scholarly journals Prevention of Recurrent Acute Uncomplicated Cystitis by Increasing Daily Water in Premenopausal Women: A Prospective, Randomized, Controlled Study

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S736-S736 ◽  
Author(s):  
Thomas M Hooton ◽  
Mariacristina Vecchio ◽  
Alison Iroz ◽  
Ivan Tack ◽  
Quentin Dornic ◽  
...  
Keyword(s):  
Water Intake ◽  
Fluid Intake ◽  
Urine Volume ◽  
Control Group ◽  
Total Fluid Intake ◽  
Water Group ◽  
Daily Water Intake ◽  
Daily Water ◽  
The Mean ◽  
Total Fluid

Abstract Background Increased hydration is commonly recommended as a preventive measure for women with recurrent acute uncomplicated cystitis (rAUC), but supportive data are sparse. The aim of this study was to assess the efficacy of increased daily water intake on the frequency of rAUC in premenopausal women. Methods 140 healthy premenopausal asymptomatic women drinking less than 1.5 L of total fluid daily (24 hours) and suffering from rAUC (33 episodes in the past year) were randomized to receive, in addition to their usual daily fluid intake, either 1.5 L water daily (water group) or no additional fluids (control group), for 12 months. Assessments of daily water and total fluid intake, urine volume and osmolality, number of urine voids, and occurrence of AUC symptoms and a reminder to notify investigators of any such symptoms were performed at baseline, 6- and 12-month clinic visits in addition to monthly telephone calls. The primary outcome was frequency of rAUC episodes (31 AUC symptom and 3103 CFU/mL of a uropathogen in voided urine) over 12 months. Results Between baseline and 12 month’s follow-up, the water group, compared with the control group, had statistically significant increases in mean daily water intake (1.15 vs. −0.01 L), total fluid intake (1.65 vs. 0.03 L), urine volume (1.40 vs. 0.04 L), and number of urine voids (2.2 vs. −0.2), and a decrease in urine osmolality (−408 vs. −35 mOsm/Kg). The mean number of rAUC episodes in the water group was significantly less than in the control group (1.6 vs. 3.1; odds ratio 0.52, 95% CI 0.46–0.60, 
P < 0.0001) (figure shows cumulative sum of AUC episodes over 12 months in both study groups). The mean number of antimicrobial regimens used to treat AUC events was 1.8 in the water group vs. 3.5 in the control group (P < 0.0001). In addition, the mean number of days to first rAUC and the mean number of days between rAUC episodes was longer in the water group compared with the control group (148 vs. 93,
 P = 0.0005 and 143 vs. 85, P < 0.0001, respectively). Conclusions Our results provide strong evidence that increased water intake is an effective antimicrobial-sparing preventive strategy for women with rAUC. Increasing daily water intake by approximately 1.5 L reduced rAUC episodes by 48% and antimicrobial regimens by 47% over 12 months. Disclosures M. Vecchio, Danone Research: Employee, Salary. A. Iroz, Dzanone Research: Employee, Salary. I. Tack, Danone Research: Consultant, Consulting fee and Speaker honorarium. Q. Dornic, Danone research: Employee, Salary. I. Seksek, Danone Research: Employee, Salary.

scholarly journals Effect of dietary water intake on urinary output, specific gravity and relative supersaturation for calcium oxalate and struvite in the cat

2011 ◽  
Vol 106 (S1) ◽  
pp. S128-S130 ◽  
Author(s):  
Catherine M. F. Buckley ◽  
Amanda Hawthorne ◽  
Alison Colyer ◽  
Abigail E. Stevenson
Keyword(s):  
Specific Gravity ◽  
Calcium Oxalate ◽  
Water Intake ◽  
Fluid Intake ◽  
Human Subjects ◽  
Urine Volume ◽  
Total Fluid Intake ◽  
Significant Difference ◽  
Dry Food ◽  
Total Fluid

