Serum iron profile and ELISA-based detection of antibodies against the iron-regulated protein HupB of Mycobacterium tuberculosis in TB patients and household contacts in Hyderabad (Andhra Pradesh), India

2012 ◽  
Vol 107 (1) ◽  
pp. 43-50 ◽  
Author(s):  
S. Sivakolundu ◽  
U. D. Mannela ◽  
S. Jain ◽  
A. Srikantam ◽  
S. Peri ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Serum Iron ◽  
Andhra Pradesh ◽  
Household Contacts ◽  
Iron Profile

Serum Iron profile in Female patients of Melasma-A case control study

2017 ◽  
Vol 4 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Iram Qazi ◽  
◽  
Naina Kala Dogra ◽  
Devraj Dogra ◽  
◽  
...  
Keyword(s):  
Serum Iron ◽  
Case Control Study ◽  
Case Control ◽  
Female Patients ◽  
Iron Profile ◽  
Control Study

Correlation of Iron Profile with Different Stages of Chronic Kidney Disease in Children Presenting at a Tertiary Care Hospital

2021 ◽  
Vol 15 (8) ◽  
pp. 2013-2016
Author(s):  
Shahid Ishaq ◽  
Muhammad Imran ◽  
Hashim Raza ◽  
Khuram Rashid ◽  
Muhammad Imran Ashraf ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Iron Overload ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Tertiary Care ◽  
Transferrin Saturation ◽  
Maintenance Hemodialysis ◽  
Care Hospital ◽  
Iron Profile

Aim: To determine correlation of iron profile in children with different stages of chronic kidney disease (CKD) presenting to tertiary care hospital. Methodology: A total of 81 children with chronic kidney disease stage having glomerular filtration rate (GFR) less than 90 (ml/min/m2) aged 1 – 14 years of either sex were included. Three ml serum sample was taken in vial by hospital duty doctor for serum ferritin level, serum iron, transferrin saturation and total iron binding capacity. The sample was sent to hospital laboratory for reporting. Iron profiling was done evaluating hemoglobin (g/dl), serum iron (ug/dl), serum ferritin (ng/ml), transferrin saturation (%) and total iron binding capacity (ug/dl) while iron load was defined as serum ferritin levels above 300 ng/ml. Correlation of iron profile with different stages of CKD was determined applying one-way analysis of variance (ANOVA). Results: In a total 81 children, 46 (56.8%) were boys while overall mean age was 7.79±2.30 years. Mean duration on hemodialysis was 11.52 ± 9.97 months. Iron overload was observed in 26 (32.1%) children. Significant association of age above 7 years (p=0.031) and residential status as rural (p=0.017) was noted with iron overload whereas iron overload was increasing with increase in stages of CKD (p=0.002). Hemoglobin levels decreased significantly with increase in stages of CKD (p<0.001). Serum iron levels increased significantly with increase in the CKD stages (p=0.039). Serum ferritin levels were increasing significantly with the increase in CKD stages (p=0.031). Transferrin saturation also increased significant with increase in CKD stages (p=0.027). Conclusion: High frequency of iron overload was noted in children with CKD on maintenance hemodialysis and there was linear relationship with stages of CKD and iron overload. Significant correlation of hemoglobin, serum iron, serum ferritin and transferrin saturation was observed with different stages of CKD. Keywords: Iron overload, maintenance hemodialysis, ferritin level.

scholarly journals Mycobacterium tuberculosis Beijing Lineage and Risk for Tuberculosis in Child Household Contacts, Peru

2020 ◽  
Vol 26 (3) ◽  
pp. 568-578 ◽  
Author(s):  
Chuan-Chin Huang ◽  
Alexander L. Chu ◽  
Mercedes C. Becerra ◽  
Jerome T. Galea ◽  
Roger Calderón ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Household Contacts

scholarly journals Sex and age differences inMycobacterium tuberculosisinfection in Brazil

2018 ◽  
Vol 146 (12) ◽  
pp. 1503-1510 ◽  
Author(s):  
P. Fernandes ◽  
Y. Ma ◽  
M. Gaeddert ◽  
T. Tsacogianis ◽  
P. Marques-Rodrigues ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Tuberculin Skin Test ◽  
Age Differences ◽  
Host Susceptibility ◽  
Sputum Smear ◽  
Pulmonary Tb ◽  
Household Contacts ◽  
Exposure Data ◽  
Multivariable Modelling ◽  
Sex And Age Differences

AbstractGlobally, the prevalence of tuberculosis (TB) disease is higher in males. This study examined the effect of sex and age onMycobacterium tuberculosis(Mtb) infection. Demographic and exposure data were collected on household contacts of sputum smear-positive pulmonary TB patients in Brazil. Contacts with tuberculin skin test induration ⩾10 mm at baseline or 12 weeks were considered Mtb infected. The study enrolled 917 household contacts from 160 households; 508 (55.4%) were female, median age was 21.0 years (range 0.30–87.0) and 609 (66.4%) had Mtb infection. The proportion infected increased with age from 63.3% in girls <5 years to 75.4% in women ⩾40 years and from 44.9% in boys <5 years to 73.6% in men ⩾40 years. Multivariable modelling showed the odds of infection increased between age 5 and 14 years among female contacts (OR 1.5 per 5-year age increase; 95% CI 1.1–2.2;P= 0.02) and between ages 0–4 and 15–39 years among male contacts (OR 2.7, 95% CI 0.83–8.9 and 1.1, 95% CI 0.99–1.3 per 5-year age increase;P= 0.10, 0.07, respectively). The study suggests that the age at which Mtb infection increases most is different in females compared with males. Studies are needed to explore whether these findings are due to differences in host susceptibility, exposure outside the household or other factors.

