Deranged hembiosynthetic pathway in gasoline dispensers in Nigeria: Implications for risk of myeloproliferative disorders and chemoprevention

Objectives: There is increasing exposure to petrochemicals, including benzene, particularly in the low and medium-income countries. Benzene is a component of many petrochemicals and a ubiquitous environmental pollutant. Phenol is one of its principal metabolites and serves as a biomarker of exposure to benzene. The mechanism of its toxicity is incompletely elucidated. Benzene’s interaction with key micronutrients; copper (Cu), iron (Fe), and zinc (Zn) in the haemopoietic system has only been poorly explored, particularly in the developing countries where their status is variable and uncertain, with attendant intense exposure to petrochemicals. Material and Methods: Two groups of 50 gasoline dispensers (GDs) and 50 non-occupationally exposed participants were selected from Oye Local Government Area, Nigeria. The duration of occupational exposure was 2–10 years. Serum levels of Cu, Fe, and Zn were determined using flame atomic absorption spectrophotometry while heme and phenol were determined by standard spectrophotometry. Results: Phenol was significantly higher in GDs (P = 0.000), compared to controls (P < 0.05). The micronutrients, Cu, Fe, and Zn were all significantly decreased in GDs compared to controls (P = 0.000 in all cases). Phenol and Fe demonstrated significant inverse correlation (r = −0.557, P = 0.00), while heme and Zn also exhibited inverse correlation respectively to phenol (r = −0.38, P = 0.01; r = −0.37, P = 0.01). Conclusion: These data suggest intense perturbation of the haemopoietic system in GDs; likely from altered xenobiotic metabolism requiring heme in cytochrome P450; cell cycle dysregulation, where Zn is pivotal, p53 suppression also dependent on Zn and oxidative stress all converging in haemopoietic dysregulation. Importantly, depression of these micronutrients implies potentiation of myelotoxicity and risk of myeloproliferation, probably arising from alterations in transcription, differentiation errors, genome instability, and derangement in cell signal transduction moderated by Zn; accentuating risk of myeloproliferation; suggesting a role for these micronutrients in chemoprevention. Understanding these events may be important in risk assessment, policy formulation, regulatory measures and chemoprevention in GDs and the general population.

Composition and process approaches underpinning the mechanical properties of oleogels

Consumers are becoming aware of the relevance of eating low levels of trans and saturated fats in processed foods. In addition, many countries are adopting regulatory measures on the use of these ingredients. For this reason, the exploration of new technologies capable of producing structures that trap liquid oil (composed of unsaturated fatty acids, considered healthier) has been widely investigated in order to replace saturated and trans fats in food products. One of the most promising technologies is the so-called oleogels, which present a great challenge to mimic sensory attributes related to the texture of processed foods based on saturated fats. In this review, we discuss how the different approaches used in the production of oleogels, direct or indirect methods, as well as compositional variables, such as oleogelators and mixing ratio, can directly influence the mechanical properties of these structures. An overview of the parameters that can interfere with these properties contributes to a better understanding of the building of the oleogels and their possible applications.

Environmental Policy for the Restriction on the Use of Plastic Products in Taiwan: Regulatory Measures, Implementation Status and COVID-19’s Impacts on Plastic Products Recycling

In response to international trends regarding the reduction in plastic waste (or plastic pollution), this work used the official statistics that were recently released, focusing on regulatory actions restricting the use of plastic products and/or the increase in recycling in Taiwan. In addition, the impacts of the COVID-19 pandemic on plastic waste generation and plastic products’ recycling were also addressed in the present study. The results showed that the plastic compositions in the garbage slightly increased in recent years, suggesting that the effect of restrictions on the use of plastic products in Taiwan was not significant, even though the regulatory measures have been implemented since 2002. However, chlorine contents in the garbage were significantly increased in 2020. The increase could be attributed to the fact that kitchen waste (containing salt), household waste containing disinfectant (e.g., chlorine dioxide, sodium hypochlorite) or PVC-made products were generated more during the COVID-19 pandemic. Furthermore, the data also indicated that the monthly quantities of recycled plastic containers and other plastic products had no significant change since January 2020, especially in the outbreak period from May 2021 to July 2021.

