scholarly journals Restorative Effects of Aloe Vera Gel on Alcohol Induced Hepato-Nephrocellular Dysfunction

2021 ◽  
Vol 65 (1) ◽  
pp. 1-8
Author(s):  
D. I. Akinloye ◽  
R. N. Ugbaja ◽  
O. A. Dosumu ◽  
A. J. Akamo ◽  
A. S. James ◽  
...  
Keyword(s):  
Aloe Vera ◽  
Albino Rats ◽  
Gamma Glutamyl Transferase ◽  
Distilled Water ◽  
Glutathione S Transferase ◽  
Aloe Vera Gel ◽  
Anti Oxidant ◽  
Excessive Alcohol ◽  
Group B ◽  
Glutamyl Transferase

Abstract Excessive alcohol intake is associated with pathological conditions that are detrimental. Aloe vera is a plant that possesses antimicrobial and anti-oxidant properties. This study investigated the effects of Aloe vera gel on alcohol induced hepato-nephrocellular dysfunction in rats using the specific activities of glutathione-S-transferase (GST), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT) and lactate dehydrogenase (LDH) as well as concentration of some electrolytes as indices. Six groups of male albino rats containing 5 rats each were used in the experiments. Groups A and B were administered distilled water and 50 % (v/v) alcohol for 21 days respectively. Groups C and D were administered 50 % (v/v) alcohol, while groups E and F were administered distilled water for the first 14 days, followed by co-administration (without stopping alcohol or distilled water administrations) of 125 mg and 250 mg.kg–1 body weight Aloe vera gel respectively for 7 days. The administration of Aloe vera gel extract significantly modulated serum electrolytes imbalances with concomitant lowering of ALT, AST, ALP, GGT, LDH and GST rates when compared to group B. These results suggested the restoration of alcohol induced dys-function by Aloe vera gel.

scholarly journals Protective potentials of ethyl acetate-ethanolic fraction of Carica papaya leaves against acetaminophen-induced liver damage in rats

2020 ◽  
Vol 12 (3) ◽  
pp. 556-567
Author(s):  
Hussein O. B. OLOYEDE ◽  
Halimat Y. LUKMAN ◽  
Musa O. SALAWU
Keyword(s):  
Ethyl Acetate ◽  
Liver Damage ◽  
Carica Papaya ◽  
Female Rats ◽  
Albino Rats ◽  
Gamma Glutamyl Transferase ◽  
Group A ◽  
Extract Fraction ◽  
Group B ◽  
Glutamyl Transferase

The liver is an important organ performing vital roles that become affected when damaged. The protective potential of ethyl acetate-ethanolic fraction of Carica papaya leaves on acetaminophen-induced liver damage in female albino rats was investigated. Forty female rats were completely randomized into eight groups (A-H) of five rats each. Group A (control), received 1 ml of distilled water, group B (untreated) received 250 mgkg-1  bw of acetaminophen, group C received  silymarin (50 mgkg-1 bw) followed by actaminophen (250 mgkg-1 bw),  groups D-G received 100, 200, 400 and 600 mgkg-1  bw of ethyl acetate-ethanolic fraction of Carica papaya leaves respectively; followed by acetaminophen administration (250 mgkg-1 bw), while group H (toxicity control) received 600 mgkg-1 bw extract fraction daily. Ethyl acetate-ethanolic fraction of Carica papaya leaves significantly (p<0.05) decreased the activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase and bilirubin concentration and increased the concentrations of total protein and albumin in acetaminophen-induced liver damaged rats when compared with the untreated group. Prevention of liver damage was observed in the groups pre-administered 400 and 600 mgkg-1 bw of the extract fraction as well as the silymarin group. Activities of superoxide dismutase and catalase and the concentration of glutathione were significantly (p<0.05) increased while the concentration of malondialdehyde was significantly (p<0.05) decreased in rats pre-administered with silymarin or the extract fraction when compared with the acetaminophen-induced rats. Ethyl acetate-ethanolic fraction of Carica papaya leaves prevented acetaminophen-induced rat liver damage probably mainly due to the antioxidant constituents of the fraction.

scholarly journals Effect of nanopolysaccharide (BSEPS) from Bacillus subtilis sp. on thioacetamide-induced liver fibrosis in rats

2019 ◽  
Vol 43 (1) ◽  
Author(s):  
Manal G. Mahmoud ◽  
Mohsen S. Asker ◽  
Mohamed E. El Awady ◽  
Amal I. Hassan ◽  
Nadia A. R. Zaharan ◽  
...  
Keyword(s):  
Bacillus Subtilis ◽  
Liver Fibrosis ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Periodate Oxidation ◽  
Hepatic Tissue ◽  
Albino Rats ◽  
Gamma Glutamyl Transferase ◽  
Glutamyl Transferase ◽  
Tgf Β1

