scholarly journals Effect of Local versus Systemic Steroids in Treatment of Children with Otitis Media with Effusion

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A G Shafik ◽  
M S Hassabalah ◽  
A M Maarouf ◽  
M K Elghobashy
Keyword(s):  
Allergic Rhinitis ◽  
Otitis Media ◽  
Clinical Symptoms ◽  
Otitis Media With Effusion ◽  
University Hospital ◽  
Adjunctive Treatment ◽  
Oral Steroid ◽  
Adenoid Hypertrophy ◽  
Systemic Steroids ◽  
Significant Difference

Abstract Background otitis media with effusion (OME) or glue ear is the collection of fluid behind the tympanic membrane without inflammatory signs present for 6 weeks. Aim of the Work comparing the effect of intra nasal versus systemic steroids in treatment of children with Otitis media with effusion as regard: Improvement of clinical symptoms and Audiological findings. Subjects and Methods this study is a prospective, case control study on the effects of intranasal versus systemic steroids on children with otitis media with effusion. This thesis study was conducted on 30 patients diagnosed according to clinical and audiological assessment recruited from otorhinolaryngology outpatient clinic Ain Shams university hospital from October 2017 to July 2018. An informed consent was obtained from each patient or control or their legal guardians before enrolment in the study. Results however, statistically there is no significant relation between the occurrence of complete resolution of OME and the route of administration of steroid (either intranasal or systemic), whatever the cause either allergic rhinitis or adenoid hypertrophy. So we can use either intranasal or systemic steroids in management of otitis media with effusion in children with either allergic rhinitis or adenoid hypertrophy or both. Conclusion both topical intranasal and oral steroids are effective adjunctive treatment for OME in children in the short term, without significant difference between the two methods, and thus oral steroid complications could be avoided using local steroid spray.

scholarly journals A study on the effect of adenoidectomy with tonsillectomy in otitis media with effusion in children

2017 ◽  
Vol 5 (5) ◽  
pp. 1796 ◽  
Author(s):  
Ajayan P. V. ◽  
Divya Raj M. L. ◽  
Anju Mariam Jacob
Keyword(s):  
Otitis Media ◽  
Complete Resolution ◽  
Clinical Symptoms ◽  
Otitis Media With Effusion ◽  
Learning Ability ◽  
Government Medical College ◽  
Adenoid Hypertrophy ◽  
Tonsillar Hypertrophy ◽  
Chi Square ◽  
Medical College

Background: The aural symptoms attributed to adenoid hypertrophy are Eustachian tube block (ET) and otitis media with effusion (OME). It is thought that adenoid hypertrophy causes a block in air flow through the ET, thus creating a negative pressure in the middle ear leading to effusion which acts as a focus of infection. The role of hypertrophied tonsils in the aetiology of OME is controversial. Adenoid and tonsillar hypertrophy and associated inflammation continue to be a major problem in paediatric age group despite the advances in medicine. Otitis media with effusion is a treatable cause of deafness which may hamper the learning ability of a child. This study was undertaken to study the effect of adenoidectomy with tonsillectomy on established otitis media with effusion in children.Methods: 35 children presenting to the department of ENT, Government Medical College, Thrissur, Kerala, India over one and a half years with features suggestive of secretory otitis media, tonsillar and adenoid hypertrophy who underwent adenoidectomy with tonsillectomy in Government Medical College, Thrissur, Kerala, India were included in the study. A predesigned questionnaire was prepared which included details on clinical symptoms, relevant investigations and preoperative and postoperative evaluation of hearing after 6 weeks and 3 months. Data collected was analyzed using paired t-test and chi square test to determine the improvement in hearing after 6 weeks and 3 months following surgery.Results: Out of the 35 children included in the study, it was seen that 56% of cases, after 6 weeks showed complete resolution of OME which improved to 67% after 3 months. This was assessed by PTA and tympanometry. 33% showed partial improvement with Type C curve in tympanometry and improvement in PTA values.Conclusions: All cases of OME associated with adenoid and tonsillar hypertrophy responded to our treatment with 67% showing complete cure of the condition. It can be assumed that, in the 33% partial responders there may be other factors like allergy, anatomical deformities, immunological which prevented the complete resolution of symptoms in OME. 

Fractalkine (CX3CL1) and its receptor (CX3CR1) in children with hypertrophic adenoid and chronic otitis media with effusion

2019 ◽  
Vol 45 (1) ◽  
pp. 44-50
Author(s):  
Serhat Inan ◽  
Seda Türkoğlu Babakurban ◽  
Selim Sermed Erbek ◽  
Yunus Kasım Terzi ◽  
Feride Iffet Sahin
Keyword(s):  
Otitis Media ◽  
Otitis Media With Effusion ◽  
Inflammatory Diseases ◽  
Chronic Otitis Media ◽  
Adenoid Hypertrophy ◽  
Tissue Samples ◽  
Expression Levels ◽  
Adenoid Tissue ◽  
Significant Difference ◽  
Receptor Cx3cr1

