P0838HYPERPROLACTINEMIA IN CKD PATIENTS AND ITS ASSOCIATION WITH STRENGHT, SEXUAL DYSFUNCTION ANS QUALITY OF LIFE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Pedro do Valle Teichman ◽  
Gabrielle Zanotto de Oliveira ◽  
Samile Sallaberry Echeverria Silveira ◽  
Carlos Alberto Angarita Jaime ◽  
Mariana Lopes De Castro ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sexual Dysfunction ◽  
Handgrip Strength ◽  
Stage Iv ◽  
Free Testosterone ◽  
Serum Prolactin ◽  
Hormone Production ◽  
Ckd Stage ◽  
Male Patients

Abstract Background and Aims Hyperprolactinemia is a hormonal disorder associated with many diseases, including chronic kidney disease (CKD). Some studies have shown that serum prolactin (PRL) levels increase as CKD progresses, due to decreased renal clearance and increased production. This prolactin retention leads to inhibition of gonadotropic hormone production, and testosterone deficiency in male patients with CKD. Thus, this study aimed to evaluate PRL levels in male patients with different stages of CKD and its association with clinical and laboratory characteristics, strength, sexual dysfunction, and quality of life. Method This is a transversal study conducted in a tertiary hospital in southern Brazil. Patients with CKD stage IV and V were included and divided into three groups: 1) stage IV; 2) non-dialysis-dependent stage V and; 3) dialysis-dependent stage V (VD). Patients with prescribed hormone therapy were excluded. PRL, creatinine, testosterone, estradiol, albumin, SHBG, LH, and FSH levels were measured. Free testosterone was estimated by the Vermeulen equation. Patients were also evaluated for strength and musculoskeletal function through the “handgrip strength” test. For evaluation of the quality of life and sexual dysfunction, validated questionnaires were applied: AMS (Aging Male's Symptoms Scale), ADAM (Androgen Deficiency in the Aging Male) and SF-36 Health. Results In this study, 164 patients were included (IV=75; V=41; VD=48). The mean age was 64 [55-71] years and BMI 26,9 [23,3-30,04] kg/m2. The dialysis-dependent group had higher prevalence of hyperprolactinemia (22,6% vs. 49% vs. 66%, p<0,001), higher PRL (13,4 vs. 19,43 vs. 26,13, p<0,001) and estradiol (25,6 vs. 24,4 vs. 30,5, p=0,041). PRL levels were positive correlated with CKD stage (rs=0,482, p<0,001) and creatinine (rs=0,467, p<0,001) and negative correlated with testosterone (rs=-0,286, p<0,001) and free testosterone levels (rs=-0,307, p<0,001). There was no difference in PRL levels between hemodialysis and peritoneal dialysis (p=1,000). Analyzes related to the association of PRL levels with strength, quality of life, and sexual dysfunction are still being analyzed. Conclusion Hyperprolactinemia is associated with the severity of CKD, with a higher prevalence in dialysis patients. The relation of PRL levels with strength, quality of life, and sexual dysfunction are being evaluated.

scholarly journals Bupropion as a Treatment for Sexual Dysfunction Among Chronic Kidney Disease Patients

2019 ◽  
Author(s):  
Abolfazl Ghoreishi ◽  
Lila Dashtaki ◽  
Bahareh Hajisalimi
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Erectile Dysfunction ◽  
Sexual Dysfunction ◽  
Kidney Disease ◽  
Sexual Function ◽  
Total Quality ◽  
Significant Difference ◽  
Male Patients

Sexual dysfunction is a common complication among male patients with chronic kidney disease. Common disturbances include erectile dysfunction, decreased libido, and infertility. Sexual dysfunction is a multifactorial problem, and the treatment options are limited, it associated with lower quality of life scores in patients. Chronic kidney disease also has a critically impairing effect on the quality of life. To investigate the efficacy of bupropion on sexual dysfunction and quality of life in men with chronic kidney disease, a single-blind placebo-controlled trial was conducted. A total of 40 male patients with chronic kidney disease suffering from erectile dysfunction (Mean age 41/25±8/8) were randomly assigned to receive 10 weeks of treatment with either bupropion or placebo. Sexual function and quality of life were assessed by IIEF5 and WHOQOL-BREF questionnaires, respectively. Baseline demographic and clinical features were similar in both groups. The results showed a significant difference between the intervention and control groups in sexual function (P=0/005) and total quality of life (P=0/001); also the difference was significant in physical health (P=0/012), psychological health (P<0/001) and social relationship (P<0/001) domains. Our findings suggest that Bupropion is effective and safe for treating sexual dysfunction in men with chronic kidney disease and also could positively affect the quality of life among the patients. © 2019 Tehran University of Medical Sciences. All rights reserved. Acta Med Iran 2019;57(5):320-327.

