Intensity of spinal inflammation is associated with radiological structural damage in patients with active axial spondyloarthritis

Abstract Objective The aim was to investigate the relationship between the intensity of spinal inflammation using the apparent diffusion coefficient (ADC) and radiographic progression in axial SpA. Methods This is a cross-sectional study of participants with axial SpA and back pain. Clinical, biochemical and radiological parameters were collected. The ankylosing spondylitis disease activity score (ASDAS)-CRP was determined. Radiographic progression was represented by the modified Stoke ankylosing spondylitis spine score (mSASSS). MRI with short tau inversion recovery (STIR) and diffusion-weighted imaging sequences were performed simultaneously. Inflammatory lesions on STIR were used for the Spondyloarthritis Research Consortium of Canada (SPARCC) MRI indexes and as references in outlining regions of interest in ADC maps to produce mean (ADCmean) and maximal (ADCmax) ADC values. Univariate and multivariate linear regression analyses were used to determine independent associations between ADC and radiographic progression. Results The 84 participants with identifiable lesions on spinal ADC maps recruited were characterized by a mean (s.d.) age of 45.01 (13.68) years, long disease duration [13.40 (11.01) years] and moderate clinical disease activity [ASDAS-CRP 2.07 (0.83)]. Multivariate regression analysis using ADCmean as the independent variable showed that age (regression coefficient [B] = 0.34; P = 0.01), male sex (B = 0.25; P = 0.04) and ADCmean (B = 0.30; P = 0.01) were positively associated with mSASSS. Multivariate regression analysis using ADCmax as the independent variable showed a tendency for ADCmax to be associated with mSASSS (B = 0.21; P = 0.07). Conclusion The intensity of spinal inflammation as determined by ADC is associated with radiographic progression in participants with active axial SpA.

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THE CORRELATION BETWEEN BONE DENSITY AND SOME CLINICAL AND SUBCLINICAL FACTORS IN THE PATIENTS WITH DIALYSIS CHRONIC KIDNEY DISEASE

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2020.4.10 ◽

2020 ◽

pp. 75-82

Author(s):

Minh Nguyen Thanh ◽

Tam Vo

Keyword(s):

Chronic Kidney Disease ◽

Regression Analysis ◽

Bone Density ◽

Kidney Disease ◽

Multivariate Regression ◽

Multivariate Regression Analysis ◽

Cross Sectional Study ◽

Ho Chi Minh City ◽

Cross Sectional ◽

End Stage

Objectives: To investigate the correlation between bone density and osteoporosis with some clinical and subclinical factors in patients with dialysis chronic kidney patients. Materials and Methods: Descriptive cross-sectional study, include 163 patients with dialysis chronic kidney disease, from January 2017 to December 2018 at the Department of Haemodyalysis, District 2 Hospital, Ho Chi Minh City. Results: Bone density was negatively correlated with age at the lumbar spine (LS) (r = - 0.225), total hip (total H) (r = - 0.288), femoral neck (FN) (r = - 0.352); with urea at the total H (r = - 0.206), FN (r = - 0.194); with PTH at LS (r = - 0.266), total H (r = - 0.219), FN (r = - 0.168); with β2 Microglobulin at the LS (r = - 0.269). Bone density was positively correlated with glomerular filtration rate at the LS (r = 0.200), FN (r = 0.179); with vitamin D at the LS (r = 0.218) and total H (r = 0.179). Multivariate regression analysis of the risk of decreased bone density at the FN has 2 factors: age (OR = 1.117), PTH (OR = 1.001); at the LS, there are 3 factors: gender (OR = 4.572), PTH (OR=4.078), age (OR = 1.045); at the total H, there are 2 factors: PTH (OR = 3.683), age (OR = 1.117). Osteoporosis in all 3 positions was related to sex (p < 0.05) and age group (p < 0.01). Osteoporosis was associated with PTH, Phosphorus, Aluminum disorders at the FN (p < 0.05), with PTH at the LS (p < 0.05), with PTH, calcium at the total H (p < 0.05). Multivariate regression analysis of the risk of osteoporosis has 3 factors: age (OR = 4.058), PTH (OR = 2.967), female (OR = 2.841). Conclusion: Bone density, osteoporosis is correlated, associated with common factors and factors associated with bone mineral disorders in patients with dialysis chronic kidney disease (CKD - MBD). Key words: End-stage chronic kidney disease, dialysis, bone density