REGULATORY IMPACT ASSESSMENT IN THE AREA OF THE EURASIAN ECONOMIC UNION: PECULIARITIES OF FORMATION AND CURRENT STATUS

This article examines the process of formation of the regulatory impact assessment as a main tool of regulatory policy in the area of the Eurasian Economic Union. The influence of the taken regulatory measures on the activity of the entities is identified. The reasons for the necessity to develop regulatory impact assessment as a legal institution are described, its advantages are determined, the peculiarities of the development of this institution are studied. Legal framework that serves as a basis for assessment functioning is examined. The reasons for uneven development of the institution of assessment in the Eurasian area are understood, typical country peculiarities are given. On the basis of the conducted analysis suggestions for the improvement of the mechanism of the regulatory impact assessment are generated and its development perspectives are identified.

Ethical Thoughts of the Regulation of False Information in Social Media: Based on Legitimacy and Social Justice

It is now common for social media to regulate rumors. They claim that the purpose of this action is to safeguard social interests. However, some cases have proved that the regulation of rumor has exceeded the necessary limit, but also showed the partiality of the regulation object and the irrationality of the “rumor” standard. Although freedom of speech has boundaries, the regulation of social media is much stricter than it, which hurts social media to play its role as a public sphere. We can’t ask individuals to take too much responsibility for rumor spreading. At the same time, we can’t easily take harsh regulatory measures such as deplatforming and even legal sanctions against individuals, because this will lead to the lack of legitimacy of the regulatory behavior of social media and the aftereffect of injustice.

Synonyms and Symptoms of COVID-19 and Individual and Official Actions against the Disease—A Brief Online Survey 6 Months into the Pandemic and on the Threshold of the Second Wave in Germany

To control the ongoing global pandemic due to SARS-CoV-2, we need to influence people’s behavior. To do so, we require information on people’s knowledge and perception of the disease and their opinions about the importance of containment measures. Therefore, in August 2020, we conducted an anonymous cross-sectional online survey on these topics in 913 participants in Germany. Participants completed a questionnaire on various synonyms and symptoms of corona virus and specified the importance they attributed to individual and regulatory measures. The virus was linked more closely with most synonyms and the discovery in China than with the places of the first larger European outbreaks. General (cold-like) symptoms, such as “cough” and “fever,” were more widely known than COVID-19-specific ones, e.g., “loss of taste and smell.” The widely promoted individual measures “distancing,” “hygiene,” and “(facial) mask wearing” were rated as highly important, as were the corresponding official measures, e.g., the “distancing rule” and “mask mandate.” However, the “corona warning app” and a “vaccine mandate” were rated as less important. A subgroup analysis showed broad agreement between the subgroups on nearly all issues. In conclusion, the survey provided information about the German population’s perception and knowledge of the coronavirus five months into the pandemic; however, participants were younger and more educated than a representative sample. To learn from the beginning and still ongoing pandemic and develop concepts for the future, we need more conclusive studies, especially on the acceptance of further specified lockdowns, the population’s willingness to be vaccinated, and the influence of misinformation on public opinion.

The impact of COVID-19 pandemic course in the number and severity of hospitalizations for other natural causes in a large urban center in Brazil

The COVID-19 pandemic may indirectly impact hospitalizations for other natural causes. Belo Horizonte is a city with 2.5 million inhabitants in Brazil, one of the most hardly-hit countries by the pandemic, where local authorities monitored hospitalizations daily to guide regulatory measures. In an ecological, time-series study, we investigated how the pandemic impacted the number and severity of public hospitalizations by other natural causes in the city, during 2020. We assessed the number and proportion of intensive care unit (ICU) admissions and in-hospital deaths for all-natural causes, COVID-19, non-COVID-19 natural causes, and four disease groups: infectious, respiratory, cardiovascular, and neoplasms. Observed data from epidemiological week (EW) 9 (first diagnosis of COVID-19) to EW 48, 2020, was compared to the mean for the same EW of 2015–2019 and differences were tested by Wilcoxon rank-sum test. The five-week moving averages of the studied variables in 2020 were compared to that of 2015–2019 to describe the influence of regulatory measures on the indicators. During the studied period, there was 54,722 hospitalizations by non-COVID-19 natural causes, representing a 28% decline compared to the previous five years (p<0.001). There was a concurrent significant increase in the proportion of ICU admissions and deaths. The greater reductions were simultaneous to the first social distancing decree or occurred in the peak of COVID-19 hospitalizations, suggesting different drivers. Hospitalizations by specific causes decreased significantly, with greater increase in ICU admissions and deaths for infectious, cardiovascular, and respiratory diseases than for neoplasms. While the first reduction may have resulted from avoidance of contact with healthcare facilities, the second reduction may represent competing causes for hospital beds with COVID-19 after reopening of activities. Health policies must include protocols to address hospitalizations by other causes during this or future pandemics, and a plan to face the rebound effect for elective deferred procedures.

