African Health Leaders

2015 ◽  
Keyword(s):  
Health Systems ◽  
Child Mortality ◽  
Neglected Tropical Diseases ◽  
Tropical Diseases ◽  
Online Resource ◽  
African Health ◽  
The World ◽  
The Future ◽  
Low Expectations ◽  
Global Solidarity

Most accounts of health and healthcare in Africa are written by foreigners. African Health Leaders: Making Change and Claiming the Future redresses the balance. Written by Africans, who have themselves led improvements in their own countries, this online resource discusses the creativity, innovation and leadership that has been involved tackling everything from HIV/AIDs, to maternal, and child mortality and neglected tropical diseases. It celebrates their achievements and shows how, over three generations, African health leaders are creating a distinctively African vision of health and health systems. It covers how African Health Leaders are claiming the future - in Africa, but also by sharing their insights and knowledge globally and contributing fully to improving health throughout the world, and illustrates how African leadership can enable foreign agencies and individuals working in Africa to avoid all those misunderstandings and misinterpretations of culture and context which lead to wasted efforts and frustrated hopes. It also addresses the need to tackle weak governance, corrupt systems and low expectations and sets out what Africa needs from the rest of the world in the spirit of global solidarity - not primarily in aid, but through investment, collaboration, partnership and co-development.

Heterocycles in the Treatment of Neglected Tropical Diseases

2020 ◽  
Vol 27 ◽  
Author(s):  
Kush K. Maheshwari ◽  
Debasish Bandyopadhyay
Keyword(s):  
Developing Countries ◽  
Heterocyclic Compounds ◽  
Neglected Tropical Diseases ◽  
World Health ◽  
Current Status ◽  
Poor People ◽  
Tropical Diseases ◽  
Concise Review ◽  
The World ◽  
Health Organization

Background: Neglected tropical diseases (NTDs) affect a huge population of the world and majority of the victims belong to the poor community of the developing countries. Until now, the World Health Organization (WHO) has identified 20 tropical diseases as NTDs that must be addressed with high priority. However, many heterocyclic scaffolds have demonstrated potent therapeutic activity against several NTDs. Objective: There are three major objectives: (1) To discuss the causes, symptoms, and current status of all the 20 NTDs; (2) To explore the available heterocyclic drugs, and their mechanism of actions (if known) that are being used to treat NTDs; (3) To develop general awareness on NTDs among the medicinal/health research community and beyond. Methods: The 20 NTDs have been discussed according to their alphabetic orders along with the possible heterocyclic remedies. Current status of treatment with an emphasis on the heterocyclic drugs (commercially available and investigational) has been outlined. In addition, brief discussion of the impacts of NTDs on socio-economic condition is included. Results: NTDs are often difficult to diagnose and the problem is worsened by the unhealthy hygiene, improper awareness, and inadequate healthcare in the developing countries where these diseases primarily affect poor people. The statistics include duration of suffering, numbers affected, and access to healthcare and medication. The mechanism of actions of various heterocyclic drugs, if reported, have been briefly summarized. Conclusion: Scientists and pharmaceutical corporations should allocate more resources to reveal the in-depth mechanism of actions of many heterocyclic drugs that are currently being used for the treatment of NTDs. Analysis of current heterocyclic compounds and development of new medications can help in the fight to reduce/remove the devastating effects of NTDs. An opinion-based concise review has been presented. Based on available literature, this is the first effect to present all the 20 NTDs and related heterocyclic compounds under the same umbrella.

scholarly journals The untapped cell biology of neglected tropical diseases

2016 ◽  
Vol 27 (5) ◽  
pp. 739-743 ◽  
Author(s):  
William Sullivan
Keyword(s):  
World Health Organization ◽  
Cell Biology ◽  
High Probability ◽  
Neglected Tropical Diseases ◽  
World Health ◽  
Tropical Diseases ◽  
Cellular Mechanisms ◽  
The World ◽  
Health Organization

The World Health Organization lists a constellation of 17 tropical diseases that afflict approximately one in six individuals on the planet and, until recently, few resources have been devoted to the treatment and eradication of those diseases. They are often referred to as the diseases of the “bottom billion,” because they are most prevalent among the poorest individuals in impoverished tropical nations. However, the few studies that have been performed reveal an extraordinary world of molecular and cellular adaptations that facilitate the pathogens’ survival in hosts ranging from insects to humans. A compelling case can be made that even a modest investment toward understanding the basic molecular and cell biology of these neglected pathogens has a high probability of yielding exciting new cellular mechanisms and insights into novel ways of combating these diseases.