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Abstract 412: Obesity is an Independent Predictor Of Arterial Stiffness

Hypertension ◽

10.1161/hyp.62.suppl_1.a412 ◽

2013 ◽

Vol 62 (suppl_1) ◽

Author(s):

Mohan Thanikachalam ◽

Shasha Bai ◽

Vijayakumar Harivanzan ◽

Ragavendra R Baliga ◽

William T Abraham ◽

...

Keyword(s):

Blood Pressure ◽

Regression Analysis ◽

Arterial Stiffness ◽

Multivariate Regression ◽

Independent Predictor ◽

Density Lipoprotein ◽

Multivariate Regression Analysis ◽

Population Based ◽

Cross Sectional Survey ◽

Cross Sectional

Background Arterial stiffness assessed by carotid-femoral pulse wave velocity (PWV) is an independent predictor of cardiovascular morbidity and mortality. We aimed to investigate how various measures of obesity affect arterial stiffness. Methods We conducted a population-based cross-sectional survey in 8,042 South Indians above the age of 20 years. Following completion of a detailed medical history questionnaire, all participants underwent haemodynamic screening including brachial and central blood pressure, and PWV measurements using a high-fidelity applanation tonometry. The study included anthropometric measurements and fasting blood for total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and blood glucose (BG) levels. After the exclusion of people with previous history of diabetes, hypertension and dyslipidemia on drug therapy, 5,841 subjects (mean age 41.6 years; 58% women) constituted the study sample Results In an univariate analysis, PWV correlated positively with age, mean blood pressure (MAP), heart rate (HR), body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), body fat percent (BF%), TC, TG, LDL and BG levels (P <0.001) and negatively with HDL levels (P=0.005). In a multivariate regression analysis, majority of the PWV variability in the model was accounted for by MAP and age, (cumulative adjusted R2 change of 32.79% as compared to the total adjusted R2 change of 35.25%). However, BMI (β= 0.042; adjusted R2 change=2.83%; p<0.001) independently correlated with PWV and its contribution to the PWV variability was far more significant compared to LDL, BG and TG (cumulative adjusted R2 change=1.08%). Multivariate regression analysis using the WC, WHR, or BF% instead of the BMI continued to demonstrate a significant independent effect of obesity parameters on PWV. Conclusion: In a large a population-based cross-sectional survey the study demonstrates a positive, independent association between obesity parameters and increased arterial stiffness.

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miRNA-451a and miRNA-125a Expression Levels in Ankylosing Spondylitis: Impact on Disease Diagnosis, Prognosis, and Outcomes

Journal of Immunology Research ◽

10.1155/2020/2180913 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Dina Salem Fotoh ◽

Rasha Ibrahim Noreldin ◽

Mohamed Soliman Rizk ◽

Maha Mohamed Elsabaawy ◽

Heba Ahmed Esaily

Keyword(s):

