Mainstreaming Human Rights across WHO

2018 ◽  
Author(s):  
Rebekah Thomas ◽  
Veronica Magar
Keyword(s):  
Human Rights ◽  
Gender Equity ◽  
Integrated Approach ◽  
World Health ◽  
Health Programs ◽  
Health Staff ◽  
Wide Range ◽  
Public Health Staff ◽  
Health Organization ◽  
Core Part

This chapter describes the efforts undertaken since 2013 to mainstream gender, equity, and human rights into the programs, policies, and practices of the World Health Organization (WHO). With a largely medical and public health staff, for whom the language of rights remains unfamiliar, and an organization focused on providing technical and normative support, WHO is thought to be ill-equipped to make human rights a core part of its activities. However, there are signs that this is changing. Starting with the adoption of an integrated approach to gender, equity, and human rights in 2012, this chapter explores how these cross-cutting values are being mainstreamed into the Organization, and also how norms and principles of human rights and the core attributes of a right to health are finding resonance across a wide range of health programs.

scholarly journals A PTPmu Biomarker is Associated with Increased Survival in Gliomas

2019 ◽  
Vol 20 (10) ◽  
pp. 2372 ◽  
Author(s):  
Mette L. Johansen ◽  
Jason Vincent ◽  
Haley Gittleman ◽  
Sonya E. L. Craig ◽  
Marta Couce ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Integrated Approach ◽  
Tissue Microarrays ◽  
Adolescent And Young Adult ◽  
World Health ◽  
Lower Grade ◽  
Oligodendroglial Tumors ◽  
Molecular Approaches ◽  
Wide Range ◽  
Health Organization

An integrated approach has been adopted by the World Health Organization (WHO) for diagnosing brain tumors. This approach relies on the molecular characterization of biopsied tissue in conjunction with standard histology. Diffuse gliomas (grade II to grade IV malignant brain tumors) have a wide range in overall survival, from months for the worst cases of glioblastoma (GBM) to years for lower grade astrocytic and oligodendroglial tumors. We previously identified a change in the cell adhesion molecule PTPmu in brain tumors that results in the generation of proteolytic fragments. We developed agents to detect this cell surface-associated biomarker of the tumor microenvironment. In the current study, we evaluated the PTPmu biomarker in tissue microarrays and individual tumor samples of adolescent and young adult (n = 25) and adult (n = 69) glioma populations using a fluorescent histochemical reagent, SBK4-TR, that recognizes the PTPmu biomarker. We correlated staining with clinical data and found that high levels of the PTPmu biomarker correlate with increased survival of glioma patients, including those with GBM. Patients with high PTPmu live for 48 months on average, whereas PTPmu low patients live only 22 months. PTPmu high staining indicates a doubling of patient survival. Use of the agent to detect the PTPmu biomarker would allow differentiation of glioma patients with distinct survival outcomes and would complement current molecular approaches used in glioma prognosis.

As(III) Removal by Dynamic Adsorption onto Amberlite XAD7 Functionalized with Crown Ether and Doped with Fe(III) Ions

2019 ◽  
Vol 70 (7) ◽  
pp. 2330-2334
Author(s):  
Mihaela Ciopec ◽  
Adina Negrea ◽  
Narcis Duteanu ◽  
Corneliu Mircea Davidescu ◽  
Iosif Hulka ◽  
...  
Keyword(s):  
Adsorption Process ◽  
Arsenic Removal ◽  
Arsenic Concentration ◽  
Fixed Bed ◽  
World Health ◽  
Arsenic Content ◽  
Arsenic Adsorption ◽  
Stage Of Development ◽  
Wide Range ◽  
Health Organization

