An Integrative Approach to the Assessment and Treatment of Inflammatory Conditions

2017 ◽  
Author(s):  
Mark Liponis ◽  
Bettina Martin
Keyword(s):  
Integrative Approach ◽  
The Past ◽  
Inflammatory Conditions ◽  
Improved Outcomes ◽  
Targeted Treatments ◽  
Great Progress ◽  
Assessment And Treatment ◽  
The Many ◽  
Made In

The past two decades have seen great progress in recognizing the importance of inflammation in medicine. Increased focus on inflammation in both prevention and treatment has improved outcomes and quality of life in chronic diseases. Science has improved our understanding of inflammation’s many causes and effects on health, and many advances have been made in the availability of targeted therapeutic options for treating inflammation. This chapter gives an overview of recognizing the many causes of inflammation, its many targeted treatments strategies, and the questions that still surround it. It discusses several integrative approaches to reducing inflammation, including exercise, diet, and different strategies for managing sleep, mood, and stress, such as meditation and massage.

scholarly journals MARINE SALVAGE SERVICES AND SPILL PREVENTION IN THE 21st CENTURY

1997 ◽  
Vol 1997 (1) ◽  
pp. 579-581
Author(s):  
John Arnold Witte
Keyword(s):  
Union Member ◽  
Technological Breakthrough ◽  
The Past ◽  
Great Progress ◽  
The Media ◽  
The Many ◽  
The Right ◽  
Oil Spill Cleanup ◽  
Effective Service ◽  
Made In

ABSTRACT The past two decades have seen no major technological breakthrough in the field of oil spill cleanup. It is likely that intervention by salvors will remain the preferred solution (“keeping the oil in the ship”). International Salvage Union member companies provide an effective service; they recovered more than 2 million tons of oils and chemicals from 141 ship casualties during 1995. However, spill prevention is an “invisible success” and, as such, doesn't make news. Meanwhile, the media remain strongly attracted to the few spills that still occur. During the past 20 years, great progress has been made in improving maritime safety and reducing the incidence of significant spills. Occasionally, however, things go badly wrong and a major pollution threat develops, together with the potential for huge claims. The members of the International Salvage Union want to take all possible measures to optimize salvage response in such situations. Salvors frequently work together, pooling resources and expertise to maximize operational success. In addition, arrangements are now in place that encourage salvors to respond to spill threats in highly adverse circumstances. Further improvements will materialize if the many parties involved in major casualty response draw closer together. More cooperation between these interests is vital. The new agreement on Article 14 salvage operations negotiated between the International Salvage Union and the International Group of P&I Clubs is an encouraging step in the right direction.

Evidence-based Assessment

2010 ◽  
pp. 76-98
Author(s):  
John Hunsley ◽  
Eric J. Mash
Keyword(s):  
Decision Making ◽  
Clinical Assessment ◽  
Assessment Process ◽  
Evidence Based ◽  
The Past ◽  
Specific Assessment ◽  
The Many ◽  
Selection Of ◽  
Made In

Evidence-based assessment relies on research and theory to inform the selection of constructs to be assessed for a specific assessment purpose, the methods and measures to be used in the assessment, and the manner in which the assessment process unfolds. An evidence-based approach to clinical assessment necessitates the recognition that, even when evidence-based instruments are used, the assessment process is a decision-making task in which hypotheses must be iteratively formulated and tested. In this chapter, we review (a) the progress that has been made in developing an evidence-based approach to clinical assessment in the past decade and (b) the many challenges that lie ahead if clinical assessment is to be truly evidence-based.

scholarly journals Late Effects and Survivorship Issues in Patients with Neuroblastoma

Children ◽  
2018 ◽  
Vol 5 (8) ◽  
pp. 107 ◽  
Author(s):  
Danielle Friedman ◽  
Tara Henderson
Keyword(s):  
Late Effects ◽  
Survival Rates ◽  
Premature Mortality ◽  
The Past ◽  
Excess Morbidity ◽  
Related Risk ◽  
Impaired Quality ◽  
Made In

Over the past two decades, marked progress has been made in understanding the biology of neuroblastoma; this has led to refined risk stratification and treatment modifications with resultant increasing 5-year survival rates for children with neuroblastoma. Survivors, however, remain at risk for a wide variety of potential treatment-related complications, or “late effects”, which may lead to excess morbidity and premature mortality in this cohort. This review summarizes the existing survivorship literature on long-term health outcomes for survivors of neuroblastoma, focusing specifically on potential injury to the endocrine, sensory, cardiovascular, pulmonary, and renal systems, as well as survivors’ treatment-related risk for subsequent neoplasms and impaired quality of life. Additional work is needed to assess the potential late effects of newer multimodality therapies with the aim of optimizing long-term medical and psychosocial outcomes for all survivors of neuroblastoma.

