scholarly journals 0353 Objectively Measured Sleep and Components of Metabolic Syndrome in Well-Functioning Older Adults

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A134-A134
Author(s):  
S Hossain ◽  
A J Alfini ◽  
A A Wanigatunga ◽  
D M Rojo-Wissar ◽  
J A Schrack ◽  
...  
Keyword(s):  
Older Adults ◽  
Metabolic Syndrome ◽  
Depressive Symptoms ◽  
Research Program ◽  
Lower Odds ◽  
Intramural Research Program ◽  
Wrist Actigraphy ◽  
Sleep Parameters ◽  
Objectively Measured ◽  
Metabolic Syndrome Components

Abstract Introduction Prior studies tying sleep to metabolic syndrome in older adults have mostly used self-report sleep measures. We investigated the association between actigraphic sleep parameters and metabolic syndrome components in well-functioning older adults. Methods We studied 434 participants in the Baltimore Longitudinal Study of Aging (aged 71.1±12.8 years, 41.4% women) with 6.6±1.0 nights of wrist actigraphy and data on metabolic syndrome components: blood triglyceride (TG) level >150 mg/dL; high density lipoprotein (HDL) <50 mg/dL; and waist circumference (WC) >88.9 cm for women and >101.6 cm for men. Sleep parameters were the primary predictors and metabolic syndrome components the outcomes. Logistic regression was performed, and results are expressed as odds ratio (OR) with p-values. Results After adjusting for age, sex, race and education, higher sleep efficiency (SEFF; per 10%) was associated with a lower odds of high WC (SEFF OR=0.60, p=0.01) and, compared to participants in the intermediate total sleep time tertile (5.5 to 6.8 h), those in the shortest tertile (<5.5 h) had a slightly lower odds of high WC (TST OR=0.98, p=0.02). In adjusted models, greater wake after sleep onset (WASO; per 30 min), greater average wake bout length (WBL; per min), and lower SEFF (per 10%) were associated with a greater odds of poor HDL level (<50 mg/dL) (WASO OR=1.37, p=0.05; WBL OR=1.49, p=0.007; SEFF OR=0.72, p=0.04). After further adjustment for BMI and depressive symptoms, only the association between longer WBL and poor HDL level remained significant (OR=1.48, p=0.01). There were no associations between sleep parameters and TG level. Conclusion Among well-functioning older adults, greater WASO but lower TST and SE are associated with poorer metabolic syndrome components. Longitudinal research is needed to evaluate the temporal associations of objectively measured poor sleep and metabolic syndrome components and evaluate the roles of BMI and depressive symptoms in these associations. Support The first author is supported by a Postdoctoral Fellowship by the Intramural Research Program (IRP) at the National Institute on Aging (NIA). This study was supported in part by National Institute on Aging (NIA) grant R01AG050507, the NIA Intramural Research Program (IRP), and Research and Development Contract HHSN-260-2004-00012C.

545 Actigraphic sleep parameters and anxiety symptoms among community-dwelling older adults

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A215-A215
Author(s):  
Alice Ding ◽  
Emily Smail ◽  
Alfonso Alfini ◽  
Adam Spira
Keyword(s):  
Older Adults ◽  
Anxiety Symptoms ◽  
Community Dwelling ◽  
Depression Symptoms ◽  
Cross Sectional ◽  
Subsequent Change ◽  
Wrist Actigraphy ◽  
Sleep Parameters ◽  
Objectively Measured ◽  
Community Dwelling Older Adults

