Hematological profile including alkali resistant hemoglobin of neonates at birth using cord blood in relation to gestational age and maternal diseases

Background: The importance of complete hemogram along with the hematological indices in the diagnosis of neonatal health cannot be overemphasized. There is a severe paucity of relevant data regarding neonatal hematological profile in relation to gestational age and maternal diseases in this part of the country. With this perspective, the authors intended to do a pilot study to analyse the haematological profile of neonates of different gestational ages and different maternal diseases born in a teriary care hospital in Eastern India.Methods: This is a cross sectional study design based on cord blood sample of newborns and their mothers recruited from those admitted in the gynae and obstetric department in IPGME&R. The umbilical cord blood was collected from the newborn babies and then examined for different haematological parameters. The data obtained was statistically analysed.Results: While there has been a sequential rise of fetal red cell count, hemoglobin and the total white cell count neutrophils with gestational age, the mean corpuscular cell volume decreased. All these values were comprised to varying degrees in maternal diseases except for nucleated rell blood cells which conspicuously increased in neonates of diabetic mothers.Conclusions: In this study, a small attempt was made to assess the haematological profile (including alkali resistant hemoglobin) of the newborns in relation to gestational age and maternal diseases in the population attending a tertiary care hospital in Eastern India.

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Relationship between Maternal Hemoglobin Concentration to the Newborn Cord Blood Hemoglobin and Serum Concentration

10.53350/pjmhs211572320 ◽

2021 ◽

Vol 15 (7) ◽

pp. 2320-2322

Author(s):

Samreen Fakeer Muhammad ◽

Parigul Baloch ◽

Shakeel Akbar ◽

Safia Ewaz Ali ◽

Shazia Saeed ◽

...

Keyword(s):

Cord Blood ◽

Tertiary Care ◽

Hemoglobin Concentration ◽

University Hospital ◽

Full Blood Count ◽

Cord Blood Sample ◽

Care Hospital ◽

Cross Sectional ◽

Ferritin Concentration ◽

Blood Hemoglobin

Objective: To determine the mean cord blood hemoglobin and ferritin concentration in newborn of anemic mothers. Study Design: Cross sectional Place and Duration: Gynae & Obs department of Dow University Hospital, a tertiary care hospital in Karachi, Pakistan during the period from January, 2018 to July, 2019. Methodology: A total of 100 anemic pregnant women as per inclusion and exclusion criteria were included in this study. Cord blood sample (5ml) was obtained by sterile needle puncture immediately after cord clamping. 2ml will collected in EDTA bottle for full blood count analysis and 3ml collected in plain bottle for serum ferritin analysis. Final outcome was recorded on approved proforma. Results: The average age of the patients was 29.33±3.23 years. Mean cord blood hemoglobin and ferritin concentration in newborn of anemic mothers was 14.78±1.62 g/dl and 94.10±67.47 u/ml. Conclusion: We found that average hemoglobin of the women recruited in our study was 9.59±0.815 g/dl however we could find no correlation between mean cord blood hemoglobin and ferritin concentration in newborn of anemic mothers. Key Words: Cord blood Hemoglobin, Ferritin, Anemic mothers

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Gestational Age Specific Postnatal Growth Curves for Singleton Babies in Tertiary Hospital of Western Nepal

Journal of Nepal Medical Association ◽

10.31729/jnma.3105 ◽

2017 ◽

Vol 56 (207) ◽

pp. 325-330

Author(s):

Santosh Pathak ◽

Nagendra Chaudhary ◽

Prativa Dhakal ◽

Shyam Kumar Mahato ◽

Sandeep Shrestha ◽

...

