Sucrose and sweet taste

2013 ◽  
pp. 508-516 ◽  
Author(s):  
Denise Harrison ◽  
Vanessa C. Z. Anseloni ◽  
Janet Yamada ◽  
Mariana Bueno
Keyword(s):  
Neonatal Period ◽  
Sweet Taste ◽  
Research Knowledge ◽  
Human Infants ◽  
Analgesic Effects ◽  
Young Infants ◽  
Period Effects ◽  
Abundant Evidence ◽  
Endogenous Opiate ◽  
The Relationship

Abundant evidence demonstrates pain-reducing effects of sweet solutions in human infants and animals. Analgesic effects persist up to around 1 year of age in human infants, although the effects are more moderate than seen in the neonatal period. Effects are considered to be due to the relationship between sweet taste and the endogenous opiate system. Yet, despite extensive research, knowledge gaps remain relating to the exact mechanisms, the effectiveness and safety of sweet solutions when given over prolonged periods to preterm and sick infants, the effectiveness in sick infants receiving concomitant analgesics, and the effectiveness in children older than 12 months of age. Based on the extensive evidence to support sweet solutions, their use can be recommended prior to commonly performed short lasting minor painful procedures in newborn and young infants.

Sucrose and sweet taste

2021 ◽  
pp. 511-519
Author(s):  
Denise Harrison ◽  
Janet Yamada ◽  
Mariana Bueno
Keyword(s):  
Neonatal Period ◽  
Sweet Taste ◽  
Research Knowledge ◽  
Human Infants ◽  
Analgesic Effects ◽  
Young Infants ◽  
Published Evidence ◽  
Endogenous Opiate ◽  
The Relationship ◽  
Mechanisms Of Analgesia

Abundant published evidence demonstrates the pain-reducing effects of sweet solutions in human infants and animals. Analgesic effects persist up to around 1 year of age in human infants, though there is less research to support analgesic effects in older infants and, for the existing research, effects are more moderate than seen in the neonatal period. Though the exact mechanisms are unclear, analgesic effects are believed to be due to the relationship between sweet taste and the endogenous opiate system. Based on the extensive evidence to support sweet solutions, their use can be recommended prior to commonly performed short-lasting minor painful procedures in newborn and young infants. Despite extensive research, knowledge gaps and controversies remain relating to the mechanisms of analgesia; the effectiveness and safety of sweet solutions when given over prolonged periods to preterm and sick infants; the effectiveness in sick infants receiving concomitant analgesics; and the effectiveness in children older than 12 months of age.

scholarly journals Mechanisms of Sucrose and Non-Nutritive Sucking in Procedural Pain Management in Infants

2001 ◽  
Vol 6 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Sharyn Gibbins ◽  
Bonnie Stevens
Keyword(s):  
Newborn Infants ◽  
Sweet Taste ◽  
Full Term ◽  
Sufficient Evidence ◽  
Procedural Pain ◽  
Endogenous Opioid ◽  
Human Infants ◽  
Term Infants ◽  
Analgesic Effects ◽  
Nutritive Sucking

The administration of sucrose with and without non-nutritive sucking (NNS) has been examined for relieving procedural pain in newborn infants. The calming and pain-relieving effects of sucrose are thought to be mediated by endogenous opioid pathways activated by sweet taste. The orogustatory effects of sucrose have been demonstrated in animal newborns, and in preterm and full term human infants during painful procedures. In contrast to sucrose, the analgesic effects of NNS are hypothesized to be activated through nonopioid pathways by stimulation of orotactile and mechanoreceptor mechanisms. Although there is uncertainty as to whether the effects of sucrose and NNS are synergistic or additive, there is sufficient evidence to support the efficacy of combining the two interventions for procedural pain relief in infants. In this review article, the underlying mechanisms of sucrose and NNS, separately and in combination for relieving procedural pain in preterm and full term infants, are examined. Clinical and research implications are addressed.

