Correlation between severity of migraine attacks and IgE level in peripheral blood

2016 ◽  
Vol 40 (3) ◽  
Author(s):  
Maryam Hassanpour Moghadam ◽  
Hamidreza Ardalani ◽  
Alireza Alehashemi ◽  
Mahboobeh Adami Dehkordi ◽  
Mojtaba Meshkat
Keyword(s):  
Inflammatory Mediators ◽  
Peripheral Blood ◽  
Migraine Headache ◽  
Clinical Symptoms ◽  
Allergic Sensitization ◽  
Allergic Diseases ◽  
University Hospital ◽  
Migraine Headaches ◽  
Treatment And Prevention ◽  
Significant Difference

Abstract: The correlation between allergic diseases and migraine is partially due to a better understanding of inflammatory mediators with vasoactive function that play an important role in these diseases. This study aimed to evaluate the correlation between allergic sensitization and severity of migraine.: This study was carried out on 212 patients who suffered from migraine headache in a university hospital in Mashhad, Iran. All of these patients were evaluated for allergic rhinitis (AR) by measuring the IgE level in peripheral blood and assessing the clinical symptoms of AR. Prevalence of AR in migraine patients and degree of allergic sensitization was assessed in this study.: The prevalence of AR in migraine patients was 78.30%. Total IgE levels in the peripheral blood in migraine patients with AR were found to be significantly (p<0.0001) higher than those without migraines. There was a significant difference between severity of AR (higher level of IgE) and severity of migraine attacks (p<0.0001), but there was not any significant difference between severity of AR and other factors.: We propose that inflammatory mediators play a key role in triggering migraine attacks. Thus, effective treatment of AR in migraine patients plays an important role in treatment and prevention of migraine headaches.

Prophylactic Effect of Memantine on Chronic Migraine Headache

2019 ◽  
Vol 16 (12) ◽  
pp. 5327-5331
Author(s):  
Davood Kashipazha ◽  
Sahereh Emadi
Keyword(s):  
Chronic Migraine ◽  
Migraine Headache ◽  
Migraine Treatment ◽  
Prophylactic Effect ◽  
Migraine Headaches ◽  
Treatment And Prevention ◽  
Significant Difference ◽  
High Prevalence ◽  
The Mean

Given the high prevalence of migraine treatment failure and resistance to existing drugs and side effects of drugs, finding alternative therapies for refractory patients or chronic migraine is essential. Fifty four patients with migraine headaches were stochastic classified to the 2 groups: placebo and memantine. In first one, memantine is managed at a dose of 20 mg in a day, that enhanced 4 weeks to this dose, and in second group placebo was given. The severity, duration, incapacity, and frequency of migraine headache attacks were recorded at the starting of the research, and the end of first, second, third and fourth months of the study. The mean of VAS score did not have a significant difference at the beginning of the study and at the end of the first month, however here was a significant decrease in the memantine group, during the end of second, third and fourth. After 4 months of behaving, MIDAS score were 22.44±10.62 in the memantine group, when in the placebo group, this was 14.47±1.79 (p <0.0001). The outcomes shows the role of memantine on the treatment and prevention of chronic migraine headaches. In addition, the migraine headaches incidence is mainly decreased in the memantine group in comparison to placebo at the end of the research.

scholarly journals Effect of Local versus Systemic Steroids in Treatment of Children with Otitis Media with Effusion

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A G Shafik ◽  
M S Hassabalah ◽  
A M Maarouf ◽  
M K Elghobashy
Keyword(s):  
Allergic Rhinitis ◽  
Otitis Media ◽  
Clinical Symptoms ◽  
Otitis Media With Effusion ◽  
University Hospital ◽  
Adjunctive Treatment ◽  
Oral Steroid ◽  
Adenoid Hypertrophy ◽  
Systemic Steroids ◽  
Significant Difference