Ankylosing Spondylitis ◽

Disease Activity ◽

Expression Profile ◽

Structural Damage ◽

Activity Index ◽

Disease Activity Index ◽

Disease Diagnosis ◽

Cross Sectional ◽

Expression Levels ◽

Therapeutic Implications

Background. Early diagnosis of ankylosing spondylitis (AS) is yet not elucidated, with a potential diagnostic glance of microRNAs (miRNAs). Aim. Study the expression profile of miRNA-451a and miRNA-125a in AS patients and their impact on disease activity and prognosis. Methods. A cross-sectional study included 55 AS patients diagnosed according to modified New York criteria in 1984 with 55 matched healthy controls. History, clinical examination, and disease activity assessment with Bath ankylosing spondylitis disease activity index (BASDAI) were done. Full laboratory and radiological assessment along with expression profile of m iRNA-451a and miRNA-125a were tabulated and analyzed. Results. Higher expression levels of miRNA-125a and lower of miRNA-451a in AS patients compared to controls. Furthermore, miRNA-125a expression was high in active AS patients compared to inactive patients and controls ( 7.0 ± 3.4 vs. 4.1 ± 2.1 vs. 2.6 ± 0.6 , p < 0.001 , respectively). miRNA-451a was significantly lower in active AS patients compared to inactive patients and controls ( 2.2 ± 1.1 vs. 4.1 ± 2.3 vs. 7.1 ± 4.5 , respectively). Both miRNAs (miRNA-125a and miRNA-451a) had evident accuracy for AS diagnosis with areas under the curve (AUC) of 0.788 and 0.802, respectively. miRNA-125a had potential impact on AS activity with AUC of 0.777. Plasma levels of both miRNAs were able to distinguish AS patients with structural damage with AUCs 0.775 and 0.692, respectively. Conclusions. Both miRNA-451a and miRNA-125a were found to be of great value as sensitive noninvasive diagnostic, prognostic, and disease burden biomarker of AS patients in Egypt with suggested further studies for future therapeutic implications.

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Ultrasound verified enthesophytes are associated with radiographic progression at entheses in psoriatic arthritis

Rheumatology ◽

10.1093/rheumatology/keaa028 ◽

2020 ◽

Vol 59 (10) ◽

pp. 2893-2897

Author(s):

Angelika Lackner ◽

Daniel Heber ◽

Philipp Bosch ◽

Gabriel Adelsmayr ◽

Christina Duftner ◽

...

Keyword(s):

Psoriatic Arthritis ◽

Disease Activity ◽

Multivariate Regression ◽

Disease Duration ◽

Radiographic Progression ◽

Power Doppler ◽

Multivariate Regression Analysis ◽

X Ray ◽

Ultrasound Findings ◽

Ultrasound Score

Abstract Objectives The aim of this prospective study was to examine whether ultrasound or clinical abnormalities at enthesal sites predict radiographic progression at entheses in psoriatic arthritis (PsA). Methods Consecutive PsA patients were included and subjected to clinical and ultrasound assessments at 14 entheses at baseline, 6 and 12 months. Radiographs were performed at 0 and 12 months. By US, we investigated structural (erosions, osteophytes) and inflammatory changes [grey scale (0–32) and power Doppler (0–14, range global ultrasound score 0–140)], and radiographs were evaluated for enthesophytes and erosions (score range 0–56). Multivariate regression models were conducted to identify the possible association of clinical and ultrasound findings with radiographic progression. Results We examined 83 patients at baseline, of whom 43 (51.8%) had complete clinical, ultrasound and X-ray data. Twenty-four of 43 patients (55.8%) developed radiographic progression of entheses. These patients were younger (49.6 vs 59.3, P =0.005), had shorter disease duration (9.7 vs 17.9 years, P=0.015) and lower clinical disease activity at 6-months [disease activity in psoriatic arthritis (DAPSA) 6.7 vs 17.0, P=0.018] as compared with patients without progression. Non-progressors had higher ultrasound enthesophyte scores at baseline than progressors (20 vs 15, P<0.05). The multivariate regression analysis revealed that 48.6% of the variance of the X-ray score at 12-months follow-up (RegcoeffB = 0.827, P=0.000) could be explained by the baseline US enthesophyte score. Conclusion Our data indicate that radiographic progression at entheses is linked with age, disease duration and ultrasound verified enthesophytes at baseline. No other ultrasound parameter predicted radiographic progression at entheses.

