From ‘vast extended prospect’ to ‘the spectacle of nature’

2020 ◽  
pp. 72-97
Author(s):  
Simon Bainbridge
Keyword(s):  
Ann Radcliffe ◽  
Romantic Period ◽  
Starting Point ◽  
Wide Range ◽  
Visual Dimension ◽  
John Brown

This chapter takes as its starting point William Wordsworth’s ascent of Snowdon in 1791 and Keats’s ‘fag & tug’ up Ben Nevis in 1818 to show how the writers participated in the period’s developing mountaineering culture. It investigates the visual dimension of the two poets’ ascents, locating their climbs within the optically-motivated culture of Romantic-period climbing and showing how ascent made possible new ways of seeing. To trace the developing aesthetics of elevated viewing, the chapter examines a wide range of travel texts by writers including the following: Thomas Pennant, John Brown, William Hutchinson, Charles Moritz, Ann Radcliffe, James Denholm, Adam Walker, John Stoddart, William Green, Jonathan Otley, and Edward Baines. Within the context of this developing literature of mountaineering, it argues that Wordsworth’s and Keats’s mountain-top experiences can be best understood within the evolving framework of ‘the spectacle of Nature’.

Mountaineering and British Romanticism

2020 ◽  
Author(s):  
Simon Bainbridge
Keyword(s):  
Samuel Taylor Coleridge ◽  
John Keats ◽  
Power Dynamics ◽  
Ann Radcliffe ◽  
Romantic Period ◽  
The Sublime ◽  
Wide Range ◽  
Visual Sovereignty ◽  
Romantic Era ◽  
The Relationship

This book examines the relationship between Romantic-period writing and the activity that Samuel Taylor Coleridge christened ‘mountaineering’ in 1802. It argues that mountaineering developed as a pursuit in Britain during the Romantic era, earlier than is generally recognized, and shows how writers including William and Dorothy Wordsworth, Ann Radcliffe, Samuel Taylor Coleridge, John Keats, and Walter Scott were central to the activity’s evolution. It explores how the desire for physical ascent shaped Romantic-period literary culture, and investigates how the figure of the mountaineer became crucial to creative identities and literary outputs. Illustrated with twenty-five images from the period, the book shows how mountaineering in Britain had its origins in scientific research, antiquarian travel, and the search for the picturesque and the sublime. It considers how writers engaged with mountaineering’s power dynamics and investigates issues including the politics of the summit view (what Wordsworth terms ‘visual sovereignty’), the relationships between different types of ‘mountaineers’, and the role of women in the developing cultures of ascent. Placing the work of canonical writers alongside a wide range of other types of mountaineering literature, this book reassesses key Romantic-period terms and ideas, such as vision, insight, elevation, revelation, transcendence and the sublime. It opens up new ways of understanding the relationship between Romantic-period writers and the world that they experienced through their feet and hands, as well as their eyes, as they moved through the challenging landscapes of the British mountains.

Discovery of Antibacterial Agents Inhibiting the Energy-Coupling Factor (ECF) Transporters by Structure-Based Virtual Screening

2020 ◽  
Author(s):  
Eleonora Diamanti ◽  
Inda Setyawati ◽  
Spyridon Bousis ◽  
leticia mojas ◽  
lotteke Swier ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
Energy Coupling ◽  
Coupling Factor ◽  
Design Synthesis ◽  
Screening Design ◽  
Starting Point ◽  
Wide Range ◽  
Vitamin Uptake

Here, we report on the virtual screening, design, synthesis and structure–activity relationships (SARs) of the first class of selective, antibacterial agents against the energy-coupling factor (ECF) transporters. The ECF transporters are a family of transmembrane proteins involved in the uptake of vitamins in a wide range of bacteria. Inhibition of the activity of these proteins could reduce the viability of pathogens that depend on vitamin uptake. Because of their central role in the metabolism of bacteria and their absence in humans, ECF transporters are novel potential antimicrobial targets to tackle infection. The hit compound’s metabolic and plasma stability, the potency (20, MIC Streptococcus pneumoniae = 2 µg/mL), the absence of cytotoxicity and a lack of resistance development under the conditions tested here suggest that this scaffold may represent a promising starting point for the development of novel antimicrobial agents with an unprecedented mechanism of action.<br>

scholarly journals Consumer Neuroscience Techniques in Advertising Research: A Bibliometric Citation Analysis