Abstract Background Nanomedicine contributes to the efficiency of pharmacological treatments and progresses rapidly. The present study was designed to produce exopolysaccharide (BSEPS) from Bacillus subtilis sp. strain reported in our previous study was further characterized, and its BSEPS for synthesis of the nanoparticle Ag-BSEPS using microwave heating to determine the possible effects of a prepared solution containing Ag-BSEPS versus thioacetamide (TAA) evoked liver fibrosis in Wister albino rats. Nanoparticles with silver (Ag) core have been synthesized in an aqueous solution after exposure of BSEPS to periodate oxidation. Animals were split into four groups: I - control rats, water ad libitum for 6 weeks; II - rats were injected with TAA 200 mg/kg-1 3 times/week for 4 weeks IP; III - Ag-BSEPS 100 mg/kg-1 IP twice a week for 6 weeks; and IV - TAA, as group II followed by Ag-BSEPS as group III. The antifibrotic effects of Ag-BSEPS were appraised by determining different hepatotoxicity indices, oxidative stress, and inflammatory and liver fibrosis markers. Results Nanoparticles were obtained with a diameter size range of 50–100 nm characterized by SEM and TEM without using any harmful reagents. Results evinced considerably reduced activity of liver functions such as transaminases (AST, ALT), gamma-glutamyl transferase (GGT), and alkaline phosphatase (ALP) in the group which received TAA followed by Ag-BSEPS compared to the other group which received only TAA. In the current results, the administration of Ag-BSEPS showed an improvement in the proinflammatory cytokines. On the contrary, the antioxidant enzymes in liver homogenates revealed significant improvement (concentration of glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), and catalase (CAT) increases) in animals with TAA-induced liver damage followed by Ag-BSEPS. Moreover, the activities of the fibrotic markers transforming growth factor-beta 1(TGF-β1) and type III pro-collagen (PCIII) were increased in liver tissues in the group which was given TAA alone as compared to the controls. The percentage of fibrosis of hepatic tissue had a positive correlation with the levels of PCIII and TGF-β1, followed by Ag-BSEPS compared to the TAA group without nanocomposite treatment. Microscopic examinations revealed inhibitory effects of Ag-BSEPS on inflammatory changes and deterrent of liver fibrosis. Conclusion It was suggested that the biochemical and histological amelioration observed in Ag-BSEPS (100 mg/kg-1 twice a week for 6 weeks) treated the fibrotic rats.

scholarly journals Ameliorative Effects of Aloe Vera Gel Extract on Circulatory and Tissue Lipid Profile Status in Streptozotocin-Induced Diabetic Rats

2018 ◽  
Vol 9 (1) ◽  
pp. 11-26
Author(s):  
RN Ugbaja ◽  
DI Akinloye ◽  
AJ Akamo ◽  
EI Ugwor ◽  
OO IIesanmi ◽  
...  
Keyword(s):  
Aloe Vera ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Lipid Profiles ◽  
Albino Rats ◽  
Tissue Lipid ◽  
Rbc Membrane ◽  
Aloe Vera Gel ◽  
Lipid Parameters ◽  
Scientific Rationale

Diabetes is characterized by hyperglycaemia with alterations of lipid parameters. The effects of Aloe vera (A.V) gel extract on lipid profiles of streptozotocin-induced diabetic rats were investigated. Seventy-two male albino rats were randomly divided into six groups of 12 rats each; control, diabetic control, 4 ml/kg and 8 ml/kg body weight (b.w.) A.V, 10 mg/kg b.w. glibenclimide and non-diabetic 8 ml/kg b.w. A.V groups. They were treated for 14 and 28 days. The plasma and HDL lipid profiles (triacylglycerols, cholesterol and phospholipids) of the diabetic rats were significantly (p<0.05) increased, while those of the VLDL+LDL, RBC, RBC membrane and organs were observed to be significantly (p<0.05) reduced, when compared to the control after 14 and 28 days of treatment. A.V gel extract significantly (p<0.05) ameliorated the disruptions observed in the lipid profiles of the diabetic and thus provide a scientific rationale for the use of Aloe vera as a therapeutic agent.Bangladesh J Med Biochem 2016; 9(1): 11-26