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AB0725 FACTORS ASSOCIATED WITH RADIOGRAPHIC SPINAL INVOLVEMENT IN SPONDYLOARTHRITIS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.4372 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1657.2-1657

Author(s):

M. Slouma ◽

S. Rahmouni ◽

R. Dhahri ◽

I. Gharsallah ◽

N. Boussetta ◽

...

Keyword(s):

Ankylosing Spondylitis ◽

Disease Activity ◽

Structural Damage ◽

Disease Duration ◽

Diagnostic Delay ◽

Cross Sectional Study ◽

Cross Sectional ◽

Positive Correlation ◽

Factors Associated ◽

The Mean

Background:Spondyloarthritis (SpA) is characterized by significant radiographic changes in the spine. The structural spine damage can be assessed using several scorings such as the Bath AS Radiology Index (BASRI) and the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS).Objectives:We aimed to identify factors associated with structural damage in the spine using these scores.Methods:We conducted a cross-sectional study including patients with SpA diagnosed according to the assessment of Spondyloarthritis International Society criteria.To assess the radiographic involvement of the spine, we used the mSASSS, the BASRI-spine (BASRI-S), the BASRI-lumber (BASRI-L) and the BASRI-cervical (BASRI-C).Disease activity was assessed using the BASDAI and ASDAS-CRP.Results:Among the 112 patients, 72.32% were men. The mean age was 43.78 ± 12,91 years. The mean age at diagnosis was 37.8 ± 13.45 years. The diagnostic delay of 37,8 ± 46 months.Forty-nine patients were smockers (43.8%).The mean BASDAI score and ASDAS–CRP score were 4.04 ± 1.99 and 3.30 ± 0.87.The mean ESR and CRP were 36.21 ± 27 (mm/H) and 31.28 ± 47.25 mg/LThe mean BASRI-S was 3,99 ± 21,96 and the mean mSASSS was 10,26 ± 15,41.Twenty-five patients (22.3%) had non-radiographic axial SpA.Men had higher BARSI-L (1.36 vs 0.7, p= 0.045) and BASRI-S (4.3 vs 3.09; p=0.047) than women.Moreover, smokers’ patients had higher mSASSS (14.07 vs 7.02; p=0.031), BASRI-C (1.23 vs 0.62; p=0.031), and BASRI-S (4.82 vs 3.35; p= 0.009) than nonsmokers’ patients.A positive correlation was noted between age and BASRI-C (r= 0.260, p=0.012). There was no correlation between age at the onset of SpA and structural spine damage.We found a positive correlation between disease duration and the following scores: BASRI-C (r=0.245, p=0.018) and BASRI-S (r=0.274, p=0.003).Patients with non-radiographic axial SpA had lower mSASSS (4.05 vs 12.14; p=0.034), BASRI-s (1.2 vs 4.9; p< 10-3), and BASRI-L (0.42 vs 1.4; p=0.003) than patients with radiographic axial SpA.There was no correlation between the radiographic index and BASDAI and ASDAS-CRP.Conclusion:We confirmed previous observations that male gender, smoking and disease duration are associated with structural damage in the spine [1].However, CRP and other inflammatory biomarkers were not associated with radiographic evidence of spine involvement.As observed in previous studies, the radiographic spine damage did not correlate with disease activity (BASDAI) [1].References:[1]Sari I, Haroon N. Radiographic Progression in Ankylosing Spondylitis: From Prognostication to Disease Modification. Curr Rheumatol Rep. 2018 Nov 8;20(12):82.Disclosure of Interests:None declared

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Determinants of Family Planning Use Among Turkish Married Men Who Live in South East Turkey

American Journal of Men s Health ◽

10.1177/1557988312471556 ◽

2013 ◽

Vol 7 (3) ◽

pp. 255-264 ◽

Cited By ~ 5

Author(s):