Abstract Introduction A number of cross-sectional studies have found that elevated levels of anxiety are associated with poor sleep among healthy older adults, but most have used self-reported sleep measures. We investigated the longitudinal association between objectively measured sleep (by wrist actigraphy) and subsequent change in anxiety symptoms in this population. Methods We studied 555 community-dwelling older adults (mean age 72.52±7.35, 77.48% white, 53.15% women) in the National Social Health and Aging Project (NSHAP) study who completed 3 nights of wrist actigraphy at wave 2 (2010–2011) and the Hospital Anxiety and Depression Scale at waves 2 and 3 (2015–2016). Actigraphic sleep parameters were averaged across nights and included: total sleep time (TST; minutes), percent sleep (%), wake after sleep onset (WASO; minutes), and sleep fragmentation. Change in anxiety was calculated as the difference between anxiety scores at wave 3 and wave 2. Results After adjusting for age, race, sex, education, body mass index, number of medical conditions, depression symptoms, and anxiety scores at wave 2, we found no significant associations between any actigraphic sleep parameter and subsequent change in anxiety symptoms (all p ≥ 0.390). Additional analyses revealed no significant cross-sectional associations at wave 2 (p ≥ 0.390). Conclusion We found no evidence for an association between actigraphic sleep and anxiety symptoms, or change in anxiety symptoms, in community-dwelling older adults. Additional studies using clinical anxiety disorder diagnoses are needed to evaluate the extent to which objectively measured sleep disturbance predicts clinically significant anxiety in older adults. Support (if any) American Academy of Sleep Medicine Foundation (#223-BS-19).

scholarly journals Challenging the “jolly fat” hypothesis among older adults: High body mass index predicts increases in depressive symptoms over a 5-year period

2016 ◽  
Vol 23 (1) ◽  
pp. 48-58 ◽  
Author(s):  
Peter Joseph Dearborn ◽  
Michael A Robbins ◽  
Merrill F Elias
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Depressive Symptoms ◽  
Body Mass ◽  
Functional Limitations ◽  
High Body Mass Index ◽  
Obesity Prevalence ◽  
Community Based ◽  
Objectively Measured

Several investigators have observed lowered risk of depression among obese older adults, coining the “jolly fat” hypothesis. We examined this hypothesis using baseline and a 5-year follow-up body mass index, depressive symptoms, and covariates from 638 community-based older adults. High objectively measured body mass index and functional limitations predicted increased future depressive symptoms. However, symptoms did not predict future body mass index. Self-reported body mass index showed similar associations despite underestimating obesity prevalence. Results did not differ on the basis of gender. Results for this study, the first longitudinal reciprocal risk analysis between objectively measured body mass index and depressive symptoms among older adults, do not support the “jolly fat” hypothesis.

scholarly journals Association between objectively measured walking steps and sleep in community-dwelling older adults: A prospective cohort study

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243910
Author(s):  
Noriyuki Kimura ◽  
Yasuhiro Aso ◽  
Kenichi Yabuuchi ◽  
Etsuro Matsubara
Keyword(s):  
Older Adults ◽  
Sleep Disturbances ◽  
Linear Regression Analysis ◽  
Community Dwelling ◽  
Sleep Efficiency ◽  
Ageing Society ◽  
Sleep Parameters ◽  
Objectively Measured ◽  
Community Dwelling Older Adults ◽  
The Relationship

Physical inactivity and sleep disturbances are major problems in an ageing society. There is increasing evidence that physical activity is associated with sleep quality. However, the association between daily walking steps and sleep remain unclear. This prospective study examined the relationship between objectively measured daily walking steps and sleep parameters in Japanese community-dwelling older adults. In total, 855 community-dwelling individuals aged 65 and above, with an uninterrupted follow-up from August 2015 to March 2016, were enrolled. The participants wore a wristband sensor for an average of 7.8 days every three months. Multiple linear regression analysis was performed to examine the relationship between daily walking steps and sleep parameters, including the total sleep time, sleep efficiency, time awake after sleep onset (WASO), awakening time count during the night, and naptime. The median (interquartile range, IQR) age of the participants was 73 (69–78) years, with 317 (37.1%) men and 538 (62.9%) women. The median (IQR) educational level was 12 (11–12) years, and the median (IQR) Mini-Mental State Examination score was 29 (27–30) points. The number of daily walking steps showed a positive correlation with sleep efficiency and an inverse correlation with WASO, awakening time count, and naptime, after adjusting for covariates and correcting for the false discovery rate (β = 0.098, 95% confidence interval [CI]: 0.034 to 0.162, p = 0.003; β = −0.107, 95% CI: −0.172 to −0.043, p = 0.001; β = −0.105, 95% CI: −0.17 to −0.04, p = 0.002; and β = −0.31, 95% CI: −0.371 to −0.249, p < 0.001, respectively). Our results can help promote walking as an intervention for preventing sleep disturbances in community-dwelling older adults.

