Definition and Incidence of Adverse Events

2018 ◽  
pp. 136-140
Author(s):  
David Fagin
Keyword(s):  
Side Effects ◽  
Adverse Events ◽  
Supportive Care ◽  
American Academy ◽  
Procedural Sedation ◽  
Patient Harm ◽  
Timely Manner ◽  
Psychological Conditions ◽  
American Academy Of Pediatrics ◽  
National Organizations

To perform effective and safe procedural sedation, one must be knowledgeable about the adverse events that can occur with the administration of various sedatives and analgesics. Adverse events (sometimes thought of as complications of care) are often predictable if the sedationist properly assesses the patient’s physiologic and psychological conditions and understands the side effects of the medications administered and the procedural conditions that may exacerbate risk. With such preparation, the sedationist can monitor for the event and can either prevent it or provide supportive care in a timely manner. The American Academy of Pediatrics and other national organizations have developed guidelines for caring for patients requiring procedural sedation with the intent of informing sedationists of the risks involved in sedation care and the skills and equipment needed to ameliorate or prevent patient harm. Adverse events can be classified as minor, moderate, and major.

GRULEE AWARD PRESENTATION

PEDIATRICS ◽  
1966 ◽  
Vol 37 (1) ◽  
pp. 136-137
Keyword(s):  
American Academy ◽  
Medical Society ◽  
State University ◽  
University Of Minnesota ◽  
Louisiana State University ◽  
School Of Medicine ◽  
American Academy Of Pediatrics ◽  
National Organizations ◽  
College Of Nursing ◽  
The University

THE recipient of the Clifford G. Grulee Award of the American Academy of Pediatrics for 1965 is Clarence H. Webb of Shreveport, Louisiana. Born in Shreveport in 1902, Dr. Webb was graduated from Tulane University in 1923 and received his M.D. degree from the same university in 1925. Later—in 1931—he received the M.S. degree in pediatrics from the University of Chicago, where he completed a residency at the Bobs Roberts Hospital. Previously he had a year of residency at the University of Minnesota Hospital. Dr. Webb has been in the private practice of pediatrics in Shreveport since 1931. He has also been visiting lecturer at the Tulane School of Medicine since 1947 and professor of pediatrics in the Postgraduate School of the Louisiana State University School of Medicine since 1956. In addition, he finds time to lecture at the Northwestern College of Nursing in Natchitoches. He holds staff appointments at four private hospitals in the Shreveport area and is chief of pediatrics at Confederate Memorial Hospital. Dr. Webb is a member of a number of medical organizations and has served as president of the Louisiana and Shreveport Pediatric Societies, as well as president of the Shreveport Medical Society. He has been active in many local, state, and national organizations, including the Boy Scouts of America, the Louisiana Public Health Association, from which he received its annual award in 1957; the American Anthropological Association, and the Society for American Archeology. Dr. Webb served as president of the American Academy of Pediatrics in 1962-1963, previously serving as a member of the Executive Board and as chairman of District VIII. These services were outstanding and important.

Valproic Acid: A Different View

PEDIATRICS ◽  
1982 ◽  
Vol 70 (2) ◽  
pp. 331-331
Author(s):  
J. Kiffin Penry
Keyword(s):  
Valproic Acid ◽  
Side Effects ◽  
American Academy ◽  
Antiepileptic Drug ◽  
Antiepileptic Drugs ◽  
Published Data ◽  
American Academy Of Pediatrics

The Committee on Drugs of the American Academy of Pediatrics has prepared a statement on the benefits and risks of the antiepileptic drug valproic acid; this statement appears in this issue of Pediatrics (70:316, 1982). This report is extensive and objective in its review of published data on valproic acid, and is of great value to practicing pediatricians for that reason. However, the review fails to place vaiproic acid in perspective with other marketed antiepileptic drugs, which in many instances have equally serious side effects.

Letters to the Editor

PEDIATRICS ◽  
1973 ◽  
Vol 52 (5) ◽  
pp. 754-754
Author(s):  
Keyword(s):  
Side Effects ◽  
American Academy ◽  
Medical Literature ◽  
Letters To The Editor ◽  
Anticonvulsant Agents ◽  
American Academy Of Pediatrics

The Committee offers the following comments: The Committee on Drugs of the American Academy of Pediatrics appreciates the communication from Drs. Livingston, Berman, and Pauli concerning the use of amphetamines in the management of epilepsy. The Committee has carefully considered the two indications which Drs. Livingston et al. have raised in their letter. A thorough search of the medical literature by the Committee has failed to reveal any data documenting the efficacy of amphetamines in counteracting the side effects of usual anticonvulsant agents.

