scholarly journals Fluid Intake and Vasopressin: Connecting the Dots

2016 ◽  
Vol 68 (Suppl. 2) ◽  
pp. 6-11 ◽  
Author(s):  
Isabelle Guelinckx ◽  
Mariacristina Vecchio ◽  
Erica T. Perrier ◽  
Guillaume Lemetais

In the last decade, cross-sectional and multiple cohort studies have associated total fluid intake or water intake with the risk for chronic kidney disease (CKD) and even the risk of developing hyperglycemia. Urine biomarkers have also been linked to the risk of CKD and lithiasis, and these biomarkers respond quickly to variations in fluid intake. High circulating copeptin levels, a surrogate marker of arginine vasopressin, have been associated with metabolic syndrome, renal dysfunction and increased risk for diabetes mellitus, cardiovascular disease and death. The aim of this paper was to explore how the various findings on water intake, hydration and health are interconnected, to highlight current gaps in our understanding and to propose a model that links water intake, homeostatic mechanisms to maintain water balance and health outcomes. Since plasma copeptin and vasopressin have been demonstrated to be sensitive to changes in water intake, inversely associated with 24-hour urine volume, and associated with urine biomarkers and fluid intake, vasopressin is proposed as the central player in this theoretical physiological model.

2016 ◽  
Vol 68 (Suppl. 2) ◽  
pp. 12-18 ◽  
Author(s):  
Homero Martinez ◽  
Isabelle Guelinckx ◽  
Jordi Salas-Salvadó ◽  
Joan Gandy ◽  
Stavros A. Kavouras ◽  
...  

Objective: To assess the intake of water and all other beverages in children, adolescents and adults. Methods: Three thousand six hundred eleven children (8 ± 2 years), 8,109 adolescents (13 ± 2 years) and 16,276 adults (40 ± 14 years) (47% men) were recruited in 15 cross-sectional surveys (liquid intake across 7 days, Liq.In7 study) and completed a 7-day fluid-specific record to assess total fluid intake (TFI), where TFI was defined as the sum of drinking water and other type of beverages. Results: The median TFI was 1.2, 1.2 and 1.8 liters/day in children, adolescents and adults respectively, with important differences observed between countries. Only 39% of children, 25% of adolescents and 51% of adults met the European Food Safety Authority adequate intake (AI) recommendations of water from fluids. In the surveys of Spain, France, Belgium, Germany, Turkey, Iran, Indonesia and China, water was the major contributor (47-78%) to TFI. In the adult surveys of UK, Poland, Japan and Argentina, hot beverages were the highest contributor to TFI. The fluid intake of children and adolescents in Mexico, Brazil, Argentina and Uruguay was characterized by a contribution of juices and sweet beverages that was as important as the contribution of water to TFI. Conclusion: Given that a relatively high proportion of subjects, especially children and adolescents, failed to meet the recommended AI of water from fluids and that water intake was not the highest contributor to TFI in all countries, undertaking actions to increase water intake are warranted.


2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S736-S736 ◽  
Author(s):  
Thomas M Hooton ◽  
Mariacristina Vecchio ◽  
Alison Iroz ◽  
Ivan Tack ◽  
Quentin Dornic ◽  
...  

