Oral Lactoferrin versus Ferrous Sulfate for the Treatment of Iron Deficiency Anemia during Second Trimester among Egyptian ladies

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Karam M Bayoumy ◽  
Nermeen A. M Elghareeb ◽  
Samar G Ragab
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Ferrous Sulfate ◽  
Public Health Problem ◽  
Sulfate Group ◽  
Deficiency Anemia ◽  
Major Public Health Problem ◽  
Second Trimester ◽  
Once Daily ◽  
Before And After

Abstract Background Iron deficiency anemia (IDA) is a major public health problem in Egypt, especially among pregnant women. The most commonly used treatment is oral administration of iron as ferrous sulfate which often fails to exert significant effects with many adverse effects. Lactoferrin is a glycoprotein which belongs to proteins capable of binding and transferring iron. This study was done to evaluate the effectiveness, safety and acceptability of lactoferrin in comparison to ferrous sulfate. Methods This randomized clinical trial was conducted in outpatient clinic under supervision of department of Obstetrics and Gynecology, Faculty of medicine, Ain Shams University, Cairo, Egypt from August 2019 to February 2020. 140 women with iron deficiency anemia in second trimester were recruited and randomly assigned to either group. First group received lactoferrin 200 mg sachets once daily and second group received 100 mg of dried ferrous sulfate capsules twice daily for 4 consecutive weeks. Hemoglobin, hematocrit levels, mean corpuscular volume, and serum ferritin were assessed before and after therapy. Results The increase in haemoglobin was significantly higher in lactoferrin group. Number of cases achieved Hb level ≥10.5 was significantly more frequent in lactoferrin group. Compliance was significantly more frequent in lactoferrin group than in ferrous sulfate group. Maternal side effects were significantly less frequent in lactoferrin group than in ferrous sulfate group. Conclusion Oral lactoferrin is well tolerated and effective as compared to traditional treatment by ferrous sulfate.

scholarly journals A Life Course Approach to the Prevention of Iron Deficiency Anemia in Indonesia

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 277
Author(s):  
Ali Sungkar ◽  
Saptawati Bardosono ◽  
Rima Irwinda ◽  
Nurul R. M. Manikam ◽  
Rini Sekartini ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Life Stage ◽  
Public Health Problem ◽  
Nutritional Intervention ◽  
Deficiency Anemia ◽  
Clinical Psychologist ◽  
Major Public Health Problem ◽  
Nutritional Interventions ◽  
Long Term Impact

Iron deficiency anemia (IDA) has a long-term impact on each life stage and remains worldwide a major public health problem. Eleven experts were invited to participate in a virtual meeting to discuss the present situation and the available intervention to prevent iron deficiency anemia in Indonesia. The experts consisted of obstetric gynecologists, pediatricians, nutritionists, midwives, a clinical psychologist, and an education expert. Existing interventions focus attention on preconception and early childhood stages. Considering the inter-generational effects of IDA, we call attention to expanding strategies to all life stages through integrating political, educational, and nutritional interventions. The experts agreed that health education and nutritional intervention should be started since adolescence. Further research to explore the effectiveness of these interventions would be important for many regions in the world. The outcome of this Indonesian consensus is applicable worldwide.

scholarly journals Urinary schistosomiasis and iron deficiency anemia among Malian school children

2009 ◽  
Vol 9 (30) ◽  
pp. 1845-1858
Author(s):  
Mohamed Ayoya ◽  
◽  
KM Koné ◽  
AK Traoré ◽  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
School Children ◽  
Schistosoma Haematobium ◽  
Public Health Problem ◽  
Capital City ◽  
Deficiency Anemia ◽  
Sample Population ◽  
Major Public Health Problem ◽  
Urinary Schistosomiasis

