Diagnosis and Treatment Efficacy of Functional Non-Retentive Fecal Soiling in Childhood

2001 ◽  
Vol 32 ◽  
pp. S42-S43 ◽  
Author(s):  
M. A. Benninga ◽  
J. A.J.M. Taminiau
Keyword(s):  
Treatment Efficacy ◽  
Diagnosis And Treatment ◽  
Fecal Soiling

scholarly journals Exploiting Clonal Evolution to Improve the Diagnosis and Treatment Efficacy Prediction in Pediatric AML

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1995
Author(s):  
Salvatore Nicola Bertuccio ◽  
Laura Anselmi ◽  
Riccardo Masetti ◽  
Annalisa Lonetti ◽  
Sara Cerasi ◽  
...  
Keyword(s):  
Treatment Efficacy ◽  
Clonal Evolution ◽  
Poor Response ◽  
Point Of View ◽  
Diagnosis And Treatment ◽  
Preclinical Model ◽  
Therapeutic Protocols ◽  
Pediatric Aml ◽  
Patients Experience ◽  
Efficacy Prediction

Despite improvements in therapeutic protocols and in risk stratification, acute myeloid leukemia (AML) remains the leading cause of childhood leukemic mortality. Indeed, the overall survival accounts for ~70% but still ~30% of pediatric patients experience relapse, with poor response to conventional chemotherapy. Thus, there is an urgent need to improve diagnosis and treatment efficacy prediction in the context of this disease. Nowadays, in the era of high throughput techniques, AML has emerged as an extremely heterogeneous disease from a genetic point of view. Different subclones characterized by specific molecular profiles display different degrees of susceptibility to conventional treatments. In this review, we describe in detail this genetic heterogeneity of pediatric AML and how it is linked to relapse in terms of clonal evolution. We highlight some innovative tools to characterize minor subclones that could help to enhance diagnosis and a preclinical model suitable for drugs screening. The final ambition of research is represented by targeted therapy, which could improve the prognosis of pediatric AML patients, as well as to limit the side toxicity of current treatments.

The Application of Forensic Podiatry to Clinical Practice

2020 ◽  
Vol 110 (2) ◽  
Author(s):  
Michael S. Nirenberg ◽  
Jai Saxelby ◽  
Rachel Vernon ◽  
Wesley Vernon
Keyword(s):  
Clinical Practice ◽  
Criminal Justice ◽  
Criminal Justice System ◽  
Treatment Efficacy ◽  
Justice System ◽  
Research Process ◽  
Clinical Treatment ◽  
Diagnosis And Treatment ◽  
Foot And Ankle ◽  
Forensic Podiatry

The practice of the clinical podiatrist traditionally focuses on the diagnosis and treatment of conditions of the foot, ankle, and related structures of the leg. Clinical podiatrists are expected to be mindful of “the principles and applications of scientific enquiry.” This includes the evaluation of treatment efficacy and the research process. In contrast, the forensic podiatrist specializes in the analysis of foot-, ankle-, and gait-related evidence in the context of the criminal justice system. Although forensic podiatry is a separate, specialized field, many aspects of this discipline can be useful in the clinical treatment and management of foot and ankle problems. The authors, who are forensic podiatrists, contend that the clinical podiatrist can gain significant insights from the field of forensic podiatry. This article aims to provide clinical podiatrists with an overview of the principles and methods that have been tested and applied by forensic podiatrists in their practice, and suggests that the clinical practice of the nonforensic foot practitioner may benefit from such knowledge.

scholarly journals Automated determination of neutrophil VCS parameters in diagnosis and treatment efficacy of neonatal sepsis

2011 ◽  
Vol 71 (1) ◽  
pp. 121-125 ◽  
Author(s):  
Istemi H. Celik ◽  
Gamze Demirel ◽  
Hatice T. Aksoy ◽  
Omer Erdeve ◽  
Ece Tuncer ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Treatment Efficacy ◽  
Diagnosis And Treatment ◽  
Automated Determination

scholarly journals Predictive value of cerebrospinal fluid lactate for the diagnosis and treatment efficacy of post-neurosurgery bacterial meningitis

