scholarly journals Cord Blood Antibody Seroprevalance Against Diphtheria, Pertussis, Measles, Mumps and Rubella among Term Healthy Indian Newborns

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S323-S324 ◽  
Author(s):  
Deepak James ◽  
Jula Lavanya ◽  
Sanjay Verma ◽  
Amit Rawat ◽  
Venkataseshan S ◽  
...  
Keyword(s):  
Cord Blood ◽  
Tertiary Care ◽  
Cord Blood Sample ◽  
Care Hospital ◽  
Vaccine Preventable Diseases ◽  
Northern India ◽  
Young Infants ◽  
Tdap Vaccine ◽  
Protective Antibodies ◽  
Term Newborns

Abstract Background The resurgence of vaccine preventable diseases in young infants is a matter of concern worldwide. The aim of our study was to determine the seroprevalance of protective antibodies against diphtheria, pertussis, measles, mumps and rubella antigens in cord blood among term Indian newborns, at birth. Methods Apparently healthy term newborns, delivered at a tertiary care hospital in Northern India, over two year period (Apr 15-March 17) were enrolled after taking informed written consent from their parents; and their cord blood sample was collected. Ethical clearance was obtained from Institute Ethics committee, before enrolling subjects. Cord blood samples were tested for antibodies using commercial ELISA kits IMMUNOLAB IgG. Results A total of 160 newborns (M:F = 86:74) were enrolled. In our study, antibodies (IgG) against diphtheria toxin (DT) were > 0.1 IU/mL in 44.4% (71/160), 0.01 to 0.1 IU/mL in 53.1% (85/160) and < 0.01 IU/mL in 2.5% (4/160). None of their mothers received Tdap vaccine in past. Antibodies (IgG) against pertussis toxin (PT) > 40 U/mL were seen in 41.2% (66/160). Out of these 66 children, 23 had titres > 100 U/mL. Total of 58.8% (94/160) children had antibodies < 40 U/mL. Out of these 94 children, 48 had titers < 20 U/mL. Antibodies (IgG) against measles antigen were > 12 IU/mL in 88.8% (142/160). A total of 11.2 (18/160) had titers below 12 IU/mL. Out of these 18 children, 5 had titers < 6 IU/mL. Antibodies (IgG) against mumps antigen were > 12 IU/mL in 83.1% (133/160). A total of 16.9% (27/160) had titers below 12 IU/mL. Out of these 27 children, 12 had titers < 6 IU/mL. Antibodies (IgG) against rubella antigen were > 12 IU/mL in 83.7% (134/160). A total of 16.3% (26/160) had titers below 12 IU/mL. Out of these 26 children, 22 had titers < 6 IU/mL. Conclusion Only 44.4% of studied newborns were fully protected (> 0.1 IU/mL) against diphtheria, because of maternal antibodies. As correlates of protection for pertussis are not yet defined; those having anti-PT titers >100 IU/mL i.e., 14.3% (23/160) were most protected; while those having titers < 20 U/mL i.e., 30% (48/160) were least protected. Out of studied newborns, fully protected (>12 IU/mL) against measles, mumps and rubella were 88.8%, 83.1% and 83.7% respectively. Acknowledgement. PGI Intramural research grant Disclosures All authors: No reported disclosures.

scholarly journals Relationship between Maternal Hemoglobin Concentration to the Newborn Cord Blood Hemoglobin and Serum Concentration

2021 ◽  
Vol 15 (7) ◽  
pp. 2320-2322
Author(s):  
Samreen Fakeer Muhammad ◽  
Parigul Baloch ◽  
Shakeel Akbar ◽  
Safia Ewaz Ali ◽  
Shazia Saeed ◽  
...  
Keyword(s):  
Cord Blood ◽  
Tertiary Care ◽  
Hemoglobin Concentration ◽  
University Hospital ◽  
Full Blood Count ◽  
Cord Blood Sample ◽  
Care Hospital ◽  
Cross Sectional ◽  
Ferritin Concentration ◽  
Blood Hemoglobin

