scholarly journals Superabsorbent poly(acrylic acid) and antioxidant poly(ester amide) hybrid hydrogel for enhanced wound healing

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Jianhua Zhang ◽  
Junfei Hu ◽  
Baoshu Chen ◽  
Tianbao Zhao ◽  
Zhipeng Gu
Keyword(s):  
Wound Healing ◽  
Acrylic Acid ◽  
Protein Denaturation ◽  
Healing Process ◽  
Antioxidant Properties ◽  
Skin Damage ◽  
Hybrid Hydrogel ◽  
Hydrogel Scaffolds ◽  
Hybrid Hydrogels ◽  
Poly Acrylic Acid

Abstract Wound healing dressing is increasingly needed in clinical owing to the large quantity of skin damage annually. Excessive reactive oxygen species (ROS) produced through internal or external environmental influences can lead to lipid peroxidation, protein denaturation, and even DNA damage, and ultimately have harmful effects on cells. Aiming to sufficiently contact with the wound microenvironment and scavenge ROS, superabsorbent poly (acrylic acid) and antioxidant poly (ester amide) (PAA/PEA) hybrid hydrogel has been developed to enhance wound healing. The physical and chemical properties of hybrid hydrogels were studied by Fourier-transform infrared (FTIR) absorption spectrum, compression, swelling, degradation, etc. Besides, the antioxidant properties of hybrid hydrogels can be investigated through the free radical scavenging experiment, and corresponding antioxidant indicators have been tested at the cellular level. Hybrid hydrogel scaffolds supported the proliferation of human umbilical vein endothelial cells and fibroblasts, as well as accelerated angiogenesis and skin regeneration in wounds. The healing properties of wounds in vivo were further assessed on mouse skin wounds. Results showed that PAA/PEA hybrid hydrogel scaffolds significantly accelerated the wound healing process through enhancing granulation formation and re-epithelialization. In summary, these superabsorbent and antioxidative hybrid hydrogels could be served as an excellent wound dressing for full-thickness wound healing.

scholarly journals Wound healing action of topical nitric oxide releasing poly(acrylic acid)/pluronic F127 hydrogel membranes

2016 ◽  
Author(s):  
LUCAS MILITÃO ◽  
MARCELO GANZAROLLI DE OLIVEIRA ◽  
MATHILDE CHAMPEAU ◽  
CARLOS P. JARA ◽  
ELIANA PEREIRA DE ARAUJO
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Acrylic Acid ◽  
Pluronic F127 ◽  
Hydrogel Membranes ◽  
Nitric Oxide Releasing ◽  
Poly Acrylic Acid

A multifunctional poly(acrylic acid)/gelatin hydrogel

2009 ◽  
Vol 24 (5) ◽  
pp. 1653-1661 ◽  
Author(s):  
Qunwei Tang ◽  
Jihuai Wu ◽  
Jianming Lin ◽  
Shijun Fan ◽  
De Hu
Keyword(s):  
Acrylic Acid ◽  
Transport Model ◽  
Interpenetrating Network ◽  
Hybrid Hydrogel ◽  
Elongation At Break ◽  
Gelatin Hydrogel ◽  
Preparation Conditions ◽  
Aqueous Solution Polymerization ◽  
Poly Acrylic Acid

A poly(acrylic acid)/gelatin interpenetrating network hydrogel was synthesized by aqueous solution polymerization. The influences of preparation conditions including cross-linker, initiator, gelatin content, and neutralization degree on the swelling ratios of the hydrogels are investigated. The swelling, mechanical strength, biodegradability, and drug-release properties of poly(acrylic acid)/gelatin hydrogel are evaluated. The hydrogel has excellent mechanical properties; tensile strength is 1500 kPa, and elongation at break is 887%, respectively. The in vitro biodegradation shows that an interpenetrating network structure exists in the poly(acrylic acid)/gelatin hybrid hydrogel. A release study indicates that the theophylline release from the hydrogel depends on the cross-linking density of the hydrogel and pH of the medium, and the drug diffusion obeys an anomalous transport model.

scholarly journals Dexpanthenol in Wound Healing after Medical and Cosmetic Interventions (Postprocedure Wound Healing)

