scholarly journals 1200 Seasonal Variation In RHR Measured By A Wearable Ring

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A459-A459
Author(s):  
H Koskimaki ◽  
H Kinnunen ◽  
S Ronka ◽  
B Smarr
Keyword(s):  
Seasonal Variation ◽  
Northern Hemisphere ◽  
Cardiovascular Fitness ◽  
Ambient Conditions ◽  
Seasonal Factors ◽  
Large Populations ◽  
Working Age ◽  
Health Related ◽  
Length Of The Day

Abstract Introduction Resting heart rate (RHR) associates with cardiovascular fitness, acute and chronic health status, and mental stress. Nightly sleep provides an excellent measurement time because ambient conditions are constant and confounding factors are controlled. Relatively low RHR is seen as a mark of better health, performance, and recovery levels. Over the past few years, development of wearable devices has made it possible to follow the course of individual RHR as long-term time series, which enables observation of how behavioural, societal and seasonal factors affect RHR at population scale. Methods In this study, mean individual nightly RHR of each calendar day was studied from all Oura ring users starting from July 2016 (n=1415) and ending at March 2019 (n=57.278). The subjects were 36 percent female and 64 percent male, mostly in working age: 20-30-year (15%), 30-50 years (60%), and 50-60-years (16%). Majority of the ring users live in the Northern Hemisphere, and minority (n = 1.500) in the Southern Hemisphere. Results With users from Northern Hemisphere, the yearly RHR peaks in December and lowers between April and August. The magnitude of seasonal variation was observed to be roughly 2 bpm: In 2018, March averages 1.6 bpm higher than August, and December averages 2.1 bpm higher than August. Looking at subjects from New Zealand and Australia, exactly opposite phase was observed, so that both hemispheres followed the length of the day. Apparently, RHR yearly fluctuations are based on biological factors like Sun light and ambient temperature. Both hemispheres also demonstrated weekly peaks at weekends (+1.6 bpm), and a most district peak at each New Year night. Conclusion The long-term RHR was shown to be affected by biological, societal, and lifestyle factors. We find that long-term wearable data from the Ring can reveal health related physiological effects across large populations, including seasonality. Support This work was supported by Oura Health Ltd.

Infodemiology of Bell’s palsy: Tracing the seasonality of facial paralysis

2021 ◽  
pp. 1-9
Author(s):  
Ender Salbaş ◽  
Sertaç Ketenci
Keyword(s):  
Seasonal Variation ◽  
Southern Hemisphere ◽  
Facial Paralysis ◽  
Northern Hemisphere ◽  
Bell’S Palsy ◽  
Google Trends ◽  
Time Interval ◽  
Bell's Palsy ◽  
Search Volume ◽  
Health Related

BACKGROUND: Although there are a few studies on the seasonality of facial paralysis, no studies have utilized internet data for this purpose. The use of internet data to investigate diseases and user-contributed health-related content is increasingly prevalent, and has earned the name “infodemiology”. OBJECTIVE: This study aims to use Google Trends data to investigate whether there is a seasonal variation in facial paralysis. METHODS: In this observational study, the search volume for the terms “facial paralysis” and “Bell’s palsy” for a total of 19 countries was queried from Google Trends, selecting the time interval between January 2004 and October 2020. RESULTS: In the Cosinor analysis of data from a total of 19 countries, from both northern and southern hemisphere, a statistically significant seasonality was found in the search volume of facial paralysis. It was observed that facial paralysis peaked in spring in the northern hemisphere and in winter in the southern hemisphere. CONCLUSION: Internet search query data showed that facial paralysis has a seasonal variation, with peaks in spring for the northern hemisphere and winter for the southern hemisphere. Further studies are needed to understand the deviation between hemispheres and the cause of the peak in winter-spring season.