Arsenic content in groundwater�s present a wide range of concentration, ranging from hundreds of micrograms to thousands of micrograms of arsenic per litter, while the maximum permitted arsenic concentration established by World Health Organization (WHO) is 10 mg L-1. According to the WHO all people, regardless of their stage of development and their social economic condition, have the right to have access to adequate drinking water. The most efficient and economic technique used for arsenic removal is represented by adsorption. In order to make this remediation technique more affordable and environmentally friendly is important to new materials with advance adsorbent properties. Novelty of present paper is represented by the usage of a new adsorbent material obtained by physical - chemical modification of Amberlite XAD polymers using crown ethers followed by iron doping, due to well-known affinity of arsenic for iron ions. Present paper aims to test the obtained modified Amberlite polymer for arsenic removal from real groundwater by using adsorption in a fixed bed column, establishing in this way a mechanism for the adsorption process. During experimental work was studied the influence of competing ions from real water into the arsenic adsorption process.

scholarly journals The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

Toxins ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 451
Author(s):  
José María Gutiérrez ◽  
Laura-Oana Albulescu ◽  
Rachel H. Clare ◽  
Nicholas R. Casewell ◽  
Tarek Mohamed Abd Abd El-Aziz ◽  
...  
Keyword(s):  
Snake Venom ◽  
Serine Proteinase ◽  
Global Strategy ◽  
World Health ◽  
Wide Range ◽  
Variable Chemical ◽  
Snake Venom Metalloproteinase ◽  
Health Organization ◽  
The Impact ◽  
Natural And Synthetic

A global strategy, under the coordination of the World Health Organization, is being unfolded to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure safe and effective treatments. The mainstay in the therapy of snakebite envenoming is the administration of animal-derived antivenoms. In addition, new therapeutic options are being explored, including recombinant antibodies and natural and synthetic toxin inhibitors. In this review, snake venom toxins are classified in terms of their abundance and toxicity, and priority actions are being proposed in the search for snake venom metalloproteinase (SVMP), phospholipase A2 (PLA2), three-finger toxin (3FTx), and serine proteinase (SVSP) inhibitors. Natural inhibitors include compounds isolated from plants, animal sera, and mast cells, whereas synthetic inhibitors comprise a wide range of molecules of a variable chemical nature. Some of the most promising inhibitors, especially SVMP and PLA2 inhibitors, have been developed for other diseases and are being repurposed for snakebite envenoming. In addition, the search for drugs aimed at controlling endogenous processes generated in the course of envenoming is being pursued. The present review summarizes some of the most promising developments in this field and discusses issues that need to be considered for the effective translation of this knowledge to improve therapies for tackling snakebite envenoming.

scholarly journals Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia

Blood ◽  
2012 ◽  
Vol 120 (4) ◽  
pp. 748-760 ◽  
Author(s):  
Cassandra D. Josephson ◽  
Suzanne Granger ◽  
Susan F. Assmann ◽  
Marta-Inés Castillejo ◽  
Ronald G. Strauss ◽  
...  
Keyword(s):  
Bleeding Risk ◽  
World Health ◽  
Age Group ◽  
Transplant Recipients ◽  
Disease Treatment ◽  
Platelet Counts ◽  
Wide Range ◽  
Treatment Category ◽  
Dose Trial ◽  
Health Organization

Age-group analyses were conducted of patients in the prophylactic platelet dose trial (PLADO), which evaluated the relation between platelet dose per transfusion and bleeding. Hospitalized patients with treatment-induced hypoproliferative thrombocytopenia were randomly assigned to 1 of 3 platelet doses: 1.1 × 1011, 2.2 × 1011, or 4.4 × 1011 platelets/m2 per transfusion, given for morning counts of ≤ 10 000 platelets/μL. Daily hemostatic assessments were performed. The primary end point (percentage of patients who developed grade 2 or higher World Health Organization bleeding) was evaluated in 198 children (0-18 years) and 1044 adults. Although platelet dose did not predict bleeding for any age group, children overall had a significantly higher risk of grade 2 or higher bleeding than adults (86%, 88%, 77% vs 67% of patients aged 0-5 years, 6-12 years, 13-18 years, vs adults, respectively) and more days with grade 2 or higher bleeding (median, 3 days in each pediatric group vs 1 day in adults; P < .001). The effect of age on bleeding differed by disease treatment category and was most pronounced among autologous transplant recipients. Pediatric subjects were at higher risk of bleeding over a wide range of platelet counts, indicating that their excess bleeding risk may be because of factors other than platelet counts. This trial was registered at www.clinicaltrials.gov as #NCT00128713.