Abstract Background otitis media with effusion (OME) or glue ear is the collection of fluid behind the tympanic membrane without inflammatory signs present for 6 weeks. Aim of the Work comparing the effect of intra nasal versus systemic steroids in treatment of children with Otitis media with effusion as regard: Improvement of clinical symptoms and Audiological findings. Subjects and Methods this study is a prospective, case control study on the effects of intranasal versus systemic steroids on children with otitis media with effusion. This thesis study was conducted on 30 patients diagnosed according to clinical and audiological assessment recruited from otorhinolaryngology outpatient clinic Ain Shams university hospital from October 2017 to July 2018. An informed consent was obtained from each patient or control or their legal guardians before enrolment in the study. Results however, statistically there is no significant relation between the occurrence of complete resolution of OME and the route of administration of steroid (either intranasal or systemic), whatever the cause either allergic rhinitis or adenoid hypertrophy. So we can use either intranasal or systemic steroids in management of otitis media with effusion in children with either allergic rhinitis or adenoid hypertrophy or both. Conclusion both topical intranasal and oral steroids are effective adjunctive treatment for OME in children in the short term, without significant difference between the two methods, and thus oral steroid complications could be avoided using local steroid spray.

Excellent Long-Term Survival of Patients with Waldenström‘s Macroglobulinemia (WM) treated in Private Oncology Practices and a University hospital with different Treatment Strategies

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 2671-2671
Author(s):  
Manfred Hensel ◽  
Jürgen Brust ◽  
Christoph Plöger ◽  
Dieter Schuster ◽  
Marie-Luise Memmer ◽  
...  
Keyword(s):  
Overall Survival ◽  
Research Funding ◽  
Standard Treatment ◽  
Clinical Symptoms ◽  
B Cell Lymphoma ◽  
Immunoglobulin M ◽  
University Hospital ◽  
Term Survival ◽  
Significant Difference ◽  
Time To First Treatment

Abstract Abstract 2671 Background: WM is a rare type of malignant B-cell lymphoma, defined as a lymphoplasmocytic lymphoma in bone marrow and a monoclonal gammopathy of immunoglobulin-M (IgM) type. Due to the paucity of large clinical trials, a standard treatment regimen is still controversial. The purpose of this study was to compare the standard treatment and outcome of patients (pts) treated in private oncology practices (PP) and a university hospital (UH) in a region of southern Germany (Nordbaden). Methods: We retrospectively reviewed the charts of all pts with WM of the last 2 decades of 4 PP in Mannheim, Heidelberg, Karlsruhe and Speyer and the department of hematology of the University of Heidelberg. Results: 170 patients with WM could be identified, 74 from PP, 96 from the UH. The median age of the 170 pts was 63.3 years (range 29.1–88.5). The clinical symptoms were splenomegaly in 21.2%, hyperviscosity in 15.9%, lymphadenopathy in 15.9%, and polyneuropathy in 11.2%. 12.9% had a previous phase of IgM-MGUS. Pts from PP were older (median 65.3 vs. 62.5, p=0.01). Mean hemoglobine level at diagnosis was lower in pts from UH (11.4 vs. 12.2, p=0.04). There was no significant difference in mean platelet count, IgM and ß2-microglobuline level at diagnosis. 54% of pts from PP have received treatment during the observation time, as compared to 78.1% of the UH (p<0.001). The most common first line treatment protocols of PP were Chlorambucil (17/40, 42.5%), Bendamustin (17.5%) and Rituximab(R)-Bendamustin (17.5%). The UH most commonly administered R-Pentostatin-Cyclophosphamide (28%), Chlorambucil (17.3%) and COP (16%). 35% of the treated pts of PP have received R, as compared to 62.6% of the pts of the UH (p<0.001). 60% of the treated pts of PP have received Bendamustin, as compared to 8% of the pts of the UH (p<0.001). The time to first treatment was significantly shorter in pts from the UH (median 13.7 mo.) as compared to PP (52.9 mo.) (p=0.05). Median overall survival of all pts was 25.0 yrs and did not differ between PP and UH. Conclusion: Pts with WM treated in PP were older and had higher initial hemoglobin levels as compared to pts from the UH. Treatment differs significantly between PP and UH. Time to first treatment was significantly shorter in pts from UH. Overall survival was excellent, and better than reported previously. Disclosures: Hensel: Roche: Honoraria, Research Funding; Mundipharma: Research Funding.

scholarly journals Effect of Traditional Chinese Medicine on Inflammatory Mediators in Pediatric Asthma

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Hui Du ◽  
Yonghong Wang ◽  
Yumin Shi ◽  
Jian Yu ◽  
Wen Sun ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Mrna Expression ◽  
Inflammatory Mediators ◽  
Peripheral Blood ◽  
Transforming Growth Factor ◽  
Pediatric Asthma ◽  
Enzyme Linked Immunosorbent Assay ◽  
Significant Difference ◽  
Before And After

