The impact of SARS-Cov-2 on the Nervous system and Mental Health

2021 ◽  
Vol 19 ◽  
Author(s):  
Mohamed Said Boulkrane ◽  
Victoria Ilina ◽  
Roman Melchakov ◽  
Mikhail Arisov ◽  
Julia Fedotova ◽  
...  

: The World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. The current review aims to provide the available evidence about the effects of SARS-CoV-2 infection on mental health. The present data suggest that SARS-CoV-2 produces a wide range of impairments and disorders of the brain. However, a limited number of studies investigated the neuroinvasive potential of SARS-CoV-2. Although the main features and outcomes of COVID-19 are linked to severe acute respiratory illness. The possible damages on the brain should be considered, too.

Toxins ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 451
Author(s):  
José María Gutiérrez ◽  
Laura-Oana Albulescu ◽  
Rachel H. Clare ◽  
Nicholas R. Casewell ◽  
Tarek Mohamed Abd Abd El-Aziz ◽  
...  

A global strategy, under the coordination of the World Health Organization, is being unfolded to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure safe and effective treatments. The mainstay in the therapy of snakebite envenoming is the administration of animal-derived antivenoms. In addition, new therapeutic options are being explored, including recombinant antibodies and natural and synthetic toxin inhibitors. In this review, snake venom toxins are classified in terms of their abundance and toxicity, and priority actions are being proposed in the search for snake venom metalloproteinase (SVMP), phospholipase A2 (PLA2), three-finger toxin (3FTx), and serine proteinase (SVSP) inhibitors. Natural inhibitors include compounds isolated from plants, animal sera, and mast cells, whereas synthetic inhibitors comprise a wide range of molecules of a variable chemical nature. Some of the most promising inhibitors, especially SVMP and PLA2 inhibitors, have been developed for other diseases and are being repurposed for snakebite envenoming. In addition, the search for drugs aimed at controlling endogenous processes generated in the course of envenoming is being pursued. The present review summarizes some of the most promising developments in this field and discusses issues that need to be considered for the effective translation of this knowledge to improve therapies for tackling snakebite envenoming.


2021 ◽  
Vol 104 (2) ◽  
pp. 003685042110198
Author(s):  
Helen Onyeaka ◽  
Christian K Anumudu ◽  
Zainab T Al-Sharify ◽  
Esther Egele-Godswill ◽  
Paul Mbaegbu

COVID-19, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), was declared a pandemic by the World Health Organization (WHO) on the 11th of March 2020, leading to some form of lockdown across almost all countries of the world. The extent of the global pandemic due to COVID-19 has a significant impact on our lives that must be studied carefully to combat it. This study highlights the impacts of the COVID-19 pandemic lockdown on crucial aspects of daily life globally, including; Food security, Global economy, Education, Tourism, hospitality, sports and leisure, Gender Relation, Domestic Violence/Abuse, Mental Health and Environmental air pollution through a systematic search of the literature. The COVID-19 global lockdown was initiated to stem the spread of the virus and ‘flatten the curve’ of the pandemic. However, the impact of the lockdown has had far-reaching effects in different strata of life, including; changes in the accessibility and structure of education delivery to students, food insecurity as a result of unavailability and fluctuation in prices, the depression of the global economy, increase in mental health challenges, wellbeing and quality of life amongst others. This review article highlights the impacts of the COVID-19 pandemic lockdown across the globe. As the global lockdown is being lifted in a phased manner in various countries of the world, it is necessary to explore its impacts to understand its consequences comprehensively. This will guide future decisions that will be made in a possible future wave of the COVID-19 pandemic or other global disease outbreak.


Coronavirus disease (COVID-19) has been declared a pandemic by the World Health Organization on the 11th March 2020. COVID-19 has a wide range of effects. Increased Covid-19 infection is a major risk factor due to human unconsciousness and disobedience. The effects are increasing gradually. Therefore, the Bangladesh government has imposed a lockdown, but the outcome is adverse to this lockdown. It has shown us the real situation in our economic, social, education, service, and health sectors. It reveals, in particular, that, as a result of Covid-19, our health sector, which is a basic human need, has entirely broken down, and that, as a result of the epidemic, our educational system has also been impacted. Generally speaking, the education sector will suffer significant damage. Our main purpose in this paper is to show the impact of Covid-19 on different sectors of our country.