It has been reported that daily fluid intake influences urinary dilution, and consequently the risk of urolithiasis in human subjects and dogs. The aim of the present study was to investigate the role of dietary moisture on urinary parameters in healthy adult cats by comparing nutritionally standardised diets, varying only in moisture content. A total of six cats were fed a complete dry food (6·3 % moisture) hydrated to 25·4, 53·2 and 73·3 % moisture for 3 weeks in a randomised block cross-over design. Urinary specific gravity (SG), urine volume, water drunk and total fluid intake were measured daily; relative supersaturation (RSS) for calcium oxalate (CaOx) and struvite was calculated using the SUPERSAT computer program. Cats fed the 73·3 % moisture diet produced urine with a significantly lower SG (P < 0·001) compared with diets containing 53·2 % moisture or lower. Mean RSS for CaOx was approaching the undersaturated zone (1·14 (sem 0·21); P = 0·001) for cats fed the diet with 73·3 % moisture and significantly lower than the 6·3 % moisture diet (CaOx RSS 2·29 (sem 0·21)). The effect of diet on struvite RSS was less clear, with no significant difference between treatment groups. Total fluid intake was significantly increased (P < 0·001) in the 73·3 % moisture diet (144·7 (sem 5·2) ml, or 30 ml/kg body weight per d) compared with the 6·3 % (103·4 (sem 5·3) ml), 25·4 % (98·6 (sem 5·3) ml) and 53·3 % (104·7 (sem 5·3) ml) moisture diets, despite voluntary water intake decreasing as dietary moisture intake increased. Cats fed the 73·3 % moisture diet had a higher total daily fluid intake resulting in a more dilute urine with a lower risk of CaOx when compared with the lower-moisture diets.

scholarly journals Drinking Water Upon Awakening, a Habit Related To a Higher Total Fluid Intake and Water Intake

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Isabelle Guelinckx ◽  
Rizki Pohan ◽  
Romain Monrozier ◽  
Saptawati Bardosono
Keyword(s):  
Drinking Water ◽  
Water Intake ◽  
Fluid Intake ◽  
Total Fluid Intake ◽  
Total Fluid

scholarly journals Association Between Daily Water Intake and 24-hour Urine Volume Among Adolescents With Kidney Stones

Urology ◽  
2020 ◽  
Vol 140 ◽  
pp. 150-154 ◽  
Author(s):  
Joshua Bernard ◽  
Lihai Song ◽  
Brittney Henderson ◽  
Gregory E. Tasian
Keyword(s):  
Water Intake ◽  
Kidney Stones ◽  
Urine Volume ◽  
Daily Water Intake ◽  
Daily Water

scholarly journals Harmonized Cross-Sectional Surveys Focused on Fluid Intake in Children, Adolescents and Adults: The Liq.In7 Initiative

2016 ◽  
Vol 68 (Suppl. 2) ◽  
pp. 12-18 ◽  
Author(s):  
Homero Martinez ◽  
Isabelle Guelinckx ◽  
Jordi Salas-Salvadó ◽  
Joan Gandy ◽  
Stavros A. Kavouras ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Water Intake ◽  
Fluid Intake ◽  
Major Contributor ◽  
Adequate Intake ◽  
Total Fluid Intake ◽  
Cross Sectional ◽  
Increase Water Intake ◽  
Adolescents And Adults ◽  
Total Fluid

Objective: To assess the intake of water and all other beverages in children, adolescents and adults. Methods: Three thousand six hundred eleven children (8 ± 2 years), 8,109 adolescents (13 ± 2 years) and 16,276 adults (40 ± 14 years) (47% men) were recruited in 15 cross-sectional surveys (liquid intake across 7 days, Liq.In7 study) and completed a 7-day fluid-specific record to assess total fluid intake (TFI), where TFI was defined as the sum of drinking water and other type of beverages. Results: The median TFI was 1.2, 1.2 and 1.8 liters/day in children, adolescents and adults respectively, with important differences observed between countries. Only 39% of children, 25% of adolescents and 51% of adults met the European Food Safety Authority adequate intake (AI) recommendations of water from fluids. In the surveys of Spain, France, Belgium, Germany, Turkey, Iran, Indonesia and China, water was the major contributor (47-78%) to TFI. In the adult surveys of UK, Poland, Japan and Argentina, hot beverages were the highest contributor to TFI. The fluid intake of children and adolescents in Mexico, Brazil, Argentina and Uruguay was characterized by a contribution of juices and sweet beverages that was as important as the contribution of water to TFI. Conclusion: Given that a relatively high proportion of subjects, especially children and adolescents, failed to meet the recommended AI of water from fluids and that water intake was not the highest contributor to TFI in all countries, undertaking actions to increase water intake are warranted.

scholarly journals MP12-01 RELATIONSHIP BETWEEN DAILY WATER INTAKE AND 24-HOUR URINE VOLUME IN ADOLESCENTS WITH KIDNEY STONES

2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
Joshua Bernard* ◽  
Lihai Song ◽  
Brittney Henderson ◽  
Steven Warner ◽  
Gregory Tasian
Keyword(s):  
Water Intake ◽  
Kidney Stones ◽  
Urine Volume ◽  
Daily Water Intake ◽  
Daily Water

scholarly journals Increasing Water Intake in Chronic Kidney Disease: Why? Safe? Possible?