STUDY ON EVALUATION OF SERUM GAMMA-GLUTAMYL TRANSFERASE (GGT) LEVELS IN ACUTE CORONARY SYNDROME

2021 ◽  
pp. 39-40
Author(s):  
Avtar Singh Dhanju ◽  
Deepshikha Singla ◽  
Pashaura Singh ◽  
Ajay Chhabra ◽  
Sukhraj Kaur
Keyword(s):  
Acute Coronary Syndrome ◽  
Cross Sectional Study ◽  
Gamma Glutamyl Transferase ◽  
Cross Sectional ◽  
Gamma Glutamyl ◽  
Coronary Syndrome ◽  
Healthy Control ◽  
Group A ◽  
Group B ◽  
Glutamyl Transferase

Aim: The present study was undertaken with the aim to evaluate serum Gamma Glutamyl Transferase (GGT) levels in patients of acute coronary syndrome. Methodology: This cross-sectional study was conducted on 50 cases with acute coronary syndrome (Group A) and 50 healthy control subjects (Group B) meeting inclusion and exclusion criteria. Results: There is signicant rise in serum GGT levels in patients presenting with ACS in Group A as compared to Group B. Conclusion: Higher levels of GGT in ACS patients with risk factors such as hypertension, dyslipidemia and smoking may serve as biomarker to predict the occurrence of ACS.

Aloe Vera: The Miracle Plant and its Therapeutic Uses

2017 ◽  
Vol 54 (4) ◽  
pp. 474
Author(s):  
Gurpreet Kaur
Keyword(s):  
Medicinal Plant ◽  
Human Body ◽  
Aloe Vera ◽  
Healing Touch ◽  
Therapeutic Uses ◽  
Aloe Vera Gel ◽  
Bactericidal Properties ◽  
Anti Oxidant ◽  
Sugar Levels ◽  
Insect Bites

Aloe vera is a wonder plant with health benefits so myriad and astounding that hardly any part of human body remains uninfluenced by its healing touch. It acts as a natural fighter against all sorts of infection, an efficient anti oxidant, helps in treating all digestion related problems, heartburn, arthritis, stress, diabetes, rheumatism pain, asthma, cancer and AIDS. It also acts as a laxative, beauty enhancer and it has an effect on lowering blood sugar levels in diabetics. Aloe vera is the oldest medicinal plant ever known and the most applied medicinal plant worldwide. Extracts of Aloe vera is a proven skin healer. Aloe vera help to soothe skin injuries affected by burning, skin irritations, cuts and insect bites and its bactericidal properties relieve itching and skin swellings. Aloe is a powerful detoxifier, antiseptic and tonic for the nervous system. It also has immune-boosting and anti-viral properties. Aloe vera is a useful source of vitamins. Aloe vera gel contains a large range of vitamins - even vitamin B12, Vitamin A, contains B-Group vitamins, Vitamin C, Vitamin E and folic acid. Aloe vera gel contains important ingredients including 19 of the 20 amino acids needed by the human body and seven of the eight essential ones that just cannot be made. Commercially, aloe can be found in pills, sprays, ointments, lotions, liquids, drinks, jellies and creams, to name a few of the thousands of products available.

scholarly journals PROTECTIVE ROLE AND ANTIOXIDANT ACTIVITY OF AQUEOUS EXTRACT OF ROSMARINUS OFFICINALIS AGAINST TRICHLOROACETATE-INDUCED TOXICITY IN LIVER OF MALE RATS

2018 ◽  
Vol 11 (6) ◽  
pp. 420
Author(s):  
Medhat Mostafa Abozid ◽  
Hoda Ea Farid
Keyword(s):  
Aqueous Extract ◽  
Liver Damage ◽  
Protective Role ◽  
Rosmarinus Officinalis ◽  
Male Rats ◽  
Control Group ◽  
Albino Rats ◽  
Gamma Glutamyl Transferase ◽  
Group I ◽  
Glutamyl Transferase

 Objective: The current study was designed to estimate the potential protective role of the aqueous extract of rosemary (AER) (Rosmarinus officinalis) against trichloroacetic acid (TCA)-created hepatotoxicity in male albino rats.Methods: Forty male albino rats were separated into four groups of ten: Group I served as control; Group II was given AER (200 mg/kg/day) by gavage; Group III received TCA at the dose 50 mg/kg/day, and Group V was treated with AER (200 mg/kg/day) and received TCA (50 mg/kg/day). The experiment was carried out for 2 months.Results: The toxicity of TCA for rats was revealed by an elevation in liver marker enzymes activities (gamma-glutamyl transferase [GGT], alkaline phosphatase [ALP], aspartate transaminase [AST], alanine aminotransferase [ALT]) and conjugated bilirubin (CB) level, and a decrease in albumin and total protein (TP) levels. The TCA administration also caused a significant increase in the activities of catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD), and also malondialdehyde (MDA) level in liver tissues. These biochemical effects were accompanied by histological indicators of liver damage. Treatment with ARE recovered the liver damage instigated by TCA, as showed by perfection of liver enzyme markers (GGT, ALT, AST, ALP), CB, TP and albumin; as well as antioxidant parameters (CAT, SOD, GPx) and lipid peroxidation (MDA) and amelioration of histopathology changes in the liver tissues.Conclusion: It could be concluded that AER supplementation for 2 months in TCA-induced toxicity in rats benefited hepatic antioxidant status and improved liver injury and damage in male albino rats exposed to TCA.

