scholarly journals SURG-23. INTRAPARENCHYMAL MUCOSA-ASSOCIATED LYMPHOID TISSUE (MALT) LYMPHOMA: A NOVEL DISEASE PRESENTATION

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi244-vi244
Author(s):  
Mostafa Fatehi ◽  
Charles Haw
Keyword(s):  
Lymphoid Tissue ◽  
Marginal Zone ◽  
Low Grade ◽  
Review Of The Literature ◽  
Glial Tumor ◽  
Radiologic Diagnosis ◽  
Adjuvant Therapies ◽  
Intracranial Lesions ◽  
The Brain ◽  
Radiologic Features

Abstract INTRODUCTION Low grade B-cell lymphomas arising from the marginal zone of secondary lymphatic follicles constitute less than 10% of lymphomas. This condition was initially described in the stomach and the nasopharynx. However, there have been several reports of isolated dural-based intracranial lesions. METHODS A review of the literature using the EMBASE and MEDLINE databases yielded 12 previous cases of dural MALT lymphomas but none that were entirely intra-parenchymal. RESULTS Here, we present the case of a 67 year male who was found to have a convexity meningioma; and another, intra-parenchymal, lesion with radiologic features consistent with a low grade glial tumor. Upon resection of both lesions, the intra-axial tumor was found to be a mucosa-associated lymphoid tissue lymphoma. He has subsequently been referred for initiation of needing adjuvant therapies. CONCLUSIONS In addition to posing challenges for radiologic diagnosis, this case presents questions regarding the oncologic management of MALT lesions in the brain.

scholarly journals A case of primary mucosa-associated lymphoid tissue lymphoma of the prostate

Rare Tumors ◽  
2009 ◽  
Vol 1 (2) ◽  
pp. 169-170
Author(s):  
Noriko Koga ◽  
Masanori Noguchi ◽  
Fukuko Moriya ◽  
Kouichi Ohshima ◽  
Nobuyuki Yoshitake ◽  
...  
Keyword(s):  
B Cell ◽  
Lymphoid Tissue ◽  
Marginal Zone ◽  
Specific Antigen ◽  
Bone Marrow Aspiration ◽  
External Beam Radiation ◽  
Low Grade ◽  
Beam Radiation ◽  
Malt Type Lymphoma ◽  
Immunohistochemical Studies

We report a case of primary mucosa-associated lymphoid tissue (MALT) lymphoma of the prostate. A 67-year-old man presented with urinary obstruction and an elevated prostate-specific antigen (PSA) level. A physical examination revealed mild prostate enlargement and no lymphadenopathy. A needle biopsy and immunohistochemical studies of the prostate were performed, which revealed marginal zone B-cell MALT-type lymphoma. A bone marrow aspiration and biopsy did not show involvement by lymphoma. Magnetic resonance imaging (MRI) of the abdomen and the pelvis revealed no lymphadenopathy or ascites. There was no involvement of other sites by lymphoma. The patient was diagnosed and staged as extranodal marginal zone B-cell MALT-type lymphoma of the prostate, low grade and stage I. The patient received external beam radiation therapy to the prostate with a total dose of 3600cGy in 22 fractions, and became free of disease within the following 15 months.

Abnormal Wnt signaling and stem cell activation in reactive lymphoid tissue and low-grade marginal zone lymphoma

2010 ◽  
Vol 51 (5) ◽  
pp. 906-910 ◽  
Author(s):  
Da Zhang ◽  
Maura F. O'neil ◽  
Mark T. Cunningham ◽  
Fang Fan ◽  
Mojtaba Olyaee ◽  
...  
Keyword(s):  
Stem Cell ◽  
Wnt Signaling ◽  
Lymphoid Tissue ◽  
Cell Activation ◽  
Marginal Zone ◽  
Marginal Zone Lymphoma ◽  
Low Grade

Gastric marginal zone B-cell lymphomas of MALT type develop along 2 distinct pathogenetic pathways

Blood ◽  
2002 ◽  
Vol 99 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Petr Starostik ◽  
Jochen Patzner ◽  
Axel Greiner ◽  
Stephan Schwarz ◽  
Jörg Kalla ◽  
...  
Keyword(s):  
B Cell ◽  
Lymphoid Tissue ◽  
Gene Locus ◽  
Marginal Zone ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Low Grade ◽  
High Grade ◽  
Clonal Proliferation ◽  
Large B Cell Lymphoma