2015 ◽  
Vol 66 (Suppl. 3) ◽  
pp. 18-21 ◽  
Author(s):  
William F. Clark ◽  
Jessica M. Sontrop ◽  
Louise Moist ◽  
S.-H. Huang
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Adverse Effects ◽  
Water Intake ◽  
Serum Sodium ◽  
Fluid Intake ◽  
Controlled Trial ◽  
Urine Volume ◽  
Control Group

Increased water intake may slow the progression of chronic kidney disease by lowering vasopressin levels. Prior to initiating a large randomized controlled trial on the effect of increased water intake on renal decline, we conducted a six-week pilot study to examine the safety and feasibility of asking adults with chronic kidney disease to increase their water intake. We randomly assigned 29 patients to either a hydration or a control group. The hydration group was asked to increase water intake by 1 to 1.5 l/day relative to their weight, gender, and 24 h urine osmolality, in addition to usual consumed beverages; the control group was asked to continue with usual fluid intake. After six weeks, the change in urine volume was significantly different between groups (0.9 l/day; p = 0.002) with no change in serum sodium and no serious adverse effects. Similarly, preliminary results of our large clinical trial of the same intervention (489 patients enrolled to date) demonstrated a significant separation between groups on 24 h urine volume (at 12 months the mean difference between groups was 1.2 l/day; p < 0.001) with no serious adverse effects. Serum sodium has remained stable in both groups over follow-up. To our knowledge, this trial is currently the largest of its kind to date; the significant separation between groups with respect to urine volume indicates that we will have scientifically reliable data on the effect of increased fluid intake on renal decline. The analysis of primary and secondary outcomes will be conducted at the conclusion of follow-up in July 2016.

scholarly journals Fluid Intake and Vasopressin: Connecting the Dots

2016 ◽  
Vol 68 (Suppl. 2) ◽  
pp. 6-11 ◽  
Author(s):  
Isabelle Guelinckx ◽  
Mariacristina Vecchio ◽  
Erica T. Perrier ◽  
Guillaume Lemetais
Keyword(s):  
Water Intake ◽  
Fluid Intake ◽  
Urine Volume ◽  
Surrogate Marker ◽  
Physiological Model ◽  
Total Fluid Intake ◽  
Cross Sectional ◽  
Urine Biomarkers ◽  
Increased Risk ◽  
Connecting The Dots

In the last decade, cross-sectional and multiple cohort studies have associated total fluid intake or water intake with the risk for chronic kidney disease (CKD) and even the risk of developing hyperglycemia. Urine biomarkers have also been linked to the risk of CKD and lithiasis, and these biomarkers respond quickly to variations in fluid intake. High circulating copeptin levels, a surrogate marker of arginine vasopressin, have been associated with metabolic syndrome, renal dysfunction and increased risk for diabetes mellitus, cardiovascular disease and death. The aim of this paper was to explore how the various findings on water intake, hydration and health are interconnected, to highlight current gaps in our understanding and to propose a model that links water intake, homeostatic mechanisms to maintain water balance and health outcomes. Since plasma copeptin and vasopressin have been demonstrated to be sensitive to changes in water intake, inversely associated with 24-hour urine volume, and associated with urine biomarkers and fluid intake, vasopressin is proposed as the central player in this theoretical physiological model.

scholarly journals Evaluation of Fluid Intake in College Students During the Initial Response to the COVID-19 Pandemic

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 222-222
Author(s):  
Shaylynn Glenn ◽  
Cory Butts ◽  
Samantha Scarneo-Miller ◽  
William Adams
Keyword(s):  
College Students ◽  
Water Intake ◽  
Fluid Intake ◽  
Initial Response ◽  
The United States ◽  
Plain Water ◽  
Total Fluid Intake ◽  
Living Situation ◽  
Academic Standing ◽  
Total Fluid