2021 ◽  
Vol 13 (3) ◽  
pp. 1589
Author(s):  
Juan Sánchez-Fernández ◽  
Luis-Alberto Casado-Aranda ◽  
Ana-Belén Bastidas-Manzano
Keyword(s):  
Self Report ◽  
Future Research ◽  
Complex Nature ◽  
Clear Understanding ◽  
Continuous Growth ◽  
Main Research ◽  
Consumer Neuroscience ◽  
Starting Point ◽  
Wide Range ◽  
Performance Analysis Tools

The limitations of self-report techniques (i.e., questionnaires or surveys) in measuring consumer response to advertising stimuli have necessitated more objective and accurate tools from the fields of neuroscience and psychology for the study of consumer behavior, resulting in the creation of consumer neuroscience. This recent marketing sub-field stems from a wide range of disciplines and applies multiple types of techniques to diverse advertising subdomains (e.g., advertising constructs, media elements, or prediction strategies). Due to its complex nature and continuous growth, this area of research calls for a clear understanding of its evolution, current scope, and potential domains in the field of advertising. Thus, this current research is among the first to apply a bibliometric approach to clarify the main research streams analyzing advertising persuasion using neuroimaging. Particularly, this paper combines a comprehensive review with performance analysis tools of 203 papers published between 1986 and 2019 in outlets indexed by the ISI Web of Science database. Our findings describe the research tools, journals, and themes that are worth considering in future research. The current study also provides an agenda for future research and therefore constitutes a starting point for advertising academics and professionals intending to use neuroimaging techniques.

Energy-minimization multiscale based mesoscale modeling and applications in gas-fluidized catalytic reactors

2019 ◽  
Vol 35 (8) ◽  
pp. 879-915 ◽  
Author(s):  
Bona Lu ◽  
Yan Niu ◽  
Feiguo Chen ◽  
Nouman Ahmad ◽  
Wei Wang ◽  
...  
Keyword(s):  
Energy Minimization ◽  
Fluid Model ◽  
Scale Up ◽  
Flow Characteristics ◽  
Chemical Kinetic ◽  
Mesoscale Modeling ◽  
Catalytic Reactors ◽  
Chemical Kinetic Model ◽  
Starting Point ◽  
Wide Range

Abstract Gas-solid fluidization is intrinsically dynamic and manifests mesoscale structures spanning a wide range of length and timescales. When involved with reactions, more complex phenomena emerge and thus pose bigger challenges for modeling. As the mesoscale is critical to understand multiphase reactive flows, which the conventional two-fluid model without mesoscale modeling may be inadequate to resolve even using extremely fine grids, this review attempts to demonstrate that the energy-minimization multiscale (EMMS) model could be a starting point to develop such mesoscale modeling. Then, the EMMS-based mesoscale modeling with emphasis on formulation of drag coefficients for different fluidization regimes, modification of mass transfer coefficient, and other extensions are discussed in an attempt to resolve the emerging challenges. Its applications with examples of development of novel fluid catalytic cracking and methanol-to-olefins processes prove that the mesoscale modeling plays a remarkable role in improving the predictions in hydrodynamic behaviors and overall reaction rate. However, the product content primarily depends on the chemical kinetic model itself, suggesting the necessity of an effective coupling between chemical kinetics and flow characteristics. The mesoscale modeling can be believed to accelerate the traditional experimental-based scale-up process with much lower cost in the future.

scholarly journals Development of Permeability Models for Saturated Fluid Flow across Arrays of Fibre Clusters

2002 ◽  
Vol 11 (3) ◽  
pp. 096369350201100
Author(s):  
E.M. Gravel ◽  
T.D. Papathanasiou
Keyword(s):  
Analytical Models ◽  
Dual Porosity ◽  
Hydraulic Permeability ◽  
Fibrous Media ◽  
Fibre Bundles ◽  
Hexagonal Packing ◽  
Composites Manufacturing ◽  
Starting Point ◽  
Wide Range ◽  
Flow Through