Keyword(s):

Birth Weight ◽

Gestational Age ◽

Economic Status ◽

Tertiary Care ◽

Growth Curves ◽

Tertiary Hospital ◽

Care Hospital ◽

Cross Sectional ◽

Intrauterine Growth ◽

Geographical Regions

Introduction: Measurement of birth weight (BW), crown heel length (CHL), head circumference (HC) and chest circumference used to assess the intrauterine growth of a baby vary with altitude, race, gender, socio economic status, maternal size, and maternal diseases. The study aimed to construct centile charts for BW, CHL and HC for new born at different gestational ages in western Nepal. Methods: This was a descriptive cross sectional study done over a period of 15 months in a tertiary care hospital of western Nepal. BW, length, HC and CC were measured within 12-24 hours of birth. Gestational age was estimated from first day of last menstrual period, maternal ultrasonology and New Ballard’s scoring system. Microsoft 2007 Excel and SPSS-16 was used for data analysis. Cole’s Lambda Mu Sigma method was used for constructing centile curves. Results: Out of 2000 babies analysed, 1910 samples were used to construct smoothed intrauterine growth curve of BW, CHL, and HC from 33-42 weeks of gestation. 57.35% (1147) were male, mean gestational age was 38.13 ±2.44 weeks, where 21.5% were preterm and 1.7% post term. The means of BW, CHL, HC and CC were 2744.78 gm, 47.80 cm, 33.18 cm, and 30.20 cm with standard deviations of 528.29, 3.124, 1.78, and 2.35 respectively. These data vary as compared to the Kathmandu data, in case of birth weight for 10th and 90th centiles, and at 90th centile in case of length. Conclusions: This necessitates the update in the existing growth charts and develop in different geographical regions of a country.

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Frequency of infantile colic in neonates presenting At Tertiary Care Hospital.

The Professional Medical Journal ◽

10.29309/tpmj/2020.27.11.4588 ◽

2020 ◽

Vol 27 (11) ◽

pp. 2357-2362

Author(s):

Anwar Muhammad ◽

Muhammad Asghar Ali ◽

Ali Hammad

Keyword(s):

Gestational Age ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Cross Sectional Study ◽

P Value ◽

Care Hospital ◽

Infantile Colic ◽

Cross Sectional ◽

Alternative Measures ◽

Hospital Study

Objectives: To determine the frequency of infantile colic in neonates presenting at tertiary care hospital. Study Design: Cross Sectional Study. Setting: Department of Neonatology, Civil Hospital, Bahawalpur. Period: From January 2018 to August 2018. Material & Methods: Total 467 neonates either male or female were selected for this study. Total 467 neonates with complaints of crying and fussing either male or female were selected for this study and infantile colic was assessed in selected neonates by using Wessel criteria. Results: Total 467 neonates were selected for this study. Mean age of the neonates was 24.94 ± 2.39 months, mean gestational age and mean weight was 39.42 ± 1.22 weeks and 3.27 ± 0.62g respectively. Infantile colic was found in 322 (69%) neonates. Infantile colic was found in 61 (33.33%) neonates, 136 (94.44%) neonates, 75 (87.21%) neonates and 50 (92.59%) neonates respectively. Statistically significant association between infantile colic and type of feeding with p value 0.000. Infantile colic was found in 147 (84.97%), 95 (67.86), 62 (49.21%) and 18 (64.29%) neonates respectively in 37 weeks, 38 weeks, 39 weeks and 40 weeks gestational age group. Statistically insignificant association between infantile colic and gestational age was noted with p value 0.000. Conclusion: Results of present study showed higher rate of colic in infants. Development of colic was highly associated with gestational age, birth weight and type of feeding. There is no effective medical treatment (like anti-colic and herbal drugs) but alternative measures may relieve or prevent further colic attacks.

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Prevalence of iron deficiency and thalassemia in patients presenting Tertiary Care Hospital.

The Professional Medical Journal ◽

10.29309/tpmj/2020.27.12.4643 ◽

2020 ◽

Vol 27 (12) ◽

pp. 2618-2621

Author(s):

Nadia Taj ◽

Saba Javed ◽

Munazza Munir ◽

Anam Naz ◽

Asma Sajid ◽

...