Abstract Background Increased hydration is commonly recommended as a preventive measure for women with recurrent acute uncomplicated cystitis (rAUC), but supportive data are sparse. The aim of this study was to assess the efficacy of increased daily water intake on the frequency of rAUC in premenopausal women. Methods 140 healthy premenopausal asymptomatic women drinking less than 1.5 L of total fluid daily (24 hours) and suffering from rAUC (33 episodes in the past year) were randomized to receive, in addition to their usual daily fluid intake, either 1.5 L water daily (water group) or no additional fluids (control group), for 12 months. Assessments of daily water and total fluid intake, urine volume and osmolality, number of urine voids, and occurrence of AUC symptoms and a reminder to notify investigators of any such symptoms were performed at baseline, 6- and 12-month clinic visits in addition to monthly telephone calls. The primary outcome was frequency of rAUC episodes (31 AUC symptom and 3103 CFU/mL of a uropathogen in voided urine) over 12 months. Results Between baseline and 12 month’s follow-up, the water group, compared with the control group, had statistically significant increases in mean daily water intake (1.15 vs. −0.01 L), total fluid intake (1.65 vs. 0.03 L), urine volume (1.40 vs. 0.04 L), and number of urine voids (2.2 vs. −0.2), and a decrease in urine osmolality (−408 vs. −35 mOsm/Kg). The mean number of rAUC episodes in the water group was significantly less than in the control group (1.6 vs. 3.1; odds ratio 0.52, 95% CI 0.46–0.60, 
P < 0.0001) (figure shows cumulative sum of AUC episodes over 12 months in both study groups). The mean number of antimicrobial regimens used to treat AUC events was 1.8 in the water group vs. 3.5 in the control group (P < 0.0001). In addition, the mean number of days to first rAUC and the mean number of days between rAUC episodes was longer in the water group compared with the control group (148 vs. 93,
 P = 0.0005 and 143 vs. 85, P < 0.0001, respectively). Conclusions Our results provide strong evidence that increased water intake is an effective antimicrobial-sparing preventive strategy for women with rAUC. Increasing daily water intake by approximately 1.5 L reduced rAUC episodes by 48% and antimicrobial regimens by 47% over 12 months. Disclosures M. Vecchio, Danone Research: Employee, Salary. A. Iroz, Dzanone Research: Employee, Salary. I. Tack, Danone Research: Consultant, Consulting fee and Speaker honorarium. Q. Dornic, Danone research: Employee, Salary. I. Seksek, Danone Research: Employee, Salary.


2011 ◽  
Vol 106 (S1) ◽  
pp. S128-S130 ◽  
Author(s):  
Catherine M. F. Buckley ◽  
Amanda Hawthorne ◽  
Alison Colyer ◽  
Abigail E. Stevenson

It has been reported that daily fluid intake influences urinary dilution, and consequently the risk of urolithiasis in human subjects and dogs. The aim of the present study was to investigate the role of dietary moisture on urinary parameters in healthy adult cats by comparing nutritionally standardised diets, varying only in moisture content. A total of six cats were fed a complete dry food (6·3 % moisture) hydrated to 25·4, 53·2 and 73·3 % moisture for 3 weeks in a randomised block cross-over design. Urinary specific gravity (SG), urine volume, water drunk and total fluid intake were measured daily; relative supersaturation (RSS) for calcium oxalate (CaOx) and struvite was calculated using the SUPERSAT computer program. Cats fed the 73·3 % moisture diet produced urine with a significantly lower SG (P < 0·001) compared with diets containing 53·2 % moisture or lower. Mean RSS for CaOx was approaching the undersaturated zone (1·14 (sem 0·21); P = 0·001) for cats fed the diet with 73·3 % moisture and significantly lower than the 6·3 % moisture diet (CaOx RSS 2·29 (sem 0·21)). The effect of diet on struvite RSS was less clear, with no significant difference between treatment groups. Total fluid intake was significantly increased (P < 0·001) in the 73·3 % moisture diet (144·7 (sem 5·2) ml, or 30 ml/kg body weight per d) compared with the 6·3 % (103·4 (sem 5·3) ml), 25·4 % (98·6 (sem 5·3) ml) and 53·3 % (104·7 (sem 5·3) ml) moisture diets, despite voluntary water intake decreasing as dietary moisture intake increased. Cats fed the 73·3 % moisture diet had a higher total daily fluid intake resulting in a more dilute urine with a lower risk of CaOx when compared with the lower-moisture diets.