Introduction

2006 ◽  
Vol 51 (2-3) ◽  
pp. 99-104
Author(s):  
Peter Avery ◽  
Alexandra D’Arcy ◽  
Keren Rice
Keyword(s):  
World Englishes ◽  
Canadian English ◽  
The Past ◽  
English Usage ◽  
The Status ◽  
Oxford Dictionary ◽  
The Many ◽  
Quality Of Research

The past twenty-five years have seen an enormous growth in research into World Englishes, reflecting a new recognition of the status of the many national English dialects. Canadian English has been no exception to this trend and we have witnessed a dramatic increase in the quantity and quality of research into this variety. The stature it is now accorded as a separate dialect of English is reflected in the number of dictionaries, thesauruses, usage guides, and other reference works published since the late 1990s that were devoted specifically to Canadian English (e.g., Guide to Canadian English usage; Canadian Oxford dictionary; Oxford Canadian Dictionary; Collins essential Canadian English dictionary and thesaurus; Fitzhenry and Whiteside Canadian thesaurus) as well as audio-visual productions (e.g., Dialects of Canadian English; Talking Canadian).

scholarly journals A Morphological and Histological Investigation of Imperfect Lungfish Fin Regeneration

2021 ◽  
Vol 9 ◽  
Author(s):  
Vivien Bothe ◽  
Igor Schneider ◽  
Nadia B. Fröbisch
Keyword(s):  
Tissue Regeneration ◽  
Molecular Mechanisms ◽  
Limb Regeneration ◽  
Body Parts ◽  
Serial Sections ◽  
Fin Regeneration ◽  
X Ray ◽  
The Past ◽  
Great Progress ◽  
Made In

Regeneration, the replacement of body parts in a living animal, has excited scientists for centuries and our knowledge of vertebrate appendage regeneration has increased significantly over the past decades. While the ability of amniotes to regenerate body parts is very limited, members of other vertebrate clades have been shown to have rather high regenerative capacities. Among tetrapods (four-limbed vertebrates), only salamanders show unparalleled capacities of epimorphic tissue regeneration including replacement of organ and body parts in an apparently perfect fashion. The closest living relatives of Tetrapoda, the lungfish, show regenerative abilities that are comparable to those of salamanders and recent studies suggest that these high regenerative capacities may indeed be ancestral for bony fish (osteichthyans) including tetrapods. While great progress has been made in recent years in understanding the cellular and molecular mechanisms deployed during appendage regeneration, comparatively few studies have investigated gross morphological and histological features of regenerated fins and limbs. Likewise, rather little is known about how fin regeneration compares morphologically to salamander limb regeneration. In this study, we investigated the morphology and histology of regenerated fins in all three modern lungfish families. Data from histological serial sections, 3D reconstructions, and x-ray microtomography scans were analyzed to assess morphological features, quality and pathologies in lungfish fin regenerates. We found several anomalies resulting from imperfect regeneration in regenerated fins in all investigated lungfish species, including fusion of skeletal elements, additional or fewer elements, and distal branching. The similarity of patterns in regeneration abnormalities compared to salamander limb regeneration lends further support to the hypothesis that high regenerative capacities are plesiomorphic for sarcopterygians.

scholarly journals Recent advances in the tandem annulation of 1,3-enynes to functionalized pyridine and pyrrole derivatives

2021 ◽  
Vol 17 ◽  
pp. 2462-2476
Author(s):  
Yi Liu ◽  
Puying Luo ◽  
Yang Fu ◽  
Tianxin Hao ◽  
Xuan Liu ◽  
...  
Keyword(s):  
Reaction Mechanisms ◽  
Structural Motifs ◽  
Pyrrole Derivatives ◽  
The Past ◽  
Recent Advances ◽  
Functionalized Pyridine ◽  
Great Progress ◽  
Made In

Great progress has been made in the tandem annulation of enynes in the past few years. This review only presents the corresponding reactions of 1,3-enyne structural motifs to provide the functionalized pyridine and pyrrole derivatives. The functionalization reactions cover iodination, bromination, trifluoromethylation, azidation, carbonylation, arylation, alkylation, selenylation, sulfenylation, amidation, esterification, and hydroxylation. We also briefly introduce the applications of the products and the reaction mechanisms for the synthesis of corresponding N-heterocycles.

What are axial spondyloarthritis and ankylosing spondylitis?