Keyword(s):

Iron Deficiency ◽

Gestational Age ◽

Tertiary Care ◽

Tertiary Hospital ◽

Cross Sectional Study ◽

Care Hospital ◽

Contributing Factors ◽

Cross Sectional ◽

Iron Deficient ◽

Tertiary Care Hospitals

Objectives: To find the frequency of iron deficient anemia and thalassemia in anemic patient reporting in tertiary hospital in Multan. Study Design: Cross Sectional study. Setting: Department of Obstetrics and Gynecology in Nishtar Hospital, Multan. Period: 20th October 2018 to 20th April 2019. Material & Method: In this study total 260 females with anemia HB<10.5g/dl were incorporated. Blood of all the patients were collected following the septic measures in CBC vial for counting of hemoglobin and blood investigation serum ferritin [<11ng/ml] and HB electrophoresis HBA [>6]. Gestational age was predicted depending upon last period of menstruation. Results: Age of patients in this study was between 24 to 34 year with the average age of 29.9±2.3 year, average gestational age 33.2±2.11 week, average parity 1.46±1.3. Iron deficient anemia was observed in 88.4 percent patient. Thalassemia was observed in 5.7 percent patient. Conclusion: The results of our study revealed that iron deficiency and thalassemia are significant contributing factors of anemia in patients reporting tertiary care hospitals Multan. General screening for carriers of thalassemia should be provided to all pregnant females attending prenatal care.

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Cord Blood Antibody Seroprevalance Against Diphtheria, Pertussis, Measles, Mumps and Rubella among Term Healthy Indian Newborns

Open Forum Infectious Diseases ◽

10.1093/ofid/ofx163.762 ◽

2017 ◽

Vol 4 (suppl_1) ◽

pp. S323-S324 ◽

Cited By ~ 1

Author(s):

Deepak James ◽

Jula Lavanya ◽

Sanjay Verma ◽

Amit Rawat ◽

Venkataseshan S ◽

...

Keyword(s):

Cord Blood ◽

Tertiary Care ◽

Cord Blood Sample ◽

Care Hospital ◽

Vaccine Preventable Diseases ◽

Northern India ◽

Young Infants ◽

Tdap Vaccine ◽

Protective Antibodies ◽

Term Newborns

Abstract Background The resurgence of vaccine preventable diseases in young infants is a matter of concern worldwide. The aim of our study was to determine the seroprevalance of protective antibodies against diphtheria, pertussis, measles, mumps and rubella antigens in cord blood among term Indian newborns, at birth. Methods Apparently healthy term newborns, delivered at a tertiary care hospital in Northern India, over two year period (Apr 15-March 17) were enrolled after taking informed written consent from their parents; and their cord blood sample was collected. Ethical clearance was obtained from Institute Ethics committee, before enrolling subjects. Cord blood samples were tested for antibodies using commercial ELISA kits IMMUNOLAB IgG. Results A total of 160 newborns (M:F = 86:74) were enrolled. In our study, antibodies (IgG) against diphtheria toxin (DT) were > 0.1 IU/mL in 44.4% (71/160), 0.01 to 0.1 IU/mL in 53.1% (85/160) and < 0.01 IU/mL in 2.5% (4/160). None of their mothers received Tdap vaccine in past. Antibodies (IgG) against pertussis toxin (PT) > 40 U/mL were seen in 41.2% (66/160). Out of these 66 children, 23 had titres > 100 U/mL. Total of 58.8% (94/160) children had antibodies < 40 U/mL. Out of these 94 children, 48 had titers < 20 U/mL. Antibodies (IgG) against measles antigen were > 12 IU/mL in 88.8% (142/160). A total of 11.2 (18/160) had titers below 12 IU/mL. Out of these 18 children, 5 had titers < 6 IU/mL. Antibodies (IgG) against mumps antigen were > 12 IU/mL in 83.1% (133/160). A total of 16.9% (27/160) had titers below 12 IU/mL. Out of these 27 children, 12 had titers < 6 IU/mL. Antibodies (IgG) against rubella antigen were > 12 IU/mL in 83.7% (134/160). A total of 16.3% (26/160) had titers below 12 IU/mL. Out of these 26 children, 22 had titers < 6 IU/mL. Conclusion Only 44.4% of studied newborns were fully protected (> 0.1 IU/mL) against diphtheria, because of maternal antibodies. As correlates of protection for pertussis are not yet defined; those having anti-PT titers >100 IU/mL i.e., 14.3% (23/160) were most protected; while those having titers < 20 U/mL i.e., 30% (48/160) were least protected. Out of studied newborns, fully protected (>12 IU/mL) against measles, mumps and rubella were 88.8%, 83.1% and 83.7% respectively. Acknowledgement. PGI Intramural research grant Disclosures All authors: No reported disclosures.