scholarly journals Effects of Morning Versus Evening Home-Based Exercise on Subjective and Objective Sleep Parameters in Older Adults: A Randomized Controlled Trial

2020 ◽  
pp. 089198872092470
Author(s):  
Jaehoon Seol ◽  
Yuya Fujii ◽  
Taiki Inoue ◽  
Naruki Kitano ◽  
Kenji Tsunoda ◽  
...  
Keyword(s):  
Older Adults ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Exercise Group ◽  
Healthy Older Adults ◽  
Low Intensity ◽  
Randomized Controlled ◽  
Home Based ◽  
Sleep Parameters ◽  
Objectively Measured

Objective: This study aimed to determine whether the timing of exercise influenced the effects of home-based low-intensity stepping exercises on the sleep parameters of older adults. Method: For 8 weeks, 60 healthy older adults participated in a randomized controlled trial, performing low-intensity aerobic exercise (70-80 bpm) for about 30 minutes every day at home, either in the morning (from waking until 12:00) or evening (18:00 to bedtime). Results: In the evening exercise group, both subjectively and objectively measured sleep latency significantly improved throughout the intervention. Further, postintervention subjective sleep satisfaction was significantly higher in the evening group (6.2 ± 1.3 points) than in the morning group (5.2 ± 1.4 points; P = .006). Additionally, sleep variables related to evening exercise had larger effect sizes (Cohen d) than those performed in the morning. Conclusion: Engaging in low-intensity stepping exercises during the evening is potentially a useful nonpharmacological approach to improving sleep quality among older adults.

scholarly journals EXTERNAL HOME DISREPAIR ASSOCIATED WITH OBJECTIVE SLEEP DISTURBANCES IN LOW-INCOME OLDER ADULTS WITH DISABILITIES

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S922-S922
Author(s):  
Safiyyah M Okoye ◽  
Nancy Perrin ◽  
Sarah Szanton ◽  
Adam P Spira
Keyword(s):  
Older Adults ◽  
Low Income ◽  
Sleep Disturbances ◽  
Socioeconomically Disadvantaged ◽  
Neighborhood Conditions ◽  
Adults With Disabilities ◽  
Time In Bed ◽  
Wrist Actigraphy ◽  
Objectively Measured ◽  
Home Conditions

Abstract Sleep disturbances are linked to poor health, loss of independence and mortality in older adults. Rates of poor sleep are higher among socioeconomically disadvantaged older adults. Understanding how environmental factors may affect sleep in this population could lead to interventions to improve sleep-related health outcomes. We determined cross-sectional associations of home and neighborhood conditions with sleep parameters, measured by wrist actigraphy, in 136 low-income, predominantly African-American older adults with disabilities. Primary predictors were third-party-rated objective indicators of disrepair or disorder based on: 1) inside-home conditions (e.g., evidence of pests, tripping hazards, clutter); 2) outside-home conditions (e.g., broken windows, crumbling foundation); and 3) neighborhood conditions (e.g., litter, graffiti, vacant buildings). Outcomes were actigraphic total sleep time (TST; total number of minutes in bed spent asleep), wake time after sleep onset (WASO; total number of minutes spent awake after initially falling asleep), and sleep efficiency (SE; % of time in bed spent asleep). Presence of one or more outside-home conditions indicating disrepair or disorder was associated with 36.3-minutes shorter TST, 18.1-minutes more WASO, and 4.7% lower SE (all p &lt;0.05). Conditions inside the home and of the neighborhood were not associated with sleep. These preliminary findings suggest that among low-income older adults with disabilities, external-home disrepair is associated with objectively measured WASO, TST, and SE. External-home disrepair may affect sleep through physical, psychosocial and behavioral pathways. Further research should examine longitudinal associations between external-home conditions and objectively measured sleep in socioeconomically disadvantaged older adults.