Objective. To observe the effects of empirical prescriptions of traditional Chinese medicine (TCM) on inflammatory mediators in pediatric asthma and to explore the underlying molecular mechanism in the treatment of asthma.Methods. A total of 182 children with asthma were randomly placed into either the TCM group (n=97) or the salbutamol and montelukast (SM) group (n=85). Patients in the TCM group were treated with a series of empirical prescriptions of TCM, while those in the SM group received salbutamol and montelukast. Both groups received their respective treatment for 12 weeks. There were 35 patients in TCM group and 34 patients in SM group providing venous blood. Real-time PCR was used to determine the mRNA expression levels of interleukin- (IL-) 10, IL-17, matrix metalloproteinase-9 (MMP-9), and transforming growth factorβ1 (TGF-β1) in peripheral blood mononuclear cells before and after treatment. Enzyme-linked immunosorbent assay was used to measure the levels of IL-10, IL-17, MMP-9, and TGF-β1 in peripheral blood before and after treatment.Results. The mRNA expression of TGF-β1 in the SM group was downregulated (P=0.00) after treatment. No significant differences were found between the TCM group and the SM group after treatment (P>0.05). In the TCM group, the levels of IL-10, IL-17, and MMP-9 significantly decreased after treatment (P=0.01, 0.04, and 0.03, resp.). In the SM group, IL-17, MMP-9, and TGF-β1 levels significantly decreased after treatment (P=0.00, 0.03, and 0.00, resp.). There was no significant difference between the two groups regarding the levels of IL-10, IL-17, TGF-β1, and MMP-9 (P>0.05). The difference of the level of IL-17 was negatively correlated with the change of C-ACT score in TCM group and SM group.Conclusion. TCM has a regulatory effect on the balance of some inflammatory mediators in pediatric asthma.

scholarly journals Human rhinoviruses, allergy, and asthma: a clinical approach

Medicina ◽  
2009 ◽  
Vol 45 (11) ◽  
pp. 839 ◽  
Author(s):  
Regina Ėmužytė ◽  
Regina Firantienė ◽  
Rasa Petraitytė ◽  
Kęstutis Sasnauskas
Keyword(s):  
Viral Infections ◽  
Allergic Sensitization ◽  
Allergic Diseases ◽  
Allergen Exposure ◽  
Human Rhinovirus ◽  
Atopic Asthma ◽  
Immune Stimulation ◽  
Treatment And Prevention ◽  
Asthma Exacerbations ◽  
Allergy And Asthma

The prevalence of allergic diseases is increasing in Lithuania as in the world. The prevalence of allergic sensitization is often higher than 50% of the population. The “hygiene hypothesis” proposed that reduced immune-stimulation by infections may have resulted in the more widespread clinical expression of atopic disease. However, it alone does not provide an adequate explanation for the observed increase of allergic diseases. Human rhinovirus infections are the major infections with a worldwide distribution. Viral infections of the respiratory tract are the most common triggers of acute asthma exacerbations. These exacerbations are poorly responsive to current asthma therapies and new approaches to therapy are needed. The aim of this review is to present the current knowledge and clinical implications of human rhinovirus infection in allergy and asthma development and needs for further research. Recent evidence has shown that the immune responses to human rhinoviruses differ between asthmatic and nonasthmatic subjects. Novel insights into the mechanisms of virus-induced asthma exacerbations support the possibility that viral infections may be involved in the epithelial cells damage, inflammation, and airway hyperresponsiveness as well as in profibrotic response and induction of airway remodeling. The data of original investigations support the concept that the immune stimulation by rhinovirus infections contributes to the development of asthma, when an atopic host is infected with human rhinoviruses. Early rhinoviral wheezing is the predictor of subsequent asthma development in high-risk children. Synergistic effect of allergic sensitization, allergen exposure, and viral infection was suggested in the increased risk of hospitalization for asthma in both children and adults. Timing of allergen exposure may be important in a synergistic outcome. The increased susceptibility to rhinovirus infections was identified in atopic asthma. This review also presents the current options on the treatment and prevention of virus-induced asthma. Further studies are needed in order to differentiate between the response to viruses of healthy and atopic or nonatopic asthmatic children and adults. New research data may lead to novel strategies in treatment and prevention of asthma exacerbations as well as prevention of asthma induction

scholarly journals It's Fournier's gangrene still dangerous?