Anemia continues to be a major public health problem in many countries. The prevalence and intensity of urinary schistosomiasis, which contributes to anemia, often peak at school age adding to that age group’s nutrition and disease burdens. However, unlike malaria and hookworm infections, little is known on the role of urinary schistosomiasis in iron deficiency anemia. The objective of this study was to assess the prevalence of iron deficiency anemia and the effect of iron supplementation on hemoglobin (Hb) and serum ferritin (SF) levels among school children infected with Schistosoma haematobium in Bamako, the capital city of Mali. A total of 150 anemic school children between 7 and 12 years were randomly assigned to receive either 40mg/kg of praziquantel or 40mg/kg of praziquantel (P) + daily 66 mg of iron (Fe), five days a week for three months. Hb and SF were measured at baseline and at 6 and 12 weeks of the intervention. Only children who had complete Hb and SF data at each stage of the trial were included in the statistical analyses (n = 74 in the P+Fe group; n = 66 in the P group). At baseline, mean Hb (g/dl) was 10.53±0.93 in the P group and 10.47±1.17 in the Fe+P group; mean SF (µg/l) was 34.39±37.58 in the P group and 29.82±23.34 in the Fe+P group, and the prevalence of iron deficiency was 17.2%. At 6 and 12 weeks of the intervention, there was an important reduction in anemia and in iron deficiency in both treatment groups. Mean Hb (g/dl) was higher in the Fe+P group (11.63±0.88 and 11.55±0.94) than in the P group (11.14±0.98 and 10.84±0.86) at 6 and 12 weeks, respectively. Mean SF (µg/l) was also higher in the P+Fe group (74.26±40 and 100.29±53.92) than in the P group(40.65±35.63 and 40.70±29.57) at 6 and 12 weeks, respectively. In these Schistosoma haematobium infected children, iron deficiency was prevalent and treatments with P alone or in combination with Fe supplementation were able to increase hemoglobin and iron stores. Neither P nor P+Fe by alone completely reversed anemia in this sample population.

scholarly journals Catfish Oil (Pangasius hypophthalmus) effect to ferritin and sTfR in iron deficiency anemia

2021 ◽  
Vol 10 (1) ◽  
pp. 28-35
Author(s):  
Hersanti Sulistyaningrum ◽  
Fronthea Swastawati ◽  
Maria Mexitalia ◽  
Etika Ratna Noer
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Ferrous Sulfate ◽  
Wistar Rats ◽  
Heme Iron ◽  
Deficiency Anemia ◽  
Significant Difference ◽  
Before And After ◽  
Male Wistar Rats ◽  
Catfish Oil

Background: Iron deficiency anemia is a micronutrient problem and the prevalence is still high. Catfish oil (Pangasius hypophthalmus) is a natural source of heme iron which can improve body iron levels.Objectives: This study was aimed to examine and analyze the effect of catfish oil on ferritin and sTfR levels in male wistar rats with iron deficiency anemia models.Materials and Methods: This study was conducted on male wistar rats which were divided into groups C- (standard feed), C+ (standard feed but had the iron removed), X1 (standard feed without iron but was supplemented with catfish oil), X2 (standard feed without iron but was supplemented with ferrous sulfate) for 14 days. Ferritin and sTfR levels were measured before and after intervention using ELISA.Results: The study showed an increase ferritin levels in X1 (21.87 ng/ml ±0.76), X2 (24.47 ng/ml ±0.54) and there was no significant difference between the two (p=0.069; p>0.05); a decrease in C- (0.25 ng/ml ±0.43), C+ (0.32 ng/ml ±0.059) (p=0.00; p<0.05). The sTfR levels decreased before and after intervention (p=0.00; p<0.05) in C+ (0.24 μ/mL ±0.99), X1 (60.66 μ/mL ±0.29), X2 (62.10 μ/mL ±0.90) and increased in C- (0.40 μ/mL ±0.97).Conclusions: The study indicates ferritin levels increased in the rats receiving catfish oil is not different from the rats that received ferrous sulfate and sTfR levels decreased significantly in wistar rats with iron deficiency anemia receiving catfish oil although the results were not as good as ferrous sulfate supplementation

scholarly journals Prevalence of Iron Deficiency Anemia among University Students in Hodeida Province, Yemen

Anemia ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Abdullah Ahmed Al-alimi ◽  
Salem Bashanfer ◽  
Mohammed Abdo Morish
Keyword(s):  
Iron Deficiency ◽  
University Students ◽  
Iron Deficiency Anemia ◽  
Binding Capacity ◽  
Harmful Effect ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
Deficiency Anemia ◽  
Major Public Health Problem ◽  
Cross Sectional