scholarly journals Neglected tropical diseases in Brazil

2009 ◽  
Vol 51 (5) ◽  
pp. 247-253 ◽  
Author(s):  
José Angelo L. Lindoso ◽  
Ana Angélica B.P. Lindoso
Keyword(s):  
Neglected Tropical Diseases ◽  
Clinical Manifestations ◽  
Northern Region ◽  
New Drugs ◽  
World Health ◽  
Tropical Diseases ◽  
The North ◽  
The World ◽  
The Status ◽  
Health Organization

Poverty is intrinsically related to the incidence of Neglected Tropical Diseases (NTDs). The main countries that have the lowest human development indices (HDI) and the highest burdens of NTDs are located in tropical and subtropical regions of the world. Among these countries is Brazil, which is ranked 70th in HDI. Nine out of the ten NTDs established by the World Health Organization (WHO) are present in Brazil. Leishmaniasis, tuberculosis, dengue fever and leprosy are present over almost the entire Brazilian territory. More than 90% of malaria cases occur in the Northern region of the country, and lymphatic filariasis and onchocerciasis occur in outbreaks in a particular region. The North and Northeast regions of Brazil have the lowest HDIs and the highest rates of NTDs. These diseases are considered neglected because there is not important investment in projects for the development of new drugs and vaccines and existing programs to control these diseases are not sufficient. Another problem related to NTDs is co-infection with HIV, which favors the occurrence of severe clinical manifestations and therapeutic failure. In this article, we describe the status of the main NTDs currently occurring in Brazil and relate them to the HDI and poverty.

scholarly journals New global targets for NTDs in the WHO roadmap 2021–2030

2021 ◽  
Vol 15 (5) ◽  
pp. e0009373
Author(s):  
Adriano Casulli
Keyword(s):  
Prevention And Control ◽  
Neglected Tropical Diseases ◽  
World Health ◽  
Neglected Diseases ◽  
Tropical Diseases ◽  
Future Prospects ◽  
The World ◽  
Health Organization ◽  
And Control ◽  
Second World

The second World Neglected Tropical Diseases (NTDs) Day was celebrated on 30 January 2021. To mark the occasion, the World Health Organization (WHO) launched its roadmap for NTDs for the period 2021 to 2030, which is aimed at increasing prevention and control of these too-long neglected diseases. Described here is a global overview on past achievements, current challenges, and future prospects for the WHO NTDs roadmap 2021–2030.

scholarly journals Impact of COVID-19 Pandemic towards Common Neglected Tropical Diseases among Indigenous Group in Malaysia

2020 ◽  
Author(s):  
Mehru Nisha ◽  
Muhammad Alif Naim ◽  
Fabian Davamani
Keyword(s):  
Neglected Tropical Diseases ◽  
Indigenous Communities ◽  
Tropical Diseases ◽  
Orang Asli ◽  
Minority Community ◽  
The Poor ◽  
Indigenous Group ◽  
High Prevalence ◽  
The World ◽  
Infection Monitoring

Abstract The coronavirus disease 2019 is a pandemic which heavily affected all walks of around the world. Whilst all people are affected could be from to job losses, increase in poverty, sudden death of family member or loved ones and so many others, the indigenous communities in Malaysia do face severity of the Covid 19 pandemic effect. As being the minority community with lack of proper income, lack of education and incapable of adjusting themselves to new norm and living in areas with high prevalence of disease for the poor, like neglected tropical diseases- the overall impact of Covid 19 showed inequalities for the Indigenous (Orang Asli) community in Malaysia. Here we discuss on some of the challenges faced by Orang Asli community in Malaysia and how the pandemic hampered neglected tropical diseases like STHs infection monitoring in Malaysia.

scholarly journals Strengthening data collection for neglected tropical diseases: What data are needed for models to better inform tailored intervention programmes?