Simge Zeyneloğlu ◽

Sezer Kısa ◽

Leyla DelibaŞ

Keyword(s):

Regression Analysis ◽

Family Planning ◽

Multivariate Regression ◽

Multivariate Regression Analysis ◽

Cross Sectional Survey ◽

Chi Square ◽

Cross Sectional ◽

Married Men ◽

Planning Methods ◽

Chi Square Analysis

This study assesses the determinants of family planning methods use by Turkish married men in South East Anatolia. A descriptive and cross-sectional survey research design was used among 1,352 men aged 20 to 52 years who lived in South East Turkey. A pilot-tested questionnaire was used to collect data. Descriptive statistics, chi-square, and multivariate regression analysis were used. The rate of nonusage of contraceptive methods among the participants was 60.4%. Within the nonusers, 34.9% reported a religious prohibition and 9.4% had misconceptions about family planning. Chi-square analysis determined four factors that were significantly related to the men’s usage of contraception. These factors are the following: the men’s age, educational level, number of existing children, and their perception of their household income level. These four factors were also subjected to multivariate regression analysis, the results of which were used to compute odds ratios for each value of each factor indicating the likelihood for using contraception by men within each group. Male-specific family planning programs can make an important contribution to the overall efforts to improve the usage of contraceptives by men. It is important to note that family planning services and education programs related to family planning should be appropriate for men.

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TAX RATE AND NON-DEBT TAX SHIELD

Jurnal Riset Manajemen dan Bisnis (JRMB) Fakultas Ekonomi UNIAT ◽

10.36226/jrmb.v4i2.261 ◽

2019 ◽

Vol 4 (2) ◽

pp. 257-268

Author(s):

Adrian Teja

Keyword(s):

Regression Analysis ◽

Multivariate Regression ◽

Multivariate Regression Analysis ◽

Tax Rates ◽

Tax Rate ◽

Tax Shield ◽

Research Findings ◽

Independent Variable ◽

Debt Tax Shield ◽

One Year

Firm can minimize their tax obligation by debt tax shield and non-debt tax shield (NDTS). However, research findings on how firm treat debt tax shield and NDTS, as a substitute or as a complement, remain inconclusive. This paper objective is to provide evidence on how firm usage of NDTSchange when tax rates change in Indonesia. Multivariate regression analysis performed with NDTSas dependent variable and tax rates change and debt level as independent variable. Multivariate regression analysis covering 73 Indonesia firms with 146 observations for the period of year 2008 to year 2010. Within this period, Indonesia corporate tax rate being reduce twice from 30% in 2008 to 28% in 2009 and 25% in 2010. This research find when tax rates is decrease, public firm increase their usage of NDTSwith a lag of one year and debt financing remain increased alongside with non-debt tax shield. This finding provide support to debt tax shield and NDTSas a complement.

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β2-Microglobulin and Neutrophil Gelatinase-Associated Lipocalin, Potential Novel Urine Biomarkers in Periodontitis: A Cross-Sectional Study in Japanese

International Journal of Dentistry ◽

10.1155/2019/1394678 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10 ◽

Cited By ~ 1

Author(s):

Mayuka Nakajima ◽

Michihiro Hosojima ◽

Koichi Tabeta ◽

Sayuri Miyauchi ◽

Miki Yamada-Hara ◽

...