Abstract Background Adenoid hypertrophy (AH) is one of the possible causes of chronic inflammation in the middle ear. It has been suggested that CX3CL1 and its specific receptor (CX3CR1) could be related with the pathogenesis of some inflammatory diseases. The aim of the present study was to evaluate the role of CX3CL1 and CX3CR1 in the pathogenesis of AH with chronic otitis media with effusion (COME) in children. Materials and methods Adenoid tissue samples were obtained from 91 pediatric patients and divided into two groups: adenoidectomy only for AH (n: 47) and adenoidectomy in conjunction with ventilation tube insertion for AH + COME (n: 44). Expression levels of CX3CL1 and CX3CR1 genes were compared. Results Expression levels of CX3CL1 and CX3CR1 in hypertrophic adenoid tissue were not significantly different between the AH + COME and AH only groups. Although no significant difference was detected in the expression of CX3CL1 in the adenoid samples, the expression of CX3CR1 was higher in children older than 48 months. Conclusions When allergy, atopy and chronic adenoiditis does not exist to obstructive adenoid hypertrophy, inflammatory fractalkine chemokine expression levels in adenoid tissue was not observed to be increased in children with COME.

scholarly journals Chronic Otitis Media with Effusion in Chronic Sinusitis with Polyps

2018 ◽  
Vol 97 (8) ◽  
pp. E13-E18 ◽  
Author(s):  
Mary Daval ◽  
Hervé Picard ◽  
Emilie Bequignon ◽  
Philippe Bedbeder ◽  
André Coste ◽  
...  
Keyword(s):  
Otitis Media ◽  
Nasal Polyposis ◽  
Otitis Media With Effusion ◽  
Demographic Data ◽  
Chronic Otitis Media ◽  
Pure Tone Audiometry ◽  
Upper Airway ◽  
Control Group ◽  
Cross Sectional ◽  
Significant Difference

The relationship between otitis media with effusion (OME) and chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unclear. We conducted a cross-sectional study of 80 consecutively presenting patients—42 males and 38 females, aged 15 to 76 years (median: 48)—who were diagnosed with CRSwNP. Our aim was to ascertain the prevalence of OME in CRSwNP patients, to determine whether the severity of CRSwNP affected OME, and to identify risk factors for OME in CRSwNP patients. The severity of CRSwNP was assessed on the basis of nasal symptoms, endoscopic nasal examinations, and Lund-Mackay staging scores. In addition to demographic data, we obtained information on each patient's history of otitis, otoscopic findings, and the results of pure-tone audiometry and tympanometry. We then compared the data between CRSwNP patients with OME (n = 20) and those without (n = 60). In the OME group, a conductive hearing loss was present in 16 patients (80.0%); all patients in the control group had normal hearing. With regard to symptoms, only rhinorrhea appeared to be more common in patients with OME than in those without, although the difference was not statistically significant. We found no significant difference in nasal polyposis grades between the two groups. Also, we found no correlations between the risk of OME and previous surgical treatment, asthma, allergy, aspirin intolerance, aspirin and/or NSAID intolerance, aspirin and/or sulfite intolerance, and aspirin-exacerbated respiratory disease. Based on our findings, we conclude that OME occurs frequently during the evolution of CRSwNP, even when the nasal disease is well controlled. This finding suggests the possible presence, in OME and/or CRSwNP, of a global inflammatory process that involves the epithelium in both the middle ear and upper airway.

Age: An effect modifier of the association between allergic rhinitis and Otitis media with effusion

2015 ◽  
Vol 126 (7) ◽  
pp. 1687-1692 ◽  
Author(s):  
Rachel E. Roditi ◽  
Maria Veling ◽  
Jennifer J. Shin
Keyword(s):  
Allergic Rhinitis ◽  
Otitis Media ◽  
Otitis Media With Effusion ◽  
Effect Modifier

Correlation between severity of migraine attacks and IgE level in peripheral blood

2016 ◽  
Vol 40 (3) ◽  
Author(s):  
Maryam Hassanpour Moghadam ◽  
Hamidreza Ardalani ◽  
Alireza Alehashemi ◽  
Mahboobeh Adami Dehkordi ◽  
Mojtaba Meshkat
Keyword(s):  
Inflammatory Mediators ◽  
Peripheral Blood ◽  
Migraine Headache ◽  
Clinical Symptoms ◽  
Allergic Sensitization ◽  
Allergic Diseases ◽  
University Hospital ◽  
Migraine Headaches ◽  
Treatment And Prevention ◽  
Significant Difference

Abstract: The correlation between allergic diseases and migraine is partially due to a better understanding of inflammatory mediators with vasoactive function that play an important role in these diseases. This study aimed to evaluate the correlation between allergic sensitization and severity of migraine.: This study was carried out on 212 patients who suffered from migraine headache in a university hospital in Mashhad, Iran. All of these patients were evaluated for allergic rhinitis (AR) by measuring the IgE level in peripheral blood and assessing the clinical symptoms of AR. Prevalence of AR in migraine patients and degree of allergic sensitization was assessed in this study.: The prevalence of AR in migraine patients was 78.30%. Total IgE levels in the peripheral blood in migraine patients with AR were found to be significantly (p<0.0001) higher than those without migraines. There was a significant difference between severity of AR (higher level of IgE) and severity of migraine attacks (p<0.0001), but there was not any significant difference between severity of AR and other factors.: We propose that inflammatory mediators play a key role in triggering migraine attacks. Thus, effective treatment of AR in migraine patients plays an important role in treatment and prevention of migraine headaches.

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