2017 ◽  
Vol 70 (Suppl. 1) ◽  
pp. 13-17 ◽  
Author(s):  
Saptawati Bardosono ◽  
Clémentine Morin ◽  
Isabelle Guelinckx ◽  
Rizki Pohan

The primary aim of this cross-sectional survey was to assess the total fluid intake (TFI; sum of drinking water and all other fluids) and the intake of water and all other types of beverages in a sample of pregnant and breastfeeding women representative of Java-Island, Indonesia. Therefore, 299 pregnant and 296 breastfeeding women completed a 7-day fluid-specific record. A secondary aim was to estimate the total water intake (TWI; sum of water from fluids and food moisture), and one 24-h recall was performed to determine water intake from food moisture. The median TFI of pregnant and breastfeeding women were 2,250 (1,800-2,800) and 2,360 (1,954-2,968) mL/day, respectively. The largest contributor to TFI was water (72 and 77% for pregnant/breastfeeding women, respectively). Pregnant women to the extent of 42% and 54% of breastfeeding women did not reach the adequate intake (AI) of water from fluids. In pregnant and breastfeeding women, the median water intake from foods was 592 and 613 mL/day, representing 21 and 20% of TWI. Concluding that a high proportion of the pregnant and breastfeeding subjects did not reach the AI of water from fluid, it seems important to put in place actions such as providing education materials and ensuring access to safe water. Moreover, future surveys should dedicate attention to the assessment of fluid intake and hydration status among pregnant and breastfeeding women in other countries.


2021 ◽  
Vol 10 ◽  
Author(s):  
Espen Heen ◽  
Amal A. Yassin ◽  
Ahmed A. Madar ◽  
Maria Romøren

Abstract The study objective was to measure fluid intake and associations with background characteristics and hydration biomarkers in healthy, free-living, non-pregnant women aged 15–69 years from Hargeisa city. We also wanted to estimate the proportion of euhydrated participants and corresponding biomarker cut-off values. Data from 136 women, collected through diaries and questionnaires, 24h urine samples and anthropometric measurements, were obtained with a cross-sectional, purposeful sampling from fifty-two school and health clusters, representing approximately 2250 women. The mean (95 % CI) 24 h total fluid intake (TFI) for all women was 2⋅04 (1⋅88, 2⋅20) litres. In multivariate regression with weight, age, parity and a chronic health problem, only weight remained a predictor (P 0.034, B 0.0156 (l/kg)). Pure water, Somali tea and juice from powder and syrup represented 49⋅3, 24⋅6 and 11⋅7 % of TFI throughout the year, respectively. Mean (95 % CI) 24 h urine volume (Uvol) was 1⋅28 (1⋅17, 1⋅39) litres. TFI correlated strongly with 24 h urine units (r 0.67) and Uvol (r 0.59). Approximately 40 % of the women showed inadequate hydration, using a threshold of urine specific gravity (Usg) of 1⋅013 and urine colour (Ucol) of 4. Five percent had Usg > 1⋅020 and concomitant Ucol > 6, indicating dehydration. TFI lower cut-offs for euhydrated, non-breast-feeding women were 1⋅77 litres and for breast-feeding, 2⋅13 litres. Euhydration cut-off for Uvol was 0⋅95 litre, equalling 9⋅2 urine units. With the knowledge of adverse health effects of habitual hypohydration, Somaliland women should be encouraged to a higher fluid intake.


2015 ◽  
Vol 54 (S2) ◽  
pp. 57-67 ◽  
Author(s):  
Iris Iglesia ◽  
Isabelle Guelinckx ◽  
Pilar M. De Miguel-Etayo ◽  
Esther M. González-Gil ◽  
Jordi Salas-Salvadó ◽  
...  

2021 ◽  
Vol 10 ◽  
Author(s):  
Osama B. Albasheer ◽  
Abdullah Hakami ◽  
Abdullah A. Al Faqih ◽  
Ibrahim Akkam ◽  
Safwan K. Soraihy ◽  
...  