2021 ◽  
Vol 15 (5) ◽  
pp. e0009351
Author(s):  
Jaspreet Toor ◽  
Jonathan I. D. Hamley ◽  
Claudio Fronterre ◽  
María Soledad Castaño ◽  
Lloyd A. C. Chapman ◽  
...  
Keyword(s):  
Data Collection ◽  
Human African Trypanosomiasis ◽  
Neglected Tropical Diseases ◽  
World Health ◽  
Tropical Diseases ◽  
Tailored Intervention ◽  
Specific Data ◽  
Tailored Interventions ◽  
The World ◽  
Health Organization

Locally tailored interventions for neglected tropical diseases (NTDs) are becoming increasingly important for ensuring that the World Health Organization (WHO) goals for control and elimination are reached. Mathematical models, such as those developed by the NTD Modelling Consortium, are able to offer recommendations on interventions but remain constrained by the data currently available. Data collection for NTDs needs to be strengthened as better data are required to indirectly inform transmission in an area. Addressing specific data needs will improve our modelling recommendations, enabling more accurate tailoring of interventions and assessment of their progress. In this collection, we discuss the data needs for several NTDs, specifically gambiense human African trypanosomiasis, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminths (STH), trachoma, and visceral leishmaniasis. Similarities in the data needs for these NTDs highlight the potential for integration across these diseases and where possible, a wider spectrum of diseases.

The future: vision and challenges

2015 ◽  
Author(s):  
Francis Omaswa ◽  
Nigel Crisp
Keyword(s):  
Clear Vision ◽  
The World ◽  
The Future ◽  
Future Vision ◽  
Global Solidarity ◽  
At Home

Chapter 24 draws together the major themes from throughout the book and identifies the lessons that can be learned for Africa and for the rest of the world. It concludes by offering a vision for the future, which can be achieved if Africans ‘claim their own future’, if there continues to be sufficient global solidarity to support health around the world, and if the countries of the continent develop a clear vision of ‘health made at home’.

The Global Politics of Neglected Tropical Diseases

2019 ◽  
pp. 567-582
Author(s):  
Obijiofor Aginam
Keyword(s):  
Socioeconomic Development ◽  
Neglected Tropical Diseases ◽  
International Health ◽  
Global Politics ◽  
World Health ◽  
Tropical Diseases ◽  
Mortality And Morbidity ◽  
The World ◽  
Health Organization ◽  
The Cost

Neglected tropical diseases (NTDs) are a diverse group of diseases that are prevalent among the poorest populations of the world. They pose a formidable obstacle to the socioeconomic development of the already impoverished communities where they are prevalent. Over the past several decades the World Health Organization (WHO)—as the directing and coordinating authority on international health work—has led global efforts to tackle the mortality and morbidity burdens of NTDs. In partnership with other actors, WHO’s global NTD Plan and Roadmap have oscillated between the politics and financial constraints of the organisation as an intergovernmental organisation of sovereign states and the lack of incentives to catalyse private and corporate actors towards effective action. The global politics of NTDs is now firmly anchored on public-private partnerships. These partnerships nonetheless raise questions about the moral obligation towards underwriting the cost of eradicating these diseases in the developing world. The chapter argues that enlightened self-interest and humanitarianism should compel the industrialised world towards a pragmatic action to address the mortality and morbidity burdens of NTDs among the poorest populations of the world.

Targeting pteridine reductase 1 and dihydrofolate reductase: the old is a new trend for leishmaniasis drug discovery

2019 ◽  
Vol 11 (16) ◽  
pp. 2107-2130 ◽  
Author(s):  
Gustavo Machado das Neves ◽  
Luciano P Kagami ◽  
Itamar L Gonçalves ◽  
Vera L Eifler-Lima
Keyword(s):  
Dihydrofolate Reductase ◽  
Drug Targets ◽  
Neglected Tropical Diseases ◽  
Molecular Targets ◽  
New Drugs ◽  
Tropical Diseases ◽  
The World ◽  
Leishmania Spp ◽  
Systemic Manifestations ◽  
Potential Drug Targets

Leishmaniasis is one of the major neglected tropical diseases in the world and it is considered endemic in 88 countries. This disease is transmitted by a Leishmania spp. infected sandfly and it may lead to cutaneous or systemic manifestations. The preconized treatment has low efficacy and there are cases of resistance to some drugs. Therefore, the search for new efficient molecular targets that can lead to the preparation of new drugs must be pursued. This review aims to evaluate both Leishmania enzymes PTR1 and DHFR-TS as potential drug targets, highlight their inhibitors and to discuss critically the use of chemoinformatics to elucidate interactions and propose new molecules against these enzymes.

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