Abstract
Recently in many industries biologically synthesized silver nanoparticles are used as an alternative for their biomedicinal applications predominantly demonstrated as an effective agent in the diabetes treatment. On the other hand, oxidative stress crucially associated with the pathogenesis of diabetic comorbidities like diabetic hepatopathy, which is less common. Thus, the existing study explored the protective role of biologically synthesized silver nanoparticles (AV-AgNPs) against hepatic toxicity persuaded by streptozotocin (STZ) in rats. Wistar male albino rats (200 ± 20 g) were segregated into five groups (n=10) and designated as, Group I-Control (no treatment); Group II-Diabetic control (35 mg/kg single dose of streptozotocin, IP); Group III-Diabetic treated with AV-AgNPs (10 mg/kg); Group IV-Diabetic treated with aloe vera leaves extract (AVLE) (100 mg/kg); Group V-Diabetic treated with glibenclamide (GLB) (600 μg/kg) orally. After treatment of 28 days, animals were euthanized and collected blood and liver specimens for investigations of biochemical, oxidative stress, antioxidant, and histological parameters. Outcomes of the study exhibited that STZ persuades diabetes and hepatic impairments indicated by significant raised (p<0.05) in the levels of blood glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, (ALP), and malondialdehyde (MDA) with decreased catalase (CAT), superoxide dismutase (SOD), and glutathione reductase (GSH) enzymes activities. AV-AgNPs treatment reverted and reestablished the liver enzymes levels, antioxidant enzymes, and histological damages of the liver persuaded by STZ near to normal. In general, these results suggested that AV-AgNPs may have antioxidant potentials and proved to be hepatoprotective therefore, they could be used for the treatment of diabetic hepatopathy and other liver injuries.
Effect of Aloe Vera gel and Selenium on Cisplatin‐induced oxidative stress in Wister albino rats (LB155)
