SUBMAXIMAL OXYGEN PULSE DIVIDED BY BODY WEIGHT DURING INCREMENTAL EXERCISE TEST1

Background: Obesity is associated with insulin resistance (IR). Through exercise insulin resistant obese patients can effectively improve their cardiorespiratory fitness (CRF). The effect of exercise on patients CRF can be determined by oxygen pulse (PO2) analysis. Despite its usefulness, there is limited literature on PO2 analysis in patients with obesity and insulin resistance. Objective: The goal of the present study is to evaluate the relation between PO2 and IR in sedentary obese women. Methods: 55 women were submitted to a maximal exercise test for evaluation of maximal oxygen consumption and PO2. The subjects with a Homeostatic model assessment of IR index greater or equal to 2.5 were considered as insulin-resistant. Participants were divided into 2 groups, IR group (n=35) and Non-IR group (n=20). Results: IR group had lower values of PO2 relative to body weight (11.0±1.7 versus 12.6±1.4 ml∙kg∙beats-1, p=0.001) and relative to lean mass (21.7±2.9 versus 23.2±2.8 ml∙kg∙beats-1, p=0.038) than Non- IR group. No statistical differences were found in maximal oxygen consumption between groups (Non IR=1.53±0.27 L∙min-1, IR=1.51±0.28 L∙min-1; p=0.386). PO2 relative to body weight and HOMA-IR was inversely correlated (p<0.001; r=-0.465). Logistic regression analysis showed an association between PO2 relative to weight (p=0.001, OR=0.47) and fat free mass (p=0.01, OR=0.73), both models adjusted by age. Conclusions: This study demonstrates a relation between HOMA-IR and PO2. Our results suggest that PO2 could be a protective factor against insulin resistance.

Download Full-text

Patterns of Oxygen Pulse Response to Incremental Exercise in Patients with Chronic Obstructive Pulmonary Disease – An Observational Study

10.1183/1393003.congress-2017.pa2236 ◽

2017 ◽

Author(s):

Ming-Lung Chuang ◽

I-Feng Lin

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Observational Study ◽

Pulmonary Disease ◽

Pulse Response ◽

Incremental Exercise ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Oxygen Pulse

Download Full-text

The Morphology of Vacuolated Cells in the Liver Following Administration of Vitamin A.

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100072484 ◽

1973 ◽

Vol 31 ◽

pp. 408-409

Author(s):

Odell T. Minick ◽

Hidejiro Yokoo ◽

Fawzia Batti

Keyword(s):

Electron Microscopy ◽

Body Weight ◽

Vitamin A ◽

Light And Electron Microscopy ◽

Liver Cells ◽

Prominent Feature ◽

Vascular Space ◽

Vacuolated Cell ◽

Vacuolated Cells ◽

Vacuolated Cytoplasm

Vacuolated cells in the liver of young rats were studied by light and electron microscopy following the administration of vitamin A (200 units per gram of body weight). Their characteristics were compared with similar cells found in untreated animals.In rats given vitamin A, cells with vacuolated cytoplasm were a prominent feature. These cells were found mostly in a perisinusoidal location, although some appeared to be in between liver cells (Fig. 1). Electron microscopy confirmed their location in Disse's space adjacent to the sinusoid and in recesses between liver cells. Some appeared to be bordering the lumen of the sinusoid, but careful observation usually revealed a tenuous endothelial process separating the vacuolated cell from the vascular space. In appropriate sections, fenestrations in the thin endothelial processes were noted (Fig. 2, arrow).

Download Full-text

Nucleolar Segregation and Chronic Methanol Intoxication

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100063718 ◽

1969 ◽

Vol 27 ◽

pp. 360-361

Author(s):

Julio H. Garcia ◽

Janice P. Van Zandt

Keyword(s):

Body Weight ◽

Methyl Alcohol ◽

Rhesus Monkeys ◽

Repeated Administration ◽

Serum Levels ◽

Methanol Intoxication ◽

Intragastric Tube ◽

Nucleolar Segregation

Repeated administration of methyl alcohol to Rhesus monkeys (Maccaca mulata) by intragastric tube resulted in ultrastructural abnormalities of hepatocytes, which persisted in one animal twelve weeks after discontinuation of the methyl alcohol regime. With dosages ranging between 3.0 to 6.0 gms. of methanol per kg. of body weight, the serum levels attained within a few hours averaged approximately 475 mg. per cent.