Dual porosity fibrous media are important in a number of applications, ranging from bioreactor design and transport in living systems to composites manufacturing. In the present study we are concerned with the development of predictive models for the hydraulic permeability ( Kp) of various arrays of fibre bundles. For this we carry out extensive computations for viscous flow through arrays of fibre bundles using the Boundary Element Method (BEM) implemented on a multi-processor computer. Up to 350 individual filaments, arranged in square or hexagonal packing within bundles, which are also arranged in square of hexagonal packing, are included in each simulation. These are simple but not trivial models for fibrous preforms used in composites manufacturing – dual porosity systems characterised by different inter- and intra-tow porosities. The way these porosities affect the hydraulic permeability of such media is currently unknown and is elucidated through our simulations. Following numerical solution of the governing equations, ( Kp) is calculated from the computed flowrate through Darcy's law and is expressed as function of the inter- and intra-tow porosities (φ, φt) and of the filament radius ( Rf). Numerical results are also compared to analytical models. The latter form the starting point in the development of a dimensionless correlation for the permeability of such dual porosity media. It is found that the numerically computed permeabilities follow that correlation for a wide range of φ i, φt and Rf.

Adopting SCAMPER`S Strategies to Incorporate the Sustainability Concepts Within Architectural Design Process

2021 ◽  
Author(s):  
Farhan Ali ◽  
Keyword(s):  
Design Process ◽  
Creative Thinking ◽  
Architectural Design ◽  
Divergent Thinking ◽  
Functional Performance ◽  
Necessary Condition ◽  
Existing Building ◽  
Starting Point ◽  
Wide Range ◽  
The Aesthetic

Thinking creatively, is a necessary condition of the Design process to transform ideas into novel solutions and break barriers to creativity. Although, there are many techniques and ways to stimulate creative thinking for designers, however, this research paper adopts SCAMPER; which is acronym of: Substitute- Combine-Adapt- Modify or Magnify-Put to another use-Eliminate-Reverse or Rearrange- to integrate the sustainability concepts within architectural design process. Many creative artifacts have been designed consciously or unconsciously adopting SCAMPER strategies such as rehabilitation and reuse projects to improve the functional performance or the aesthetic sense of an existing building for the better. SCAMPER is recognized as a divergent thinking tool are used during the initial ideation stage, aims to leave the usual way of thinking to generate a wide range of new ideas that will lead to new insights, original ideas, and creative solutions to problems. The research focuses on applying this method in the architectural design, which is rarely researched, through reviewing seven examples that have been designed consciously or unconsciously adopting SCAMPER mnemonic techniques. The paper aims to establish a starting point for further research to deepen it and study its potentials in solving architectural design problems.

iPod Listening as an I-voice

2021 ◽  
pp. 668-689
Author(s):  
Carlo Cenciarelli
Keyword(s):  
Film Theory ◽  
Cultural Construction ◽  
First Person ◽  
Alternative Route ◽  
Self And Other ◽  
Starting Point ◽  
Wide Range ◽  
Listening And Speaking

Walkman and iPod devices have often been discussed in quasi-cinematic terms. This typically implies an analogy between the personal stereo user and the transcendental subject of film theory, who is allowed to see and hear without being seen or heard. This chapter offers an alternative route. Taking as starting point a cinematic moment in which iPod listening is turned into a first-person voiceover, it suggests that cinematic and personal stereo listening share not only an orientation towards privatization and individualization but also a fantasy of communication: one that blurs the lines between “self” and “other” and between listening and speaking. Analyzing a wide range of films and historical marketing campaigns by Sony and Apple, the chapter shows how mainstream cinema—through its representational tropes and modes of spectatorial address—feeds into a broader cultural construction of personal stereo listening as a highly individualized activity that is always imaginatively open-ended.