Association of serum iron and response to immune checkpoint inhibitors (ICIs) in metastatic clear cell renal cell carcinoma (mccRCC).

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 723-723
Author(s):  
Nityam Rathi ◽  
David D. Stenehjem ◽  
Neeraj Agarwal ◽  
Andrew W Hahn ◽  
Deepika Sirohi ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Iron ◽  
Clear Cell ◽  
Checkpoint Inhibitors ◽  
Transferrin Saturation ◽  
Iron Level ◽  
Eligibility Criteria ◽  
Cell Renal Cell Carcinoma ◽  
Serum Iron Level ◽  
Iron Profile

723 Background: ICIs have improved survival in mRCC patients (pts), yet response rates (RR) to these treatments are variable. Biomarkers predictive of response to ICIs may improve outcomes for mccRCC pts. Genes that promote tumor-specific iron accumulation such as hepcidin (HAMP) or transferrin (TF) are significantly correlated with decreased overall survival in clear cell RCC (TCGA-KIRC). Iron deficiency in cancer patients is positively correlated with tumor stage and inversely proportional to treatment response (PMID: 23567147). Here, we investigate whether serum iron profile may be associated with response to ICIs in mccRCC pts. Methods: Clinical data was obtained from an mRCC registry at the Huntsman Cancer Institute, University of Utah. Analyses were limited to mccRCC pts who had serum iron studies within 6 months before initiating an ICI and had been assessed for RR. ICIs included nivolumab + ipilimumab, atezolizumab, or nivolumab alone. Responses were defined as complete response (CR), partial response (PR), stable disease (SD), or progressive disease (PD) by RECIST criteria. Clinical benefit (CB) was defined as CR + PR + SD. Descriptive statistics were used to assess associations between iron stores and response to ICIs and IMDC criteria. Results: 36 pts met all aforementioned eligibility criteria (29 were of IMDC intermediate risk, 7 were of IMDC poor risk). 5 pts received a first-line ICI, and the remaining 31 pts received ICIs as salvage therapy. Pts with CB had a significantly higher median serum iron level compared to those with no CB (59 vs 38.5 ug/dL; p=0.024). Furthermore, pts with normal transferrin saturation (TSAT %) were more likely to derive CB from ICIs (p=0.048). No association was found between serum ferritin (a marker of inflammation and tissue iron) and response to ICIs. Conclusions: In this hypothesis-generating study, increased serum iron, and TSAT levels within the normal range are associated with an increased likelihood of response to ICIs in pts with mccRCC. Once validated, these results may establish serum iron profile as a predictive marker of response to ICIs, in addition to providing the rationale for ruling out iron deficiency before starting ICIs.

scholarly journals A chain-binomial model for intra-household spread of Mycobacterium tuberculosis in a low socio-economic setting in Pakistan

2006 ◽  
Vol 135 (1) ◽  
pp. 27-33 ◽  
Author(s):  
S. AKHTAR ◽  
T. E. CARPENTER ◽  
S. K. RATHI
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Antibiotic Therapy ◽  
Goodness Of Fit ◽  
Index Case ◽  
Substantial Reduction ◽  
Educational Programme ◽  
Maximum Likelihood Estimates ◽  
Binomial Model ◽  
Goodness Of Fit Test ◽  
Household Contacts

A simulation study using Greenwood's chain-binomial model was carried out to elucidate the spread and control of Mycobacterium tuberculosis among the household contacts of infectious pulmonary tuberculosis (TB) patients. Based on the observed data, the maximum-likelihood estimates (±S.E.) of chain-binomial probabilities of intra-household M. tuberculosis transmission from an index case in 3-person and 4-person households were 0·313±0·008 and 0·325±0·009 respectively. The χ2 goodness-of-fit test of observed and simulated mean expected frequencies of cases revealed good fit for 3-person (P=0·979) and 4-person (P=0·546) households. With the assumption of varying risk of M. tuberculosis transmission across the households under β-distribution, goodness-of-fit tests of observed and mean simulated expected frequencies revealed the inadequacy of Greenwood's chain-binomial model both for 3-person (P=0·0185) and 4-person (P<0·001) households. Simulated M. tuberculosis control strategy comprising efficient diagnosis, segregation and prompt antibiotic therapy of index pulmonary TB patients showed a substantial reduction of new cases among the household contacts in both household sizes. In conclusion, segregation coupled with prompt antibiotic therapy of the index case, chemoprophylaxis of M. tuberculosis-exposed household contacts, and the assessment of household environmental risks to devise and implement an educational programme may help reduce the TB burden in this and similar settings.

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