2021 ◽  
Vol 6 (25) ◽  
pp. 01-14
Author(s):  
Siti Aisyah Mohamad Zin ◽  
Raja Nurul Hafizah Raja Ismail ◽  
Wan Nur Ainna Waheda Rozali ◽  
Nor Kalsum Mohd Isa

The COVID-19 pandemic is a major concern to the community around the globe at the moment and the World Health Organization (WHO) records a total of more than 200 million cases worldwide. The spread of the COVID-19 pandemic has had a huge impact on the world community, especially in Malaysia, from the socio-economic aspect that leads to mental health issues. The implementation of the Movement Control Order (MCO) to Malaysians is aimed at breaking the chain of pandemics by making social distancing which began on March 18, 2020, has changed the societal life pattern, especially for adolescents. If it is not managed properly, emotional conflicts such as depression, stress, anxiety, and untreated panic attacks can even affect the mental health of adolescents. There are numerous recent studies on the COVID-19 pandemic have been conducted by researchers from around the world. The COVID-19 outbreak has also affected the education sector in the country. Face-to-face learning cannot be conducted, hence, requires students to learn from home. The Ministry of Education in Malaysia has introduced a new platform to help students to continue their learning through an online learning system. Online learning has its own pros and cons. In these challenging times, the field of education is not falling behind in undergoing a transformation towards a more advanced and systematic learning process. Therefore, online learning is the best way to ensure that students do not fall behind in their studies even when they are at home. However, the implementation of online learning has the potential to affect the mental health of students such as feelings of stress, fear, anxiety, worry, and depression due to not being able to balance the use of computers during learning and to complete assignments as well as internet data problems. A study by the World Health Organization (WHO) found that the number of victims of depression worldwide is estimated to reach 300 million people and the average is of adolescents. This is the silent killer of this generation which is the pillar and hope of the country, therefore it should be given attention and proper treatment. A literature review through the content analysis method is used in this paper to look at the challenges and solutions to the recovery of emotional conflict and mental health. Thus, this paper aims to look at the challenges of this pandemic exploring scientifically the impact of COVID-19 especially in terms of emotional and mental health as well as the impact on the national education system. The attitude of "prevent before it gets worse" is very critical and needs to be given serious attention by the community in facing the escalating challenges during this COVID-19. An understanding of the effects of emotions could generate appropriate prevention measures and approaches that can be implemented to ensure that emotional conflicts can be treated to save those adolescents and inevitably to ensure the well-being of individuals affected by the COVID-19 outbreak.


2021 ◽  
Vol 2 (2) ◽  
pp. 79-89
Author(s):  
Lia Umi Mulyana ◽  
Muhammad Ihsan ◽  
Yuni Amelia

The global pandemic that set by the World Health Organization on January 30, 2020 as a result of the new disease of Covid-19 has made many major changes, one of them in education where learning system are done through online. Online learning policies during the Covid-19 pandemic are the main solution to keeping the learning process going.This thesis aims to find out what impact of English online learning has on students' mental health during the covid-19 pandemic at SMA Negeri 2 Sojol  and To find out what factors hindered students in the process of English online learning at SMA Negeri 2 Sojol. In this research, the researcher applied a descriptive qualitative research which were located at SMA Negeri 2 Sojol. Data sources obtained through primary and secondary data. Data collection techniques used are  questionnaire and interviews. Based on the results of the questioner showed that they tend to just felt bored, difficult to concentrate, feelings of fear or worry if they are unable to collect tasks on time as well as their difficulty in understanding the material when English online learning during the covid-19 pandemic. Where it is caused by several factors such as poor internet network, residential environment and also monotonous teaching techniques from English teachers.


2019 ◽  
Vol 9 (3) ◽  
pp. 772-780
Author(s):  
Anil Chankaramangalam Mathew ◽  
Jibin K Benny ◽  
Dona Maria Philip ◽  
C Dhanya ◽  
Melvin Joy ◽  
...  

Background: According to the recommendations from The World Health Organization, exclusive breast feeding (EBF) should be given to infants for the first six months for healthy growth and development. However, developing countries have a wide range of variation in the practice of EBF. From this study, we aim to estimate the duration of EBF and find the impact of socio-demographic characteristics on EBF. Materials and Methods: This study was conducted at PSG Institute of Medical Sciences and Research, Coimbatore in the month of July 2018. Mothers with children aged below 4 years attending the paediatric outpatient department were included in the study. Kaplan-Meier curve analysis and logistic regression analysis were employed. Results: Our analysis indicates that the prevalence of EBF was 58.4% among infants up to 6 months of age with mean duration of EBF 4.52 months. It was observed that mothers of a younger age (15-24 years) and with lower socio-economic status were negatively associated with the practice of providing EBF to infants up to six months of age. Conclusion: The findings clearly indicate that the interventions related to EBF up to six months of age should be targeted at women in the lower socio-economic status and at younger ages.


