scholarly journals The impact of eNOS, MTR and MTHFR polymorphisms on renal graft survival in children and young adults

2009 ◽  
Vol 24 (9) ◽  
pp. 2931-2937
Author(s):  
L. Artifoni ◽  
E. Benetti ◽  
S. Centi ◽  
S. Negrisolo ◽  
G. M. Ghiggeri ◽  
...  
Keyword(s):  
Young Adults ◽  
Graft Survival ◽  
Mthfr Polymorphisms ◽  
Renal Graft ◽  
Children And Young Adults ◽  
The Impact ◽  
Renal Graft Survival

The impact of donor age on renal graft survival

2000 ◽  
Vol 32 (1) ◽  
pp. 136-138 ◽  
Author(s):  
J.I Roodnat ◽  
R Zietse ◽  
P.G.H Mulder ◽  
J Rischen-Vos ◽  
T van Gelder ◽  
...  
Keyword(s):  
Graft Survival ◽  
Donor Age ◽  
Renal Graft ◽  
The Impact ◽  
Renal Graft Survival

THE IMPACT OF PERIPHERAL VASCULAR DISEASE ON PATIENT AND RENAL GRAFT SURVIVAL IN DIABETICS.

2000 ◽  
Vol 69 (Supplement) ◽  
pp. S329
Author(s):  
Mohamed El-Ghoroury ◽  
Robert Provenzano ◽  
Linda Morrison
Keyword(s):  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Graft Survival ◽  
Peripheral Vascular ◽  
Renal Graft ◽  
The Impact ◽  
Renal Graft Survival

Role of plasma homocysteine levels and MTHFR polymorphisms on IQ scores in children and young adults with epilepsy treated with antiepileptic drugs

2013 ◽  
Vol 29 (3) ◽  
pp. 548-551 ◽  
Author(s):  
Gabriella Di Rosa ◽  
Patrizia Lenzo ◽  
Eleonora Parisi ◽  
Milena Neri ◽  
Silvia Guerrera ◽  
...  
Keyword(s):  
Young Adults ◽  
Antiepileptic Drugs ◽  
Plasma Homocysteine ◽  
Mthfr Polymorphisms ◽  
Children And Young Adults ◽  
Iq Scores

Assessing Barriers to Medication Adherence in Pediatric and Adolescent and Young Adult (AYA) Patients on Anticoagulation

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 9-10
Author(s):  
Kevin E Todd ◽  
Meghan E Mcgrady ◽  
Anne Blackmore ◽  
Carrie Hennessey ◽  
Lori Luchtman-Jones
Keyword(s):  
Young Adults ◽  
Linear Regression ◽  
Medication Administration ◽  
Self Report ◽  
Adolescent And Young Adult ◽  
The Past ◽  
Children And Young Adults ◽  
The Impact ◽  
The Relationship ◽  
Lower Adherence