scholarly journals An Innovative Approach to Designing Digital Health Solutions Addressing the Unmet Needs of Obese Patients in Europe

2021 ◽  
Vol 18 (2) ◽  
pp. 579
Author(s):  
Roberta Patalano ◽  
Vincenzo De Luca ◽  
Jess Vogt ◽  
Strahil Birov ◽  
Lucia Giovannelli ◽  
...  
Keyword(s):  
Unmet Needs ◽  
Negative Impact ◽  
Digital Health ◽  
Integrated Approach ◽  
World Health ◽  
Obese Patients ◽  
Unhealthy Lifestyle ◽  
Significant Negative Impact ◽  
Related Quality ◽  
Health Organization

According to the World Health Organization (WHO), the worldwide obesity rate has tripled since 1975. In Europe, more than half of the population is overweight and obese. Around 2.8 million people die each year worldwide as a result of conditions linked to being overweight or obese. This study aimed to analyze the policies, approaches, and solutions that address the social and health unmet needs of obese patients, at different levels, in order to simulate the definition of an integrated approach, and to provide and share examples of innovative solutions supporting health promotion, disease prevention, and integration of services to improve the collaboration between the different health and care stakeholders involved across the country and in the lives of obese patients. A collaborative approach involving various levels of government and regional experts from different European countries was applied to identify, explore, and evaluate different aspects of the topic, from the innovation perspective and focusing on a European and a regional vision. Currently, people prefer more foods rich in fats, sugars, and salt/sodium than fruits, vegetables, and fiber. This behavior leads to a significant negative impact on their health-related quality of life. Changes in healthcare systems, healthy policy, and approaches to patient care and better implementation of the different prevention strategies between all the stakeholders are needed, taking advantage of the digital transformation of health and care. Such changes can support obese patients in their fight against an unhealthy lifestyle and at the same time reduce healthcare costs.

The impact of SARS-Cov-2 on the Nervous system and Mental Health

2021 ◽  
Vol 19 ◽  
Author(s):  
Mohamed Said Boulkrane ◽  
Victoria Ilina ◽  
Roman Melchakov ◽  
Mikhail Arisov ◽  
Julia Fedotova ◽  
...  
Keyword(s):  
Mental Health ◽  
Respiratory Illness ◽  
World Health ◽  
Current Review ◽  
Wide Range ◽  
Serious Disease ◽  
Health Organization ◽  
The Impact ◽  
The Brain ◽  
Severe Acute Respiratory Illness

: The World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. The current review aims to provide the available evidence about the effects of SARS-CoV-2 infection on mental health. The present data suggest that SARS-CoV-2 produces a wide range of impairments and disorders of the brain. However, a limited number of studies investigated the neuroinvasive potential of SARS-CoV-2. Although the main features and outcomes of COVID-19 are linked to severe acute respiratory illness. The possible damages on the brain should be considered, too.

scholarly journals The WHO European health for all database

2003 ◽  
Vol 7 (6) ◽  
Author(s):  
Keyword(s):  
World Health ◽  
Health Statistics ◽  
Regional Office ◽  
International Context ◽  
Health Trends ◽  
Wide Range ◽  
The World ◽  
European Health ◽  
Health Organization ◽  
Health Situation

The European health for all database provides easy and rapid access to a wide range of basic health statistics (indicators) for the 51 Member States of the World Health Organization (WHO) European Region. It was developed by the WHO Regional Office for Europe in the mid 1980s to support the monitoring of health trends in the Region. The database is a helpful tool for international comparison and for assessing the health situation and trends in any European country in an international context.