Background. Iron deficiency anemia (IDA) is one of the most common types of nutritional anemia in the worldwide and considered a major public health problem in developing countries especially in Yemen. Therefore, this cross-sectional study was conducted to determine the prevalence and risk factors of IDA among apparently healthy Yemeni students at Hodeida University. Method. Five hundred blood samples (326 males and 174 females) were collected randomly from medical students at Hodeida University. Participants were subjected to different tests including complete blood counts (CBC), serum ferritin (SF), serum iron (SI), and total iron binding capacity (TIBC). Moreover, a questionnaire was designed to collect demographics, food and drink habits, and socioeconomic status. Result. The overall prevalence of IDA was 30.4%  (n=152), of whom 54.00% were females (n=82) and 46.0% were males (n=70). Students aged 20–22 years were found more anemic with prevalence 59.2% than students aged 17–19 years (25.0%) and 23–25 years (15.8%). Statistical analysis showed regularly having breakfast had significant (p < 0.001) role in preventing development of IDA compared with irregularly having breakfast. Infrequent consumption of vegetables/fruits; meat, fish, chicken; tea drinking; low household income; smoking and khat (Catha edulis) chewing showed a significant role (p < 0.001) in provoking of IDA, whereas consumption of coffee and cola showed insignificant influence (p=0.585; p=0.513) on IDA. Conclusion. This study revealed that the majority of university students, especially females, have IDA that might become worse by malnutrition, lifestyle habits, and lack of awareness. Our results suggest that IDA can be prevented by providing proper knowledge on the healthful diet, improved lifestyle, and harmful effect of IDA to the students.

scholarly journals Efficacy, Tolerability, and Acceptability of Iron Hydroxide Polymaltose Complex versus Ferrous Sulfate: A Randomized Trial in Pediatric Patients with Iron Deficiency Anemia

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Beril Yasa ◽  
Leyla Agaoglu ◽  
Emin Unuvar
Keyword(s):  
Iron Deficiency ◽  
Adverse Events ◽  
Iron Deficiency Anemia ◽  
Ferrous Sulfate ◽  
Iron Hydroxide ◽  
Similar Efficacy ◽  
Deficiency Anemia ◽  
Open Label ◽  
Once Daily ◽  
Gastrointestinal Adverse Events

Iron polymaltose complex (IPC) offers similar efficacy with superior tolerability to ferrous sulfate in adults, but randomized trials in children are rare. In a prospective, open-label, 4-month study, 103 children aged >6 months with iron deficiency anemia (IDA) were randomized to IPC once daily or ferrous sulfate twice daily, (both 5 mg iron/kg/day). Mean increases in Hb to months 1 and 4 with IPC were1.2±0.9 g/dL and2.3±1.3 g/dL, respectively, (bothP=0.001versus baseline) and1.8±1.7 g/dL and3.0±2.3 g/dL with ferrous sulfate (bothP=0.001versus baseline) (n.s. between groups). Gastrointestinal adverse events occurred in 26.9% and 50.9% of IPC and ferrous sulfate patients, respectively (P=0.012). Mean acceptability score at month 4 was superior with IPC versus ferrous sulfate (1.63±0.56versus2.14±0.75,P=0.001). Efficacy was comparable with IPC and ferrous sulfate over a four-month period in children with IDA, but IPC was associated with fewer gastrointestinal adverse events and better treatment acceptability.

scholarly journals A Study to Assess the Knowledge on Iron Deficiency Anemia among Reproductive Age Group (20-45 Year) Women in Selected Rural Area of Lucknow

2021 ◽  
Vol 01 (01) ◽  
pp. 24-28
Author(s):  
Laxmi Shukla ◽  
◽  
Dimpal Singh ◽  
Ranjeet Kumar ◽  
Sabiya Khatoon ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Public Health Problem ◽  
Reproductive Age ◽  
Deficiency Anemia ◽  
Major Public Health Problem ◽  
Age Group ◽  
Mortality And Morbidity ◽  
Level Of Knowledge ◽  
Reproductive Age Group

