The Role of Splanchnic Glucose Output in Determining Glycemic Responses After Mixed Meal in Type II Diabetic Patients and Normal Subjects

Pancreas ◽  
1987 ◽  
Vol 2 (4) ◽  
pp. 386-392 ◽  
Author(s):  
Kwame Osei
Keyword(s):  
Normal Subjects ◽  
Diabetic Patients ◽  
Type Ii ◽  
Mixed Meal ◽  
Glucose Output

Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics

Diabetes ◽  
1987 ◽  
Vol 36 (3) ◽  
pp. 274-283 ◽  
Author(s):  
A. D. Baron ◽  
L. Schaeffer ◽  
P. Shragg ◽  
O. G. Kolterman
Keyword(s):  
Type Ii ◽  
Hepatic Glucose Output ◽  
Hepatic Glucose ◽  
Type Ii Diabetics ◽  
Glucose Output

Haemoglobin and flow-mediated vasodilation

2006 ◽  
Vol 110 (4) ◽  
pp. 467-473 ◽  
Author(s):  
Per Lav Madsen ◽  
Michaela Scheuermann Freestone ◽  
Stefan Neubauer ◽  
Keith Channon ◽  
Kieran Clarke
Keyword(s):  
Radial Artery ◽  
Vascular Endothelium ◽  
Type Ii Diabetes ◽  
Normal Subjects ◽  
Diabetic Patients ◽  
Type Ii ◽  
Peripheral Vasodilation ◽  
Hb Concentration ◽  
Flow Mediated Vasodilation ◽  
The Relationship

A low [Hb] (Hb concentration) is out-balanced by peripheral vasodilation via mechanisms that are incompletely understood. Peripheral vasodilation is influenced by NO (nitric oxide) released from vascular endothelium in response to increased vessel wall shear stress, and absorption by Hb is the main mechanism by which the bioactivity of NO is disarmed. Thus we propose that graded NO absorption is the mechanism through which a low [Hb] is related to peripheral vasodilation. In the present study, we examined the relationship between [Hb] and FMD (flow-mediated vasodilation; 5 min of cuff ischaemia) of the radial and brachial arteries in 33 normal subjects and in 13 patients with Type II diabetes, known to have impaired NO-mediated vasodilation. The smaller radial artery provided the more sensitive test, as it had a 2-fold larger FMD than the brachial artery (22±18% compared with 9±18% respectively, in normal subjects; means±S.D., P<0.05). FMD of the radial artery had a negative correlation with [Hb] (r2=−0.66, P<0.05; n=27). In subjects with [Hb] below and above the median of 14.1 g/dl, the radial artery FMD was 30±22% compared with 13±12% respectively (P<0.05). In diabetic patients, FMD was lower and a co-variation with [Hb] could not be established. Thus, in normal subjects, NO-mediated endothelium-related vasodilation at least partly out-balanced the ‘added burden’ of a low [Hb] during post-ischaemic reperfusion.

The Effects of Ramadan Fasting on Certain Biochemical Parameters in Normal Subjects and in Type II Diabetic Patients

1994 ◽  
Vol 14 (2) ◽  
pp. 139-141 ◽  
Author(s):  
Abdel Fattah A. Al-Hader ◽  
Niazy A. Abu-Farsakh ◽  
Said Y. Khatib ◽  
Zuheir A. Hasan
Keyword(s):  
Biochemical Parameters ◽  
Normal Subjects ◽  
Diabetic Patients ◽  
Type Ii ◽  
Ramadan Fasting

scholarly journals A PROSPECTIVE STUDY ON ROLE OF VITAMIN E SUPPLEMENTATION IN TYPE 2 DIABETES MELLITUS

2018 ◽  
Vol 11 ◽  
Author(s):  
Pavithra D ◽  
Praveen D ◽  
Vijey Aanandhi M
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin E ◽  
Blood Sugar ◽  
Test Group ◽  
Hypoglycemic Agents ◽  
Control Group ◽  
Diabetic Patients ◽  
Type Ii ◽  
Vitamin E Supplementation

Aim and Objective: The aim of the study was to evaluate the role of Vitamin E supplementation in Type II diabetes mellitus (DM), to determines whether people with Type II DM treated with hypoglycemic agents alone, with or without Vitamin E, to determines the drug interaction in such treatment regimen, and to evaluates the Safety of the regimen.Methods: Type II DM patients with or without complications were included in this study along with serum glycated hemoglobin (HbA1c) concentration between 7.5% and 9.5%. They are divided into test group (which received hypoglycemic agent along with Vitamin E 4000 IU) and control group. Body mass index (BMI) status, fasting blood sugar (FBS), and post-prandial blood sugar (PPBS) were noted once in a month, HbA1c percentage, total cholesterol level (TC), and serum Vitamin E level were estimated and noted for every 3 months at total 9 months of this study. Patients with other comorbid conditions were prominent in this study.Results: It is perceptible with the analysis of obtained data that FBS, PPBS, HbA1c percentage, TC level, and BMI status of the patients were declined gradually in test group (patients with Vitamin E supplementation along with their hypoglycemic agents). Thus, antioxidant therapy is highly propitious whereby delaying the onset of complications in patients with DM. This development would be highly helpful for diabetic patients.

scholarly journals Investigating the Factors Affecting the Self-care Behaviors Status of Patients With Type II Diabetes and the Role of Demographic Variables: a Case Study in Iran