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Correlation of neonatal gestational age with foot length and right nipple to umbilicus distance

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20202141 ◽

2020 ◽

Vol 7 (6) ◽

pp. 1319

Author(s):

Ajay K. Keshwani ◽

Swati S. Suroshe

Keyword(s):

Birth Weight ◽

Gestational Age ◽

Tertiary Care ◽

Large For Gestational Age ◽

P Value ◽

Care Hospital ◽

Cross Sectional ◽

Systematic Analysis ◽

Neonatal Deaths ◽

Foot Length

Background: India contributes to one fifth of global live births and more than a quarter of neonatal deaths. A systematic analysis of global, regional and national causes of child mortality in 2013 identified preterm birth complications and infections to be the two major causes of neonatal deaths in India. So, there is need of a simple, easy to use and reliable screening tool for assessment of gestational age at peripheral level for early referral of a neonate to a tertiary care hospital, thereby reducing neonatal mortality.Methods: A hospital based observational cross-sectional study included 350 live new-borns within 48 hours of birth, from September 2018 to February 2019. Gestational age assessed by new ballard score, birth weight, foot length and right nipple to umbilicus distance were noted. Babies categorised as per the gestational age profile as small, appropriate and large for gestational age using fenton charts. Data analysis done, correlation coefficient, and p value calculated to obtain results.Results: Out of 350 babies, males (185) outnumbered females (165); 154 were LBW, 89 VLBW and 76 were ELBW. AGA neonates were 193, and 157 belonged to SGA. There were no post-term and large for gestational age newborns. Both foot length and right nipple to umbilicus distance correlated well with gestational age in all age groups (p<0.001).Conclusions: Foot length as well as right nipple to umbilicus distance can be used as a reliable tool for assessment of gestational age and birth weight of newborns by any health care professional to identify and refer high risk neonate.

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Perinatal variables influencing cord blood thyroid stimulating hormone

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20182560 ◽

2018 ◽

Vol 5 (4) ◽

pp. 1537 ◽

Cited By ~ 1

Author(s):

Manasi D. Garg ◽

Poornima Kumar ◽

Sakthi Abirami ◽

Manikandan M. ◽

Lalitha Krishnan

Keyword(s):