Abstract Objectives To evaluate fluid intake of college students during the initial response to the COVID-19 pandemic. Methods College students (n = 1015 (75.5% Female); 59 freshmen, 139 sophomores, 264 juniors, 245 seniors, 289 graduate) participated in an online questionnaire from colleges/universities within the United States during the Spring 2020 academic semester. Participants were asked about their fluid intake over the previous 30 days using the BEVQ-15. The questionnaire consisted of demographic and living status questions as well as 16 questions detailing type (e.g., water, milk, etc.), frequency (“how often”), and volume of fluids for each consumption (“how much each time”). Kruskal-Wallis analyses (test statistic reported as chi-square, χ2) were used to compare the total fluid intake, frequency of plain water intake, and volume with each consumption between those with and without a change in living situation and by academic standing. Data reported as (median [interquartile range]). Results A change in living status was reported by 426/1015 (42%) participants. Median fluid intake was 1848 mL ([1295, 2532] mL) for all participants. Total fluid intake [χ2(1) = 18.07, P &lt; 0.001] was different between those with (1709 [1199, 2366] mL) and without (1940 [1378, 2644] mL) a change in living situation. However, the volume of plain water intake was not different between those with (710 [473, 1420] mL) and without (1065 [591, 1420] mL) a change in living situation [χ2(1) = 2.81, P = 0.09]. Frequency [χ2(1) = 3.10, P = 0.08] and the volume with each consumption [χ2(1) = 1.16, P = 0.28] of plain water were also not different based on a change in living situation. Academic standing impacted the volume of total fluid intake [χ2(4) = 14.33, P = 0.006], with juniors (1751 [1161, 2455] mL) reporting less than graduate students (1940 [1041, 2780] mL, P = 0.01). Conclusions These data suggest a change in living situation affected total fluid intake, however, there were no differences in the frequency and volume of plain water intake. Further, academic standing impacted the fluid intake behaviors. Future investigations are warranted to evaluate factors guiding fluid intake frequency and volumes in the college student population. Funding Sources N/A

scholarly journals Differing Water Intake and Hydration Status in Three European Countries—A Day-to-Day Analysis

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 773 ◽  
Author(s):  
Hans Braun ◽  
Judith von Andrian-Werburg ◽  
Olga Malisova ◽  
Adelais Athanasatou ◽  
Maria Kapsokefalou ◽  
...  
Keyword(s):  
Water Intake ◽  
Urine Volume ◽  
Urine Osmolality ◽  
Hydration Status ◽  
Body Studies ◽  
Daily Water Intake ◽  
Adequate Hydration ◽  
Daily Water ◽  
The Individual ◽  
Number Of Individuals

Adequate hydration is essential for maintaining health and functionality of the human body. Studies assessing both daily water intake and hydration status are lacking. This study explored data from the European Hydration Research Study (EHRS) and focused on total water intake (TWI), 24 h hydration status, and day-to-day variations in a sample of 573 healthy adults. TWI was assessed by food records and hydration status (urine osmolality and urine volume) was measured from 24 urine samples collected over seven consecutive days. On all weekdays, mean TWI was higher (p < 0.001 for all days) for the German subjects compared to the Greek and Spanish participants. In 37% of the male and 22% of the female subjects, the individual mean TWI was below the European Food Safety Authority (EFSA) recommendation, with 16% men (4% women) being below the EFSA recommendation on every testing day. Twenty-four hour urine osmolality was lower in women compared to men (595 ± 261 vs. 681 ± 237 mOsmol/kg; p < 0.001). More men (40%) showed a urine osmolality ≥800 mOsmol/kg at least on four days of the study period compared to women (26%) and more participants from Spain (46%) compared to Greece (29%) and Germany (11%). A large number of individuals showed an inadequate hydration status on several days per week, which may have a negative health and cognitive impact on daily life.

scholarly journals No effect of increased water intake on blood viscosity and cardiovascular risk factors

2006 ◽  
Vol 96 (6) ◽  
pp. 993-996 ◽  
Author(s):  
Serena Tonstad ◽  
Tor Ole Klemsdal ◽  
Sverre Landaas ◽  
Aud Høieggen
Keyword(s):  
Risk Factors ◽  
Water Intake ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Fluid Intake ◽  
Intervention Group ◽  
Urine Volume ◽  
Control Group ◽  
Whole Blood Viscosity ◽  
Blueberry Juice

Observational data have suggested that increased water intake decreases the risk of CHD. A postulated mechanism is that increased water ingestion reduces blood viscosity. The aim of the present study was to assess the effect of increased fluid intake on blood viscosity. Men (n 67) and postmenopausal women (n 27) with one or more risk factors for CVD who reported intake of ≤ 0·5 litres water daily were randomised to a control group (n 31), an intervention group (n 32) that increased their daily water intake by 1 litre/d and an intervention group (n 31) that ingested 1 litre blueberry juice/d. All were encouraged to continue their usual diet and lifestyle. Whole-blood viscosity and blood and urine chemistries were measured by standard techniques after 2 and 4 weeks. Urine volume increased (by a median of 872 and 725 ml in the water and blueberry juice groups, respectively, v. 10 ml in the control group; P ≤ 0·002), confirming the subjects' adherence to the protocol. Urine osmolality and urinary levels of Na, K and creatinine decreased in the water and blueberry juice groups v. the controls (P < 0·05). No change was seen in whole-blood viscosity or in levels of fibrinogen, total protein, lipids, glucose, insulin, C-peptide or other chemistry and haematology variables. In conclusion, a postulated protective effect of increased water or fluid intake is not explained by a change in blood viscosity and increased fluid intake does not influence CVD risk factors in the short term.

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