2020 ◽  
Vol 13 (7) ◽  
pp. 138
Author(s):  
Julian Gorski ◽  
Ehrhardt Proksch ◽  
Jens Malte Baron ◽  
Daphne Schmid ◽  
Lei Zhang
Keyword(s):  
Wound Healing ◽  
Clinical Studies ◽  
New Technologies ◽  
Healing Process ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Skin Damage ◽  
Published Evidence ◽  
Superficial Skin

With the availability of new technologies, the number of subjects undergoing medical and cosmetic interventions is increasing. Many procedures (e.g., ablative fractional laser treatment) resulting in superficial/minor wounds require appropriate aftercare to prevent complications in wound healing and poor cosmetic outcome. We review the published evidence of the usefulness of topical dexpanthenol in postprocedure wound healing and the associated mechanisms of action at the molecular level. A search in the PubMed and Embase databases was performed to query the terms dexpanthenol, panthenol, superficial wound, minor wound, wound healing, skin repair, and postprocedure. Search results were categorized as clinical trials and in vitro studies. In vitro and clinical studies provided evidence that topically applied dexpanthenol promotes superficial and postprocedure wound healing. Latest findings confirmed that dexpanthenol upregulates genes that are critical for the healing process. The gene expression data are of clinical relevance as evidenced by prospective clinical studies indicating that topical dexpanthenol accelerates wound healing with rapid re-epithelialization and restoration of skin barrier function following skin injury. It can therefore be inferred that topical dexpanthenol represents an appropriate and state-of-the-art treatment option for superficial postprocedure wounds, especially when applied early after the superficial skin damage.

scholarly journals Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2286 ◽  
Author(s):  
Sibusiso Alven ◽  
Xhamla Nqoro ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Wound Healing ◽  
Transmission Rate ◽  
Biological Activities ◽  
Drug Loading ◽  
Healing Process ◽  
Antioxidant Properties ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Microbial Invasion ◽  
Good Biocompatibility

Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

Tofu-Based Hybrid Hydrogels with Antioxidant and Low Immunogenicity Activity for Enhanced Wound Healing

2019 ◽  
Vol 15 (7) ◽  
pp. 1371-1383 ◽  
Author(s):  
Jun Huang ◽  
Long Chen ◽  
Qijuan Yuan ◽  
Zhipeng Gu ◽  
Jun Wu
Keyword(s):  
Wound Healing ◽  
Free Radicals ◽  
Antioxidant Activities ◽  
Skin Wound ◽  
Hybrid Hydrogel ◽  
Wound Model ◽  
Hybrid Hydrogels ◽  
Thickness Skin ◽  
Regeneration Effect

Free radicals and inflammation in the skin suffering from trauma cause oxidative damage and delayed healing, leading to adverse wound conditions. To adequately investigate the effects of free radicals and controlled immunogenicity for wound healing, we propose a tofu-based hybrid hydrogel with antioxidant and low immunogenicity properties that can be used for wound healing. Tofu, a food source material, was introduced for the first time into gelatin methacryloyl (GelMA) hydrogels by the photo-crosslinking method. The results demonstrated that the incorporation of tofu influenced the pores, swelling, water vapor transmission and compressive properties of hydrogels greatly. The antioxidant activities of hydrogels had been enhanced with increasing rations of tofu, and the fibroblast culture showed good proliferation on the hybrid hydrogels, as well as slight immunogenicity, thereby inducing the M2 differentiation of macrophages. Further, a full-thickness skin wound model was created to study the healing effect of hybrid hydrogels. In vivo results confirmed that the antioxidant activity and slight immunological stimulation properties of tofu hydrogels could accelerate the wound healing rate and improve the skin tissue regeneration effect. The present study validates that the tofu-based hybrid hydrogels have multiple bioactivities and could be potential antioxidant and immunoregulation hydrogels in wound healing applications.

scholarly journals The Role of Antioxidants on Wound Healing: A Review of the Current Evidence

2021 ◽  
Vol 10 (16) ◽  
pp. 3558
Author(s):  
Inés María Comino-Sanz ◽  
María Dolores López-Franco ◽  
Begoña Castro ◽  
Pedro Luis Pancorbo-Hidalgo
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Antioxidant Properties ◽  
Basic Research ◽  
Redox Balance ◽  
Current Evidence ◽  
Antioxidant Compounds ◽  
Normal Wound Healing ◽  
Wound Healing Response