Newborn Screening ◽

Cord Blood ◽

Congenital Hypothyroidism ◽

Gestational Age ◽

Maternal Age ◽

Tertiary Care ◽

Mode Of Delivery ◽

Thyroid Stimulating Hormone ◽

Care Hospital ◽

Stimulating Hormone

Background: Newborn screening using cord blood Thyroid Stimulating Hormone (TSH) is an effective and an easy way to screen babies for congenital hypothyroidism. Congenital hypothyroidism is a common preventable and treatable cause of mental retardation. Early diagnosis with the help of newborn screening aids in timely management and decreased morbidity. Various maternal and neonatal variables can affect cord blood TSH level thereby affecting the accurate diagnosis of congenital hypothyroidism. This study aims at studying the perinatal variables affecting cord blood TSH.Methods: In a retrospective cross-sectional study conducted in a tertiary care hospital, the hospital case records of 1465 newborn and their mother were studied for variables including cord blood TSH, maternal age, mode of delivery, parity, gender of baby, gestational age and growth of baby. The effect of these perinatal variables on cord blood TSH was analysed statistically. P value below 0.05 was considered as statistically significant. The statistical analysis was done used the SPSS software version 18.0.Results: The median cord blood TSH was 8 microIU/ml (IQR= 6-12) with 8.1% newborns having values more than 20 microIU/ml. Cord blood TSH was significantly raised in male babies (p <0.01) and in neonates born by assisted vaginal delivery (p <0.01). Significant increase in cord blood TSH (p <0.02) was observed in neonates born to primiparous mothers. Maternal age, gestational age of the newborn and growth of the newborn did not have significant effect on cord blood TSH values.Conclusions: The mode of delivery, parity and gender of the baby were found to be significant variables affecting cord blood TSH values. Hence, cord blood TSH values should be interpreted in the light of these perinatal variables.

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A clinicohematological profile of splenomegaly

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20191704 ◽

2019 ◽

Vol 7 (5) ◽

pp. 1934

Author(s):

Ashwini Tangde ◽

Bharat Sonwane ◽

Rajan Bindu

Keyword(s):

Hematological Parameters ◽

Tertiary Care ◽

Care Hospital ◽

Cross Sectional ◽

Additional Tool ◽

Medical College ◽

Hematological Profile ◽

Diagnostic Clue ◽

Clinical Conditions ◽

Age Range

Background: Splenomegaly is a matter of considerable clinical concern as spleen is not normally palpable. Splenomegaly is associated with large number of disorders including hematological, infectious, congestive states related to portal hypertension, lymphohematogenous disorders, immunological conditions, storage disorders and miscellaneous conditions. So, all the cases of splenomegaly should be thoroughly investigated to ascertain etiology. Splenomegaly can be an important diagnostic clue to existence of an underlying pathology. The aim and objective of present study was to find out relative frequency of clinical conditions associated with splenomegaly, to study clinic-hematological profile of splenomegaly and to find out the role of hematological investigations as a diagnostic tool in elucidating etiopathogenesis of splenomegaly.Methods: This was a cross sectional, observational study. Study was conducted on 135 pediatric as well as adult patients with splenomegaly admitted in medical ward, Government Medical College and tertiary care hospital Aurangabad, Maharashtra, India from December 2015 to October 2017. Hematological parameters of 135 cases of splenomegaly were analysed and correlated with clinical findings.Results: Study comprises 135 patients. Age range was 3 months to 78 years. Males (54.81%) were affected more commonly than females (45.19%). The most common presenting complaint was fever (59.26%) followed by generalized weakness (51.11%) and pallor (44.44%). Majority of cases (48.15%) had grade II splenomegaly. Splenomegaly was associated with hepatomegaly (60.74%) and lymphadenopathy (18.52%). The commonest cause of splenomegaly found was anemia (39.26%) followed by hematological malignancies (20.74%), congestive states (11.85%) and infections (11.85%). Hematological investigations revealed diagnosis in majority of cases (71%).Conclusions: Splenomegaly is an important clinical sign that must be investigated thoroughly as most of the common causes are treatable. Hematological causes outnumbered the non-hematological causes of splenomegaly. Hematological profile in cases of enlarged spleen are of utmost importance as a diagnostic or additional tool in elucidating the etiogenesis of splenomegaly.

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Thyroid hormone profile in apparently healthy pregnant women attending in a tertiary care hospital of Bangladesh

Bangabandhu Sheikh Mujib Medical University Journal ◽

10.3329/bsmmuj.v8i2.28928 ◽

2016 ◽

Vol 8 (2) ◽

pp. 91

Author(s):

Murshed Ahamed Khan ◽

M.A. Hasanat ◽

Md. Jahangir Alam ◽

Md. Anwar Hossain ◽

Ahmed Abu Saleh ◽

...

