Basics of Clinical Research

Author(s):  
Rui Nakamura ◽  
Faiza Khawaja ◽  
Laura Castillo-Saavedra ◽  
Felipe Fregni ◽  
Steven D Freedman ◽  
...  

Chapter 1 explores the history, ethical issues, and importance of regulations in clinical research. The history of clinical research is long and fascinating, starting from dietary therapy, such as legumes and lemons, and advancing to modern-day drugs and regulations. Advances in medical treatments today have been achieved because of the application of knowledge gained from experiments conducted hundreds of years ago. The rules and regulations were required to address unethical issues and the misuse of the clinical research. The chapter asserts that the development of clinical research regulations may still be under development in terms of optimizing safety and the use of future drugs and medical devices.

2017 ◽  
Vol 1 (S1) ◽  
pp. 51-52
Author(s):  
Victoria Straughn ◽  
Erin Haynes ◽  
Emma Jones ◽  
Jacqueline Knapke

OBJECTIVES/SPECIFIC AIMS: The goal of this innovative course is to provide community members with sufficient information to either join or decline participation in clinical research. We anticipate that they will gain knowledge in why research is conducted, the ways participants are recruited, the history of research, regulations that guide research today, participant protections, understand the consent process, their risks and benefits of participating in clinical research. METHODS/STUDY POPULATION: We will recruit interested community members via flyers placed at the training location and at other local community centers and agencies that receive heavy foot traffic. The course is listed in the Communiversity catalogue which is distributed in hardcopy (over 30,000) and email each semester. The course will be taught by a longstanding community member and research coordinator at the University of Cincinnati. Each session will be highly interactive including videos, role-play, and discussion of the presented research topics. Evaluation will occur both pre and post-session, along with pre and post-course. RESULTS/ANTICIPATED RESULTS: We anticipate 20–30 participants at each of the 4 sessions. We anticipate that we will learn current perceptions of clinical research and barriers to their participation to enable improved research recruitment. In addition, we will gain new insights into clinical research needs of the community. DISCUSSION/SIGNIFICANCE OF IMPACT: Through these interactive sessions, we will learn why community members participate in research and their barriers to participating. Understanding the perception of research by the target community is critical when developing clinical research recruitment strategies. We will also be developing a more educated community towards clinical research. We will also gain great insight into new clinical research directions as indicated by community members.


Author(s):  
Михаил Андреевич Вишняк

Вниманию русскоязычного читателя предлагается первая часть перевода с новогреческого на русский язык книги Ὁ Θεολογικός Διάλογος Ὀρθοδόξων καί Ἀντιχαλκηδονίων (παρελθόν - παρόν - μέλλον): Μία ἁγιορειτική συμβολή. Ἅγιον Ὄρος: Ἱερά Μονή Ὁσίου Γρηγορίου, 2018 (841 σ.). Это издание посвящено богословскому диалогу между Православной Церковью и антихалкидонитами и включает в себя все тексты соответствующей тематики, составленные на Святой Горе Афон в период 1991-2015 гг. Настоящая публикация включает перевод предисловия архим. Христофора, игумена монастыря Григориат, и части введения (гл. 1, пп. 1-3). Перевод снабжён также предисловием переводчика, в котором кратко изложена история богословского диалога, цель издания и его перевода на русский язык, которая заключается в содействии плодотворному и согласному со Священным Преданием воссоединению антихалкидонитов с Церковью. The Russian-speaking reader is presented with the first part of the translation into Russian from the modern Greek of the book Ὁ Θεολογικός Διάλογος Ὀρθοδόξων καί Ἀντιχαλκηδονίων (παρελθόν - παρόν - μέλλον): Μία ἁγιορειτική συμβολή. Ἅγιον Ὄρος: Ἱερά Μονή Ὁσίου Γρηγορίου, 2018 (841 p.). This edition is devoted to the Theological Dialogue between the Orthodox Church and the non-Chalcedonians and includes all texts of the relevant topics, published on the Holy Mount Athos in the period 1991-2015. This publication includes a translation of the Prologue of archim. Christophoros, the abbot of the monastery of St. Gregory, and of a part of the Introduction (Chapter 1, paragraphs 1-3). The translation is also provided with a preface of the translator, which summarizes the history of the Theological Dialogue, the purpose of the publication and its translation into Russian, which is to contribute to the fruitful and consistent with the Holy Tradition reunification of the non-Chalcedonians with the Church.


2006 ◽  
Vol 23 (3) ◽  
pp. 98-100
Author(s):  
Muhamad Ali

Studies of Islam in Southeast Asia have sought to better understand its multifacetedand complex dimensions, although one may make a generalizedcategorization of Muslim beliefs and practices based on a fundamental differencein ideologies and strategies, such as cultural and political Islam.Anna M. Gade’s Perfection Makes Practice stresses the cultural aspect ofIndonesian Muslim practices by analyzing the practices of reciting andmemorizing the Qur’an, as well as the annual competition.Muslim engagement with the Qur’an has tended to emphasize the cognitiveover the psychological dimension. Perfection Makes Practice analyzesthe role of emotion in these undertakings through a combination ofapproaches, particularly the history of religions, ethnography, psychology,and anthropology. By investigating Qur’anic practitioners in Makassar,South Sulawesi, during the 1990s, Gade argues that the perfection of theQur’an as a perceived, learned, and performed text has made and remade thepractitioners, as well as other members of the Muslim community, to renewor increase their engagement with the holy text. In this process, she suggests,moods and motivation are crucial to preserving the recited Qur’an and revitalizingthe Muslim community.In chapter 1, Gade begins with a theoretical consideration for her casestudy. Drawing from concepts that emphasize the importance of feeling andemotion in ritual and religious experience, she develops a conceptualizationof this engagement. In chapter 2, Gade explains memorization within thecontext of the self and social relations. She argues that Qur’anic memorizershave a special relationship with its style and structure, as well as with thesocial milieu. Although Qur’anic memorization is a normal practice for mostMuslims, its practitioners have learned how to memorize and recite beautifullysome or all of the Qur’an’s verses, a process that requires emotion ...