scholarly journals Study of High sensitive C - reactive protein and Gamma-glutamyl transferase in Type 2 Diabetes Mellitus with Hypertension

2020 ◽  
Vol 11 (3) ◽  
pp. 3478-3483
Author(s):  
Ramya S ◽  
Sureka Varalakshmi V ◽  
Uma Maheswari K ◽  
Chandan Bala R
Keyword(s):  
Diabetes Mellitus ◽  
Gamma Glutamyl Transferase ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Significant Difference ◽  
Group A ◽  
Hs Crp ◽  
Group B ◽  
Glutamyl Transferase

C-reactive protein (CRP), produced by the hepatocytes is a primary inflammatory marker of T2DM. Higher levels of gamma-glutamyl transferase enzyme (GGT) and Hs CRP (High sensitive CRP)are associated with the complication of poor glycemic control.This study was aimed to find the association of Hs CRP and GGT for cardiovascular risk factors in Type 2 diabetes mellitus (T2DM)and Hypertension in the suburbs of Chennai. This study includes 57 subjects with T2DM and Hypertension (Group A) and 62 subjects with T2DM (GroupB) within the age group of 40-60 years. FBS, HbA1C, Hs CRP, GGT and blood pressure were determined. Statistical analysis was performed using Statistical Package for the SPSS 17 version. Mean values of FBS, blood HbA1C, Hs CRP and GGT were significantly higher among participants of Group A than Group B. Significant difference of FBS, HbA1C were found between the two groups. In contrast, no significant difference of GGT was found between the groups. Differences were considered statistically significant at two-sided P < 0.05. Within the group, Hs CRP shows the significance and positive correlation with FBS, SBP and DBP. Still, GGT does not show any significance in Group A. In contrast, in Group B, both Hs CRP and GGT shows the importance and positive correlation with FBS and HbA1C.It is concluded that high levels of HsCRP are associated with T2DM and Hypertension, indicating increased cardiovascular risk, and it should be included in regular monitoring of type-2 diabetic patients.

scholarly journals Comparative Evaluation of Aloe vera and Diclofenac on Body Weight, Blood Pressure and Renal Function of Hypertensive Rats

2021 ◽  
Vol 35 (1) ◽  
pp. 39-44
Author(s):  
Nadeem Yaqoob
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Body Weight ◽  
Systolic Blood Pressure ◽  
Aloe Vera ◽  
Treated Group ◽  
Control Group ◽  
Hypertensive Rats ◽  
Aloe Vera Gel ◽  
Group B

Introduction: NSAIDs are known to cause salt and water retention leading to hypertension and renal impairment. Aloe vera gel has been used in medicinal preparations for decades. Limited data is available regarding effect of Aloe vera on renal function. There is a need to search this aspect of Aloe vera, to use it judiciously. Aims & Objectives: To estimate and compare the effects of Aloe vera and diclofenac on systolic blood pressure and renal functions of hypertensive rats. Place and duration of study: This study was conducted at Post Graduate Medical Institute Lahore, Sargodha Medical College, Sargodha and Department of Pharmacy, University of Sargodha for the period of three months. Material & Methods: Male Sprague Dawley rats (n=24) were divided into four groups; Group A (Normal control), Group B (Hypertensive control), Group C (Aloe vera treated) and Group D (Diclofenac treated). Hypertension was induced in groups B, C and D by 20% sucrose diet in 8 weeks. After induction of hypertension, distilled water, dried Aloe vera gel 400 mg/kg and diclofenac 12 mg/kg were given orally to group B, C and D respectively for 2 weeks as a single morning dose. Body weight and systolic blood pressure were measured weekly, while serum creatinine, creatinine clearance and urinary proteins were estimated and compared at 0, 8 and 10 weeks. Data was analyzed using SPSS 23 and p value of ?0.05 was considered significant. Results: Diclofenac decreased body weight of rats non-significantly and increased systolic blood pressure significantly (p< 0.03) whereas Aloe vera increased body weight significantly (p<0.012) and had no significant effect on systolic blood pressure. Diclofenac treated group showed deterioration of renal function as compared to Aloe vera treated group numerically. Conclusion: Aloe vera may be safer anti-inflammatory agent than diclofenac for treatment of chronic inflammatory conditions if the patient also has hypertension or renal disease.

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