2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Sana Saffiruddin Shaikh ◽  
Anooja P. Jose ◽  
Disha Anil Nerkar ◽  
Midhuna Vijaykumar KV ◽  
Saquib Khaleel Shaikh

Abstract Background Coronavirus (SARS-CoV-2), the cause of COVID-19, a fatal disease emerged from Wuhan, a large city in the Chinese province of Hubei in December 2019. Main body of abstract The World Health Organization declared COVID-19 as a pandemic due to its spread to other countries inside and outside Asia. Initial confirmation of the pandemic shows patient exposure to the Huanan seafood market. Bats might be a significant host for the spread of coronaviruses via an unknown intermediate host. The human-to-human transfer has become a significant concern due to one of the significant reasons that is asymptomatic carriers or silent spreaders. No data is obtained regarding prophylactic treatment for COVID-19, although many clinical trials are underway. Conclusion The most effective weapon is prevention and precaution to avoid the spread of the pandemic. In this current review, we outline pathogenesis, diagnosis, treatment, ongoing clinical trials, prevention, and precautions. We have also highlighted the impact of pandemic worldwide and challenges that can help to overcome the fatal disease in the future.


Lubricants ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 15
Author(s):  
Valentin L. Popov ◽  
Aleksandr M. Poliakov ◽  
Vladimir I. Pakhaliuk

Synovial joints are unique biological tribosystems that allow a person to perform a wide range of movements with minimal energy consumption. In recent years, they have been increasingly called “smart friction units” due to their ability to self-repair and adapt to changing operating conditions. However, in reality, the elements of the internal structure of the joints under the influence of many factors can degrade rather quickly, leading to serious disease such as osteoarthritis. According to the World Health Organization, osteoarthritis is already one of the 10 most disabling diseases in developed countries. In this regard, at present, fundamental research on synovial joints remains highly relevant. Despite the fact that the synovial joints have already been studied fully, many issues related to their operating, prevention, development of pathology, diagnosis and treatment require more detailed consideration. In this article, we discuss the urgent problems that need to be solved for the development of new pharmacological agents, biomaterials, scaffolds, implants and rehabilitation devices for the prevention, rehabilitation and improvement of the treatment effectiveness of synovial joints at various stages of osteoarthritis.


2021 ◽  
Vol 33 (S1) ◽  
pp. 96-97
Author(s):  
Sofia Ramos Ferreira ◽  
Daniela Pereira ◽  
Horácio Firmino

Background:Since the disease caused by the SARS-Cov-2 virus was declared a pandemic by the World Health Organization, countries around the globe adopted measures of social distancing to limit the spread of the virus. Although social distancingmeasures are essential preventive mechanisms, they can promote feelings of loneliness and influence the onset or exacerbation of psychiatric disorders. Current knowledge about the impact of COVID-19 on mental health - and in particular on mental health of the geriatric population - is still scarce.Research Objective:The present review aimed to analyze the COVID-19 pandemic impact on the elderly´s mental health and to suggest measures that can mitigate this impact.Method:A non-systematic review of the literature, through bibliographic research in Pubmed and Embase databases - using the keywords “COVID-19", “SARS-CoV-2", “Coronavirus”, “Aging”, “Older adults”, “Elderly”, “Quarantine” and “Mental health” -was performed.Preliminary results of the ongoing study:The available literature points towards a likely increase in mental disorders as a result of the COVID-19 pandemic. This phenomena may be particularly relevant in the elderly population. Several measures – pharmacological and non-pharmacological – can help to maintain the physical and mental health of the elderly.Conclusion:The COVID-19 pandemic had an important impact in elderly’s mental health. This subject should be addressed by profissionals/caregivers and measures tominimize negative consequences are in order.


2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Hayat Ouassou ◽  
Loubna Kharchoufa ◽  
Mohamed Bouhrim ◽  
Nour Elhouda Daoudi ◽  
Hamada Imtara ◽  
...  

Coronavirus Disease 2019 (COVID-19) has become a major health problem causing severe acute respiratory illness in humans. It has spread rapidly around the globe since its first identification in Wuhan, China, in December 2019. The causative virus is called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the World Health Organization (WHO) named the new epidemic disease Coronavirus Disease (COVID-19). The incidence of COVID-19 continues to increase with more than three million confirmed cases and over 244,000 deaths worldwide. There is currently no specific treatment or vaccine against COVID-19. Therefore, in the absence of pharmaceutical interventions, the implementation of precautions and hygienic measures will be essential to control and to minimize human transmission of the virus. In this review, we highlight the epidemiology, transmission, symptoms, and treatment of this disease, as well as future strategies to manage the spread of this fatal coronavirus.


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