Download Full-text

Electron microscopic radioautographic studies on the incorporation of 3H proline in the glomerular basement membrane (GBM) in antistreptococcal-cell-membrane (SCM) injected mice

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100111057 ◽

1984 ◽

Vol 42 ◽

pp. 188-189

Author(s):

R.P. Nayyar ◽

C.F. Lange ◽

J. L. Borke

Keyword(s):

Body Weight ◽

Cell Membrane ◽

Basement Membrane ◽

Glomerular Basement Membrane ◽

Mesangial Matrix ◽

Electron Microscopic ◽

Group A ◽

Injection Protocol

Streptococcal cell membrane (SCM) antiserum injected mice show a significant thickening of glomerular basement membrane (GBM) and an increase in mesangial matrix within 4 to 24 hours of antiserum administration (1,2,3). This study was undertaken to evaluate the incorporation of 3H proline into glomerular cells and GBM under normal and anti-SCM induced conditions. Mice were administered, intraperitoneally, 0.1 ml of normal or anti-SCM serum followed by a 10 µC/g body weight injection of 3H proline. Details of the preparation of anti-SCM (Group A type 12 streptococcal pyogenes) and other sera and injection protocol have been described elsewhere (2). After 15 minutes of isotope injection a chase of cold proline was given and animal sacrificed at 20 minutes, 1,2,4,8,24 and 48 hours. One of the removed kidneys was processed for immunofluorescence, light and electron microscopic radioautographic studies; second kidney was used for GBM isolation and aminoacid analysis.

Download Full-text

Correlated changes in fertility and fitness traits in lines of oMt1a-oGH transgenic mice selected for increased 8-week body weight *

Journal of Animal Breeding and Genetics ◽

10.1046/j.1439-0388.2000.00208.x ◽

2000 ◽

Vol 117 (2) ◽

pp. 83-95 ◽

Cited By ~ 1

Author(s):

F. Siewerdt ◽

E. J. Eisen ◽

J. D. Murray

Keyword(s):

Body Weight ◽

Transgenic Mice ◽

Fitness Traits

Download Full-text

How to Maintain a Healthy Body Weight

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.76.4.208 ◽

2006 ◽

Vol 76 (4) ◽

pp. 208-215 ◽

Cited By ~ 10

Author(s):

Astrup

Keyword(s):

Physical Activity ◽

Type 2 Diabetes ◽

Weight Loss ◽

Body Weight ◽

Glycemic Index ◽

Dairy Products ◽

Weight Control ◽

Healthy Body Weight ◽

Healthy Body

The epidemic of both obesity and type 2 diabetes is due to environmental factors, but the individuals developing the conditions possess a strong genetic predisposition. Observational surveys and intervention studies have shown that excess body fatness is the major environmental cause of type 2 diabetes, and that even a minor weight loss can prevent its development in high-risk subjects. Maintenance of a healthy body weight in susceptible individuals requires 45–60 minutes physical activity daily, a fat-reduced diet with plenty of fruit, vegetables, whole grain, and lean meat and dairy products, and moderate consumption of calorie containing beverages. The use of table values to predict the glycemic index of meals is of little – if any – value, and the role of a low-glycemic index diet for body weight control is controversial. The replacement of starchy carbohydrates with protein from lean meat and lean dairy products enhances satiety, and facilitate weight control. It is possible that dairy calcium also promotes weight loss, although the mechanism of action remains unclear. A weight loss of 5–10% can be induced in almost all obese patients providing treatment is offered by a professional team consisting of a physician and dieticians or nurses trained to focus on weight loss and maintenance. Whereas increasing daily physical activity and regular exercise does not significantly effect the rate of weight loss in the induction phase, it plays an important role in the weight maintenance phase due to an impact on daily energy expenditure and also to a direct enhancement of insulin sensitivity.

Download Full-text

L-Ascorbic Acid Addition to Chitosan Reduces Body Weight in Overweight Women

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000187 ◽

2014 ◽

Vol 84 (1-2) ◽

pp. 5-11 ◽

Cited By ~ 1

Author(s):

Eun Y. Jung ◽

Sung C. Jun ◽

Un J. Chang ◽

Hyung J. Suh

Keyword(s):

Ascorbic Acid ◽

Body Weight ◽

Fat Body ◽

Body Weight Gain ◽

Skinfold Thickness ◽

The Body ◽

Control Group ◽

Percentage Body Fat ◽

Overweight Women ◽

Body Weights

Previously, we have found that the addition of L-ascorbic acid to chitosan enhanced the reduction in body weight gain in guinea pigs fed a high-fat diet. We hypothesized that the addition of L-ascorbic acid to chitosan would accelerate the reduction of body weight in humans, similar to the animal model. Overweight subjects administered chitosan with or without L-ascorbic acid for 8 weeks, were assigned to three groups: Control group (N = 26, placebo, vehicle only), Chito group (N = 27, 3 g/day chitosan), and Chito-vita group (N = 27, 3 g/day chitosan plus 2 g/day L-ascorbic acid). The body weights and body mass index (BMI) of the Chito and Chito-vita groups decreased significantly (p < 0.05) compared to the Control group. The BMI of the Chito-vita group decreased significantly compared to the Chito group (Chito: -1.0 kg/m2 vs. Chito-vita: -1.6 kg/m2, p < 0.05). The results showed that the chitosan enhanced reduction of body weight and BMI was accentuated by the addition of L-ascorbic acid. The fat mass, percentage body fat, body circumference, and skinfold thickness in the Chito and Chito-vita groups decreased more than the Control group; however, these parameters were not significantly different between the three groups. Chitosan combined with L-ascorbic acid may be useful for controlling body weight.

Download Full-text