Effects of Contaminants on Human Health

Mapping Intimacies ◽

10.1093/med/9780190688622.003.0006 ◽

2017 ◽

Author(s):

Morton Lippmann ◽

Richard B. Schlesinger

Keyword(s):

Human Health ◽

Environmental Chemicals ◽

The Body ◽

Biological Mechanisms ◽

Dose Response Relationship ◽

Chemical Contaminants ◽

Hereditary Material ◽

Metabolic Transformation ◽

Human Health Effects ◽

Potential Human Health

This chapter describes the methodology used for evaluating potential human health effects resulting from exposure to environmental chemicals. It discusses the concept of the dose-response relationship, and reviews the processes by which chemicals may be delivered to and absorbed by the body. Concepts of the metabolic transformation of absorbed chemical are provided, as are the potential for storage and excretion. It explores the biological mechanisms and pathways underlying specific responses to chemical contaminants, which range from disruption of physiology to alteration of biochemical pathways and hereditary material. A discussion of responses due to exposure to mixtures of chemicals is provided.

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Human Health Effects of Microplastics in Drinking Water: A Review

ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT ◽

10.35627/2219-5238/2021-29-9-40-43 ◽

2021 ◽

pp. 40-43

Author(s):

PA Ganichev

Keyword(s):

Drinking Water ◽

Human Health ◽

Health Effects ◽

Citation Index ◽

Russian Science ◽

The Past ◽

Russian Science Citation Index ◽

Human Health Effects ◽

Published Research ◽

Potential Human Health

Introduction: Polymer products have become inexpensive, convenient and widely used in all spheres of everyday life recently. Microplastics are found in seawater, wastewater, fresh water, foodstuffs, and air. Over the past few years, the presence of microplastics in treated tap and bottled water has been reported, raising questions and concerns about their potential human health effects. Objective: To summarize and systematize the results of studying health effects of exposure to microplastics in potable water. Materials and methods: A literature review was done based on ten topical articles and reviews published in 2014–2021 out of 64 sources found in the PubMed and Scopus international databases and the Russian Science Citation Index (RSCI). Results and conclusions: Generalization and systematization of the published research data demonstrated the lack of strong evidence to draw conclusions about human health effects of microplastics. Information on toxicokinetics and toxicodynamics of ingested microplastic particles is absent just like the studies of the most common shapes and sizes of plastic particles and health risks from exposure to such particles in drinking water.

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Influence of triclosan biocide on human health and environment and justification of the necessity to optimise regulatory measures for its use

Ukrainian Journal of Modern Toxicological Aspects ◽

10.33273/2663-4570-2019-86-2-22-28 ◽

2019 ◽

Vol 86 (2) ◽

pp. 22-28

Author(s):

G.M. Balan ◽

S.D. Kolesnyk ◽

P.G. Zhminko ◽

N.M. Bubalo ◽

V.A. Babych

Keyword(s):

Human Health ◽

Potential Risk ◽

Endocrine Disruptor ◽

Animal Health ◽

Consumer Products ◽

The Body ◽

Woven Fabric ◽

Metabolic Transformation ◽

Regulatory Measures ◽

Beauty Products

Objective is to summarise current literature data on the adverse effects of triclosan (TCS) biocide on human and animal health and potential risk for the development of endocrine-disruptor effects forjustification of the necessity to improve regulatory measures for its use in consumer products. Material and Methods. Analysis of literature data on the ways of influence of metabolic transformation in the body and toxicokinetics of TCS, its influence on human health and environment was performed. Targets and biomarkers of TCS exposure, its toxic properties and potential risk for the formation of endocrine-disruptor effects were described. Results. Necessity to optimise regulatory measures for the use of TCS in the personal hygienic means, general and curative beauty products, woven fabric for bedlinen and underwear, etc. has been justified. Key Words: triclosan biocide, toxic properties, endocrine-disruptor effects, regulatory measures.

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