Objective: To determine the mean cord blood hemoglobin and ferritin concentration in newborn of anemic mothers. Study Design: Cross sectional Place and Duration: Gynae & Obs department of Dow University Hospital, a tertiary care hospital in Karachi, Pakistan during the period from January, 2018 to July, 2019. Methodology: A total of 100 anemic pregnant women as per inclusion and exclusion criteria were included in this study. Cord blood sample (5ml) was obtained by sterile needle puncture immediately after cord clamping. 2ml will collected in EDTA bottle for full blood count analysis and 3ml collected in plain bottle for serum ferritin analysis. Final outcome was recorded on approved proforma. Results: The average age of the patients was 29.33±3.23 years. Mean cord blood hemoglobin and ferritin concentration in newborn of anemic mothers was 14.78±1.62 g/dl and 94.10±67.47 u/ml. Conclusion: We found that average hemoglobin of the women recruited in our study was 9.59±0.815 g/dl however we could find no correlation between mean cord blood hemoglobin and ferritin concentration in newborn of anemic mothers. Key Words: Cord blood Hemoglobin, Ferritin, Anemic mothers

scholarly journals Hematological profile including alkali resistant hemoglobin of neonates at birth using cord blood in relation to gestational age and maternal diseases

2016 ◽  
Vol 5 (1) ◽  
pp. 131
Author(s):  
Debashis Bhattacharya ◽  
Sharmistha Chatterjee ◽  
Gargi Sen
Keyword(s):  
Cord Blood ◽  
Cell Count ◽  
Gestational Age ◽  
White Cell Count ◽  
Tertiary Care ◽  
Cord Blood Sample ◽  
Care Hospital ◽  
Cross Sectional ◽  
Hematological Profile ◽  
Haematological Profile

Background: The importance of complete hemogram along with the hematological indices in the diagnosis of neonatal health cannot be overemphasized. There is a severe paucity of relevant data regarding neonatal hematological profile in relation to gestational age and maternal diseases in this part of the country. With this perspective, the authors intended to do a pilot study to analyse the haematological profile of neonates of different gestational ages and different maternal diseases born in a teriary care hospital in Eastern India.Methods: This is a cross sectional study design based on cord blood sample of newborns and their mothers recruited from those admitted in the gynae and obstetric department in IPGME&R. The umbilical cord blood was collected from the newborn babies and then examined for different haematological parameters. The data obtained was statistically analysed.Results: While there has been a sequential rise of fetal red cell count, hemoglobin and the total white cell count neutrophils with gestational age, the mean corpuscular cell volume decreased. All these values were comprised to varying degrees in maternal diseases except for nucleated rell blood cells which conspicuously increased in neonates of diabetic mothers.Conclusions: In this study, a small attempt was made to assess the haematological profile (including alkali resistant hemoglobin) of the newborns in relation to gestational age and maternal diseases in the population attending a tertiary care hospital in Eastern India.

scholarly journals Microbiological Profile and Sensitivity Data among the Neonatal Population from a Tertiary Care Hospital in South India

2021 ◽  
pp. 1-6
Author(s):  
Mohamed Reshad ◽  
Balachandran Binesh ◽  
Moideen Sharief ◽  
Muheidheen Shad
Keyword(s):  
Burkholderia Cepacia ◽  
South India ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Kodamaea Ohmeri ◽  
Young Infants ◽  
Common Organism ◽  
Sensitivity Pattern ◽  
Neonatal Population

Background: Sepsis is one of the most common causes of mortality and morbidity among neonates. The prevalence of microorganisms varies with regions, and the sensitivity pattern also changes over time.   Aim: To study the prevalence of various microorganisms and their sensitivity pattern among the neonatal population in a tertiary care hospital in South India. Methods: This was a retrospective descriptive study. We screened the records of all neonates admitted to the hospital during a period starting from January 1st, 2016, to September 30th, 2018. The details of the patients with any sterile body fluids showing microbial growth were collected. Descriptive analysis was done using IBM SPSS version 20. Results: There were 77 organisms isolated during the study period, with the majority among outborn babies. Seventy-two isolates were from blood, two from CSF and urine, with one from the central line. The most common organism was Klebsiella (22%), followed by Burkholderia cepacia (12%), Staphylococcus aureus (9%), and Streptococcus agalactiae (7%). 9% of the organisms were fungus, with the most common being Kodamaea Ohmeri. Among the antibiotics tested for sensitivity, Meropenem had the maximum sensitivity ratio (84%), followed by Co-trimoxazole (83%) and Vancomycin (82%). Piperacillin tazobactam sensitivity was only 56%, and Ciprofloxacin was sensitive in 65% of cases. Most (6 out of 7) of the fungal isolates were sensitive to fluconazole. Conclusions: Klebsiella remains to be the most common organism causing severe infection in young infants. Worrying rise in the incidence of uncommon organisms (like Kodamaea Ohmeri, GBS, Burkholderia) and carbapenem resistance was noted.  It is, therefore, essential to update the antibiotic policy of the neonatal units on a timely basis.