Background of the study: Anemia continues to be a major public health problem in developing countries including India. It is the most common cause of malnutrition in the world and is the eighth leading cause of diseases in girls and women in developing counties. About one third of the global population is anemic (WHO 2010) [1]. Knowledge regarding the causes, prevention and management of iron deficiency among reproductive age women plays an important role in reducing the mortality and morbidity rates. The aim of this study is to assess the knowledge regarding iron deficiency anemia among reproductive age group women. Methodology: By using descriptive survey design, 50 women who met the criteria were selected by purposive sampling technique. Structured questionnaire was used to gather the data Data were analyzed by descriptive and inferential statistics. Results: Findings shows that 6% of reproductive age group women had inadequate level of knowledge regarding anemia, 72% had moderate level of knowledge and 22% of them had adequate level of knowledge. Conclusion: Overall findings of this study revealed that knowledge on iron deficiency anemia was inadequate among reproductive age group women. There is a need to improve the health care services, facilities and more importantly knowledge among the women on topics related to anemia and its prevention.

scholarly journals Prophylaxis for iron deficiency anemia using ferrous sulfate among infants followed up at a primary healthcare unit in the municipality of Embu-SP (2003/2004)

2008 ◽  
Vol 126 (2) ◽  
pp. 96-101 ◽  
Author(s):  
André Fernando Shibukawa ◽  
Edina Mariko Koga da Silva ◽  
Wilson André Ichiki ◽  
Maria Wany Louzada Strufaldi ◽  
Rosana Fiorini Puccini
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Primary Healthcare ◽  
Ferrous Sulfate ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
Deficiency Anemia ◽  
Important Public Health Problem ◽  
Cross Sectional ◽  
Prevalence Of Anemia

CONTEXT AND OBJECTIVE: Iron deficiency anemia is an important public health problem in Brazil. In the municipality of Embu, a population study in 1996 found anemia prevalence of 68.5% among children aged one to two years. From these data, prescription of prophylactic ferrous sulfate was instituted in 1998 for children under two years old followed up within the children's healthcare program. After five years of intervention, the prevalence of anemia and associated factors were investigated among children aged 12 to 18 months to whom guidance for prophylactic ferrous sulfate use had been given. DESIGN AND SETTING: Cross-sectional study covering October 2003 to June 2004 at a primary healthcare unit in Embu. METHODS: A randomized sample of children aged 12 to 18 months to whom guidance for prophylactic ferrous sulfate use had been given was obtained. Hemoglobin was measured in capillary blood, using HemoCue® apparatus. Hemoglobin < 11 g/100 dl was taken to indicate anemia. RESULTS: The sample comprised 118 children and anemia was found in 41.5%. There was no statistically significant association between anemia presence and the variables of sex, birth weight, neonatal intercurrences, chronic diseases, breastfeeding or iron supplementation use. There was a statistically significant association (p = 0.03) between anemia presence and per capita income, such that the higher the income was, the lower the prevalence of anemia was. CONCLUSION: The prophylaxis program against iron deficiency anemia did not achieve the expected results. New strategies must be considered in the light of the magnitude of the problem.

scholarly journals Lactoferrin Efficacy versus Ferrous Sulfate in Treatment of Children with Iron Deficiency Anemia

2021 ◽  
Vol 11 (01) ◽  
pp. e199-e204
Author(s):  
Osama Mahmoud El-Asheer ◽  
Ahmed Gaber Ahmed ◽  
Zainab AbdelAal Abdel Hafez ◽  
Marwa AbdelHafiz Dahpy ◽  
Amal AbdElSalam Soliman
Keyword(s):  
Side Effects ◽  
Iron Deficiency ◽  
Patient Compliance ◽  
Iron Deficiency Anemia ◽  
Ferrous Sulfate ◽  
Serum Iron ◽  
Deficiency Anemia ◽  
Serum Transferrin ◽  
Iron Binding ◽  
Clinical Benefits

AbstractLactoferrin (LF) is an iron-binding globular glycoprotein that is structurally and chemically similar to serum transferrin. Many studies have been done to evaluate the effect of oral LF administration on iron deficiency anemia (IDA) with controversial results. This study was designed to compare the efficacy of LF versus oral ferrous sulfate (OFS) therapy in the treatment of children with IDA. A significant increase in mean hemoglobin and serum iron concentrations was noted in the group that received oral bovine LF (11.06 ± 0.96 and 42.79 ± 6.14, respectively) versus the group that received OFS (10.24 ± 0.57 and 28.94 ± 5.05, respectively, with p < 0.001 for each) after 30 days of the treatment with fewer side effects (9.3 vs. 33.3% with p = 0.043). Oral bovine LF is a more effective and safer alternative in treating iron deficiency and IDA compared with OFS with clinical benefits of fewer side effects and better patient compliance.

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