2019 ◽  
Author(s):  
Yufang Wang ◽  
Jingchao Li ◽  
Mingli Yao ◽  
Lingyan Wang ◽  
Bin Ouyang
Keyword(s):  
Cerebrospinal Fluid ◽  
Linear Regression ◽  
Bacterial Meningitis ◽  
Roc Curve ◽  
Predictive Value ◽  
Treatment Efficacy ◽  
Curve Analysis ◽  
Diagnosis And Treatment ◽  
Roc Curve Analysis ◽  
Csf Lactate

Abstract Background: Post-neurosurgical bacterial meningitis (PNBM) is a severe complication with high morbidity and mortality. Rapid and accurate diagnosis of PNBM is difficult. Therefore, it is necessary to find more reliable markers to assist the diagnosis. This study aims to evaluate the predictive value of cerebrospinal fluid (CSF) lactate for PNBM diagnosis and treatment efficacy.Methods: Total 105 cases were enrolled in patients with clinically suspected PNBM who underwent neurosurgeries during October 2015 to December 2016. CSF lactate as well as CSF routine and biochemistry test was measured. Receivers operating characteristic (ROC) curve analysis was used to evaluate the diagnostie power of CSF lactate for PNBM. To assess the predictive value of CSF lactate for treatment efficacy, a linear regression was used and tendency diagrams of CSF lactate and glucose for each patient were drawn.Results: Fifty-four of 105 patients were diagnosed with PNBM. CSF lactate level was significantly higher in PNBM than in non-PNBM patients (p < 0.001). The ROC curve analysis showed a great diagnostic power of CSF lactate for PNBM, and the cut-off value was 4.15 mmol/L (AUC = 0.92, sensitivity, 92.6%; specificity, 74.5%). The combination of CSF lactate and glucose showed better diagnostic efficacy (AUC = 0.97, sensitivity, 94.4%; specificity, 90.2%). The linear regression showed thatΔCSF lactate inversely correlated with ΔCSF glucose and directly correlated with ΔCSF leucocyte (both p < 0.001). The tendency diagrams showed CSF lactate a better predictor for PNBM treatment efficacy than CSF glucose.Conclusion: Our study showed CSF lactate had an excellent discriminatory power in distinguishing between PNBM and non-PNBM. The combination of CSF lactate and glucose had a better diagnostic accuracy than other CSF parameters alone. CSF lactate was a reliable predictor of treatment efficacy in PNBM patients.

scholarly journals Estimating the health benefits of timely diagnosis and treatment of transthyretin amyloid cardiomyopathy

2021 ◽  
Author(s):  
Mark H Rozenbaum ◽  
Samuel Large ◽  
Rahul Bhambri ◽  
Michelle Stewart ◽  
Robert Young ◽  
...  
Keyword(s):  
Treatment Efficacy ◽  
Diagnostic Delay ◽  
Health Benefits ◽  
Delayed Diagnosis ◽  
Diagnosis And Treatment ◽  
Wild Type ◽  
Timely Diagnosis ◽  
Amyloid Cardiomyopathy ◽  
Missed Opportunity

Aim: Delayed diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) represents a missed opportunity for intervention. This study estimates the health benefits of timely diagnosis and treatment with tafamidis. Methods: A disease simulation model was developed to predict health outcomes under scenarios of timely and delayed diagnosis and treatment. Efficacy and quality of life (QoL) profiles were derived from the pivotal tafamidis trial and diagnostic delay durations from the literature. Results: Timely diagnosis and treatment were predicted to extend mean life expectancy by 5.46 and 7.76 years, relative to delayed diagnosis, for wild-type and hereditary ATTR-CM, respectively. Corresponding QALY gains were 4.50 and 6.22. Conclusion: Timely diagnosis and treatment with tafamidis are predicted to significantly improve survival and QoL for ATTR-CM patients.

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