scholarly journals Clinical outcome of infants younger than two months in children ward of a tertiary care hospital, Nepal

2016 ◽  
Vol 3 (2) ◽  
pp. 15-18
Author(s):  
Ganesh Shah ◽  
Dinesh Dharel ◽  
Anish K Shah ◽  
Bikal Sapkota ◽  
Asmita Bhattarai
Keyword(s):  
Blood Culture ◽  
Clinical Outcome ◽  
Skin Infection ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Facility ◽  
Clinical Profile ◽  
Care Hospital ◽  
Young Infants ◽  
Level Hospital

 Introductions: Newborn and young infants are most vulnerable for preventable deaths, particularly in developing countries. This study was conducted to see the clinical profile and outcome of infants less than two months of age admitted in children ward of Patan Hospital.Methods: This descriptive retrospective study was conducted at Patan Hospital, over 12 months from April 2014 to March 2015. Hospital records of all admitted infants aged less than two months were reviewed. The demographic characteristics, clinical profile and clinical outcome were descriptively analyzed.Results: Out of 2062 admissions in children ward, 614 (29.8%) were infants aged less than two months, out of which 482 were neonates less than 28 days. Among these neonates, 114 were inborn. Out of 436 infections, blood culture was positive in 37 (8.9%). There were 4 (0.04%) deaths, 4 (0.04%) referral and 22 (0.25%) left against medical advice. Infection 436 (436) was the commonest cause of illness, of which neonatal sepsis was 163 (37.4%), pneumonia 130 (30%) staphylococcal skin infection 39 (8.7%) and UTI 34 (7.8%). There were 71 (11.6%) cases of neonatal hyperbilirubinemia. Blood culture was positive in 55 (9%) with CONS being the commonest organism isolated; 19 (51.3%).Conclusions: Children ward contributes significantly to the care of sick infants less than two months of age, especially out born ones, requiring neonatal care facility in tertiary level hospital of Nepal. As most admissions are for infection, followed by hyperbilirubinemia, pediatrics wards need to be equipped and staffed accordingly to meet the need of sick young infants.Journal of Patan Academy of Health  Sciences. 2016 Dec;3(2):15-18

scholarly journals Assessment of Factors Associated with Dropout for Pentavalent Vaccine in Tertiary Care Hospital of Kathmandu, Nepal

2020 ◽  
Vol 22 (3) ◽  
pp. 106-110
Author(s):  
Supri Raj Shrestha ◽  
B Shakya ◽  
R Oli
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
College Teaching ◽  
Sampling Technique ◽  
Cost Effective ◽  
Dropout Rate ◽  
Care Hospital ◽  
Vaccine Preventable Diseases ◽  
Factors Associated ◽  
Pentavalent Vaccine

Immunization is one of the most cost-effective public health measures as it has helped in huge reduction of disease, disability and death from different infectious diseases in children by protecting them from vaccine preventable diseases. The current study aimed to study factors associated with dropout for pentavalent vaccine in tertiary care hospital of Kathmandu. A longitudinal observational study using purposive sampling technique was conducted among 196 infants. The information was obtained using self-constructed structured questionnaire from parents visiting Community Medicine OPD of Nepal Medical College Teaching Hospital. The information regarding socioeconomic characteristics of mother, gender of the infant, place of delivery of child, birth order and reasons for dropout of pentavalent third dose were taken. The dropout of third dose pentavalent vaccine was mainly seen in infant of parents living in rented house and according to gender wise, dropout was high among male infants. The different reasons for dropout of vaccine were busy parents, forgotten date, visit to other immunization centres and sick infants. Among these, the main reason for dropout of vaccine was due to infants getting sick during the time of immunization. The dropout rates between first and third dose of pentavalent vaccine were 26.3% and 30.4% respectively for two consecutive months and the overall dropout rate was 28.35%. Also, literacy level of the mother was directly associated with the immunization visit of the infant as, maximum number of infants of illiterate mother were absent for third dose of pentavalent vaccine as opposed to no absentee among master degree holding mothers. Thus, the present study provides valuable information regarding the factors associated with dropout for pentavalent vaccine.

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