2016 ◽  
Author(s):  
Stefan Siebert ◽  
Sengupta Raj ◽  
Alexander Tsoukas
Keyword(s):  
Ankylosing Spondylitis ◽  
Inflammatory Arthritis ◽  
Structural Damage ◽  
Axial Spondyloarthritis ◽  
Negative Impact ◽  
Sacroiliac Joints ◽  
Chronic Inflammatory Arthritis ◽  
The Past ◽  
Assessment And Treatment

Ankylosing spondylitis (AS) is a chronic inflammatory arthritis affecting mainly the sacroiliac joints and spine, resulting in pain, stiffness, and reduced movement. AS has a major negative impact on patients’ quality of life. AS is part of a larger group of related spondyloarthritis (SpA) conditions and patients with AS often have extra-articular manifestations of these conditions. Over the past decade, there have been major advances in the understanding of the genetics and pathophysiology of the disease. Advances in imaging have allowed patients to be diagnosed without having to develop the radiographic structural damage that characterize AS, resulting in the concept of axial spondyloarthritis (axSpA). Together with the development of highly effective TNF inhibitors, these advances have transformed the management and outlook of patients with this condition. It is hoped that further advances in diagnosis, assessment and treatment of axSpA will lead to further progress in future.

scholarly journals Khan Academy Videos in Chinese: A Case Study in OER Revision

2017 ◽  
Vol 18 (5) ◽  
Author(s):  
Allen Rao ◽  
John Hilton III ◽  
Sarah Harper
Keyword(s):  
Open Educational Resources ◽  
Educational Resources ◽  
The Past ◽  
Local Contexts ◽  
Great Progress ◽  
Open Courses ◽  
Khan Academy ◽  
Made In

<p class="3">Over the past decade, great progress has been made in improving the quality and availability of Open Educational Resources (OER). OER proponents often discuss the ability for users to revise and remix OER to make them more suitable for local contexts; however, much OER goes unmodified. This note from the field examines the efforts of NetEase Online Open Courses, a Chinese organization, to take more than two thousand Khan Academy videos and translate them into Chinese. We provide background on this initiative and also analyze site metrics to determine what type of use these derivative OER have received.</p>

Presidential Address

1913 ◽  
Vol 7 ◽  
pp. 1-24
Author(s):  
Archdeacon W. Cunningham
Keyword(s):  
Presidential Address ◽  
Young Men ◽  
British History ◽  
English History ◽  
Richard Iii ◽  
The Past ◽  
Great Progress ◽  
Made In

During the past year the Society has sustained one loss that overshadows all others. It is not for me to attempt to appreciate the value of the substantial contributions to the published sources of English history to which Mr. James Gairdner devoted himself so assiduously; I can only attempt to express the feeling which many of us here must share on the loss of our friend. I well remember the intense interest with which I read his ‘Life of Richard III.’ when it was first published in 1878, and the pleasure which I felt many years after in coming into contact with a man whom I admired so much. His constant kindliness and readiness to interest himself in and encourage the work of young men are not things to be readily forgotten. The chronicling of the blanks left in the roll of our officials and members is the saddest part of a President's duty. In my first address I expressed our sense of loss sustained through the death of Dr. Charles Gross; at this distance of time we can see more clearly than was possible four years ago how fruitful his work was. This year great progress has been made in the attempt to carry on the Bibliography of British History which he began, and during the last few weeks I have been impressed anew with the freshness and thoroughness of his studies, as I have been trying to look into and amplify the argument of his essay on Scottish Municipal History.

Review of the Electrolarynx: The Past and Present

2019 ◽  
Vol 4 (1) ◽  
pp. 118-129 ◽  
Author(s):  
Steven R. Cox
Keyword(s):  
Quality Of Life ◽  
The Past ◽  
Speech Rehabilitation ◽  
Related Quality ◽  
Potential Impact ◽  
Perceptual Characteristics ◽  
Made In ◽  
Voice And Speech

Purpose The purpose of this article is to provide a review of the neck-type electrolarynx, describe acoustic and perceptual characteristics of electrolaryngeal speech, and highlight the potential impact of electrolaryngeal speech on voice-related quality of life postlaryngectomy, concluding by describing efforts to improve electrolaryngeal speech rehabilitation. Although several alaryngeal communication options exist, the electrolarynx is the most readily available means of producing voice and speech postlaryngectomy. This is due to the small and handheld nature of an electrolaryngeal device, which is commonly placed against the neck during use. Research suggests that approximately half of laryngectomees use an electrolarynx up to 2 years postlaryngectomy. Conclusion Given the importance of the electrolarynx postlaryngectomy, decisions should be made in conjunction with the laryngectomee. It is important to ask: Why not an electrolarynx?

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