2009 ◽  
Vol 56 (1) ◽  
pp. 77-80
Author(s):  
S. Bilali ◽  
E. Celiku ◽  
V. Bilali
Keyword(s):  
Clinical Symptoms ◽  
Early Recognition ◽  
Fournier’S Gangrene ◽  
University Hospital ◽  
Prognostic Indicators ◽  
Fournier's Gangrene ◽  
Significant Difference ◽  
Radical Debridement ◽  
Aggressive Debridement ◽  
The University

Background: Fournier's gangrene is known to have an impact in the morbidity and despite antibiotics and aggressive debridement, the mortality rate remains high. Objectives: To assess the morbidity and mortality in the treatment of Fournier's gangrene in our experience. Methods: The medical records of 14 patients with Fournier's gangrene who presented at the University Hospital Center 'Mother Teresa' from January 1997 to December 2006 were reviewed retrospectively to analyze the outcome and identify the risk factor and prognostic indicators of mortality. Results: Of the 14 patients, 5 died and 9 survived. Mean age was 54 years (range from 41-61): it was 53 years in the group of survivors and 62 years in deceased group. There was a significant difference in leukocyte count between patients who survived (range 4900-17000/mm3) and those died (range 20.300- 31000/mm3). Mean hospital stay was about 19 days (range 2-57 days). Conclusion: The interval from the onset of clinical symptoms to the initial surgical intervention seems to be the most important prognostic factor with a significant impact on outcome. Despite extensive therapeutic efforts, Fournier's gangrene remains a surgical emergency and early recognition with prompt radical debridement is the mainstays of management.

Association between Childhood Allergic Diseases and Headache

2020 ◽  
Author(s):  
Sudarat Charoensanti ◽  
Suwannee Uthaisangsook ◽  
Nadda Padsee ◽  
Klaita Srisingh
Keyword(s):  
Allergic Diseases ◽  
University Hospital ◽  
Control Group ◽  
Predisposing Factor ◽  
Migraine Headaches ◽  
Allergic Symptoms ◽  
Student’S T ◽  
Headache Symptom ◽  
Allergic Disorders

AbstractAllergic disorders and headache are both common in pediatric populations. Chronic allergic disorders may affect sleep leading to chronic daily headaches. Poor controlled allergies may cause neurogenic inflammation that may be a predisposing factor to migraine headaches. We hypothesized that a higher prevalence of headaches may be found in children with allergy compared with those without allergy. Patients with either multiple allergic disorders or with poorly controlled allergic symptoms may be associated with headaches, especially migraine headaches. This study aimed to examine (1) the prevalence of headache in allergic children and (2) the association between allergic diseases and headache. Patients with allergic diseases and nonallergic children as control were recruited in the pediatric outpatient clinic of Naresuan University Hospital between January 2017 and January 2018. A neurological examination was performed by a pediatric neurologist. The questionnaire consisted of the pediatric headache symptom checklist and the items for evaluation of allergy control status. The diagnosis and classification of headache were based on the International Classification of Headache Disorders-3 criteria. The results were analyzed using the Student's t-test, chi-squared tests, odds ratios, and 95% confidence interval. One hundred fifty-five subjects were enrolled in our study, of which 85 subjects (54.8%) were diagnosed with allergic diseases. The allergic group had a significantly higher prevalence of headache than the control group (37 [43.5%] vs. 19 [27.1%], p = 0.035). The allergic group also had a significantly higher prevalence of migraine and probable migraine headache than the control group (23 [27.06%] vs. 7 [10%], p = 0.007). The prevalence of headache did not increase in subjects who had more than one allergic disease. There was no association between the control of allergy and headache. The present study showed that allergic diseases were associated with increased prevalence of headache and migraine in children. However, the control of allergic symptoms and the number of allergic diseases were not associated with headache. The physicians should be aware of headache in allergic patients and give appropriate treatment. Further study would be to identify specific biomarkers for the development of better treatment in these comorbid diseases.

scholarly journals Neonatal Outcomes of Pregnant Women With Confirmed Coronavirus Disease 2019: One-Year Experience of a Tertiary Care Center

