colitis remission for up to three months. On day 14, the administration of pain-relieving drugs (injected intraperitoneally and intrathecally) revealed a mixed nociceptive, inflammatory and neuropathic pain originating from both the peripheral and central nervous system. At this time point, the colonic histological analysis highlighted a partial restitution of the tunica mucosa, transmural collagen deposition, infiltration of mast cells and eosinophils, and upregulation of substance P (SP)-positive nerve fibers, which were surrounded by eosinophils and MHC-II-positive macrophages. A significant activation of microglia and astrocytes was observed in the dorsal and ventral horns of spinal cord. These results suggest that the persistence of visceral pain induced by colitis results from maladaptive plasticity of the enteric, peripheral and central nervous systems.

The Cutting Edge: Neurotransmitters and Brain Tissue Transplant

1991 ◽  
Vol 2 (4) ◽  
pp. 699-705
Author(s):  
V. Susan Carroll
Keyword(s):  
Nervous System ◽  
Brain Tissue ◽  
Neural Tissue ◽  
Clinical Applications ◽  
Cutting Edge ◽  
Neurologic Disorders ◽  
Neuroscience Research ◽  
Tissue Transplant ◽  
Human Nervous System

Neural tissue transplant represents one of the most exciting and controversial areas of current basic neuroscience research. It offers enormous therapeutic promise for patients with degenerative and traumatic neurologic disorders. This article reviews the functions of several common neurotransmitters and examines the clinical applications of tissue transplant into the human nervous system

scholarly journals Neurologic disorders in 4858 survivors of central nervous system tumors in childhood—an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study

2018 ◽  
Vol 21 (1) ◽  
pp. 125-136 ◽  
Author(s):  
Line Kenborg ◽  
Jeanette Falck Winther ◽  
Karen Markussen Linnet ◽  
Anja Krøyer ◽  
Vanna Albieri ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Childhood Cancer ◽  
Adult Life ◽  
Central Nervous System Tumors ◽  
Nervous System Tumors ◽  
Neurologic Disorders
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