Pension Reform in Russia: Assessing the Susceptibility of GDP Production to a Shift in the Number of the Working-Age Population

2019 ◽  
pp. 80-86
Author(s):  
T. P. Skufina ◽  
S. V. Baranov
Keyword(s):  
Pension Reform ◽  
Fixed Capital ◽  
Economic Effects ◽  
Pension Scheme ◽  
Retirement Age ◽  
Working Age ◽  
Working Age Population ◽  
Long Term Forecasting ◽  
The Impact

The presented study considers the susceptibility of gross domestic product (GDP) production to a shift in the number of the working-age population due to an increase in retirement age starting with 2019.Aim. The study aims to examine the quantitative assessments of GDP production in Russia with allowance for the changes in the number of the working-age population due to an increase in the actual retirement age.Tasks. The authors forecast the number of the working-age population with allowance for an increase in the retirement age; develop a model to establish a correlation between the number of the workingage population, investment in fixed capital, and GDP production; quantify the impact of the shift in the number of the working-age population on GDP production in Russia. Methods. This study is based on the results of modeling and long-term forecasting.Results. An economic-mathematical model to establish a correlation between the number of the working-age population, investment in fixed capital, and GDP production is presented. To specify the economic effects of a shift in the number of the working-age population due to an increase in the retirement age, Russia’s GDP production is forecasted for the “old” and “new” (increased retirement age) pension scheme. The forecast is provided for three variants of the number of the working-age population.Conclusions. It is found that with the “old” pension scheme with a lower retirement age GDP production across all three variants will decrease by 2036 compared to 2017. With regard to the “new” scheme that increases the retirement age, it is concluded that an increase in the retirement age is a factor that facilitates GDP production. However, its effect on economic growth will be insignificant.

Long Term Monitoring of the Macrobenthos of the Upper Clyde Estuary

1984 ◽  
Vol 16 (5-7) ◽  
pp. 359-373 ◽  
Author(s):  
Anne R Henderson
Keyword(s):  
Water Quality ◽  
Seasonal Variation ◽  
Organic Pollution ◽  
Long Term Changes ◽  
Pollution Loading ◽  
Faunal Density ◽  
History Of ◽  
Long Term Monitoring ◽  
Term Monitoring

The sublittoral macrobenthic invertebrate populations of the Upper Clyde Estuary are described. The estuary has a long history of organic pollution. The long term changes in species composition, faunal density and dominance patterns between 1974 and 1980 are presented. The fauna is dominated by brackish, pollution tolerant oligochaetes and polychaetes. Fluctuations in populations can be related to both seasonal variation in environmental conditions and long term improvements in water quality through a reduction in pollution loading to the estuary.

Thrombopoietin Receptor Agonists in Children with Immune Thrombocytopenia: A New Therapeutic Era

2020 ◽  
Vol 20 ◽  
Author(s):  
Giuseppe Lassandro ◽  
Valentina Palladino ◽  
Giovanni Carlo Del Vecchioa ◽  
Viviana Valeria Palmieri ◽  
Paola Carmela Corallo ◽  
...  
Keyword(s):  
Immune Thrombocytopenia ◽  
Treatment Options ◽  
Thrombopoietin Receptor Agonists ◽  
Receptor Agonists ◽  
Thrombopoietin Receptor ◽  
Related Quality ◽  
Health Related

Background and Objective: Immune thrombocytopenia (ITP) is a common bleeding disorder in childhood. The management of ITP in children is controversial, requiring personalized assessment of patients and therapeutic choices. Thrombopoietin receptor agonists (TPO-RAs), eltrombopag and romiplostim, have been shown to be safety and effective for the treatment of pediatric ITP. The aim of our research is defining the role of thrombopoietin receptor agonists in the management of pediatric ITP. Method: This review focuses on the use of TPO-RAs in pediatric ITP, in randomized trials and in clinical routine, highlighting their key role in management of the disease. Results: Eltrombopag and romiplostim appear effective treatment options for children with ITP. Several clinical studies have assessed that the use of TPO-RAs increases platelet count, decreases bleeding symptoms and improves health-related quality of life. Moreover, TPO-RAs are well tolerated with minor side effects. Conclusion: Although TPO-RAs long term efficacy and safety still require further investigations, their use is gradually expanding in clinical practice of children with ITP.

scholarly journals Occasional and persistent frequent attenders and sickness absences in occupational health primary care: a longitudinal study in Finland