Religion and the Military

2018 ◽  
pp. 535-552
Author(s):  
Leana A. Bouffard ◽  
Haerim Jin
Keyword(s):  
Criminal Justice ◽  
Military Service ◽  
Criminal Justice Policy ◽  
Future Research ◽  
Period Effects ◽  
Offending Patterns ◽  
Role Of Religion ◽  
The Military ◽  
The Relationship

This chapter provides an overview of the literature examining the role of religion and military service in the desistance process. It also identifies outstanding issues and directions for future research. It first presents an overview of research examining the role of religion in desistance and highlights measurement issues, potential intervening mechanisms, and a consideration of faith-based programs as criminal justice policy. Next, this chapter covers the relationship between military service and offending patterns, including period effects that explain variation in the relationship, selection effects, and the incorporation of military factors in criminal justice policy and programming. The chapter concludes by highlighting general conclusions from these two bodies of research and questions to be considered in future research.

Autopsy Study of Calretinin Immunohistochemistry in the Anorectal Canal in Young Infants and Potential Implications for Rectal Biopsy Approach in the Neonatal Period

2021 ◽  
pp. 109352662110301
Author(s):  
Heather Rytting ◽  
Zachary J Dureau ◽  
Jose Velazquez Vega ◽  
Beverly B Rogers ◽  
Hong Yin
Keyword(s):  
Neonatal Period ◽  
Ganglion Cells ◽  
Hirschsprung Disease ◽  
Rectal Biopsy ◽  
Autopsy Study ◽  
Pathologic Diagnosis ◽  
Young Infants ◽  
Autopsy Specimens ◽  
Pectinate Line ◽  
Age Range

Background Absent submucosal ganglion cells in biopsies 1-3 cm above the pectinate line establishes the pathologic diagnosis of Hirschsprung Disease (HD). Calretinin stains both ganglion cells and their mucosal neurites and has gained importance in HD diagnosis. Absent calretinin positive mucosal neurites in biopsies at the appropriate level above the pectinate line is highly specific for HD. Whether this applies to lower biopsies is uncertain. To address this, we studied anorectal canal autopsy specimens from infants. Methods We performed an autopsy study of infant anorectal canal specimens to describe calretinin staining in this region. Calretinin staining was correlated with histologic and gross landmarks. Results In all 15 non-HD specimens, calretinin positive mucosal neurites were present in glandular mucosa up to the anorectal line where neurites rapidly diminished. Age range was preterm 26 weeks to 3 months. Conclusions Calretinin positive mucosal neurites are present in glandular mucosa up to the anorectal line in young infants. This is potentially important regarding neonatal HD biopsy level and diagnosis. Positive calretinin staining at the anorectal line favors normal innervation making HD unlikely. Absent calretinin positive neurites in glandular mucosa is worrisome for HD in young infants, regardless of location.

BIRTH ORDER, STAGE OF INFANCY AND INFANT MORTALITY IN INDIA

2017 ◽  
Vol 50 (5) ◽  
pp. 604-625 ◽  
Author(s):  
S. K. Mishra ◽  
Bali Ram ◽  
Abhishek Singh ◽  
Awdhesh Yadav
Keyword(s):  
Infant Mortality ◽  
Birth Order ◽  
Neonatal Period ◽  
Family Health ◽  
National Family Health Survey ◽  
Female Children ◽  
National Family ◽  
Urban Rural ◽  
Using Data ◽  
The Relationship

SummaryUsing data from India’s National Family Health Survey, 2005–06 (NFHS-3), this article examines the patterns of relationship between birth order and infant mortality. The analysis controls for a number of variables, including mother’s characteristics such as age at the time of survey, current place of residence (urban/rural), years of schooling, religion, caste, and child’s sex and birth weight. A modest J-shaped relationship between birth order of children and their risk of dying in the neonatal period is found, suggesting that although both first- and last-born children are at a significantly greater risk of dying compared with those in the middle, last-borns (i.e. fourth and higher order births) are at the worst risk. However, in the post-neonatal period first-borns are not as vulnerable, but the risk increases steadily with the addition of successive births and last-borns are at much greater risk, even worse than those in the neonatal period. Although the strength of relationship between birth order and mortality is attenuated after the potential confounders are taken into account, the relationship between the two variables remains curvilinear in the neonatal period and direct in the post-neonatal period. There are marked differences in these patterns by the child’s sex. While female children are less prone to the risk of dying in the neonatal period in comparison with male children, the converse is true in the post-neonatal period. Female children not only run higher risks of dying in the post-neonatal period, but also become progressively more vulnerable with an increase in birth order.

