scholarly journals Isolated tuberculosis of the spleen presenting with fever of unknown origin in a vaccinated child

2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
Ameer Kakaje ◽  
Yousef Mahmoud ◽  
Osama Hosam Aldeen ◽  
Othman Hamdan
Keyword(s):  
Rare Case ◽  
Causes Of Death ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Bacillus Calmette Guerin ◽  
Immunocompetent Child ◽  
Mild Anaemia ◽  
History Of ◽  
Unnecessary Procedures ◽  
Immunocompromised Status

Abstract Tuberculosis (TB) is one of the top 10 causes of death worldwide and is more common in developing countries. Isolated splenic TB is typically found in trauma, miliary TB and immunocompromised status. We present a very rare case of an immunocompetent child with an isolated primary TB in the spleen. The child only had fever of unknown origin (FUO), and mild anaemia. The diagnosis was not made until splenectomy was performed. The patient took the quadruple therapy for TB, and follow-ups showed no recurrence. This case is unique because this child was immunocompetent with no history of trauma or active TB. TB diagnosis should never be ignored in FUO as this might prevent unnecessary procedures to the patient. Although the child was vaccinated with Bacillus Calmette–Guérin that usually protects against severe TB in first 5 years of life, it did not prevent from affecting the spleen.

scholarly journals Vulvar Tuberculosis—A Rare Manifestation of the Disease

2019 ◽  
Vol 41 (09) ◽  
pp. 575-578 ◽  
Author(s):  
Cristina Bragança ◽  
Inês Gonçalves ◽  
Luísa Guerreiro ◽  
Maria Janeiro
Keyword(s):  
Rare Case ◽  
Causes Of Death ◽  
World Health ◽  
Histological Findings ◽  
Chain Reaction ◽  
Rare Manifestation ◽  
The World ◽  
History Of ◽  
Polymerase Chain ◽  
Health Organization

AbstractTuberculosis is an infectious disease caused by Mycobacterium tuberculosis. According to data from the World Health Organization, this disease remains one of the leading causes of death worldwide. Although it most commonly affects the lungs, tuberculosis can compromise any organ. The present study reports a rare case of vulvar tuberculosis in a postmenopausal woman with a history of asymptomatic pulmonary and pleural tuberculosis, with no prior documented contact with the bacillus. Diagnosis was based on vulvar lesion biopsies, with histological findings suggestive of infection and isolation of M. tuberculosis by microbiological culture and polymerase chain reaction (PCR) essays. The lesions reverted to normal after tuberculostatic therapy.

scholarly journals Case Report: A rare case of BCGitis in a patient with bladder cancer treated with the BCG vaccine

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1399
Author(s):  
Domingos Sousa ◽  
Sérgio Antunes Silva ◽  
Catarina Jorge ◽  
Ana Isabel Rodrigues ◽  
Rita Martins Fernandes ◽  
...  
Keyword(s):  
Weight Loss ◽  
Bladder Cancer ◽  
Case Report ◽  
Liver Biopsy ◽  
Rare Case ◽  
Empirical Therapy ◽  
Bcg Vaccine ◽  
Bacillus Calmette Guerin ◽  
History Of ◽  
Disseminated Disease

The Bacillus Calmette Guérin (BCG) vaccine was initially produced as a vaccine against tuberculosis. BCG is an attenuated live strain of Mycobacterium bovis and has been widely used as an immunotherapy over the last years in bladder cancer. We describe a case of a 61-year-old Caucasian male with previous bladder cancer, who had been treated for the last 15 months with instillation of BCG, admitted with 3-week evolution history of fever (38ºC), asthenia, anorexia and a weight loss of 6kg. The patient’s condition deteriorated leading to sepsis. A liver biopsy was performed showing granulomatous dispersed through all the parenchyma. Empirical therapy for M. bovis was started with good response. Even though it is rare, BCGitis must be ruled out in any patient submitted to immunotherapy with BCG and prompt therapy started if disseminated disease is present, which improves the outcome.

scholarly journals Rosai Dorfman Disease

2021 ◽  
Author(s):  
Kalpana Giri ◽  
Ashok Baral ◽  
Niva Tiwari ◽  
Krishna Sharma
Keyword(s):  
Rare Case ◽  
Cervical Lymphadenopathy ◽  
Unknown Origin ◽  
Sinus Histiocytosis ◽  
Massive Lymphadenopathy ◽  
Rosai Dorfman Disease ◽  
History Of

Rosai-Dorfman disease (RDD) is referred to as Sinus Histiocytosis Massive Lymphadenopathy (SHML) of unknown origin. We are reporting a rare case of Rosai Dorfman disease, a case of 6 years old male with a history of multiple painless bilateral submandibular and cervical lymphadenopathy.

scholarly journals Fever of Unknown Origin Revealed to Be Acquired Idiopathic Generalized Anhidrosis: a Rare Case Report with Review of the Literature

2018 ◽  
Vol 107 (3) ◽  
pp. 564-570
Author(s):  
Shoko Sakano ◽  
Ryuji Okamoto ◽  
Yasuo Suzuki ◽  
Ayato Yamamoto ◽  
Hitoshi Nakaya ◽  
...  
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Review Of The Literature ◽  
Rare Case Report

Liver Abscess in Normal Children With Fever of Unknown Origin

PEDIATRICS ◽  
1978 ◽  
Vol 61 (1) ◽  
pp. 148-148
Author(s):  
Henry H. Balfour
Keyword(s):  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Blood Cultures ◽  
Abscess Drainage ◽  
Normal Children ◽  
Liver Abscesses ◽  
History Of ◽  
Liver Scan ◽  
And Staphylococcus Aureus ◽  
Normal Immune Function

The article by Kaplan and Feigin (Pediatrics 58:614, October 1976) is a useful reminder that pyogenic liver abscesses do occur in children with normal immune function, and should be included in the differential diagnosis of fever of unknown origin. In both of their patients there was no history of abdominal trauma, blood cultures were sterile, the clinical diagnosis was confirmed by liver scan, and Staphylococcus aureus organisms were isolated from the abscess drainage at surgery.

scholarly journals Mycoplasma Pneumonia: An Unrecognized Cause of Fever of Unknown Origin in an Adult

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Fatima Ali-Ahmed ◽  
Alexandra Halalau
Keyword(s):  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Source Of Infection ◽  
Left Ankle ◽  
Pulmonary Manifestations ◽  
Mycoplasma Pneumonia ◽  
History Of ◽  
Hilar Adenopathy ◽  
Chest X Ray ◽  
Tomography Scan

A 26-year-old female was admitted for fever of unknown origin (FUO), headaches, left ankle edema, and a lower extremity rash consistent with erythema nodosum. She had no respiratory symptoms or family history of autoimmune diseases. A chest X-ray was negative for pneumonia or hilar adenopathy. Extensive autoimmune workup was negative. A chest, abdomen, and pelvis computed tomography scan was unremarkable and laboratory studies revealed no source of infection. On hospital day 5, the patient developed a mild productive cough. Her Mycoplasma pneumonia (MP) IgM was high, confirming the diagnosis of MP induced FUO. She was started on azithromycin 500 mg daily and within 24 hours her fevers and headaches resolved. Her left ankle edema and EN gradually improved over a course of a few weeks. This case report highlights the need for MP testing in the evaluation of fever of unknown origin, even in the absence of pulmonary manifestations.

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