TWO BOOKS OF IMPORTANCE TO YOU

PEDIATRICS ◽  
1962 ◽  
Vol 29 (3) ◽  
pp. 475-475
Author(s):  
Carl C. Fischer
Keyword(s):  
American Academy ◽  
Executive Director ◽  
Central Office ◽  
The Other ◽  
Annual Reports ◽  
National Committee ◽  
Great Credit ◽  
American Academy Of Pediatrics ◽  
National Organizations ◽  
Speed And Accuracy

During the month of January you have received from the Central Office of the American Academy of Pediatrics, two books that we believe will be of great value to you if properly used. The first of these is a Fellowship list for 1962, which gives the alphabetical and geographic listing of all of the Fellows of the Academy. It also contains a list of the officers, the District and State Chairmen and the National Committee Members, Liaison Representatives to National Organizations, and, at the end of the book, a copy of our Constitution and By-laws. Since all the Fellows listed herein have met the basic requirements for Fellowship in the Academy, this directory may be used with confidence in the referring of patients who have moved from one area to another. The Central Office deserves great credit for the speed and accuracy with which it prepares this valuable list and places it in the hands of the membership. The other book is entitled "Annual Reports of Committee and Liaison Representatives." This compilation of the annual reports of all of our National Committees and of our Liaison Representatives was first made available to the membership in 1957 and has been sent out annually ever since. In it you will find not only the usual succinct, factual, and extremely informative reports of the Executive Director and the Secretary but also the reports of 17 National Committees, 6 Section Committees, and 22 Liaison Representatives. These reports are of importance and great inteest not only to the more than 250 Fellows of the Academy whose work as Committee members and Liaison Representatives made them possible, but also to the more than 6,000 others in whose name this work was done.

Supportive Care of Patients Undergoing Immunotherapy

2016 ◽  
Vol 12 (01) ◽  
pp. 25 ◽  
Author(s):  
Ronwyn van Eeden ◽  
Bernardo L Rapoport ◽  
◽  
Keyword(s):  
Side Effects ◽  
Adverse Events ◽  
Supportive Care ◽  
Clinical Oncology ◽  
Broad Spectrum ◽  
Paradigm Shift ◽  
Early Recognition ◽  
Morbidity And Mortality ◽  
Targeted Drugs ◽  
Aggressive Management

Immunotherapy was announced by the America Society of Clinical Oncology (ASCO) as the top cancer advance of 2015. There has been a paradigm shift towards immuno-oncology therapy, and its side effects are often referred to as immune-related adverse events (irAEs). These side effects are, in some cases, unique and very different than those associated with chemotherapy or targeted drugs. Clinicians should be aware that there is a broad spectrum of additional toxicities that can be both unpredictable and severe. Early recognition and aggressive management of irAEs are essential to decrease morbidity and mortality.

Major Adverse Events

2018 ◽  
pp. 150-153
Author(s):  
Corrie E. Chumpitazi
Keyword(s):  
Respiratory Failure ◽  
Adverse Events ◽  
Cardiovascular Collapse ◽  
Patient Harm ◽  
Psychological Conditions ◽  
Physiologic Change ◽  
Safety Studies ◽  
Pediatric Sedation ◽  
And Training ◽  
Major Adverse Events

The incidence of sedation-related adverse events depends on medication characteristics, procedure conditions, and preexisting patient physiologic and psychological conditions. Major adverse sedation-related events represent extreme physiologic change causing significant patient harm that may be long-lasting or permanent, particularly if responded to ineffectively by the sedationist. Large safety studies of pediatric sedation events suggest that events of this type occur very rarely when well-organized, equipped, and trained sedation teams are present. However, sporadic reports of death during pediatric sedation continue to surface, providing significant impetus for effective preparation and training for sedationists. Major adverse sedation-related events discussed here are aspiration, cardiovascular collapse, respiratory failure, and death.