Low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type can transform into high-grade diffuse large B-cell lymphoma (DLBCL). Up to 60% of the MALT lymphomas contain the recently described t(11;18). However, this translocation has not been detected in any DLBCL so far. To elucidate the pathogenesis of these tumors, microsatellite screening of 24 gastric MALT lymphomas was performed and the results were compared with aberrations detected in a previous study on gastric DLBCL. The most frequent aberration, found in 21% of the MALT lymphomas that were exclusively t(11;18)-negative cases, was amplification of the 3q26.2-27 region (harboring the locus of the BCL6 gene). Allelic imbalances in regions 3q26.2-27, 6q23.3-25, 7q31, 11q23-24, and 18q21 were shared by both MALT lymphoma and DLBCL. Loss of heterozygosity in regions 5q21 (APC gene locus), 9p21 (INK4A/ARF), 13q14 (RB), and 17p13(p53) and allelic imbalances in 2p16, 6p23, and 12p12-13 occurred exclusively in DLBCL. Only one of 10 t(11;18)-positive MALT lymphomas showed an additional clonal abnormality. These tumors thus display features of a clonal proliferation characterized by the presence of the t(11;18). However, they only rarely display secondary aberrations and do not seem to transform into DLBCL. In contrast, t(11;18)-negative MALT lymphomas show numerous allelic imbalances—some of them identical with aberrations seen in DLBCL—suggesting that this group is the source of tumors eventually transforming into high-grade DLBCL.

The Apoptosis Inhibitor Gene API2 and a Novel 18q Gene,MLT, Are Recurrently Rearranged in the t(11;18)(q21;q21) Associated With Mucosa-Associated Lymphoid Tissue Lymphomas

Blood ◽  
1999 ◽  
Vol 93 (11) ◽  
pp. 3601-3609 ◽  
Author(s):  
Judith Dierlamm ◽  
Mathijs Baens ◽  
Iwona Wlodarska ◽  
Margarita Stefanova-Ouzounova ◽  
Jesus Maria Hernandez ◽  
...  
Keyword(s):  
Lymphoid Tissue ◽  
Marginal Zone ◽  
Open Reading Frame ◽  
Inhibitor Of Apoptosis ◽  
Low Grade ◽  
Gene Encoding ◽  
Reading Frame ◽  
Genetic Lesion ◽  
Zone Cell ◽  
Apoptosis Inhibitor

Marginal zone cell lymphomas of the mucosa-associated lymphoid tissue (MALT) are the most common subtype of lymphoma arising at extranodal sites. The t(11;18)(q21;q21) appears to be the key genetic lesion and is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphomas. We show that the API2 gene, encoding an inhibitor of apoptosis also known as c-IAP2, HIAP1, andMIHC, and a novel gene on 18q21 characterized by several Ig-like C2-type domains, named MLT, are recurrently rearranged in the t(11;18). In both MALT lymphomas analyzed, the breakpoint inAPI2 occurred in the intron separating the exons coding respectively for the baculovirus IAP repeat domains and the caspase recruitment domain. The breakpoints within MLT differed but the open reading frame was conserved in both cases. In one case, the translocation was accompanied by a cryptic deletion involving the 3′ part of API2. As a result, the reciprocal transcript was not present, strongly suggesting that the API2-MLT fusion is involved in the oncogenesis of MALT lymphoma.

Marginal Zone Lymphoma (Low-grade B-cell Lymphoma of Mucosa-associated Lymphoid Tissue Type) of Skin and Subcutaneous Tissue

1996 ◽  
Vol 20 (8) ◽  
pp. 1011-1023 ◽  
Author(s):  
Elizabeth M. Bailey ◽  
Judith A. Ferry ◽  
Nancy L. Harris ◽  
Martin C. Mihm ◽  
Joseph O. Jacobson ◽  
...  
Keyword(s):  
B Cell ◽  
Lymphoid Tissue ◽  
Marginal Zone ◽  
Cell Lymphoma ◽  
Subcutaneous Tissue ◽  
B Cell Lymphoma ◽  
Marginal Zone Lymphoma ◽  
Tissue Type ◽  
Low Grade

scholarly journals Trisomy 3 in low-grade B-cell lymphomas of mucosa-associated lymphoid tissue

Blood ◽  
1995 ◽  
Vol 85 (8) ◽  
pp. 2000-2004 ◽  
Author(s):  
AC Wotherspoon ◽  
TM Finn ◽  
PG Isaacson
Keyword(s):  
B Cell ◽  
Malt Lymphoma ◽  
Lymphoid Tissue ◽  
Marginal Zone ◽  
B Cell Lymphoma ◽  
Low Grade ◽  
B Cell Lymphomas ◽  
Splenic Lymphoma ◽  
Trisomy 3 ◽  
Primary Splenic Lymphoma

Characteristic chromosomal aberrations have been associated with subtypes of non-Hodgkin's lymphoma with distinct clinicopathologic features. Low-grade B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) form such a group and might be expected to be characterized by a specific cytogenetic abnormality. Metaphase analyses of MALT lymphoma are rare due to problems with fresh tissue collection and poor in vitro proliferation. However, the small number of published series suggests that chromosome trisomies, particularly trisomy 3, might be characteristic of these tumors. The application of interphase cytogenetic techniques to routinely processed material allows the examination of a large series of archival cases and is particularly useful for the demonstration of chromosome trisomies. We have used this technique to analyze 70 cases of low-grade MALT lymphoma from various sites and found trisomy 3 in 60%. This finding compares with 16% in low-grade nodal B-cell lymphoma and 27% in primary splenic lymphoma of marginal zone type (splenic lymphoma with villous lymphocytes). These results provide further evidence that low-grade MALT lymphomas from all sites form a single pathologic entity distinct from nodal B-cell lymphomas. Although MALT lymphoma and primary splenic lymphoma may arise from marginal zone B cells, they are genetically distinct.