scholarly journals THE HUMAN RIGHT TO HEALTH: A RETROSPECTIVE ANALYSIS AFTER 70 YEARS OF INTERNATIONAL RECOGNITION

2018 ◽  
pp. 24-42
Author(s):  
MARÍA DALLI
Keyword(s):  
Human Rights ◽  
Right To Health ◽  
World Health ◽  
Health Coverage ◽  
Human Right ◽  
The Sustainable Development ◽  
Cultural Rights ◽  
Health Organization ◽  
The Individual ◽  
The Right

In 1948, the General Assembly of the United Nations adopted the first international text recognising universal human rights for all; the Universal Declaration of Human Rights. Article 25 recognises the right to an adequate standard of living, which includes the right to health and medical care. On the occasion of the 70th anniversary of the Declaration, this article presents an overview of the main developments that have been made towards understanding the content and implications of the right to health, as well as an analysis of some specific advancements that aim to facilitate the enforcement thereof. These include: a) the implication of private entities as responsible for right to health obligations; b) the Universal Health Coverage goal, proposed by the World Health Organization and included as one of the Sustainable Development Goals; and c) the individual complaints mechanism introduced by the Optional Protocol to the International Covenant on Economic, Social and Cultural Rights (adopted on the 10th December 2008, 60 years after the UDHR).

Intimate partner violence

2018 ◽  
pp. 465-476
Author(s):  
Carmen Wong ◽  
Wai Ching Ng ◽  
Hua Zhong ◽  
Anne Scully-Hill
Keyword(s):  
Intimate Partner Violence ◽  
Partner Violence ◽  
Integrated Approach ◽  
Intimate Partner ◽  
World Health ◽  
Physical And Mental Health ◽  
Psychological Harm ◽  
And Gender ◽  
Health Organization ◽  
Internal And External Factors

Intimate partner violence (IPV) refers to any action that causes physical, sexual, and psychological harm by intimate partners, which includes domestic violence. This chapter gives a brief overview and details the prevalence, current theories, research, and evidence, including patriarchy and gender issues. IPV is complex, with internal and external factors relating to the victim, perpetrator, family, and the community. The long-term impacts on physical and mental health are reviewed. Recent direction by the World Health Organization describes a multi-level integrated approach, which is discussed topically in terms of individual, relational, and community prevention and intervention and its challenges. Finally, policies and laws relating to IPV are reviewed. This chapter has been written collaboratively by a multidisciplinary team of medical, social, and legal professionals.

scholarly journals Rehabilitation Machine for Bariatric Individuals

Machines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 45
Author(s):  
Andrea Botta ◽  
Paride Cavallone ◽  
Luca Carbonari ◽  
Carmen Visconte ◽  
Giuseppe Quaglia
Keyword(s):  
Muscle Tone ◽  
Physical Exertion ◽  
World Health ◽  
Upper Body ◽  
Obese People ◽  
Leg Extension ◽  
Extension Mechanism ◽  
Physical Exercises ◽  
Wide Range ◽  
Health Organization

Obesity is known to be growing worldwide. The World Health Organization (WHO) reports that obesity has tripled since 1975. In 2016, 39% of adults over 18 years old were overweight, and 13% were obese. Obesity is mostly preventable by adopting lifestyle improvements, enhancing diet quality, and doing physical exercise. The workload of the physical exercises should be proportionate to the patient’s capabilities. However, it must be considered that obese people are not used to training; they may not endure physical exertion and, even more critically, they could have some psychological impediments to the workouts. Physical exercises and equipment must, therefore, guarantee comfort and prevent situations in which the bariatric individual may feel inadequate. For these reasons, this study aims to design an innovative system to approach simple physical activities, like leg and arm exercises, to bariatric users to enable them to recover mobility and muscle tone gradually. The leading feature of this architecture is the design of hidden exercise mechanisms to overcome the psychological barriers of the users toward these kinds of machines. This paper proposes the initial design of the main sub-systems composing the rehabilitation machine, namely the leg curl and leg extension mechanism and its control architecture, the upper body exercises system, and a series of regulation mechanisms required to accommodate a wide range of users. The proposed functional design will then lead to the development of a prototype to validate the machine.

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