Background: Medication nonadherence rates as high as 50-75% have been widely reported in children and adolescents with chronic medical conditions. Anticoagulation nonadherence is associated with increased morbidity and mortality from hemorrhagic and thrombotic complications, reported mostly in older adult populations. As direct oral anticoagulant use increases, it is critical that pediatric clinicians understand the prevalence, adverse sequelae, and predictors of nonadherence for various anticoagulants prescribed for children and young adults to facilitate self-management in this population. To begin to address these critical knowledge gaps, this study explored the frequency of reported barriers to anticoagulation adherence and the relationship between reported barriers and adherence among a cohort of children and young adults who were prescribed anticoagulants through a pediatric thrombosis clinic. Methods: Data for this abstract were collected as part of a quality improvement (QI) initiative in the pediatric thrombosis clinic from May 2019 to November 2019. This QI initiative included the administration of a self-report measure which asked families to rate the presence/absence of 19 barriers to adherence and respond to two items assessing adherence ("How many anticoagulation doses did you/your child miss in the past 7 days?"; "Did you/your child miss any anticoagulation doses in the past month?"). Patients aged > 10 years (yr.) and/or their caregivers (for patients 0-17 yr.) visiting the clinic for anticoagulation follow-up completed the measure. With IRB approval, results from 161 anonymous measures from 130 families (n = 37 caregivers; n = 62 patients; n = 31 patient/caregiver dyads) were analyzed. Descriptive statistics were used to summarize the most frequent barriers, rates of adherence, and concordance of barriers within patient/caregiver dyads. Linear regression was used to explore relationships between barriers and adherence after controlling for medication administration type (injections versus oral). To ensure only one measure per family was included in this analysis, the regression was run on the subset of measures completed by caregivers of children < 18 yr. and patients ≥ 18 yr. (n = 105 [37 caregivers + 62 patients + 31 caregivers from patient/caregivers dyad = 130 families; 130 - 25 families with missing adherence data = 105 families]). Results: Of 161 reporters, 120 reported at least 1 barrier. The most common barriers were medication side effects (n = 44), alterations in lifestyle secondary to medication (n = 44) and forgetting to take the medications (n = 37). The distributions of barriers by reporter and medication type are illustrated in Figure 1. Of 31 dyads, 26 reported 1 or more barriers. Only 6 caregiver/child dyads reported the same set of barriers. The remaining 77% (n = 20) of caregivers endorsed different barriers than their children. On average, patients and caregivers reported 1.85 barriers (SD = 1.95, range 0 - 10) and that they/their child took 96% of prescribed doses (SD= 9%, range = 71 - 100%). The linear regression was significant (F(2, 102) = 4.19, p = 0.02, R2 = 0.08). After controlling for medication type (p = 0.06), a greater number of barriers was significantly associated with lower adherence (t = -2.63, p = 0.01). Every one unit increase in total barriers (1 additional barrier reported) was associated with a decrease of .26% in adherence. Discussion: Although self-reported adherence was high, 75% of patients and caregivers reported 1 or more barriers to adherence. A greater number of barriers is associated with lower adherence, regardless of medication route, suggesting that addressing reported barriers might improve adherence. The spectrum of reported barriers was diverse, differing even within patient and caregiver dyads. Therefore, it is important to evaluate both patients and caregivers to fully assess the burden of barriers. Future studies are needed to evaluate the impact of addressing barriers and the relationship between anticoagulation adherence, barriers, and health outcomes. Figure 1 Disclosures Luchtman-Jones: Corgenix: Other: Provided discounted kits for study; Accriva Diagnostics: Other: Provided kits for study.

scholarly journals Impact of acute kidney injury in donors on renal graft survival: a systematic review and Meta-Analysis

Renal Failure ◽  
2018 ◽  
Vol 40 (1) ◽  
pp. 649-656 ◽  
Author(s):  
Yi-Tao Zheng ◽  
Chen-Bao Chen ◽  
Xiao-Peng Yuan ◽  
Chang-Xi Wang
Keyword(s):  
Systematic Review ◽  
Acute Kidney Injury ◽  
Graft Survival ◽  
Meta Analysis ◽  
Kidney Injury ◽  
Renal Graft ◽  
Renal Graft Survival

Abstract 368: Family History of Premature Cardiac Events and Sub Clinical Atherosclerosis in Children and Young Adults: A Systematic Review

2013 ◽  
Vol 33 (suppl_1) ◽  
Author(s):  
Pragya Sinha ◽  
Jamal S Rana ◽  
Ebenezer T Oni ◽  
Ehimen C Aneni ◽  
Roger S Blumenthal ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Young Adults ◽  
Family History ◽  
Endothelial Dysfunction ◽  
Subclinical Atherosclerosis ◽  
Vascular Inflammation ◽  
Positive Family History ◽  
Cardiac Risk Factor ◽  
Children And Young Adults ◽  
The Impact