BMJ Open ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. e024980 ◽  
Author(s):  
Tiia T M Reho ◽  
Salla A Atkins ◽  
Nina Talola ◽  
Markku P T Sumanen ◽  
Mervi Viljamaa ◽  
...  
Keyword(s):  
Primary Care ◽  
Longitudinal Study ◽  
Occupational Health ◽  
Sick Leave ◽  
Diagnostic Codes ◽  
Frequent Attenders ◽  
Frequent Attendance ◽  
Increased Risk ◽  
Working Age

ObjectivesFrequent attenders (FAs) create a substantial portion of primary care workload but little is known about FAs’ sickness absences. The aim of the study is to investigate how occasional and persistent frequent attendance is associated with sickness absences among the working population in occupational health (OH) primary care.Setting and participantsThis is a longitudinal study using medical record data (2014–2016) from an OH care provider in Finland. In total, 59 676 patients were included and categorised into occasional and persistent FAs or non-FAs. Sick-leave episodes and their lengths were collected along with associated diagnostic codes. Logistic regression was used to analyse associations between FA status and sick leaves of different lengths (1–3, 4–14 and ≥15 days).ResultsBoth occasional and persistent FA had more and longer duration of sick leave than non-FA through the study years. Persistent FAs had consistently high absence rates. Occasional FAs had elevated absence rates even 2 years after their frequent attendance period. Persistent FAs (OR=11 95% CI 7.54 to 16.06 in 2016) and occasional FAs (OR=2.95 95% CI 2.50 to 3.49 in 2016) were associated with long (≥15 days) sickness absence when compared with non-FAs. Both groups of FAs had an increased risk of long-term sick leaves indicating a risk of disability pension.ConclusionBoth occasional and persistent FAs should be identified in primary care units caring for working-age patients. As frequent attendance is associated with long sickness absences and possibly disability pensions, rehabilitation should be directed at this group to prevent work disability.

scholarly journals The impact of lymphedema on health-related quality of life up to 10 years after breast cancer treatment

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Mads G. Jørgensen ◽  
Navid M. Toyserkani ◽  
Frederik G. Hansen ◽  
Anette Bygum ◽  
Jens A. Sørensen
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Treatment ◽  
Breast Cancer Treatment ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
The Impact

AbstractThe impact of breast cancer-related lymphedema (BCRL) on long-term quality of life is unknown. The aim of this study was to investigate the impact of BCRL on health-related quality of life (HRQoL) up to 10 years after breast cancer treatment. This regional population-based study enrolled patients treated for breast cancer with axillary lymph node dissection between January 1st 2007 and December 31th 2017. Follow up and assessments of the included patients were conducted between January 2019 and May 2020. The study outcome was HRQoL, evaluated with the Lymphedema Functioning, Disability and Health Questionnaire, the Disabilities of the Arm, Shoulder and Hand Questionnaire and the Short Form (36) Health Survey Questionnaire. Multivariate linear logistic regression models adjusted for confounders provided mean score differences (MDs) with 95% confidence intervals in each HRQoL scale and item. This study enrolled 244 patients with BCRL and 823 patients without BCRL. Patients with BCRL had significantly poorer HRQoL than patients without BCRL in 16 out of 18 HRQoL subscales, for example, in physical function (MDs 27, 95%CI: 24; 30), mental health (MDs 24, 95%CI: 21; 27) and social role functioning (MDs 20, 95%CI: 17; 23). Age, BMI, BCRL severity, hand and dominant arm affection had only minor impact on HRQoL (MDs < 5), suggesting a high degree of inter-individual variation in coping with lymphedema. This study showed that BCRL is associated with long-term impairments in HRQoL, especially affecting the physical and psychosocial domains. Surprisingly, BCRL diagnosis rather than clinical severity drove the largest impairments in HRQoL.

scholarly journals Primary Prevention of Dementia: An Ethical Review

2020 ◽  
pp. 1-10
Author(s):  
Dorothee Horstkötter ◽  
Kay Deckers ◽  
Sebastian Köhler
Keyword(s):  
Synergistic Effects ◽  
Well Being ◽  
Ethical Review ◽  
Medical Risk ◽  
Medical Risk Factors ◽  
Societal Challenges ◽  
Dementia Prevention ◽  
Health Related ◽  
Personal Level