Editorial: Refashioning stories for celebrity counterpublics

2021 ◽  
Vol 10 (2) ◽  
pp. 145-152 ◽  
Author(s):  
Sabrina Moro ◽  
Samita Nandy ◽  
Kiera Obbard ◽  
Andrew Zolides
Keyword(s):  
Social Change ◽  
Identity Politics ◽  
Public Intellectuals ◽  
Special Issue ◽  
Social Significance ◽  
Starting Point ◽  
The Social ◽  
Wide Range ◽  
Dominant Ideologies ◽  
Ted Talks

Using celebrity narratives as a starting point, this Special Issue explores the social significance of storytelling for social change. It builds on the 8th Centre for Media and Celebrity Studies conference, which brought together scholars and media practitioners to explore how narratives inspired by the lives of celebrities, public intellectuals, critics and activists offer useful rhetorical tools to better understand dominant ideologies. This editorial further problematizes what it means to be a popular ‘storyteller’ using the critical lens of celebrity activism and life-writing. Throughout the issue, contributors analyse the politics of representation at play within a wide range of glamourous narratives, including documentaries, memoirs, TED talks, stand-up performances and award acceptance speeches in Hollywood and beyond. The studies show how we can strategically use aesthetic communication to shape identity politics in public personas and bring urgent social change in an image-driven celebrity culture.

scholarly journals Crystal structure of human mARC1 reveals its exceptional position among eukaryotic molybdenum enzymes

2018 ◽  
Vol 115 (47) ◽  
pp. 11958-11963 ◽  
Author(s):  
Christian Kubitza ◽  
Florian Bittner ◽  
Carsten Ginsel ◽  
Antje Havemeyer ◽  
Bernd Clement ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Catalytic Mechanism ◽  
Full Range ◽  
3D Structure ◽  
Cytochrome P450 Enzymes ◽  
Oxygenated Compounds ◽  
Online Databases ◽  
Starting Point ◽  
Wide Range ◽  
Nitrogen Containing Compounds

Biotransformation enzymes ensure a viable homeostasis by regulating reversible cycles of oxidative and reductive reactions. The metabolism of nitrogen-containing compounds is of high pharmaceutical and toxicological relevance because N-oxygenated metabolites derived from reactions mediated by cytochrome P450 enzymes or flavin-dependent monooxygenases are in some cases highly toxic or mutagenic. The molybdenum-dependent mitochondrial amidoxime-reducing component (mARC) was found to be an extremely efficient counterpart, which is able to reduce the full range of N-oxygenated compounds and thereby mediates detoxification reactions. However, the 3D structure of this enzyme was unknown. Here we present the high-resolution crystal structure of human mARC. We give detailed insight into the coordination of its molybdenum cofactor (Moco), the catalytic mechanism, and its ability to reduce a wide range of N-oxygenated compounds. The identification of two key residues will allow future discrimination between mARC paralogs and ensure correct annotation. Since our structural findings contradict in silico predictions that are currently made by online databases, we propose domain definitions for members of the superfamily of Moco sulfurase C-terminal (MOSC) domain-containing proteins. Furthermore, we present evidence for an evolutionary role of mARC for the emergence of the xanthine oxidase protein superfamily. We anticipate the hereby presented crystal structure to be a starting point for future descriptions of MOSC proteins, which are currently poorly structurally characterized.

scholarly journals What is Normalization? The Strategies Employed in Top-Down and Bottom-Up Proteome Analysis Workflows

Proteomes ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 29 ◽  
Author(s):  
Matthew B. O’Rourke ◽  
Stephanie E. L. Town ◽  
Penelope V. Dalla ◽  
Fiona Bicknell ◽  
Naomi Koh Belic ◽  
...  
Keyword(s):  
Normal State ◽  
Proteome Analysis ◽  
Biological Condition ◽  
Sample Handling ◽  
Analysis Process ◽  
Starting Point ◽  
Wide Range ◽  
Experimental Process ◽  
Definition Of ◽  
Accurate Quantification

The accurate quantification of changes in the abundance of proteins is one of the main applications of proteomics. The maintenance of accuracy can be affected by bias and error that can occur at many points in the experimental process, and normalization strategies are crucial to attempt to overcome this bias and return the sample to its regular biological condition, or normal state. Much work has been published on performing normalization on data post-acquisition with many algorithms and statistical processes available. However, there are many other sources of bias that can occur during experimental design and sample handling that are currently unaddressed. This article aims to cast light on the potential sources of bias and where normalization could be applied to return the sample to its normal state. Throughout we suggest solutions where possible but, in some cases, solutions are not available. Thus, we see this article as a starting point for discussion of the definition of and the issues surrounding the concept of normalization as it applies to the proteomic analysis of biological samples. Specifically, we discuss a wide range of different normalization techniques that can occur at each stage of the sample preparation and analysis process.

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