Author(s):  
James M. DuBois ◽  
Beth Prusaczyk

This chapter focuses primarily on the protection of human participants in D&I studies. It begins by reviewing the Belmont principles that undergird US research regulations and considering the ethical case for D&I research. It then proceeds to examine some ethical issues that might arise during the course of a public health, D&I research agenda in middle schools. It covers the ethical case for D&I research and common ethical challenges. The chapter also discusses strategies for ethical decision-making. While these strategies may be beneficial to all researchers, the authors believe they are of particular value to dissemination and implementation researchers because the nature of their work—context specific, complex, and unfamiliar to many peers, collaborators, and reviewers—means they will deal with uncertainty and conflict on a regular basis, and solutions to the problems they face will rarely be found through simple reference principles, rules, or regulations.


Author(s):  
Alan Kelly

What is scientific research? It is the process by which we learn about the world. For this research to have an impact, and positively contribute to society, it needs to be communicated to those who need to understand its outcomes and significance for them. Any piece of research is not complete until it has been recorded and passed on to those who need to know about it. So, good communication skills are a key attribute for researchers, and scientists today need to be able to communicate through a wide range of media, from formal scientific papers to presentations and social media, and to a range of audiences, from expert peers to stakeholders to the general public. In this book, the goals and nature of scientific communication are explored, from the history of scientific publication; through the stages of how papers are written, evaluated, and published; to what happens after publication, using examples from landmark historical papers. In addition, ethical issues relating to publication, and the damage caused by cases of fabrication and falsification, are explored. Other forms of scientific communication such as conference presentations are also considered, with a particular focus on presenting and writing for nonspecialist audiences, the media, and other stakeholders. Overall, this book provides a broad overview of the whole range of scientific communication and should be of interest to researchers and also those more broadly interested in the process how what scientists do every day translates into outcomes that contribute to society.


Author(s):  
Paul J. Bolt ◽  
Sharyl N. Cross

Chapter 1 explores perspectives on world order, including power relationships and the rules that shape state behavior and perceptions of legitimacy. After outlining a brief history of the relationship between Russia and China that ranged from cooperation to military clashes, the chapter details Chinese and Russian perspectives on the contemporary international order as shaped by their histories and current political situation. Chinese and Russian views largely coincide on security issues, the desirability of a more multipolar order, and institutions that would enhance their standing in the world. While the Chinese–Russian partnership has accelerated considerably, particularly since the crisis in Ukraine in 2014, there are still some areas of competition that limit the extent of the relationship.


Author(s):  
Rembert Lutjeharms

This chapter introduces the main themes of the book—Kavikarṇapūra, theology, Sanskrit poetry, and Sanskrit poetics—and provides an overview of each chapter. It briefly highlights the importance of the practice of poetry for the Caitanya Vaiṣṇava tradition, places Kavikarṇapūra in the (political) history of sixteenth‐century Bengal and Orissa as well as sketches his place in the early developments of the Caitanya Vaiṣṇava tradition (a topic more fully explored in Chapter 1). The chapter also reflects more generally on the nature of both his poetry and poetics, and highlights the way Kavikarṇapūra has so far been studied in modern scholarship.


Author(s):  
David B. Resnik

This chapter discusses some of the key ethical issues that arise in environmental health research involving human subjects, including returning individualized research results, protecting privacy and confidentiality, research on environmental interventions, intentional exposure studies, research regulations, autonomy, beneficence, informed consent, payments to subjects, and protecting vulnerable human subjects. The chapter will discuss issues that are common to all research designs, as well as those unique to certain types of designs, such as intentional exposure studies. It will also address ethical issues that arose in two important cases, the Kennedy Krieger Institute lead abatement study, and the Children’s Environmental Exposure Research Study.


2021 ◽  
pp. 097206342110115
Author(s):  
Feryad A. Hussain

Integrative models of health care have garnered increasing attention over the years and are currently being employed within acute and secondary health care services to support medical treatments in a range of specialities. Clinical hypnosis has a history of working in partnership with medical treatments quite apart from its psychiatric associations. It aims to mobilise the mind–body connection in order to identify and overcome obstacles to managing symptoms of ill health, resulting in overall improved emotional and physical well-being. This article aims to encourage the use of hypnotherapy in physical health care by highlighting the effectiveness of hypnosis as an adjunct to medical treatment and identifying barriers preventing further integrative treatments.


1998 ◽  
pp. 203-226 ◽  
Author(s):  
Patricia A. Marshall ◽  
Barbara A. Koenig ◽  
Paul Grifhorst ◽  
Mirjam van Ewijk

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