Keyword(s):

Thyroid Hormone ◽

Pregnant Women ◽

Thyroid Function ◽

Gestational Age ◽

Tertiary Care ◽

American Thyroid Association ◽

Reference Ranges ◽

Care Hospital ◽

Cross Sectional ◽

Hormone Profile

Background: Thyroid dysfunction is not uncommon in pregnancy. It should be evaluated for better outcome of pregnancy.Objective: To observe the thyroid hormone profile in apparently euthyroid pregnant women of any trimester. Methods: This cross-sectional study investigated 350 pregnant women irrespective of gestational age [(age 24±4, m±SDyr; 1st trimester = 101, 2nd trimester=111, 3rd trimester=138) for thyroid stimulating hormone (TSH) and for free thyroxine (FT4)] to assess their thyroid function during pregnancy following the criteria of American Thyroid Association (ATA).Results: Most of the mothers were housewifes (93.1 %, 326/350) of whom 46.6% were primigravida. About 63% mother had associated goiter, 58% (204/350) were euthyroid and 41 % (142/350) were subclinical hypothyroid (SCH). Frequency of goiter (63% vs. 62%, euthyroid vs. dysfunction) was not significantly different between dysfunction and normal groups. FT4 significantly correlated with gestational age (r= - 0.131, p=0.014) and TSH level (r= - 0.612, p< 0.001).Conclusion: It is concluded that many of the apparently euthyroid pregnant mother have dysfunction as defined by ATA reference ranges for TSH and FT4. Simple screening for thyroid function may have greater implication for better pregnancy outcome.

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Etiology and frequency of respiratory distress in neonates: A cross sectional study conducted in tertiary care hospital, Lahore.

The Professional Medical Journal ◽

10.29309/tpmj/2019.26.11.245 ◽

2019 ◽

Vol 26 (11) ◽

pp. 1815-1819

Author(s):

Mirza Liaqat Ali ◽

Naila Jabbar ◽

Abdul Hannan ◽

Azher

Keyword(s):

Respiratory Distress ◽

Gestational Age ◽

Tertiary Care ◽

Birth Asphyxia ◽

Cross Sectional Study ◽

Meconium Aspiration Syndrome ◽

Care Hospital ◽

Cross Sectional ◽

Meconium Aspiration ◽

New Born

Respiratory distress in neonate defines as when rate of respiration is greater than sixty in one minute, nasal flaring, grunting and intercostal / sub coastal recession is present. Various causes are reported of respiratory distress in new born. Objectives: To determine frequency of respiratory distress in new born and to Find frequency of various etiologies of respiratory distress in full term newborn admitted up to the age of 24 hours of birth in Study Design: Cross sectional studies. Setting: Neonatal unit of Jinnah Hospital Lahore. Period: From February 10, 2016 till August 10, 2016. Material and Method: SPSS v-20 was used for analysis of data like name, age, sex, gestational age, maternal record of pregnancy and fetus for etiologies of respiratory distress. Results: There were 100(66.7%) male and 50(33.3%) females in this study. The mean gestational age of these newborn was 39.51±1.51 weeks. Respiratory distress was seen in 16(10.7%) of the cases. Transient tachypnea seen in 4(25%) of the cases, Meconium aspiration syndrome was diagnosed in 2(12.5%), Pneumothorax in 3(18.8%), Congenital pneumonia in 2 (12.5%), Sepsis in 6(37.5%) and Birth asphyxia 2 (12.5%) of early neonatal age were the common observed causes. Conclusion: Respiratory distress was 1/10 of the cases. The commonest etiologies were Sepsis preceding to Respiratory distress syndrome, MAS (Meconium Aspiration Syndrome), TTN (Transient Tacyhpnea of Newborn), Pneumothorax, Congenital pneumonia, Birth asphyxia.

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