Sexual dysfunction in male patients with Parkinson’s disease: related factors and impact on quality of life

2020 ◽  
Vol 41 (8) ◽  
pp. 2201-2206
Author(s):  
Ali Shalash ◽  
Eman Hamid ◽  
Hanan Elrassas ◽  
Abdelrahman Ibrahim Abushouk ◽  
Haitham Hamdy Salem
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sexual Dysfunction ◽  
Related Factors ◽  
Male Patients

Erectile dysfunction and antipsychotics

2011 ◽  
Vol 26 (S2) ◽  
pp. 1543-1543
Author(s):  
F. Fifani ◽  
Y. Otheman ◽  
M. Outarahout ◽  
A. Ouanass
Keyword(s):  
Quality Of Life ◽  
Erectile Dysfunction ◽  
Side Effects ◽  
Sexual Dysfunction ◽  
Fluphenazine Decanoate ◽  
Antipsychotic Medications ◽  
Sexual Side Effects ◽  
Male Patients ◽  
Classification Evaluation

Sexual side effects associated with antipsychotic medications constitute an understudied set of side effects that diminish a patient's quality of life, and lead to noncompliance with treatment. Male patients frequently report disturbances in erectile and ejaculatory functioning, as well as changes in libido. The capacity to trigger sexual dysfunction differs from one antipsychotic to another. Clinicians prescribing antipsychotic medications should be familiar with the classification, evaluation and treatment of these side effects. The purpose of this study is to assess the occurrence of erectile dysfunction for 5 classes of antipsychotics (Haloperidol, Risperidone, Olanzapine, Amisulpride and Fluphenazine decanoate) in a population of 120 patients, using the International Index of Erectile Dysfunction (IIEF 5).

scholarly journals Sexual Dysfunction and its Determinants in Male Patients with Rheumatoid Arthritis

2021 ◽  
Vol 9 (B) ◽  
pp. 350-355
Author(s):  
Hassan O. Ghareeb ◽  
Ghada M. Khafagy ◽  
Hatem H. Eleishi ◽  
Hala A. Hussein ◽  
Marwa D. Hasan
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Sexual Dysfunction ◽  
Sexual Function ◽  
Disease Activity ◽  
Serum Testosterone ◽  
Sexual Problems ◽  
Psychological State ◽  
Male Patients

BACKGROUND: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease affects about 0.5–1% of adults. Sexuality is an integral part of human quality of life and responsible for our individual welfare, study the association between them is highly important as many studies revealed that sexuality is greatly affected in RA patients. AIM: This study aims to determine the possible different risk factors for sexual dysfunction (SD) in RA and to study the magnitude of SD among RA male patients. METHODS: This is a case–control study carried on 60 males – aged between 18–45 years – attending Family Medicine and Rheumatology Clinic in Kasr Alainy, Cairo University, Egypt. Participants were divided into case and control groups, both groups were matched regarding socioeconomic status. All participants were evaluated for sexual function using international index of erectile function (IIEF), psychological state using patient health questionnaire (PHQ9), disease-related disability using health assessment questionnaire, disease severity using disease activity score 28, and serum testosterone level was assessed. RESULTS: There was a statistically significant difference between both groups regarding IIEF (OR o’s SD among patients were 1.66), PHQ9, and serum testosterone (p = 0.005). There was highly statistically significant negative correlation between sexual problems and depression, disease caused disability, RA duration and there was highly statistically significant positive correlation between sexual problems and serum hormonal level. CONCLUSION: Sexual problems are a prominent problem in males who suffer from RA. Sexual function was significant associated with disease activity, depression, quality of life, and with lower levels of total and free testosterone.

Glittre ADL test in eutrophic, overweight and obese elderly

2020 ◽  
Vol 21 (1) ◽  
pp. 49
Author(s):  
Augusto Baumhardt Guidoti ◽  
Ângelo Pereira Cattani ◽  
Cintia Laura De Araujo ◽  
Fernanda Beatriz Costa Delacoste ◽  
Guilherme Scotta Hentschke ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Functional Capacity ◽  
Elderly Women ◽  
Handgrip Strength ◽  
Exercise Intolerance ◽  
World Health ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
World Health Organization Quality

The Glittre ADL-test (TGlittre) has been designed and validated to measure functional capacity during daily living activities in patients with chronic obstructive pulmonary disease (COPD) but is now used in several other situations. The aim of this study was to evaluate the applicability of TGlittre in a sample of overweight and obese eutrophic elderly. This was an experimental and cross-sectional study, which included 21 elderly women, allocated by BMI, in eutrophic (n = 8), overweight (n = 6) and obese (n = 7) groups. They were assessed for functional capacity (TGlittre and 6MWT), quality of life (QOL) with the questionnaire World Health Organization Quality of Life for Older People (WHOQOL-OLD) and handgrip strength (HGS). TGlittre correlated with age (p = 0.0040) and with 6MWT (p = 0.0086), but no statistical difference was found in TGlittre's performance time and the distance covered in 6MWT between groups. TGlittre did not correlate with HGS (p = 0.1493) and WHOQOL-Old (p = 0.0905). The data obtained in the present study corroborate that TGlittre is used as a functional measurement variable in the elderly population.Keywords: aged, obesity, exercise intolerance.­­­