BACKGROUND The association between a positive family history (PFH) of premature cardiovascular disease (PCVD) and atherosclerosis has been explored in numerous studies. In adults, various studies have confirmed a significant positive correlation between a PFH and PCVD. Scant literature however, focuses on young individuals. Nevertheless, it is important to understand the impact that a PFH has in young people because the foundations of atherosclerosis and adverse cardiac behaviors develop in youth. In this paper, we aimed to systematically review the evidence linking a PFH of PCVD to indirect markers of subclinical atherosclerosis. METHODS The search was conducted on Medline, Web of Science and Embase. ‘Family history’, ‘children/young adults’ and ‘subclinical atherosclerosis’ were the three main concepts used. Increase in mean carotid IMT (cIMT), endothelial dysfunction and vascular inflammation were used as indirect measures of subclinical atherosclerosis. RESULTS 1191 articles were identified in the initial search. 24 papers with 5400 participants were included in the final review. There were five cohort studies and nineteen case control studies from twelve countries. Mean cIMT was found to be significantly increased in those with a PFH by eleven of the fourteen papers reviewed. Endothelial dysfunction, measured by flow mediated dilatation (FMD), was found to be significantly increased in five of the seven included studies. The evidence on vascular inflammation was somewhat inconsistent with only ten of the nineteen studies demonstrating significance. The results tend to suggest that an elevated mean cIMT, as well as a greater degree of endothelial dysfunction are seen in children and young adults with a PFH of PCVD. Moreover, these differences exist in asymptomatic children as young as 8-9 years (4 studies) in the absence of any other cardiac risk factor. DISCUSSION Individuals with a PFH of PCVD have evidence of subclinical atherosclerosis in their youth demonstrating an accelerated tendency to acquire cardiovascular disease. Some of this risk may be attributable to behavioral risk clustering in families. However, a significant proportion of this elevated risk is related solely to a positive family history and needs attention.

Variability of the Mammalian Target of Rapamycin Inhibitors Is Correlated With Long-Term Renal Graft Survival

2019 ◽  
Vol 51 (2) ◽  
pp. 341-343
Author(s):  
R. Valero ◽  
A. Sanchez-Fructuoso ◽  
E. Rodrigo ◽  
L. Belmar ◽  
M.A. Cos ◽  
...  
Keyword(s):  
Graft Survival ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Renal Graft ◽  
Renal Graft Survival

scholarly journals Impact of Beef and Beef Product Intake on Cognition in Children and Young Adults: A Systematic Review

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1797
Author(s):  
Ruopeng An ◽  
Sharon M Nickols-Richardson ◽  
Naiman Khan ◽  
Jianxiu Liu ◽  
Ruidong Liu ◽  
...  
Keyword(s):  
Young Adults ◽  
Cognitive Abilities ◽  
Primary Source ◽  
Bibliographic Databases ◽  
Future Research ◽  
Republic Of The Congo ◽  
Children And Young Adults ◽  
Study Participants ◽  
Feeding Control ◽  
The Impact

(1) Background: Undernutrition and micronutrient deficiency have been consistently linked to cognitive impairment among children and young adults. As a primary source of dietary animal protein, beef consumption holds the potential to improve diet quality and positively influence cognitive function. This study systematically reviewed evidence linking beef intake to cognition among children and young adults. (2) Methods: A literature search was conducted in seven electronic bibliographic databases for studies assessing the impact of beef consumption on cognition. (3) Results: We identified eight studies reporting results from five unique interventions. Two interventions were conducted in Kenya, two in the U.S. and one in four countries including Guatemala, Pakistan, Democratic Republic of the Congo and Zambia. Only one intervention employed a non-feeding control arm and found beef consumption to improve cognitive abilities compared to the control. However, the other interventions comparing beef consumption to other food types found no consistent result. (4) Conclusions: Evidence pertaining to the impact of beef consumption on cognition remains limited due to the small and heterogeneous set of studies. Future research should adopt a population representative sample and longer follow-up period, employ a non-feeding control arm and comprehensively measure nutrient intakes among study participants.

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