scholarly journals Caregiver Status and Diet Quality in Community Dwelling Older Adults

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 205-205
Author(s):  
Sharmin Hossain ◽  
May A Beydoun ◽  
Michele K Evans ◽  
Alan B Zonderman ◽  
Marie Fanelli Kuczmarski
Keyword(s):  
Older Adults ◽  
Diet Quality ◽  
Research Program ◽  
Healthy Eating Index ◽  
Longitudinal Analyses ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Intramural Research Program ◽  
Sectional Analysis ◽  
Over Time

Abstract Objectives Prior studies on caregivers have focused mainly on the diet quality of their recipients, especially children. We investigated both cross-sectional and longitudinal associations of caregiver status and diet quality in older adults (mean 53.0 ± 9.0 years). Methods We studied participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study (57.7% women, 62% African American) between wave 3 (2009–2013) and wave 4 (2013–2018). Caregiving was assessed at both waves, starting at wave 3. Healthy Eating Index-2010 (HEI2010) score, a measure of diet quality, was assessed from two 24-hour recalls at each wave on both occasions (mean 4.1 years follow-up). Baseline caregiving (at wave 3) was examined in relation to change in HEI between waves 3 and 4. Multivariable linear regression was performed for cross-sectional analysis; mixed-effects regression was performed for longitudinal analyses. Results are expressed as β-coefficients ± standard error of means (β±SE). Results After adjusting for age, sex, race and poverty status, more time spent taking care of grandchildren (N = 2033) was associated with poor diet quality (–1.51 ± 0.55, P = 0.006) in cross-sectional analysis (wave 4 caregiving and wave 4 HEI). However, in a separate cross-sectional analysis (wave 4 only) on dual (caring for both grandchildren and an elderly person) vs. single caregivers (either grandchildren or elderly) (N = 73; 24 men & 49 women) we found no difference in diet quality. The longitudinal analyses (N = 1848) demonstrated that diet quality did not change with caregiving over time for either grandchildren (P = 0.16) or others (not children & grandchildren) (P = 0.88). Overall, women tended to have better quality diet (P &lt; 0.001) than men. Conclusions Among relatively older caregivers, cross-sectional analyses revealed an inverse effect of caregiving with diet quality. Longitudinal research is needed to evaluate the temporal associations of dual caregiving with subsequent diet quality changes over time. Funding Sources The first author is supported by a Postdoctoral Fellowship from the Intramural Research Program (IRP) at the National Institute on Aging (NIA). HANDLS is supported by the Intramural Research Program, National Institute on Aging, National Institutes of Health, grant Z01-AG000513.

scholarly journals Associations of Actigraphic Sleep Parameters With Fatigability in Older Adults

2020 ◽  
Vol 75 (9) ◽  
pp. e95-e102 ◽  
Author(s):  
Alfonso J Alfini ◽  
Jennifer A Schrack ◽  
Jacek K Urbanek ◽  
Amal A Wanigatunga ◽  
Sarah K Wanigatunga ◽  
...  
Keyword(s):  
Older Adults ◽  
Perceived Exertion ◽  
Sleep Onset ◽  
Later Life ◽  
Sleep Time ◽  
Community Dwelling ◽  
Rating Of Perceived Exertion ◽  
Poor Sleep ◽  
Wrist Actigraphy ◽  
Sleep Parameters