Half-Dose Immunization for Diphtheria, Tetanus, Pertussis: Response of Preterm Infants

PEDIATRICS ◽  
1989 ◽  
Vol 83 (4) ◽  
pp. 471-476
Author(s):  
July Bembaum ◽  
Andrea Daft ◽  
Joel Samuelson ◽  
Richard A. Polin
Keyword(s):  
Immune Response ◽  
Side Effects ◽  
American Academy ◽  
Preterm Infants ◽  
Time Intervals ◽  
Full Dose ◽  
American Academy Of Pediatrics ◽  
Half Dose ◽  
Fourth Dose ◽  
Dtp Vaccine

The American Academy of Pediatrics currently recommends administering full-dose diphtheria, tetanus, pertussis, (DTP) vaccine to preterm infants, beginning at 2 months' chronologic age. Many physicians, however, continue to administer DTP vaccine at a reduced dosage in an attempt to lessen side effects. This study was designed to quantitate the immune response of 20 preterm infants immunized with half-dose DTP vaccine and to determine the nature and extent of side effects. Control subjects were 25 preterm infants immunized with full-dose vaccine. Although 96% of infants who received a full dose were able to mount a serologic response to pertussis after a second dose of DTP, 45% of infants who received a half dose were unable to mount a similar immune response to pertussis even after a third dose of DTP and required a full-dose (fourth dose of DTP) vaccine to better ensure protection. Serologic responses to diphtheria and tetanus were similar in the two groups. The incidence of side effects in preterm infants receiving both full-dose and half-dose DTP was less than that seen in a full-term population. Thus, the physician caring for the preterm infant should adhere to the American Academy of Pediatrics' recommendation for the immunization of preterm infants and offer full-dose DTP vaccine at the routine time intervals of 2, 4, 6, and 15 or 18 months' chronologic age to ensure adequate protection.

Summary of Major Changes in the 1991 Red Book

PEDIATRICS ◽  
1991 ◽  
Vol 87 (6) ◽  
pp. 948-950
Author(s):  
Keyword(s):  
Adverse Events ◽  
Infectious Diseases ◽  
American Academy ◽  
Health Care Professionals ◽  
World Health ◽  
Related Information ◽  
American Academy Of Pediatrics ◽  
Health Organization ◽  
A Minor ◽  
Control And Management

In 1991, the new edition of the Report on the Committee on Infectious Diseases (the Red Book) has been published by the American Academy of Pediatrics (AAP), providing the most recent recommendations and guidelines for control and management of infectious diseases in infants and children.1 These recommendations and guidelines are based on information available through October, 1990 and replace those given in the 1988 Red Book. To aid physicians and other health care professionals in assimulating new recommendations and information into their practices, a summary of major changes is given in the Red Book. This summary is reprinted here (with minor changes). Subsequent recommendations of the American Academy of Pediatrics are published as committee statements in AAP News and Pediatrics. In keeping with the 2-to 3-year intervals between the editions of the Red Book, the next edition is anticipated in late 1993 or 1994. Major changes in recommendations and related information in the 1991 Red Book are summarized as follows: 1. Immunization Recommendations. The schedules for routine immunization incorporate the changes in recommendations for Haemophilus b, as of October, 1990 (See "Note.") and measles vaccines. In view of the increased complexity of immunization schedules, particular attention should be given to the footnotes in the immunization schedules. The schedule recommended by the World Health Organization Expanded Programme on Immunization (EPI) is also included. 2. Reporting of Adverse Events. The new procedure for reporting adverse events following administration of vaccines (VAERS) is described. 3. Contraindications to Vaccines. The recommendation concerning a minor illness as a possible contraindication to diphtheria-tetanus-pertussis (DTP) immunization has been modified.

Genetic testing for autistic spectrum disorders

2020 ◽  
pp. 78-79
Author(s):  
Е.А. Померанцева ◽  
А.А. Исаев ◽  
А.П. Есакова ◽  
И.В. Поволоцкая ◽  
Е.В. Денисенкова ◽  
...  
Keyword(s):  
Genetic Testing ◽  
American Academy ◽  
Autistic Spectrum Disorder ◽  
Genetic Factors ◽  
Molecular Genetic ◽  
Autistic Spectrum Disorders ◽  
Autistic Spectrum ◽  
American Academy Of Pediatrics ◽  
Spectrum Disorders ◽  
Testing Algorithm

Согласно рекомендациям Американской академии педиатрии при постановке диагноза аутизм, следует направить семью на консультацию генетика и генетическое обследование. Однако оптимальный подход к алгоритму генетического обследования при выявлении расстройства аутистического спектра еще предстоит разработать. В рамках исследования было проведено сравнение выявляемости генетических факторов аутизма различными молекулярно-генетическими тестами. According to American Academy of Pediatrics recent guidelines, each family with a child diagnosed with autistic spectrum disorder should be reffered to a medical geneticist and offered genetic tests. However, an optimal genetic testing algorithm has yet to be developed. This study was conducted to compare abilities of different molecular-genetic methods to detect genetic factors of autistic spectrum disorders.

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