Keyword(s):

Regression Analysis ◽

Multivariate Regression ◽

Multivariate Regression Analysis ◽

Cross Sectional Study ◽

Clinical Parameters ◽

High Group ◽

Cross Sectional ◽

Neutrophil Gelatinase Associated Lipocalin ◽

Urine Biomarkers ◽

Neutrophil Gelatinase

Objectives. Several serum biomarkers have been reported to increase in periodontitis patients as possible mediators linking periodontal inflammation to systemic diseases. However, the relationship between periodontitis and urine biomarkers is still unclear. The aim of this cross-sectional study was to investigate potential urine biomarkers of periodontitis in a Japanese population.Materials and Methods. This study included 108 male subjects, and microbiological and clinical parameters were evaluated as a periodontitis marker. The correlation between nine urine biomarkers (typically used to diagnose kidney disease) and periodontal parameters was analyzed. Based on the findings,β2-microglobulin (β2-MG) and neutrophil gelatinase-associated lipocalin (NGAL) were selected for comparison and multivariate regression analysis, and the Kruskal–Wallis test followed by Bonferroni correction was used to identify differences in their concentrations between the three periodontitis groups (severe, moderate, and no/mild periodontitis).Results.β2-MG and NGAL exhibited a significant correlation with clinical parameters of periodontitis. The prevalence of clinical parameters such as bleeding on probing and number of sites with probing depth (PD) ≥ 6 mm were greater in theβ2-MG high group (≥300 μg/g creatinine) than in the normal group (P=0.017and 0.019, respectively). Multivariate regression analysis indicated that the number of sites with PD ≥ 6 mm was independently associated with urineβ2-MG. Moreover, the number of sites with the clinical attachment level (CAL) ≥ 6 mm was greater in the NGAL high group (highest quartile) (P=0.041). Multivariate regression analysis showed that the number of sites with CAL ≥ 6 mm was associated independently with urine NGAL. Finally,β2-MG was significantly higher in the severe periodontitis subjects compared to the no/mild periodontitis subjects.Conclusion. The significant association between urineβ2-MG or NGAL and periodontitis was revealed. These biomarkers can potentially be used to screen for or diagnose periodontitis. This trial is registered with the UMIN Clinical Trials RegistryUMIN000013485.

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Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis: longitudinal results from the DESIR cohort

RMD Open ◽

10.1136/rmdopen-2020-001356 ◽

2020 ◽

Vol 6 (3) ◽

pp. e001356

Author(s):

Pedro D Carvalho ◽

Adeline Ruyssen-Witrand ◽

Joao Fonseca ◽

Ana Marreiros ◽

Pedro M Machado

Keyword(s):

Ankylosing Spondylitis ◽

Disease Activity ◽

Structural Damage ◽

Axial Spondyloarthritis ◽

Spinal Mobility ◽

Mobility Impairment ◽

Reactive Protein ◽

Determining Factors ◽

Disease Stages ◽

Spinal Inflammation

ObjectiveTo investigate the determinants of impaired spinal and hip mobility in patients with early axial spondyloarthritis (axSpA).MethodsFive-year longitudinal data from the DEvenir des Spondyloarthrites Indifférenciées Récentes (DESIR) cohort were analysed. Associations were investigated using generalised estimating equations, using Bath Ankylosing Spondylitis Metrology Index (BASMI) linear or each of the five components of BASMI as dependent variables, and clinical and demographic variables as independent variables in univariable models. Multivariable analyses were performed, adjusting for potential confounders.ResultsData from 644 patients and 5152 visits were analysed. Higher BASMI values were independently and positively associated with Ankylosing Spondylitis Disease Activity Score C reactive protein (ASDAS-CRP) (adjusted B (adjB)=0.21; 95% CI=0.15 to 0.28), MRI spinal inflammation score (adjB=0.11; 95% CI=0.04 to 0.19), enthesitis score (adjB=0.02; 95% CI=0.01 to 0.04) and age (adjB=0.02; 95% CI=0.01 to 0.03). All BASMI components were independently associated with ASDAS-CRP and MRI spinal inflammation, except for maximal intermalleolar distance (reflecting hip mobility), which was not associated with MRI spinal inflammation.ConclusionIn early axSpA, spinal mobility impairment is independently determined by clinical disease activity, MRI spinal inflammation, enthesitis and age. The influence of spinal inflammation prevails in early axSpA, as opposed to spinal structural damage, which may become more relevant in later disease stages.

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