2021 ◽  
Author(s):  
Neda Kianipour ◽  
Fakhrodin Chaboksavar ◽  
Mehrali Rahimi ◽  
Javad Yoosefi Lebni ◽  
Jaffar Abbas ◽  
...  
Keyword(s):  
Type Ii Diabetes ◽  
Smoking Status ◽  
Self Care ◽  
Demographic Variables ◽  
Diabetic Patients ◽  
Type Ii ◽  
Factors Affecting ◽  
Glucose Testing ◽  
Blood Glucose Testing

Abstract Background: Self-care practices in diabetes patients are crucial to keep the illness under control and prevent complications. Effective management of diabetes will be a difficult task without an adequate understanding of the current level of practice related to diabetes self-care. Therefore, this study aims to assess the factors affecting the self-care behaviors status of patients with Type II diabetes and the role of demographic variables in Iran. Methods: The present study is a descriptive-analytical study that was designed and conducted in 2020. This study's statistical population was type II diabetic patients at the Diabetes Research Center of Ayatollah Taleghani Hospital in Kermanshah who were selected by available sampling method of 280 samples. Data collection tools included demographic characteristics questionnaire and standard self-care questionnaire for the Glasgow and Tobert diabetic patients. Data were analyzed using SPSS-23 software, independent t-tests, one-way analysis of variance, and stepwise regression.Results: The mean of self-care scores was 2.07±2.08 and indicated an unfavorable condition. The highest mean scores of self-care were in the field of regular use of medications, and the lowest scores were in the field of blood-glucose testing. The mean scores of self-care were significantly different based on marital status, occupation status, residence, type of treatment, duration of diabetes, years, smoking status (P<0.05). Regression results showed that the variables predictors; type of treatment, smoking status, the complication of diabetes, education level status, place of residence explained 515% of the variance of self-care.Conclusion: The study showed that the extent to which individuals adhere to Type II diabetes recommended management is substantially low. Improving awareness of patients and the community at large is imperative, especially on the diet, exercise, blood-glucose testing, foot care, and no smoking.

Protein C Deficiency in Insulin-Dependent Diabetes: A Hyperglycemia-Related Phenomenon

1990 ◽  
Vol 64 (01) ◽  
pp. 104-107 ◽  
Author(s):  
Antonio Ceriello ◽  
Antonio Quatraro ◽  
Patrizia Dello Russo ◽  
Egidio Marchi ◽  
Miriam Barbanti ◽  
...  
Keyword(s):  
Protein C ◽  
Insulin Infusion ◽  
Inverse Correlation ◽  
Normal Subjects ◽  
Diabetic Patients ◽  
Related Phenomenon ◽  
Protein C Deficiency ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

SummaryIn 30 insulin-dependent diabetic patients protein C (PC) antigen and PC activity were significantly lower than those of matched control healthy subjects. An inverse correlation between fasting plasma glucose and both PC concentration and activity was present in diabetics, while a direct correlation between PC concentration and PC activity was observed. Induced hyperglycemia in diabetic and normal subjects was able to decrease both PC antigen levels and PC activity, and heparin reversed in part this effect.In diabetic patients euglycemia obtained by insulin infusion restored to normal the depressed PC levels. Heparin did not alter both the basal PC concentration and activity in healthy controls.These data stress the major role of hyperglycemia in determining PC decrease in diabetics, and suggest that PC reduction is probably associated to hyperglycemia-enhanced thrombin formation.

scholarly journals Effect of Caffeine on Plasma Glucose and Insulin Response to Mixed Meal Tolerance Test in Type II Diabetes

2012 ◽  
Vol 22 (2) ◽  
pp. 73-74
Author(s):  
Abu Saleh Md. Moosa ◽  
Shahina Akther
Keyword(s):  
Plasma Glucose ◽  
Type Ii Diabetes ◽  
Insulin Response ◽  
Tolerance Test ◽  
Caffeine Intake ◽  
Diabetic Patients ◽  
Type Ii ◽  
Mixed Meal ◽  
Meal Tolerance Test ◽  
Mixed Meal Tolerance Test

Caffeine containing beverages is widely used and popular world-wide. Studies showed that caffeine acutely decreased insulin sensitivity in young, non-diabetic adults.3-5 This double-blind study was carried out with habitual coffee drinkers who had at least a 6-months history of type II diabetes. The effects of caffeine on fasting glucose & insulin levels and on glucose & insulin response to a mixed-meal tolerance test were studied. The total daily caffeine intake was 375 mg in a divided schedule. Overnight fast and caffeine abstinence baseline fasting blood samples were drawn then after administration of caffeine (250 mg/day) or placebo they consumed a commercial meal that contained 75 gram of carbohydrate for mixed-meal tolerance test. Comparisons of the AUC2h values demonstrated significant caffeine effects for both plasma glucose and plasma insulin (P < 0.05) responses to the mixed-meal tolerance test. Caffeine did not affect the fasting levels of plasma glucose or insulin when compared with placebo. It may be concluded that acute administration of caffeine plus carbohydrate impaired post-prandial glucose metabolism and insulin responses. Such effects could have implication for the management of type II diabetic patients. Medicine Today 2010 Volume 22 Number 02 Page 73-74 DOI: http://dx.doi.org/10.3329/medtoday.v22i2.12437

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