Dementia poses important medical and societal challenges, and of all health risks people face in life, dementia is one of the most feared. Recent research indicates that up to about 40% of all cases of dementia might be preventable. A series of environmental, social, and medical risk-factors have been identified and that should be targeted from midlife onwards when people are still cognitively healthy. At first glance, this seems not merely advisable, but even imperative. However, these new developments trigger a series of new ethical questions and concerns which have hardly been addressed to date. Pro-active ethical reflection, however, is crucial to ensure that the interests and well-being of those affected, ultimately all of us, are adequately respected. This is the goal of the current contribution. Against the background of a concrete case in primary dementia prevention, it provides a systematic overview of the current ethical literature and sketches an ethical research agenda. First, possible benefits of increased well-being must be balanced with the burdens of being engaged in particularly long-term interventions for which it is unclear whether they will ever pay out on a personal level. Second, while knowledge about one’s options to maintain brain health might empower people, it might also undermine autonomy, put high social pressure on people, medicalize healthy adults, and stigmatize those who still develop dementia. Third, while synergistic effects might occur, the ideals of dementia prevention might also conflict with other health and non-health related values people hold in life.

scholarly journals A Conceptual Model of Long-Term Weight Loss Maintenance: The Importance of Cognitive, Empirical and Computational Approaches

2021 ◽  
Vol 18 (2) ◽  
pp. 635
Author(s):  
Darren Haywood ◽  
Blake J. Lawrence ◽  
Frank D. Baughman ◽  
Barbara A. Mullan
Keyword(s):  
Weight Loss ◽  
Weight Loss Maintenance ◽  
Computational Approaches ◽  
Healthy Habits ◽  
Health Related ◽  
The One ◽  
Major Factors ◽  
Positive Social Support ◽  
Weight Loss Interventions

Living with obesity is related to numerous negative health outcomes, including various cancers, type II diabetes, and cardiovascular disease. Although much is known about the factors associated with obesity, and a range of weight loss interventions have been established, changing health-related behaviours to positively affect obesity outcomes has proven difficult. In this paper, we first draw together major factors that have emerged within the literature on weight loss to describe a new conceptual framework of long-term weight loss maintenance. Key to this framework is the suggestion that increased positive social support influences a reduction in psychosocial stress, and that this has the effect of promoting better executive functioning which in turn facilitates the development of healthy habits and the breaking of unhealthy habits, leading to improved ongoing maintenance of weight loss. We then outline how the use of computational approaches are an essential next step, to more rigorously test conceptual frameworks, such as the one we propose, and the benefits that a mixture of conceptual, empirical and computational approaches offer to the field of health psychology.

The geography of climate migration

2021 ◽  
pp. 1-37
Author(s):  
Michał Burzyński ◽  
Frédéric Docquier ◽  
Hendrik Scheewel
Keyword(s):  
Climate Change ◽  
International Migration ◽  
First Century ◽  
Long Term Effects ◽  
Mobility Data ◽  
Rural And Urban ◽  
Working Age ◽  
Internal Mobility ◽  
Almost All

Abstract In this paper, we investigate the long-term effects of climate change on the mobility of working-age people. We use a world economy model that covers almost all the countries around the world, and distinguishes between rural and urban regions as well as between flooded and unflooded areas. The model is calibrated to match international and internal mobility data by education level for the last 30 years, and is then simulated under climate change variants. We endogenize the size, dyadic, and skill structure of climate migration. When considering moderate climate scenarios, we predict mobility responses in the range of 70–108 million workers over the course of the twenty-first century. Most of these movements are local or inter-regional. South–South international migration responses are smaller, while the South–North migration response is of the “brain drain” type and induces a permanent increase in the number of foreigners in OECD countries in the range of 6–9% only. Changes in the sea level mainly translate into forced local movements. By contrast, inter-regional and international movements are sensitive to temperature-related changes in productivity. Lastly, we show that relaxing international migration restrictions may exacerbate the poverty effect of climate change at origin if policymakers are unable to select/screen individuals in extreme poverty.

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