Breath-to-breath variability of exhaled CO2 as a marker of lung dysmaturity in infancy

2017 ◽  
Vol 123 (6) ◽  
pp. 1563-1570 ◽  
Author(s):  
Sotirios Fouzas ◽  
Ilias Theodorakopoulos ◽  
Edgar Delgado-Eckert ◽  
Philipp Latzin ◽  
Urs Frey
Keyword(s):  
Lung Disease ◽  
Preterm Infants ◽  
Chronic Lung Disease ◽  
Tidal Breathing ◽  
Term Infants ◽  
Young Infants ◽  
Postmenstrual Age ◽  
Preterm Group ◽  
Preterm Born ◽  
The Relationship

The concept of diffusional screening implies that breath-to-breath variations in CO2 clearance, when related to the variability of breathing, may contain information on the quality and utilization of the available alveolar surface. We explored the validity of the above hypothesis in a cohort of young infants of comparable postmenstrual age but born at different stages of lung maturity, namely, in term-born infants ( n = 128), preterm-born infants without chronic lung disease of infancy (CLDI; n = 53), and preterm infants with moderate/severe CLDI ( n = 87). Exhaled CO2 volume (VE,CO2) and concentration (FE,CO2) were determined by volumetric capnography, whereas their variance was assessed by linear and nonlinear variability metrics. The relationship between relative breath-to-breath change of VE,CO2 (ΔVE,CO2) and the corresponding change of tidal volume (ΔVT) was also analyzed. Nonlinear FE,CO2 variability was lower in CLDI compared with term and non-CLDI preterm group ( P < 0.001 for both comparisons). In CLDI infants, most of the VE,CO2 variability was attributed to the variability of VT ( r2 = 0.749), whereas in term and healthy preterm infants this relationship was weaker ( r2 = 0.507 and 0.630, respectively). The ΔVE,CO2 − ΔVT slope was less steep in the CLDI group (1.06 ± 0.07) compared with non-CLDI preterm (1.16 ± 0.07; P < 0.001) and term infants (1.20 ± 0.10; P < 0.001), suggesting that the more dysmature the infant lung, the less efficiently it eliminates CO2 under tidal breathing conditions. We conclude that the temporal variation of CO2 clearance may be related to the degree of lung dysmaturity in early infancy. NEW & NOTEWORTHY Young infants exhibit appreciable breath-to-breath CO2 variability that can be quantified by nonlinear variability metrics and may reflect the degree of lung dysmaturity. In infants with moderate/severe chronic lung disease of infancy (CLDI), the variability of the exhaled CO2 is mainly driven by the variability of breathing, whereas in term-born and healthy preterm infants this relationship is less strong. The slope of the relative CO2-to-volume change is less steep in CLDI infants, suggesting that dysmature lungs are less efficient in eliminating CO2 under tidal breathing conditions.

Could Different Directions of Infant Stepping Be Controlled by the Same Locomotor Central Pattern Generator?

2000 ◽  
Vol 83 (5) ◽  
pp. 2814-2824 ◽  
Author(s):  
Tania Lamb ◽  
Jaynie F. Yang
Keyword(s):  
Central Pattern Generator ◽  
Muscle Activation ◽  
Pattern Generator ◽  
Swing Phase ◽  
Smooth Transition ◽  
Cycle Duration ◽  
Human Infants ◽  
Activation Patterns ◽  
Muscle Activation Patterns ◽  
The Relationship

This study examined the idea of whether the same central pattern generator (CPG) for locomotion can control different directions of walking in humans. Fifty-two infants, aged 2–11 mo, were tested. Infants were supported to walk on a treadmill at a variety of speeds. If forward stepping was elicited, stepping in the other directions (primarily sideways and backward) was attempted. The orientation of the infant on the treadmill belt determined the direction of stepping. In some infants, we also attempted to obtain a smooth transition from one direction to another by gradually changing the orientation of the infant during a stepping sequence. Limb segment motion and surface electromyography from the muscles of the lower limb were recorded. Most infants who showed sustained forward walking also could walk in all other directions. Thirty-three of 34 infants tested could step sideways. The success of eliciting backward stepping was 69%. Most of the infants who did not meet our backward stepping criteria did, however, make stepping movements. The different directions of stepping had similar responses to changes in treadmill speed. The relationship between stance and swing phase durations and cycle duration were the same regardless of the direction of stepping across a range of speeds. Some differences were noted in the muscle activation patterns during different directions of walking. For example, the hamstrings were much more active during the swing phase of backward walking compared with forward walking. The quadriceps was more active in the trailing leg during sideways walking. In some infants, we were able to elicit stepping along a continuum of directions. We found no discrete differences in either the electromyographic patterns or the temporal parameters of stepping as the direction of stepping was gradually changed. The results support the idea that the same locomotor CPG controls different directions of stepping in human infants. The fact that most infants were able to step in all directions, the similarity in the response to speed changes, and the absence of any discrete changes as the direction of stepping was changed gradually are all consistent with this hypothesis.