Tort Liability, Combatant Activities, and the Question of Over-Deterrence

Immunity from tort liability for losses that are inflicted during warfare is often justified by a supposedly intuitive concern: without immunity, states and combatants will be over-deterred from engaging in combat. In this article, I test this common perception using three frameworks. First, I theoretically analyze the impact of tort liability on relevant state actors’ incentives to engage in warfare. This analysis suggests that tort law is likely to under-deter state actors in relation to their decisions on whether and how to conduct hostilities. Second, I test this conclusion through an original mixed-methods exploratory research, using Israel as a test case. My findings reveal that while tort liability under-deters state actors from engaging in warfare, it can prompt them to implement regulatory measures to minimize the state’s liability. Third, I offer a legal history analysis, exploring why Israel established an immunity from tort liability for losses it inflicts during combat in 1951, and why and how this immunity has expanded since. I show that as the Israel-Palestine conflict prolonged and intensified, state actors began viewing Palestinians’ tort claims as a civilian means of warfare and immunity from liability as the weapon needed for defending Israel’s interests.

An Empirical Study on the Employment Monitoring and Early Warning Mechanism of Medical Graduates in Universities with Big Data and Complex Computing System

Based on the management of big data, the analysis and forecast of the employment demand cycle business situation studied in this article is based on the employment cycle theory and a complete set of employment monitoring, employment evaluation, employment forecasting, and policy selection theories and strategies developed around the employment cycle fluctuations, a specific employment phenomenon. First, systematically evaluate the current state of the employment demand boom, appropriately reflect the hot and cold degree of the employment demand boom, and provide necessary information for the government’s regulatory measures, content, and timing. Secondly, it reflects the regulatory effects of graduate employment monitoring, judging whether graduate employment monitoring measures are properly applied, whether they have the effect of smoothing out employment fluctuations, and promoting the country’s employment demand; in addition, business decision makers can take advantage of the employment demand boom, by monitoring the information provided by the early warning system and timely foreseeing the upcoming macrocontrol measures, so that enterprises’ labor adjustments can adapt to the government’s regulatory measures. At the same time, the model proposes a prosperity index method for monitoring and early warning of the employment demand cycle. After selecting and dividing three types of prosperity indicators, the DI index reflecting the trend of the prosperity change and the CI index reflecting the strength of the prosperity change are calculated and constructed. The national employment demand boom monitoring and early warning signal system predicts the trend of the employment boom cycle outside the sample period. The experimental results show that the cyclic prosperity forecast results are consistent not only with the national employment demand prosperity in recent months, but also with the use of the structural measurement ARIMA (p, d, q) model. The alertness value is close, indicating that this indicator system has a good effect on the national employment demand boom monitoring and early warning.

Options for an environmental risk assessment of intentional and unintentional chemical mixtures under REACH: the status and ways forward

It is acknowledged that a variety of chemicals enter the environment and may cause joint effects. Chemicals regulated under the European Chemicals Regulation REACH are often part of formulated mixtures and during their processing and use in various products they can be jointly released via sewage treatment plants or diffuse sources, and may combine in the environment. One can differentiate between intentional mixtures, and unintentional mixtures. In contrast to other substance-oriented legislations, REACH contains no explicit requirements for an assessment of combined effects, exposures and risks of several components. Still, it requires ensuring the safe use of substances on their own, in mixtures, and in articles. The available options to address intentional as well as unintentional mixtures are presented and discussed with respect to their feasibility under REACH, considering the responsibilities, communication tasks and information availability of the different actors (registrants, downstream-user and authorities). Specific mixture assessments via component-based approaches require a comprehensive knowledge on substances properties, uses, fate and behaviour, and the composition of the mixture under consideration. This information is often not available to the responsible actor. In principle, intentional mixtures of known composition can be assessed by the downstream-user. But approaches have to be improved to ensure a transparent communication and sound mixture assessment. In contrast, unintentional mixtures appear to be better addressable via generic approaches such as a mixture allocation factor during the chemical safety assessment, although questions on the magnitude, implementation and legal mandates remain. Authorities can conduct specific mixture risk assessments in well-defined and prioritized cases, followed by subsequent regulatory measures. In order to address intentional and unintentional mixtures within the current REACH framework, legal mandates together with guidance for the different actors are needed. Furthermore, further data on mixture compositions, uses and co-exposures need to be made accessible via shared databases.