(1) Background: Reactive oxygen species (ROS) play a crucial role in the preparation of the normal wound healing response. Therefore, a correct balance between low or high levels of ROS is essential. Antioxidant dressings that regulate this balance are a target for new therapies. The purpose of this review is to identify the compounds with antioxidant properties that have been tested for wound healing and to summarize the available evidence on their effects. (2) Methods: A literature search was conducted and included any study that evaluated the effects or mechanisms of antioxidants in the healing process (in vitro, animal models or human studies). (3) Results: Seven compounds with antioxidant activity were identified (Curcumin, N-acetyl cysteine, Chitosan, Gallic Acid, Edaravone, Crocin, Safranal and Quercetin) and 46 studies reporting the effects on the healing process of these antioxidants compounds were included. (4) Conclusions: this review offers a map of the research on some of the antioxidant compounds with potential for use as wound therapies and basic research on redox balance and oxidative stress in the healing process. Curcumin, NAC, quercetin and chitosan are the antioxidant compounds that shown some initial evidence of efficacy, but more research in human is needed.

scholarly journals review of black seed extract as an agent in the wound healing process

2021 ◽  
Vol 1 (2) ◽  
pp. 87-96
Author(s):  
Muhammad Hakeem Mohd Zaid ◽  
Muhammad Faezuddin Hanafi ◽  
Muhammad Salahuddin Haris
Keyword(s):  
Wound Healing ◽  
Nigella Sativa ◽  
Healing Process ◽  
Antioxidant Properties ◽  
Microscopic Analysis ◽  
Seed Extract ◽  
Flowering Plant ◽  
Wound Healing Process ◽  
Black Cumin ◽  
Black Seed

Introduction: Nigella Sativa or Black Cumin is an annual flowering plant that can be used for wound treatment. In the treatment for wound healing, this plant contains many beneficial components that can help with the treatment but this plant utilisation in the medical field is still limited. This review will provide an overview of the advantages when this plant is used in the wound healing treatment. Method: The review was based on the ROSES protocol, and the databases used were ScienceDirect, PubMed, and Google Scholar. After the search, only 11 papers had been chosen to be included in the results and they were divided into four main themes that were used for the analysis of the results. Results: The themes were gross analysis, microscopic analysis, biochemical analysis and antimicrobial analysis. Conclusion: In conclusion, the black seed extract contains several valuable properties, such as antimicrobial and antioxidant properties, which help improve the wound healing process. Further study needs to be done to discover more potential of Nigella Sativa in treating the wound.

Icariin-Loaded Polyvinyl Alcohol/Agar Hydrogel: Development, Characterization, and In Vivo Evaluation in a Full-Thickness Burn Model

2019 ◽  
Vol 18 (3) ◽  
pp. 323-335 ◽  
Author(s):  
Varuna Naga Venkata Arjun Uppuluri ◽  
T. S. Shanmugarajan
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Polyvinyl Alcohol ◽  
Tissue Regeneration ◽  
Healing Process ◽  
Wound Healing Process ◽  
Full Thickness ◽  
Burn Wound ◽  
In Vivo Evaluation ◽  
Hydrogel Scaffolds

Tissue regeneration has become a promising strategy for repairing damaged skin tissues. Among the hydrogels for tissue regeneration applications, topical hydrogels have demonstrated great potential for use as 3D-scaffolds in the burn wound healing process. Currently, no report has been published specifically on icariin-loaded polyvinyl alcohol (PVA)/agar hydrogel on full-thickness burn wounds. In the present study, burn tissue regeneration based on biomimetic hydrogel scaffolds was used for repairing damaged extracellular matrix. Furthermore, a skin burn model was developed in rats, and the icariin-loaded PVA/agar hydrogels were implanted into the damaged portions. The regeneration of the damaged tissues with the help of the icariin-loaded hydrogel group exhibited new translucent skin tissues and repaired extracellular matrix, indicating that the hydrogel can enhance the wound healing process. Moreover, characterization studies such as X-ray diffraction, Fourier-transformed infrared spectroscopy, and differential scanning calorimetry reported the extent of compatibility between icariin and its polymers. Results of the field emission scanning electron microscopy images revealed the extent of the spread of icariin within the polymer-based hydrogel. Furthermore, the wound healing potential, confirmed by histopathological and histochemical findings at the end of 21 days, revealed the visual evidence for the biomimetic property of icariin-loaded PVA/agar hydrogel scaffolds with the extracellular matrix for tissue regeneration.

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