scholarly journals Novel evidence for retinoic acid‐induced G (Rig‐G) as a tumor suppressor by activating p53 signaling pathway in lung cancer

2020 ◽  
Vol 34 (9) ◽  
pp. 11900-11912
Author(s):  
Junjun Sun ◽  
Xuan Wang ◽  
Wenfang Liu ◽  
Ping Ji ◽  
Anquan Shang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Retinoic Acid ◽  
Tumor Suppressor ◽  
Signaling Pathway ◽  
P53 Signaling ◽  
P53 Signaling Pathway

scholarly journals Paired box gene 5is a novel tumor suppressor in hepatocellular carcinoma through interaction with p53 signaling pathway

Hepatology ◽  
2011 ◽  
Vol 53 (3) ◽  
pp. 843-853 ◽  
Author(s):  
Weili Liu ◽  
Xiaoxing Li ◽  
Eagle S.H. Chu ◽  
Minnie Y.Y. Go ◽  
Lixia Xu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Suppressor ◽  
Signaling Pathway ◽  
P53 Signaling ◽  
P53 Signaling Pathway

scholarly journals Fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung cancer cells by the P53 signaling pathway

2015 ◽  
Vol 35 (1) ◽  
pp. 447-453 ◽  
Author(s):  
GUANGWEI ZHONG ◽  
XI CHEN ◽  
XIA FANG ◽  
DONGSHENG WANG ◽  
MINGXUAN XIE ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Lung Cancer Cells ◽  
P53 Signaling ◽  
Cancer Tissues ◽  
P53 Signaling Pathway

scholarly journals TC2N, a novel oncogene, accelerates tumor progression by suppressing p53 signaling pathway in lung cancer

2018 ◽  
Vol 26 (7) ◽  
pp. 1235-1250 ◽  
Author(s):  
Xiang-lin Hao ◽  
Fei Han ◽  
Ning Zhang ◽  
Hong-qiang Chen ◽  
Xiao Jiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Progression ◽  
Signaling Pathway ◽  
P53 Signaling ◽  
P53 Signaling Pathway

scholarly journals Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-20
Author(s):  
Zi-hang Xu ◽  
Yang-zhuangzhuang Zhu ◽  
Lin Su ◽  
Xue-yang Tang ◽  
Chao Yao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Signaling Pathway ◽  
Caspase 3 ◽  
Suppressor Cell ◽  
Inhibitory Effect ◽  
Luminescence Signal ◽  
P53 Signaling ◽  
Myeloid Derived Suppressor Cell ◽  
Lung Cancer Model ◽  
P53 Signaling Pathway

Non-small-cell lung cancer (NSCLC) remains the most common malignancy with the highest morbidity and mortality worldwide. In our previous study, we found that a classic traditional Chinese medicine (TCM) formula Ze-Qi-Tang (ZQT), which has been used in the treatment of respiratory diseases for thousands of years, could directly inhibit the growth of human NSCLC cells via the p53 signaling pathway. In this study, we explored the immunomodulatory functions of ZQT. We found that ZQT significantly prolonged the survival of orthotopic lung cancer model mice by modulating the tumor microenvironment (TME). ZQT remarkably reduced the number of MDSCs (especially G-MDSCs) and inhibited their immunosuppressive activity by inducing apoptosis in these cells via the STAT3/S100A9/Bcl-2/caspase-3 signaling pathway. When G-MDSCs were depleted, the survival promotion effect of ZQT and its inhibitory effect on lung luminescence signal disappeared in tumor-bearing mice. This is the first study to illustrate the immunomodulatory effect of ZQT in NSCLC and the underlying molecular mechanism.

scholarly journals HAX1 enhances the survival and metastasis of non‐small cell lung cancer through the AKT / mTOR and MDM2 /p53 signaling pathway

2020 ◽  
Vol 11 (11) ◽  
pp. 3155-3167
Author(s):  
Zhigang Liang ◽  
Yuan Zhong ◽  
Lifei Meng ◽  
Yi Chen ◽  
Yahui Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Signaling Pathway ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
P53 Signaling ◽  
P53 Signaling Pathway
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