Needle Biopsy under Computerized Tomographic Control

Neurosurgery ◽  
1979 ◽  
Vol 5 (6) ◽  
pp. 671-674 ◽  
Author(s):  
Hector E. James ◽  
Michael Wells ◽  
John F. Alksne ◽  
Ingmar Wickbom ◽  
Paul Siemers ◽  
...  
Keyword(s):  
Needle Biopsy ◽  
Clinical Course ◽  
Low Grade ◽  
Twist Drill ◽  
Lesion Area ◽  
Intracranial Hematoma ◽  
Patients Âgés ◽  
Intracranial Lesions ◽  
Appropriate Therapy ◽  
The Brain

Abstract Thirteen patients with intracranial lesions were submitted to a twist drill needle biopsy under computerized tomographic (CT) control, with sedation and local anesthesia. (The patients' ages ranged from 12 to 81 years.) The final diagnoses were glioblastoma in 7 patients and 1 case each of anaplastic astrocytoma, low grade astrocytoma, thrombosed arteriovenous malformation, cerebral infarct, 3rd ventricular epidermoid, and degenerative disease of the brain. Definitive diagnosis was obtained in all but 2 patients with this technique. Appropriate therapy was subsequently instituted in 11 patients without further operation. Transiently increased weakness of the previously affected limbs was the only untoward effect (4 patients). Intracranial hematoma after this procedure was seen in 1 patient in this series, as detected by the postprocedure CT scan, but there was no change in the clinical course. All patients were treated with dexamethasone for 24 to 48 hours before and for several days after the procedure to avoid decompensation of intracranial dynamics because of edema. The procedure, including appropriate level CT scans of the lesion area, was performed in approximately 1 hour in all patients.

scholarly journals Ocular marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue masquerading as chalazion: a case report

2021 ◽  
Vol 3 (1) ◽  
pp. 57-63
Author(s):  
Nik Ahmad Mat Zaidan Syafiq ◽  
Juana Wan Ab Kadir Azida ◽  
Sagili Chandrasekhara Reddy ◽  
Ismail Fazliana
Keyword(s):  
B Cell ◽  
Lymphoid Tissue ◽  
Marginal Zone ◽  
Cell Lymphoma ◽  
Correct Diagnosis ◽  
Anterior Segment ◽  
B Cell Lymphoma ◽  
Lower Eyelid ◽  
Low Grade ◽  
The Right

A case of ocular marginal zone non-Hodgkin B-cell lymphoma of mucosa-associated lymphoid tissue of the conjunctiva masquerading as chalazion is reported in a 57-year-old Chinese man, known to have diabetes mellitus. He presented with painless swelling of the lower lid and redness in the right eye for 3 months duration. A diagnosis of chalazion was made, and incision and curettage were performed by a general ophthalmologist. The swelling worsened and spread to the whole lower lid. Magnetic resonance imaging showed a lesion involving the right periorbital region limited to the anterior orbital septum that was hypointense on T1 and hyperintense on T2. A diagnosis of periorbital cellulitis with possibility of lymphoma was suggested. When he came to our eye clinic for expert opinion, his visual acuity, anterior segment and fundus were normal except early cataract changes in both eyes. There was a hard, non-tender, immobile mass within the lower eyelid associated with conjunctival injection and chemosis. Histopathology of the conjunctival biopsy showed features of low-grade non-Hodgkin B-cell lymphoma and the immunohistochemistry report was suggestive of marginal zone lymphoma. He was treated with chemotherapy (cyclophosphamide, vincristine, prednisolone) and radiotherapy, following which the swelling resolved. When patients do not respond to treatment as expected after incision and curettage of chalazion, a high index of possibility of malignancy should be kept in mind whenever a recurrence of hard swelling is observed at the same site in the eyelid. All suspicious lesions should be biopsied to find out the correct diagnosis.

Primary low-grade B-cell lymphoma of mucosa-associated lymphoid tissue of the dura mimicking the presentation of an acute subdural hematoma

2002 ◽  
Vol 96 (3) ◽  
pp. 611-614 ◽  
Author(s):  
Pablo Goetz ◽  
Jesus Lafuente ◽  
Tomas Revesz ◽  
Malcolm Galloway ◽  
Ahmet Dogan ◽  
...  
Keyword(s):  
Subdural Hematoma ◽  
Lymphoid Tissue ◽  
Marginal Zone ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Acute Subdural Hematoma ◽  
Low Grade ◽  
Content Type ◽  
History Of ◽  
Tomography Scanning

✓ The authors present the case of a 64-year-old woman who experienced a left hemiparesis. An initial diagnosis of subdural hematoma was made based on results of computerized tomography scanning. Subsequent magnetic resonance imaging indicated an extraaxial meningioma. Histological findings confirmed an extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT). The authors outline the natural history of central nervous system lymphomas and of MALT lymphomas in other tissues. They review seven previously reported cases and emphasize the importance of recognizing these tumors as a distinct clinicopathological entity.

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