2021 ◽  
pp. 000992282110598
Author(s):  
Nuriye Asli Melekoglu ◽  
Halis Ozdemir ◽  
Seyma Yasar
Keyword(s):  
Pregnant Women ◽  
Clinical Symptoms ◽  
Care Center ◽  
Tertiary Care ◽  
Public Health Problem ◽  
University Hospital ◽  
Arterial Oxygen ◽  
Important Public Health Problem ◽  
Positive Polymerase Chain Reaction ◽  
Significant Difference

The coronavirus disease 2019 (COVID-19) pandemic became an important public health problem affecting all age groups. The aim of this study was to evaluate clinical and laboratory findings of newborns born to mothers with COVID-19. Thirty pregnant women with COVID-19 were admitted to Turgut Ozal University Hospital for delivery. Fourteen pregnant women had at least one symptom associated with COVID-19. Positive polymerase chain reaction (PCR) results were seen in only 3 (9.7%) of 31 newborns. A statistically significant difference was observed between PCR-positive and PCR-negative newborns in terms of any adverse pregnancy outcomes. Neonatal lymphocyte count and partial arterial oxygen pressure were significantly lower in the PCR-positive group. Results were also compared according to the interval from the maternal diagnosis time to delivery. Hemoglobin and hematocrit levels in newborns born to mothers diagnosed more than 7 days before delivery were significantly lower. Neonates born to mothers with COVID-19 had mild clinical symptoms and favorable outcomes.

scholarly journals Can Leech Therapy Be Used as an Alternative Treatment for Controlling Migraine Headache? A Pilot Study / Da li lečenje pijavicama može da se primenjuje kao alternativni način lečenja u kontroli migrenoznih glavobolja? Pilot studija

2015 ◽  
Vol 32 (3) ◽  
pp. 189-197 ◽  
Author(s):  
Mahmoud Bakhshi ◽  
Babak Jalalian ◽  
Maryam Valian ◽  
Saeide Shariati ◽  
Tahere Saeidi ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Pilot Study ◽  
Migraine Headache ◽  
Symptomatic Relief ◽  
Preventive Therapy ◽  
Single Session ◽  
Migraine Headaches ◽  
Leech Therapy ◽  
Significant Difference ◽  
Quasi Experimental

Abstract Leech therapy is likely to cause symptomatic relief in migraine headache sufferers, but there is little clinical data in this field. This study aimed to investigate the effectiveness of leech therapy in the management of migraine headaches. This is a quasi-experimental pilot study with a three-month post-treatment follow-up. Twenty-six patients with migraine headaches were allocated into two groups to receive either routine drug therapy (Propranolol 80 mg/day and Amytriptyline 50 mg/day) as preventive therapy or leech therapy (1-3 leeches in a single session). The severity and duration of headache were measured before intervention, as well as at week 1, and at months 1, 2, and 3 after intervention. The visual analog scale (VAS) was used to assess the severity of headache. The mean severity and duration of headaches were significantly decreased within both groups during the study period, whereas there was no significant difference between the groups after three months. The declining trend of severity and duration of headaches was seen to be highly significant in the first week of the treatment in both groups. The results of this study showed that a single session of leech therapy offers benefits equal to drug therapy in reducing pain in women with migraine headache, and can provide great symptomatic relief, lasting for at least three months.

Potential Role of Cytokines in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis

2011 ◽  
Vol 11 (1) ◽  
pp. 130-133
Author(s):  
Astra Zviedre ◽  
Arnis Engelis ◽  
Mohit Kakar ◽  
Aigars Pētersons
Keyword(s):  
Early Detection ◽  
Acute Appendicitis ◽  
Inflammatory Mediators ◽  
Potential Role ◽  
Clinical Symptoms ◽  
Future Research ◽  
Mesenteric Lymphadenitis ◽  
Proper Diagnosis ◽  
Near Future

Potential Role of Cytokines in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis Although, AAP and AML have different etiological factors, clinical symptoms are very much similar but treatment tactics in both the disease differ a lot. In case of AML, treatment is more conservative and does not require hospitalization while in case of AAP immediate hospitalization and maybe further surgery can be mandatory. With the identification of group of cytokines serum inflammatory mediators IL-8, IL-10, IL-12[p70], IL-17, TNF-a and MCP-1, it is believed early and proper diagnosis of AAP in the near future. Research of cytokines-serum inflammatory mediators has opened new opportunities for an early detection and differentiation of these two diseases in children.

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