scholarly journals The Relationship between Glucosinolates and the Sensory Characteristics of Steamed-Pureed Turnip (Brassica Rapa subsp. Rapa L.)

Foods ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1719
Author(s):  
Nurfarhana Diana Mohd Nor ◽  
Stella Lignou ◽  
Luke Bell ◽  
Carmel Houston-Price ◽  
Kate Harvey ◽  
...  
Keyword(s):  
Bitter Taste ◽  
Dry Weight ◽  
Sweet Taste ◽  
Liquid Chromatography Mass Spectrometry ◽  
Sensory Panel ◽  
Brassica Vegetables ◽  
Different Seasons ◽  
Phytochemical Compounds ◽  
Positive Correlations ◽  
The Relationship

Glucosinolates (GSLs) are phytochemical compounds that can be found in Brassica vegetables. Seven separate batches of steamed-pureed turnip were assessed for GSL content using liquid chromatography mass spectrometry (LC-MS) and for sensory attributes by sensory profiling (carried out by a trained sensory panel). Twelve individual GSLs, which included 7 aliphatic, 4 indole and 1 arylaliphatic GSL, were identified across all batches. There were significant differences in individual GSL content between batches, with gluconasturtiin as the most abundant GSL. The total GSL content ranged from 16.07 to 44.74 μmol g−1 dry weight (DW). Sensory profiling concluded there were positive correlations between GSLs and bitter taste and negative correlations between GSLs (except glucobrassicanapin) and sweet taste. The batches, which had been purchased across different seasons, all led to cooked turnip that contained substantial levels of GSLs which were subsequently all rated as bitter.

Sleep and screen exposure across the beginning of life: deciphering the links using big-data analytics

SLEEP ◽  
2020 ◽  
Author(s):  
Michal Kahn ◽  
Natalie Barnett ◽  
Assaf Glazer ◽  
Michael Gradisar
Keyword(s):  
Big Data ◽  
Online Survey ◽  
Big Data Analytics ◽  
Distinct Pattern ◽  
Portable Devices ◽  
Cross Sectional ◽  
Daytime Sleep ◽  
Young Infants ◽  
Nighttime Sleep ◽  
The Relationship

Abstract Study Objectives Evidence for the association between screen time and insufficient sleep is bourgeoning, and recent findings suggest that these associations may be more pronounced in younger compared to older children, and for portable compared to non-portable devices. However, these effects have yet to be investigated within the beginning of life. Importantly, there are no data for the relationship between screen exposure and objectively measured infant sleep. This study examined the moderating role of age for both touchscreens’ and television’s relationship with sleep, using auto-videosomnography within a big-data sample of infants. Methods The sleep of 1074 infants (46% girls) aged 0–18 months was objectively assessed using computer-vision technology in this cross-sectional study. Sleep was additionally reported by parents in an online survey, as was infant exposure to screens. Results Age significantly moderated the relationship between daytime touchscreen exposure and sleep with a distinct pattern for younger infants, in which screen exposure was associated with decreased daytime sleep, but with a proposed compensatory increase in nighttime sleep consolidation. Compared to touchscreens, television exposure was less likely to be associated with sleep metrics, and age moderated this relationship only for daytime and 24-hour sleep duration. Conclusions In young infants, a daytime-nighttime sleep “trade-off” emerged, suggesting that the displacement of daytime sleep by screens may lead to greater accumulation of sleep homeostatic pressure, which in turn facilitates more consolidated nighttime sleep.

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