Abstract Despite the hot climate and high humidity in the Jazan Region of Saudi Arabia, which increases risk for dehydration, no previous studies have assessed awareness of dehydration and fluid intake practice among adults in this region. Therefore, the aim of this cross-sectional study was to determine awareness of the dehydration state and fluid intake practices among 440 adults in the Jazan Region of Saudi Arabia. Out of the total, 51⋅8 % were male and 48⋅2 % were females. Good knowledge of dehydration definition and prevention and recommended minimum water intake was observed in 98, 95 and 75 % of the participants, respectively. Fifty-nine percent of the participants met the minimum daily requirement of 3 l or more per day. The age (95 % CI 1⋅003, 1⋅017, P value = 0⋅006), diabetes (95 % CI 1⋅028, 1⋅459, P value = 0⋅023) and prior hospitalisation due to dehydration (95 % CI 1⋅010, 1⋅378, P value = 0⋅037) were associated with higher water intake. Additional glasses of coffee (95 % CI 1⋅02, 1⋅115, P value = 0⋅004) and juice (95 % CI 1⋅039, 1⋅098, P value < 0⋅001) were associated with more water intake. The participants exhibited good knowledge of dehydration definition, symptoms and consequences. Intake of fluids such as ‘juice and coffee’ enhances more water intake. Although two-thirds of the participants met the recommended daily water intake, still one-third of them did not meet this level. Innovative approaches to enhance healthy drinking are warranted and may include partnering with patients to take an active role in hydration monitoring and increasing communication with the different healthcare providers.


2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Isabelle Guelinckx ◽  
Rizki Pohan ◽  
Romain Monrozier ◽  
Saptawati Bardosono

2021 ◽  
Author(s):  
sara beigrezaei ◽  
Mohsen Mazidi ◽  
Gordon A Ferns ◽  
Majid Ghayour-Mobarhan ◽  
Zumin Shi ◽  
...  

Abstract BackgroundExcessive daytime sleepiness (EDS) is a common sleep abnormality among adolescents, and it’s associated with increased risk of morbidity and mortality. We aimed to explore the relationships between eating behaviors and EDS among female adolscents.MethodsIn this cross-sectional study 988 Iranian adolescent girls aged between 12-18 years old were recruited. Presence of EDS was determined by the Epworth Sleepiness Scale, and eating behaviors was assessed by a pre-validated questionnaire. To investigate the association between dietary behaviors and the prevalence of EDS, we applied logistic regression analysis in crude and adjusted models (adjustments for age, physical activity, menstruation and second hand smoke and general obesity).ResultsThe prevalence of esccesive daytime sleepiness was obtained 24.3. The participants who consumed a major meal three times daily had a 0.56 lower odds for EDS compared to those who consumed a single major meal (OR: 0.46, 95% CI: 0.21- 0.91). Individuals with a ‘high-rate of food chewing’ were less likely to have EDS (OR: 0.55, 95% CI: 0.29 -1.04) compared with low and moderate rate of food chewing. Compared with those who consumed fried or spicy foods daily, individuals who never consumed fried (OR: 1.8, 95% CI: 0.55- 5.86) or spicy foods (OR: 1.71, 95% CI: 0.55- 5.29) had a greater risk for EDS. In addition, there were direct associations between lower meal regularity (OR: 0.53, 95% CI: 0.29- 0.95) and intra-meal fluid intake (OR: 3.00, 95% CI: 1.2- 7.3) with EDS in adjusted models. Neither in the crude nor in the adjusted models, were there significant associations between breakfast intake and frequency of snack consumption with EDS.ConclusionThe lowest frequency of main meal frequency, irregular meal consumption, breakfast skipping, low rate of food chewing, intra-meal fluid intake, and consumption of spicy and fried foods were associated with increased odds of EDS. Further prospective studies are required to confirm this finding.


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