Abstract Background Poor sleep may increase the likelihood of fatigue, and both are common in later life. However, prior studies of the sleep–fatigue relationship used subjective measures or were conducted in clinical populations; thus, the nature of this association in healthier community-dwelling older adults remains unclear. We studied the association of actigraphic sleep parameters with perceived fatigability—fatigue in response to a standardized task—and with conventional fatigue symptoms of low energy or tiredness. Methods We studied 382 cognitively normal participants in the Baltimore Longitudinal Study of Aging (aged 73.1 ± 10.3 years, 53.1% women) who completed 6.7 ± 0.9 days of wrist actigraphy and a perceived fatigability assessment, including rating of perceived exertion (RPE) after a 5-minute treadmill walk or the Pittsburgh Fatigability Scale (PFS). Participants also reported non-standardized symptoms of fatigue. Results After adjustment for age, sex, race, height, weight, comorbidity index, and depressive symptoms, shorter total sleep time (TST; &lt;6.3 hours vs intermediate TST ≥6.3 to 7.2 hours) was associated with high RPE fatigability (odds ratio [OR] = 2.56, 95% confidence interval [CI] = 1.29, 5.06, p = .007), high PFS physical (OR = 1.88, 95% CI = 1.04, 3.38, p = .035), and high mental fatigability (OR = 2.15, 95% CI = 1.02, 4.50, p = .044), whereas longer TST was also associated with high mental fatigability (OR = 2.19, 95% CI = 1.02, 4.71, p = .043). Additionally, longer wake bout length was associated with high RPE fatigability (OR = 1.53, 95% CI = 1.14, 2.07, p = .005), and greater wake after sleep onset was associated with high mental fatigability (OR = 1.14, 95% CI = 1.01, 1.28, p = .036). Conclusion Among well-functioning older adults, abnormal sleep duration and sleep fragmentation are associated with greater perceived fatigability.

Abstract P284: Higher Bitter Taste Perception is Associated With Lower Diabetes Risk Among Older Adults With Metabolic Syndrome - The PREDIMED-PLUS Trial

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Julie E Gervis ◽  
Oscar Coltell ◽  
José V Sorlí ◽  
Dolores Corella ◽  
Alice H Lichtenstein
Keyword(s):  
Older Adults ◽  
Metabolic Syndrome ◽  
Bitter Taste ◽  
Disease Risk ◽  
Taste Perception ◽  
Endocrine Function ◽  
Taste Receptors ◽  
Lower Odds ◽  
Diabetes Status ◽  
Unit Scale

Background: Beyond taste perception, taste receptors in the mouth and gastrointestinal tract have been linked to the regulation of energy balance, endocrine function and glucose homeostasis. Despite this, little is known about the relationship between perception for the 5 tastes (sweet, salt, sour, bitter and umami) and diet-related chronic disease risk. Objective: To investigate the association between perception for the 5 tastes and diabetes status. Methods: A cross-sectional baseline analysis was performed on older (55-75 years), overweight (BMI, ≥27-<40) adults diagnosed with metabolic syndrome who were participating in the PREDIMED-PLUS Valencia trial (N=367). Taste perception was measured by challenging participants with standard solutions representing sweet, salt, sour, bitter and umami (400 mM sucrose, 200 mM NaCl, 34 mM citric acid, 5.6 mM phenylthiocarbamide [PTC], 200 mM monopotassium glutamate, respectively) and was evaluated on a 0-5 unit scale. Diabetes status was determined by self-reported clinical diagnosis. Multivariable logistic regression models that included all 5 tastes were used to test the association between taste perception and diabetes status. Results: The prevalence of diabetes in this cohort was 38%. Compared to individuals without diabetes, individuals with diabetes had significantly lower bitter taste perception (unadjusted means: 1.6 versus 1.1 units, respectively) (t-test p<0.001). After adjusting for age, sex, smoking status, physical activity, BMI and medication use, a 1 unit increase in bitter taste perception was associated with a 42% lower odds of being diagnosed with diabetes (adjusted odds ratio [aOR] = 0.58; 95% CI = [0.38, 0.84], p<0.001). Although mean perceptions for sweet, salt, sour and umami were also lower in individuals with diabetes, the associations did not reach statistical significance. Conclusions: Among older adults with metabolic syndrome, higher bitter taste perception was associated with lower odds of being diagnosed with diabetes. Further investigations are warranted to confirm these observations and to determine whether bitter taste receptors may provide a possible therapeutic target for diabetes prevention and treatment.

Sign in / Sign up

Export Citation Format

Share Document