Sexual dysfunction, Depression and Quality of Life in Female Patients with HIV Infection

2015 ◽  
Vol 2 (2) ◽  
pp. 12-19 ◽  
Author(s):  
Sudharani P Naik ◽  
Rajesh Raman ◽  
S N Moth ◽  
Arun Kumar
Keyword(s):  
Quality Of Life ◽  
Sexual Dysfunction ◽  
Hiv Infection ◽  
Female Patients

scholarly journals Comparative analysis of postoperative sexual dysfunction and quality of life in type a aortic dissection patients of different ages

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Zeng-Rong Luo ◽  
Dong-Shan Liao ◽  
Liang-Wan Chen
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Depressive Symptoms ◽  
Sexual Dysfunction ◽  
Aortic Dissection ◽  
Physical Health ◽  
The Elderly ◽  
Type A Aortic Dissection ◽  
Postoperative Sexual Dysfunction

Abstract Background To compare postoperative sexual dysfunction (SD) and quality of life (QOL) in Type A Aortic Dissection (AAD) Patients of Different Ages. Methods From January 2018 to December 2019, 204 AAD postoperative survivors in Union Hospital of Fujian Medical University were selected and were divided into young group (less than 50 years old) and elderly group (more than 50 years old). We evaluated SD according to the male International Erectile Dysfunction Index (IIEF-5) and female sexual function index (FSFI). The Short Form 12 Health Survey Questionnaire (SF-12) and Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) were used to investigate the QOL, Quick Inventory Depressive Symptomatology-Self Report (QIDS-SR) and the Beck Depression Inventory-II (BDI-II) to investigate depressive symptoms. Results One hundred seventy-five patients completed all the questionnaire (85.8%). The total SD prevalence rate was 38.9% (68 cases), with 27.4% of the young (20 cases) and 47.1% of the elderly (48 cases). The age of non-SD and SD patients was 49.0 ± 11.5 and 56.9 ± 10.8 years, respectively (P = 0.03). Compared with non-SD patients, the total physical health of SD patients was significantly worse (P = 0.04), however, the mental health was not significantly worse (P = 0.77); the depressive symptoms did not expressed a significant difference between the SD and non-SD groups (QIDS-SR P = 0.15, BDI-II P = 0.06). Total physical health scores in the young SD group did not show significant better than elderly SD group (P = 0.24), however, total mental health scores showed significantly worse (P = 0.04), depressive symptoms scores were significantly higher (QIDS-SR P = 0.03, BDI-II P = 0.04). Conclusion The postoperative AAD SD prevalence of elderly is higher than that of young, and the total physical health of SD patients is poorer than those without SD patients. The young SD patients did not show a significant higher physical health scores than the elderly SD patients, instead, the young SD patients were more psychologically affected than the elderly SD patients, whose mental health was worse, and depression symptoms were more obvious, suggesting that the factors affecting the QOL of postoperative SD patients are related to physical factors, but the young postoperative SD patients mainly affected by psychological factors.

scholarly journals Quality of Life in CKD Patients on Low-Protein Diets in a Multiple-Choice Diet System. Comparison between a French and an Italian Experience

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1354
Author(s):  
Antioco Fois ◽  
Massimo Torreggiani ◽  
Tiziana Trabace ◽  
Antoine Chatrenet ◽  
Elisa Longhitano ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Choice ◽  
Protein Restriction ◽  
World Health ◽  
Life Questionnaire ◽  
Historical Cohort ◽  
Low Protein ◽  
Ckd Stage ◽  
The Impact

Prescribing a low-protein diet (LPD) is part of the standard management of patients in advanced stages of chronic kidney disease (CKD). However, studies on the quality of life (QoL) of patients on LPDs are lacking, and the impact these diets have on their QoL is often given as a reason for not prescribing one. We, therefore, decided to assess the QoL in a cohort of CKD stage 3–5 patients followed up by a multiple-choice diet approach in an outpatient nephrology clinic in France. To do so, we used the short version of the World Health Organization’s quality of life questionnaire and compared the results with a historical cohort of Italian patients. We enrolled 153 patients, managed with tailored protein restriction in Le Mans, and compared them with 128 patients on similar diets who had been followed in Turin (Italy). We found there were no significant differences in terms of age (median 73 vs. 74 years, respectively), gender, CKD stage, and comorbidities (Charlson’s Comorbidity Index 7 vs. 6). French patients displayed a greater body mass index (29.0 vs. 25.4, p < 0.001) and prevalence of obesity (41.2 vs. 15.0%, p < 0.001). Baseline protein intake was over the target in France (1.2 g/kg of real body weight/day). In both cohorts, the burden of comorbidities was associated with poorer physical health perception while kidney function was inversely correlated to satisfaction with social life, independently of the type of diet. Our study suggests that the type of LPD they follow does not influence QoL in CKD patients and that a personalized approach towards protein restriction is feasible, even in elderly patients.

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